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Employment (2)

University of Oxford: Oxford, Oxfordshire, GB

2021-11-01 to present | Senior Molecular Epidemiologist (Cancer Epidemiology Unit)
Employment
Source: Self-asserted source
Karl Smith-Byrne

International Agency For Research On Cancer: Lyon, FR

2017-11-01 to 2021-10-31 | Postdoctoral Fellow (Genomic Epidemiology)
Employment
Source: Self-asserted source
Karl Smith-Byrne

Education and qualifications (2)

University of Oxford: Oxford, Oxfordshire, GB

2014-10-01 to 2017-07-01 | DPhil (Nuffield Department of Population Health)
Education
Source: Self-asserted source
Karl Smith-Byrne

University of Cambridge: Cambridge, Cambridgeshire, GB

2013-10-01 to 2014-05-01 | MPhil (Biological Anthropology)
Education
Source: Self-asserted source
Karl Smith-Byrne

Works (50 of 54)

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Page 1 of 2

Reproducibility and associated regression dilution bias of accelerometer-derived physical activity and sleep in the UK Biobank

2025-01-17 | Preprint
DOI: 10.1101/2025.01.16.25320679
Contributors: Charilaos Zisou; Hannah Taylor; Ben Lacey; Imen Hammami; Rosemary Walmsley; Tessa Strain; Katrien Wijndaele; Karl Smith-Byrne; Derrick Bennett; Sarah Lewington et al.
Source: check_circle
Crossref

Prospective and genetic analyses implicate lower immunosurveillance in the aetiology of prostate cancer

2025-01-13 | Preprint
DOI: 10.21203/rs.3.rs-5684986/v1
Contributors: Karl Smith-Byrne; Mahboubeh Parsaeian; Wing Ching Chan; Joshua Atkins; Keren Papier; Trishna Desai; Zhe Huang; David Conti; David Bogumil; Jiayi Shen et al.
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Crossref

Diet-wide analyses for risk of colorectal cancer: prospective study of 12,251 incident cases among 542,778 women in the UK

Nature Communications
2025-01-08 | Journal article
DOI: 10.1038/s41467-024-55219-5
Contributors: Keren Papier; Kathryn E. Bradbury; Angela Balkwill; Isobel Barnes; Karl Smith-Byrne; Marc J. Gunter; Sonja I. Berndt; Loic Le Marchand; Anna H. Wu; Ulrike Peters et al.
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Crossref

A protocol for using human genetic data to identify circulating protein level changes that are the causal consequence of cancer processes

2024-10-18 | Preprint
DOI: 10.1101/2024.10.18.24315725
Contributors: Lisa M Hobson; Richard M Martin; Karl Smith-Byrne; George Davey Smith; Gibran Hemani; Joseph H Gilbody; James Yarmolinsky; Sarah ER Bailey; Lucy J. Goudswaard; Philip C Haycock
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Crossref

Data from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.c.6908277
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary Figure 1 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211697
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary Figure 2 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211694
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary Figure 3 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211691
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary Figure 4 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211688
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary Figure 5 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211685
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary File 1 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211682
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary Table S1 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211679
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Supplementary Table S2 from Kidney Function and Risk of Renal Cell Carcinoma

2024-10-11 | Preprint
DOI: 10.1158/1055-9965.27211676
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

Diet-wide analyses for risk of colorectal cancer: prospective study of 12,250 incident cases among 543,000 women in the UK

2024-06-13 | Preprint
DOI: 10.1101/2024.06.12.24308822
Contributors: Keren Papier; Kathryn E Bradbury; Angela Balkwill; Isobel Barnes; Karl Smith-Byrne; Marc J. Gunter; Sonja I Berndt; Loic Le Marchand; Anna H Wu; Ulrike Peters et al.
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Crossref

Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers

Nature Communications
2024-04-29 | Journal article
DOI: 10.1038/s41467-024-46834-3
Contributors: Karl Smith-Byrne; Åsa Hedman; Marios Dimitriou; Trishna Desai; Alexandr V. Sokolov; Helgi B. Schioth; Mine Koprulu; Maik Pietzner; Claudia Langenberg; Joshua Atkins et al.
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Crossref

A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator

2024-02-13 | Preprint
DOI: 10.1101/2024.02.12.24302712
Contributors: Matthew A Lee; Charlie A Hatcher; Emma Hazelwood; Lucy J Goudswaard; Konstantinos K Tsilidis; Emma E Vincent; Richard M Martin; Karl Smith-Byrne; Hermann Brenner; Iona Cheng et al.
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Crossref

Kidney Function and Risk of Renal Cell Carcinoma

Cancer Epidemiology, Biomarkers & Prevention
2023-11-01 | Journal article
DOI: 10.1158/1055-9965.EPI-23-0558
Contributors: Karine Alcala; Hana Zahed; Ricardo Cortez Cardoso Penha; Nicolas Alcala; Hilary A. Robbins; Karl Smith-Byrne; Richard M. Martin; David C. Muller; Paul Brennan; Mattias Johansson
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Crossref

The plasma proteome of plant-based diets: analyses of 1463 proteins in 50,000 people

2023-08-16 | Preprint
DOI: 10.1101/2023.08.14.23294084
Contributors: Tammy Y.N. Tong; Karl Smith-Byrne; Keren Papier; Joshua R. Atkins; Mahboubeh Parsaeian; Timothy J. Key; Ruth C. Travis
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Crossref

Identifying therapeutic targets for cancer: 2,094 circulating proteins and risk of nine cancers

2023-05-14 | Preprint
DOI: 10.1101/2023.05.05.23289547
Contributors: Karl Smith-Byrne; Åsa Hedman; Marios Dimitriou; Trishna Desai; Alexandr V. Sokolov; Helgi B. Schioth; Mine Koprulu; Maik Pietzner; Claudia Langenberg; Joshua Atkins et al.
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Crossref

The relationship between blood pressure and risk of renal cell carcinoma

International Journal Of Epidemiology
2022 | Journal article
DOI: 10.1093/ije/dyac042
Part of ISSN: 0300-5771
Part of ISSN: 1464-3685
Source: Self-asserted source
Karl Smith-Byrne

Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements

Cancer Epidemiology, Biomarkers & Prevention
2022-10-04 | Journal article
DOI: 10.1158/1055-9965.EPI-21-1033
Contributors: Karl Smith-Byrne; Agustin Cerani; Florence Guida; Sirui Zhou; Antonio Agudo; Krasimira Aleksandrova; Aurelio Barricarte; Miguel Rodríguez Barranco; Christoph H. Bochers; Inger Torhild Gram et al.
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Crossref

Reallocation of time between device-measured movement behaviours and risk of incident cardiovascular disease

British Journal of Sports Medicine
2022-09 | Journal article
DOI: 10.1136/bjsports-2021-104050
Contributors: Rosemary Walmsley; Shing Chan; Karl Smith-Byrne; Rema Ramakrishnan; Mark Woodward; Kazem Rahimi; Terence Dwyer; Derrick Bennett; Aiden Doherty
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Crossref

Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden

JNCI: Journal of the National Cancer Institute
2022-08-08 | Journal article
DOI: 10.1093/jnci/djac087
Contributors: Aurélie A G Gabriel; Joshua R Atkins; Ricardo C C Penha; Karl Smith-Byrne; Valerie Gaborieau; Catherine Voegele; Behnoush Abedi-Ardekani; Maja Milojevic; Robert Olaso; Vincent Meyer et al.
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Crossref

Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer

Cancer Causes & Control
2022-05 | Journal article
DOI: 10.1007/s10552-022-01562-1
Part of ISSN: 0957-5243
Part of ISSN: 1573-7225
Source: Self-asserted source
Karl Smith-Byrne

Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study

JNCI: Journal of the National Cancer Institute
2022-04-19 | Journal article
DOI: 10.1093/jnci/djac061
Part of ISSN: 0027-8874
Part of ISSN: 1460-2105
Source: Self-asserted source
Karl Smith-Byrne
grade
Preferred source (of 2)‎

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

[]
2022-03-22 | Preprint
DOI: 10.1101/2022.03.21.22272544
Source: Self-asserted source
Karl Smith-Byrne

Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts

JNCI Cancer Spectrum
2022-03-02 | Journal article
DOI: 10.1093/jncics/pkac009
Part of ISSN: 2515-5091
Source: Self-asserted source
Karl Smith-Byrne

Germline TYK2 mutation and cancer risk

[]
2022-01-29 | Preprint
DOI: 10.1101/2022.01.26.22269888
Source: Self-asserted source
Karl Smith-Byrne

Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer

Nature Communications
2021-12 | Journal article
DOI: 10.1038/s41467-021-26151-9
Part of ISSN: 2041-1723
Source: Self-asserted source
Karl Smith-Byrne

Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis

The Lancet
2021-11 | Journal article
DOI: 10.1016/s0140-6736(21)01920-6
Part of ISSN: 0140-6736
Source: Self-asserted source
Karl Smith-Byrne

Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence

Nature Genetics
2021-11 | Journal article
DOI: 10.1038/s41588-021-00928-6
Part of ISSN: 1061-4036
Part of ISSN: 1546-1718
Source: Self-asserted source
Karl Smith-Byrne

The blood metabolome of incident kidney cancer: A case–control study nested within the MetKid consortium

PLOS Medicine
2021-09-20 | Journal article
DOI: 10.1371/journal.pmed.1003786
Part of ISSN: 1549-1676
Source: Self-asserted source
Karl Smith-Byrne

Electronic alerts for acute kidney injury across primary and secondary care

BMJ Open Quality
2021-05 | Journal article
DOI: 10.1136/bmjoq-2020-000956
Part of ISSN: 2399-6641
Source: Self-asserted source
Karl Smith-Byrne

Systemic inflammation markers and cancer incidence in the UK Biobank

European Journal of Epidemiology
2021-05-25 | Journal article
DOI: 10.1007/s10654-021-00752-6
Part of ISSN: 0393-2990
Part of ISSN: 1573-7284
Source: Self-asserted source
Karl Smith-Byrne

Genetic analysis of lung cancer reveals novel susceptibility loci and germline impact on somatic mutation burden

2021-04-30 | Other
DOI: 10.1101/2021.04.26.21254132
Contributors: Aurélie AG Gabriel; Joshua R Atkins; Ricardo CC Penha; Karl Smith-Byrne; Valerie Gaborieau; Catherine Voegele; Behnoush Abedi-Ardekani; Maja Milojevic; Robert Olaso; Vincent Meyer et al.
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Crossref

Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
2021-04-20 | Journal article
DOI: 10.1158/1055-9965.epi-20-1690
PMID: 33879453
Source: Self-asserted source
Karl Smith-Byrne

Genetic susceptibility, elevated blood pressure, and risk of atrial fibrillation: a Mendelian randomization study.

Genome medicine
2021-03-04 | Journal article
DOI: 10.1186/s13073-021-00849-3
PMID: 33663581
PMC: PMC7934395
Source: Self-asserted source
Karl Smith-Byrne

Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study.

Cells
2021-02-15 | Journal article
DOI: 10.3390/cells10020394
PMID: 33671849
PMC: PMC7918902
Source: Self-asserted source
Karl Smith-Byrne

Prospective identification of elevated circulating CDCP1 in patients years before onset of lung cancer.

Cancer research
2021-02-11 | Journal article
DOI: 10.1158/0008-5472.can-20-3454
PMID: 33574093
Source: Self-asserted source
Karl Smith-Byrne

Accelerometer measured physical activity and the incidence of cardiovascular disease: Evidence from the UK Biobank cohort study.

PLoS medicine
2021-01-12 | Journal article
DOI: 10.1371/journal.pmed.1003487
PMID: 33434193
PMC: PMC7802951
Source: Self-asserted source
Karl Smith-Byrne

Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200 000 men in UK Biobank.

International journal of cancer
2020-12-11 | Journal article
DOI: 10.1002/ijc.33416
PMID: 33252839
Source: Self-asserted source
Karl Smith-Byrne

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction.

Nature communications
2020-11-27 | Journal article
DOI: 10.1038/s41467-020-19600-4
PMID: 33247094
PMC: PMC7695829
Source: Self-asserted source
Karl Smith-Byrne

Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank.

Cancer research
2020-07-24 | Journal article
DOI: 10.1158/0008-5472.can-20-1281
PMID: 32709735
Source: Self-asserted source
Karl Smith-Byrne

Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼430 000 women.

Annals of oncology : official journal of the European Society for Medical Oncology
2020-03-10 | Journal article
DOI: 10.1016/j.annonc.2020.01.066
PMID: 32169310
PMC: PMC7221341
Source: Self-asserted source
Karl Smith-Byrne

Self-reported and objectively measured physical activity in people with and without chronic heart failure: UK Biobank analysis.

Open heart
2020-02-19 | Journal article
DOI: 10.1136/openhrt-2019-001099
PMID: 32153787
PMC: PMC7046950
Source: Self-asserted source
Karl Smith-Byrne

Physical activity of UK adults with chronic disease: cross-sectional analysis of accelerometer-measured physical activity in 96 706 UK Biobank participants.

International journal of epidemiology
2019-08-01 | Journal article
DOI: 10.1093/ije/dyy294
PMID: 30721947
PMC: PMC6693885
Source: Self-asserted source
Karl Smith-Byrne

Response to: One size does not fit all-application of accelerometer thresholds in chronic disease.

International journal of epidemiology
2019-08-01 | Journal article
DOI: 10.1093/ije/dyz165
PMID: 31373623
PMC: PMC6830261
Source: Self-asserted source
Karl Smith-Byrne

Systolic Blood Pressure and Risk of Valvular Heart Disease: A Mendelian Randomization Study.

JAMA cardiology
2019-08-01 | Journal article
DOI: 10.1001/jamacardio.2019.2202
PMID: 31290937
PMC: PMC6624812
Source: Self-asserted source
Karl Smith-Byrne

The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition.

Annals of oncology : official journal of the European Society for Medical Oncology
2019-06-01 | Journal article
DOI: 10.1093/annonc/mdz121
PMID: 31089709
PMC: PMC6594452
Source: Self-asserted source
Karl Smith-Byrne

GWAS identifies 14 loci for device-measured physical activity and sleep duration.

Nature communications
2018-12-10 | Journal article
DOI: 10.1038/s41467-018-07743-4
PMID: 30531941
PMC: PMC6288145
Source: Self-asserted source
Karl Smith-Byrne
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