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University of Palacky in Olomouc: Olomouc, CZ

2010-01-01 to present | Senior scientist, Group leader (Institute of Molecular and Translational Medicine)
Employment
Source: Self-asserted source
Martin Mistrik

Education and qualifications (1)

University of Palacky: Olomouc, CZ

2005-09-01 to 2009-09-01 | Ph. D (Biochemistry)
Education
Source: Self-asserted source
Martin Mistrik

Works (50 of 77)

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Uncovering pre-cytokinetic block in cancer cells under shear stress using a disturbed flow-generating device

Scientific Reports
2025 | Journal article
DOI: 10.1038/S41598-024-83058-3
WOSUID: WOS:001428642300043
Contributors: Beresova, Lucie; Vitecek, Jan; Protivankova, Iva; Dudka, Michal; Chroma, Katarina; Skrott, Zdenek; Buchtova, Tereza; Polakova, Kamila; Novotny, Jan; Novakova, Ludmila et al.
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A Phase 1/2 Study of Disulfiram and Copper With Concurrent Radiation Therapy and Temozolomide for Patients With Newly Diagnosed Glioblastoma

International Journal of Radiation Oncology Biology Physics
2024 | Journal article
DOI: 10.1016/J.IJROBP.2024.05.009
WOSUID: WOS:001324888400001
Contributors: Huang, Jiayi; Campian, Jian L.; Dewees, Todd A.; Skrott, Zdenek; Mistrik, Martin; Johanns, Tanner M.; Ansstas, George; Butt, Omar; Leuthardt, Eric; Dunn, Gavin P. et al.
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Targeting p97-NPL4 pathway by copper chelators

Cancer Research
2024 | Journal article
DOI: 10.1158/1538-7445.AM2024-5788
WOSUID: WOS:001253000903286
Contributors: Mistrik, Martin; Skrott, Zdenek; Loffelmann, Martin
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Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

2024-08-19 | Preprint
DOI: 10.7554/eLife.91304.2
Contributors: Alexandra Urbancokova; Terezie Hornofova; Josef Novak; Sarka Andrs Salajkova; Sona Stemberkova Hubackova; Alena Uvizl; Tereza Buchtova; Martin Mistrik; Brian McStay; Zdenek Hodny et al.
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Crossref

Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

2024-08-19 | Preprint
DOI: 10.7554/eLife.91304
Contributors: Alexandra Urbancokova; Terezie Hornofova; Josef Novak; Sarka Andrs Salajkova; Sona Stemberkova Hubackova; Alena Uvizl; Tereza Buchtova; Martin Mistrik; Brian McStay; Zdenek Hodny et al.
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Actionable cancer vulnerability due to translational arrest, p53 aggregation and ribosome biogenesis stress evoked by the disulfiram metabolite CuET

Cell Death and Differentiation
2023 | Journal article
DOI: 10.1038/S41418-023-01167-4
WOSUID: WOS:000981375200003
Contributors: Kanellis, Dimitris C.; Zisi, Asimina; Skrott, Zdenek; Lemmens, Bennie; Espinoza, Jaime A.; Kosar, Martin; Bjorkman, Andrea; Li, Xuexin; Arampatzis, Stefanos; Bartkova, Jirina et al.
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Cannabidiol and cannabis extract protect cells against platinum-based chemotherapy via cellular uptake

Cancer Research
2023 | Journal article
DOI: 10.1158/1538-7445.AM2023-4935
WOSUID: WOS:001008499103311
Contributors: Buchtova, Tereza; Beresova, Lucie; Chroma, Katarina; Mistrik, Martin
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Cannabis-derived products antagonize platinum drugs by altered cellular transport

Biomedicine & Pharmacotherapy
2023 | Journal article
DOI: 10.1016/J.BIOPHA.2023.114801
WOSUID: WOS:000990814000001
Contributors: Buchtova, Tereza; Beresova, Lucie; Chroma, Katarina; Pluhacek, Tomas; Beres, Tibor; Kaczorova, Dominika; Tarkowski, Petr; Bartek, Jiri; Mistrik, Martin
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Compensatory interplay of p97 segregase and HSP70 chaperone protect cancer cells from heat-induced proteotoxicity

Cancer Research
2023 | Journal article
DOI: 10.1158/1538-7445.AM2023-4814
WOSUID: WOS:001008499103204
Contributors: Skrott, Zdenek; Chroma, Katarina; Muller, Petr; Panacek, Ales; Bartek, Jiri; Mistrik, Martin
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Disulfiram metabolite modulates NK and T cell cytotoxicity against metastatic colorectal cancer through tumor derived NKG2D ligands

Cancer Research
2023 | Journal article
DOI: 10.1158/1538-7445.AM2023-2329
WOSUID: WOS:001008193604196
Contributors: Dumut, Daciana Catalina; Frydrych, Ivo; Popper, Miroslav; Garic, Dusan; Paun, Radu Alexandru; Centorame, Amanda; Canavan, Olivia; Shah, Juhi; Mistrik, Martin; Dzubak, Petr et al.
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Drug-Drug Interactions of Cannabidiol with Standard-of-Care Chemotherapeutics

International Journal of Molecular Sciences
2023 | Journal article
DOI: 10.3390/IJMS24032885
WOSUID: WOS:000931899600001
Contributors: Buchtova, Tereza; Lukac, David; Skrott, Zdenek; Chroma, Katarina; Bartek, Jiri; Mistrik, Martin
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Identification of novel dithiocarbamate-copper complexes targeting p97/ NPL4 pathway in cancer cells

European Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1016/J.EJMECH.2023.115790
WOSUID: WOS:001106654000001
Contributors: Loffelmann, Martin; Skrott, Zdenek; Majera, Dusana; Starha, Pavel; Krystof, Vladimir; Mistrik, Martin
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Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

2023-08-06 | Preprint
DOI: 10.1101/2023.08.05.552131
Contributors: Alexandra Urbancokova; Terezie Hornofova; Josef Novak; Sarka Andrs Salajkova; Sona Stemberkova Hubackova; Alena Uvizl; Tereza Buchtova; Martin Mistrik; Brian Mac Stay; Zdenek Hodny et al.
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Crossref

BODIPY-aza-indole derivate complex as a selective fluorescent sensor for autolysosomes detection

Sensors and Actuators B: Chemical
2022 | Journal article
DOI: 10.1016/J.SNB.2021.130941
WOSUID: WOS:000720837000006
Contributors: Okorochenkov, Sergii; Skrott, Zdenek; Majera, Dusana; Porubsky, Martin; Mistrik, Martin; Hlavac, Jan
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Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs

Stem Cells
2022 | Journal article
DOI: 10.1093/STMCLS/SXAB004
WOSUID: WOS:000765490000005
Contributors: Giallongo, Sebastiano; Rehakova, Daniela; Biagini, Tommaso; Lo Re, Oriana; Raina, Priyanka; Lochmanova, Gabriela; Zdrahal, Zbynek; Resnick, Igor; Pata, Pille; Pata, Illar et al.
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One-Step Synthesis of Nanoliposomal Copper Diethyldithiocarbamate and Its Assessment for Cancer Therapy

Pharmaceutics
2022 | Journal article
DOI: 10.3390/PHARMACEUTICS14030640
WOSUID: WOS:000774561700001
Contributors: Paun, Radu A.; Dumut, Daciana C.; Centorame, Amanda; Thuraisingam, Thusanth; Hajduch, Marian; Mistrik, Martin; Dzubak, Petr; De Sanctis, Juan B.; Radzioch, Danuta; Tabrizian, Maryam
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A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment.

Cell death & disease
2022-03-04 | Journal article
DOI: 10.1038/s41419-022-04651-w
PMID: 35246527
PMC: PMC8897388
Source: Self-asserted source
Martin Mistrik
grade
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An efficient, non-invasive approach for <i>in-vivo</i> sampling of hair follicles: design and applications in monitoring DNA damage and aging

Aging
2021 | Journal article
WOSUID: WOS:000732027400009
Contributors: Kudlova, Natalie; Slavik, Hanus; Duskova, Pavlina; Furst, Tomas; Srovnal, Josef; Bartek, Jiri; Mistrik, Martin; Hajduch, Marian
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Dithiocarb-copper complex, CuET, demonstrates anti-neoplastic activity in mouse model of prostate cancer and prevents recurrence of tumors

Cancer Research
2021 | Journal article
WOSUID: WOS:000680263506174
Contributors: Dumut, Daciana Catalina; DeSanctis, Juan B.; Mistrik, Martin; Skrott, Zdenek; Dzubak, Petr; Bartek, Jiri; Hajduch, Marian; Radzioch, Danuta
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Skp2 and Slug Are Coexpressed in Aggressive Prostate Cancer and Inhibited by Neddylation Blockade

International Journal of Molecular Sciences
2021 | Journal article
DOI: 10.3390/IJMS22062844
WOSUID: WOS:000645776800001
Contributors: Mickova, Alena; Kharaishvili, Gvantsa; Kurfurstova, Daniela; Gachechiladze, Mariam; Kral, Milan; Vacek, Ondrej; Pokryvkova, Barbora; Mistrik, Martin; Soucek, Karel; Bouchal, Jan
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An efficient, non-invasive approach for <i>in-vivo</i> sampling of hair follicles: design and applications in monitoring DNA damage and aging.

Aging
2021-12-06 | Journal article
DOI: 10.18632/aging.203744
PMID: 34874896
PMC: PMC8714131
Source: Self-asserted source
Martin Mistrik

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects.

GeroScience
2021-11-24 | Journal article
DOI: 10.1007/s11357-021-00487-y
PMID: 34820764
PMC: PMC8612119
Source: Self-asserted source
Martin Mistrik
grade
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Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET.

Molecular oncology
2021-10-26 | Journal article
DOI: 10.1002/1878-0261.13114
PMID: 34632694
PMC: PMC8978514
Source: Self-asserted source
Martin Mistrik
grade
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Microthermal-induced subcellular-targeted protein damage in cells on plasmonic nanosilver-modified surfaces evokes a two-phase HSP-p97/VCP response.

Nature communications
2021-01-29 | Journal article
DOI: 10.1038/s41467-021-20989-9
PMID: 33514738
PMC: PMC7846584
Source: Self-asserted source
Martin Mistrik
grade
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Disulfiram anticancer metabolite, dithiocarb-copper complex, demonstrates anti-neoplastic activity against hypermutated colorectal cancers

Cancer Research
2020 | Journal article
DOI: 10.1158/1538-7445.AM2020-5246
WOSUID: WOS:000590059306279
Contributors: Dumut, Daciana Catalina; De Sanctis, Juan B.; Mistrik, Martin; Skrott, Zdenek; Dzubak, Petr; Bartek, Jiri; Hajduch, Marian; Radzioch, Danuta
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Effect of Sepatronium Bromide (YM-155) on DNA Double-Strand Breaks Repair in Cancer Cells.

International journal of molecular sciences
2020-12-11 | Journal article
DOI: 10.3390/ijms21249431
PMID: 33322336
PMC: PMC7763167
Source: Self-asserted source
Martin Mistrik
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Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway.

Cells
2020-02-18 | Journal article
DOI: 10.3390/cells9020469
PMID: 32085572
PMC: PMC7072750
Source: Self-asserted source
Martin Mistrik
grade
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Colocalization of Skp2 and Slug proteins and their possible interaction in aggressive prostate cancer

Virchows Archiv
2019 | Journal article
WOSUID: WOS:000483546901173
Contributors: Mickova, A.; Kharaishvili, G.; Kral, M.; Gachechiladze, M.; Mistrik, M.; Bouchal, J.
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Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging

Aging
2019 | Journal article
DOI: 10.18632/AGING.101922
WOSUID: WOS:000466768900026
Contributors: Turi, Zsofia; Lacey, Matthew; Mistrik, Martin; Moudry, Pavel
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Disulfiram's anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase.

Oncogene
2019-08-07 | Journal article
DOI: 10.1038/s41388-019-0915-2
PMID: 31391554
Source: Self-asserted source
Martin Mistrik
grade
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PML nuclear bodies are recruited to persistent DNA damage lesions in an RNF168-53BP1 dependent manner and contribute to DNA repair.

DNA repair
2019-04-06 | Journal article
DOI: 10.1016/j.dnarep.2019.04.001
PMID: 31009828
Source: Self-asserted source
Martin Mistrik

Alcohol-aversion drug disulfiram targets cancer via p97 segregase adaptor NPL4

Cancer Research
2018 | Journal article
DOI: 10.1158/1538-7445.AM2018-LB-264
WOSUID: WOS:000468818900410
Contributors: Mistrik, Martin; Skrott, Zdenek; Hajduch, Marian; Friis, Soren; Dzubak, Petr; Gursky, Jan; Majera, Dusana; Ozdian, Tomas; Vaclavkova, Jana; Michalova, Martina et al.
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Hair follicles as a minimally invasive resource of epithelial cells in mouse studies of ionizing radiation

Cancer Research
2018 | Journal article
DOI: 10.1158/1538-7445.AM2018-4166
WOSUID: WOS:000468819502393
Contributors: Slavik, Hanus; Mistrik, Martin; Duskova, Pavlina; Furst, Tomas; Srovnal, Josef; Hajduch, Marian
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Skp2 associates with Slug and androgen receptor in aggressive prostate cancer

Cancer Research
2018 | Journal article
DOI: 10.1158/1538-7445.PRCA2017-A006
WOSUID: WOS:000441803800024
Contributors: Bouchal, Jan; Kharaishvili, Gvantsa; Mickova, Alena; Gachechiladze, Mariam; Burdova, Alena; Mistrik, Martin; Kral, Milan; Gyorffy, Balazs; Kolar, Zdenek
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Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram.

The Prostate
2018-11-29 | Journal article
DOI: 10.1002/pros.23741
PMID: 30499118
Source: Self-asserted source
Martin Mistrik
grade
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Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer.

Frontiers in oncology
2018-10-30 | Journal article
DOI: 10.3389/fonc.2018.00459
PMID: 30425964
PMC: PMC6218402
Source: Self-asserted source
Martin Mistrik
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Replication obstacles formed within common fragile sites under replication stress are targeted by the global genomic nucleotide excision repair pathway

Cancer Research
2017 | Journal article
DOI: 10.1158/1538-7445.AM2017-1413
WOSUID: WOS:000442496703333
Contributors: Mistrik, Martin; Beresova, Lucie; Vesela, Eva; Chamrad, Ivo; Voller, Jiri; Yamada, Masayuki; Furst, Tomas; Lenobel, Rene; Chroma, Katarina; Gursky, Jan et al.
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Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells.

Cell cycle (Georgetown, Tex.)
2017-12-10 | Journal article
DOI: 10.1080/15384101.2017.1403685
PMID: 29143558
PMC: PMC5815431
Source: Self-asserted source
Martin Mistrik
grade
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

Nature
2017-12-06 | Journal article
DOI: 10.1038/nature25016
PMID: 29211715
PMC: PMC5730499
Source: Self-asserted source
Martin Mistrik
grade
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Common Chemical Inductors of Replication Stress:  Focus on Cell-Based Studies.

Biomolecules
2017-02-21 | Journal article
DOI: 10.3390/biom7010019
PMID: 28230817
PMC: PMC5372731
Source: Self-asserted source
Martin Mistrik
grade
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Laser micro-irradiations of large amounts of cells for high content applications

Cancer Research
2016 | Journal article
DOI: 10.1158/1538-7445.AM2016-3598
WOSUID: WOS:000389941705029
Contributors: Mistrik, Martin; Vesela, Eva; Furst, Tomas; Frydrych, Ivo; Gursky, Jan; Bartek, Jiri
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Super-resolution microscopy for dynamic imaging of plant cortical microtubules

New Biotechnology
2016 | Journal article
DOI: 10.1016/J.NBT.2016.06.1286
WOSUID: WOS:000393400600529
Contributors: Samajova, Olga; Komis, George; Mistrik, Martin; Ovecka, Miroslav; Bartek, Jiri; Samaj, Jozef
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Synthesis and study of novel pH-independent fluorescent mitochondrial labels based on Rhodamine B

RSC Advances
2016 | Journal article
DOI: 10.1039/C5RA20183G
WOSUID: WOS:000372253200014
Contributors: Brulikova, Lucie; Krupkova, Sona; Labora, Maitia; Motyka, Kamil; Hradilova, Ludmila; Mistrik, Martin; Bartek, Jiri; Hlavac, Jan
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Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.

Oncogene
2016-11-14 | Journal article
DOI: 10.1038/onc.2016.392
PMID: 27841863
Source: Self-asserted source
Martin Mistrik
grade
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Role of DNA Repair Factor Xeroderma Pigmentosum Protein Group C in Response to Replication Stress As Revealed by DNA Fragile Site Affinity Chromatography and Quantitative Proteomics.

Journal of proteome research
2016-11-09 | Journal article
DOI: 10.1021/acs.jproteome.6b00622
PMID: 27794614
Source: Self-asserted source
Martin Mistrik
grade
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DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.

Molecular oncology
2016-03-03 | Journal article
DOI: 10.1016/j.molonc.2016.02.005
PMID: 26987799
PMC: PMC5423169
Source: Self-asserted source
Martin Mistrik
grade
Preferred source (of 2)‎

Cells and Stripes: A novel quantitative photo-manipulation technique.

Scientific reports
2016-01-18 | Journal article
DOI: 10.1038/srep19567
PMID: 26777522
PMC: PMC4726120
Source: Self-asserted source
Martin Mistrik
grade
Preferred source (of 2)‎

Superresolution live imaging of plant cells using structured illumination microscopy.

Nature protocols
2015-07-23 | Journal article
DOI: 10.1038/nprot.2015.083
PMID: 26203822
Source: Self-asserted source
Martin Mistrik
grade
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What a 'Ku'incidence!: parallel discoveries of a new DNA repair factor.

Cell death and differentiation
2015-06-01 | Journal article
DOI: 10.1038/cdd.2015.32
PMID: 25941165
PMC: PMC4423193
Source: Self-asserted source
Martin Mistrik
grade
Preferred source (of 2)‎

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Nature
2015-03-23 | Journal article
DOI: 10.1038/nature14328
PMID: 25799992
PMC: PMC4671316
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Martin Mistrik
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Peer review (3 reviews for 3 publications/grants)

Review activity for Cell death and differentiation. (1)
Review activity for European journal of medicinal chemistry. (1)
Review activity for Life sciences. (1)
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