Personal information

Other IDs

Scopus Author ID: 56285630100
Loop profile: 2078040

Keywords

mitochondria, oxidative phosphorylation, RNA granule, translation, diseases

Countries

Canada

Activities

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Employment (2)

McGill University: Montreal, QC, CA

2005-11-01 to present | Research Associate (Human Genetics)
Employment
Source: Self-asserted source
Hana Antonicka

McGill University: Montreal, QC, CA

2000-11-01 to 2005-10-31 | Post Doctoral Fellow (Human Genetics)
Employment
Source: Self-asserted source
Hana Antonicka

Education and qualifications (3)

Univerzita Karlova: Praha, CZ

1996-09-01 to 2000-09-30 | PhD. (Biochemistry and Pathobiochemistry)
Education
Source: Self-asserted source
Hana Antonicka

Univerzita Karlova: Praha, CZ

1994-07-01 to 1996-06-30 | MSc. (Biochemistry)
Education
Source: Self-asserted source
Hana Antonicka

Univerzita Karlova: Praha, CZ

1991-09-01 to 1994-06-30 | BSc. (Chemistry)
Education
Source: Self-asserted source
Hana Antonicka

Works (42)

ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis

Life Science Alliance
2024-01 | Journal article
DOI: 10.26508/lsa.202302335
Contributors: Alexandre Janer; Jordan L Morris; Michiel Krols; Hana Antonicka; Mari J Aaltonen; Zhen-Yuan Lin; Hanish Anand; Anne-Claude Gingras; Julien Prudent; Eric A Shoubridge
Source: check_circle
Crossref

The role of the mitochondrial outer membrane protein SLC25A46 in mitochondrial fission and fusion

Life Science Alliance
2023-06 | Journal article
DOI: 10.26508/lsa.202301914
Contributors: Jana Schuettpelz; Alexandre Janer; Hana Antonicka; Eric A Shoubridge
Source: check_circle
Crossref

ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasis

2022-11-15 | Preprint
DOI: 10.1101/2022.11.14.516495
Contributors: Alexandre Janer; Jordan L. Morris; Michiel Krols; Hana Antonicka; Mari J. Aaltonen; Zhen-Yuan Lin; Anne-Claude Gingras; Julien Prudent; Eric A. Shoubridge
Source: check_circle
Crossref

SLC25A46 localizes to sites of mitochondrial fission and fusion and loss of function variants alter the oligomerization states of MFN2 and OPA1

2022-09-17 | Preprint
DOI: 10.1101/2022.09.16.508286
Contributors: Jana Schuettpelz; Alexandre Janer; Hana Antonicka; Eric A. Shoubridge
Source: check_circle
Crossref

A high-density human mitochondrial proximity interaction network

2020-04-02 | Preprint
DOI: 10.1101/2020.04.01.020479
Contributors: Hana Antonicka; Zhen-Yuan Lin; Alexandre Janer; Woranontee Weraarpachai; Anne-Claude Gingras; Eric A. Shoubridge
Source: check_circle
Crossref

A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability

EMBO Reports
2017 | Journal article
DOI: 10.15252/embr.201643391
EID:

2-s2.0-85007275942
Contributors: Antonicka, H.; Choquet, K.; Lin, Z.-Y.; Gingras, A.-C.; Kleinman, C.L.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Stomatin-like protein 2 deficiency results in impaired mitochondrial translation

PLoS ONE
2017 | Journal article
DOI: 10.1371/journal.pone.0179967
EID:

2-s2.0-85021382772
Contributors: Mitsopoulos, P.; Lapohos, O.; Weraarpachai, W.; Antonicka, H.; Chang, Y.-H.; Madrenas, J.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

A mutation in the flavin adenine dinucleotide-dependent oxidoreductase FOXRED1 results in cell-type-specific assembly defects in oxidative phosphorylation complexes I and II

Molecular and Cellular Biology
2016 | Journal article
DOI: 10.1128/MCB.00066-16
EID:

2-s2.0-84982782572
Contributors: Rendón, O.Z.; Antonicka, H.; Horvath, R.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase

Human Molecular Genetics
2015 | Journal article
DOI: 10.1093/hmg/ddv149
EID:

2-s2.0-84936763284
Contributors: Hinttala, R.; Sasarman, F.; Nishimura, T.; Antonicka, H.; Brunel-Guitton, C.; Schwartzentruber, J.; Fahiminiya, S.; Majewski, J.; Faubert, D.; Ostergaard, E. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

2015 | Journal article
DOI:

10.1016/j.celrep.2015.01.030

EID:

2-s2.0-84923069270
Contributors: Antonicka, H.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

RMND1 deficiency associated with neonatal lactic acidosis, infantile onset renal failure, deafness, and multiorgan involvement

2015 | Journal article
DOI:

10.1038/ejhg.2014.293

EID:

2-s2.0-84922663641
Contributors: Janer, A.; van Karnebeek, C.D.M.; Sasarman, F.; Antonicka, H.; Al Ghamdi, M.; Shyr, C.; Dunbar, M.; Stockler-Ispiroglu, S.; Ross, C.J.; Vallance, H. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

The 3′ addition of CCA to mitochondrial tRNA<sup>Ser(AGY)</sup> is specifically impaired in patients with mutations in the tRNA nucleotidyl transferase TRNT1

Human Molecular Genetics
2015 | Journal article
DOI: 10.1093/hmg/ddv044
EID:

2-s2.0-84929724879
Contributors: Sasarman, F.; Thiffault, I.; Weraarpachai, W.; Salomon, S.; Maftei, C.; Gauthier, J.; Ellazam, B.; Webb, N.; Antonicka, H.; Janer, A. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome

2015 | Journal article
DOI:

10.1093/hmg/ddu468

EID:

2-s2.0-84922475667
Contributors: Sasarman, F.; Nishimura, T.; Antonicka, H.; Weraarpachai, W.; Shoubridge, E.A.; Allen, B.; Burelle, Y.; Charron, G.; Coderre, L.; DesRosiers, c. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Whole-exome sequencing identifies novel ECHS1 mutations in Leigh syndrome

Human Genetics
2015 | Journal article
DOI: 10.1007/s00439-015-1577-y
EID:

2-s2.0-84938965542
Contributors: Tetreault, M.; Fahiminiya, S.; Antonicka, H.; Mitchell, G.A.; Geraghty, M.T.; Lines, M.; Boycott, K.M.; Shoubridge, E.A.; Mitchell, J.J.; Michaud, J.L. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Novel mutations in SCO1 as a cause of fatal infantile encephalopathy and lactic acidosis

2013 | Journal article
DOI:

10.1002/humu.22385

EID:

2-s2.0-84884531240
Contributors: Leary, S.C.; Antonicka, H.; Sasarman, F.; Weraarpachai, W.; Cobine, P.A.; Pan, M.; Brown, G.K.; Brown, R.; Majewski, J.; Ha, K.C.H. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression

2013 | Journal article
DOI:

10.1016/j.cmet.2013.02.006

EID:

2-s2.0-84875309966
Contributors: Antonicka, H.; Sasarman, F.; Nishimura, T.; Paupe, V.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

An RMND1 mutation causes encephalopathy associated with multiple oxidative phosphorylation complex deficiencies and a mitochondrial translation defect

2012 | Journal article
DOI:

10.1016/j.ajhg.2012.08.020

EID:

2-s2.0-84867252179
Contributors: Janer, A.; Antonicka, H.; Lalonde, E.; Nishimura, T.; Sasarman, F.; Brown, G.K.; Brown, R.M.; Majewski, J.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mutations in C12orf62, a factor that couples COX i synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis

2012 | Journal article
DOI:

10.1016/j.ajhg.2011.11.027

EID:

2-s2.0-84855835044
Contributors: Weraarpachai, W.; Sasarman, F.; Nishimura, T.; Antonicka, H.; Auré, K.; Rötig, A.; Lombs, A.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mutation in subdomain G' of mitochondrial elongation factor G1 is associated with combined OXPHOS deficiency in fibroblasts but not in muscle

2011 | Journal article
DOI:

10.1038/ejhg.2010.208

EID:

2-s2.0-79951812633
Contributors: Smits, P.; Antonicka, H.; Van Hasselt, P.M.; Weraarpachai, W.; Haller, W.; Schreurs, M.; Venselaar, H.; Rodenburg, R.J.; Smeitink, J.A.; Van Den Heuvel, L.P.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

The 2-thiouridylase function of the human MTU1 (TRMU) enzyme is dispensable for mitochondrial translation

2011 | Journal article
DOI:

10.1093/hmg/ddr397

EID:

2-s2.0-81255169321
Contributors: Sasarman, F.; Antonicka, H.; Horvath, R.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria

2010 | Journal article
DOI:

10.1091/mbc.E10-01-0047

EID:

2-s2.0-77950901962
Contributors: Sasarman, F.; Brunel-Guitton, C.; Antonicka, H.; Wai, T.; Shoubridge, E.A.; Allen, B.; Burelle, Y.; Charron, G.; Coderre, L.; DesRosiers, C. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect

2010 | Journal article
DOI:

10.1016/j.ajhg.2010.06.004

EID:

2-s2.0-77955082781
Contributors: Antonicka, H.; Østergaard, E.; Sasarman, F.; Weraarpachai, W.; Wibrand, F.; Pedersen, A.M.B.; Rodenburg, R.J.; Van Der Knaap, M.S.; Smeitink, J.A.M.; Chrzanowska-Lightowlers, Z.M. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome

2009 | Journal article
DOI:

10.1038/ng.390

EID:

2-s2.0-67649833762
Contributors: Weraarpachai, W.; Antonicka, H.; Sasarman, F.; Seeger, J.; Schrank, B.; Kolesar, J.E.; Lochmüller, H.; Chevrette, M.; Kaufman, B.A.; Horvath, R. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

A sequence predicted to form a stem-loop is proposed to be required for formation of an RNA-protein complex involving the 3'UTR of β-subunit F<inf>0</inf>F<inf>1</inf>-ATPase mRNA

Biochimica et Biophysica Acta - Bioenergetics
2008 | Journal article
DOI: 10.1016/j.bbabio.2008.05.446
EID:

2-s2.0-50949098290
Contributors: Kramarova, T.V.; Antonicka, H.; Houstek, J.; Cannon, B.; Nedergaard, J.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

The A3243G tRNA<sup>Leu(UUR)</sup> MELAS mutation causes amino acid misincorporation and a combined respiratory chain assembly defect partially suppressed by overexpression of EFTu and EFG2

Human Molecular Genetics
2008 | Journal article
DOI: 10.1093/hmg/ddn265
EID:

2-s2.0-56049087303
Contributors: Sasarman, F.; Antonicka, H.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs

2006 | Journal article
DOI:

10.1086/508434

EID:

2-s2.0-33751085653
Contributors: Smeitink, J.A.M.; Elpeleg, O.; Antonicka, H.; Diepstra, H.; Saada, A.; Smits, P.; Sasarman, F.; Vriend, G.; Jacob-Hirsch, J.; Shaag, A. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Erratum: Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type (Nature Genetics (2006) 38 (93-100))

2006 | Journal article
DOI:

10.1038/ng0806-957a

EID:

2-s2.0-33746531633
Contributors: Lerner-Ellis, J.P.; Tirone, J.C.; Pawelek, P.D.; Doré, C.; Atkinson, J.L.; Watkins, D.; Morel, C.F.; Fujiwara, T.M.; Moras, E.; Hosack, A.R. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type

2006 | Journal article
DOI:

10.1038/ng1683

EID:

2-s2.0-29444451094
Contributors: Lerner-Ellis, J.P.; Tirone, J.C.; Pawelek, P.D.; Doré, C.; Atkinson, J.L.; Watkins, D.; Morel, C.F.; Fujiwara, T.M.; Moras, E.; Hosack, A.R. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Maternal segmental disomy in Leigh syndrome with cytochrome c oxidase deficiency caused by homozygous SURF1 mutation

2006 | Journal article
DOI:

10.1055/s-2006-924227

EID:

2-s2.0-33745517589
Contributors: Van Riesen, A.K.J.; Antonicka, H.; Ohlenbusch, A.; Shoubridge, E.A.; Wilichowski, E.K.G.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1

2006 | Journal article
DOI:

10.1093/hmg/ddl106

EID:

2-s2.0-33744752749
Contributors: Antonicka, H.; Sasarman, F.; Kennaway, N.G.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndrome

2004 | Journal article
EID:

2-s2.0-3142658677
Contributors: Oquendo, C.E.; Antonicka, H.; Shoubridge, E.A.; Reardon, W.; Brown, G.K.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency

2004 | Journal article
DOI:

10.1056/NEJMoa041878

EID:

2-s2.0-8344259033
Contributors: Coenen, M.J.H.; Antonicka, H.; Ugalde, C.; Sasarman, F.; Rossi, R.; Heister, J.G.A.M.A.; Newbold, R.F.; Trijbels, F.J.M.F.; Van Den Heuvel, L.P.; Shoubridge, E.A. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Identification and Characterization of a Common Set of Complex I Assembly Intermediates in Mitochondria from Patients with Complex I Deficiency

2003 | Journal article
DOI:

10.1074/jbc.M304998200

EID:

2-s2.0-0242353332
Contributors: Antonicka, H.; Ogilvie, I.; Taivassalo, T.; Anitori, R.P.; Haller, R.G.; Vissing, J.; Kennaway, N.G.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency

2003 | Journal article
DOI:

10.1093/hmg/ddg284

EID:

2-s2.0-0142154270
Contributors: Antonicka, H.; Leary, S.C.; Guercin, G.-H.; Agar, J.N.; Horvath, R.; Kennaway, N.G.; Harding, C.O.; Jaksch, M.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy

2003 | Journal article
DOI:

10.1086/345489

EID:

2-s2.0-0037221950
Contributors: Antonicka, H.; Mattman, A.; Carlson, C.G.; Glerum, D.M.; Hoffbuhr, K.C.; Leary, S.C.; Kennaway, N.G.; Shoubridge, E.A.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

A novel principle for conferring selectivity to poly(A)-binding proteins: Interdependence of two ATP synthase β-subunit mRNA-binding proteins

2000 | Journal article
DOI:

10.1042/0264-6021:3460033

EID:

2-s2.0-0142065290
Contributors: Andersson, U.; Antonicka, H.; Houstek, J.; Cannon, B.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Prenatal diagnosis in families with cytochrome C oxidase disorder,Prenatální diagnostika v rodinách s poruchou aktivity cytochrom C oxidázy.

Ceská gynekologie / Ceská lékarská spolecnost J. Ev. Purkyne
2000 | Journal article
EID:

2-s2.0-0033651774
Contributors: Houst'ková, H.; Houstek, J.; Klement, P.; Stratilová, L.; Antonická, H.; Hansíková, H.; Hermanská, J.; Hrebícek, M.; Macek, M.; Zeman, J.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

A novel deficiency of mitochondrial ATPase of nuclear origin

1999 | Journal article
DOI:

10.1093/hmg/8.11.1967

EID:

2-s2.0-0345035257
Contributors: Houštek, J.; Klement, P.; Floryk, D.; Antonická, H.; Hermanská, J.; Kalous, M.; Hansíková, H.; Houšt'ková, H.; Chowdhury, S.K.R.; Rosipal, S. et al.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Complex approach to prenatal diagnosis of cytochrome c oxidase deficiencies

1999 | Journal article
DOI:

10.1002/(SICI)1097-0223(199906)19:6<552::AID-PD588>3.0.CO;2-C

EID:

2-s2.0-0344689921
Contributors: Houštěk, J.; Klement, P.; Heřmanská, J.; Antonická, H.; Houšťková, H.; Stratilová, L.; Wanders, R.J.A.; Zeman, J.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Defective kinetics of cytochrome c oxidase and alteration of mitochondrial membrane potential in fibroblasts and cytoplasmic hybrid cells with the mutation for myoclonus epilepsy with ragged-red fibres ('MERRF') at position 8344 nt

1999 | Journal article
DOI:

10.1042/0264-6021:3420537

EID:

2-s2.0-0033568447
Contributors: Antonická, H.; Floryk, D.; Klement, P.; Stratilová, L.; Heřmanská, J.; Houšťková, H.; Kalous, M.; Drahota, Z.; Zeman, J.; Houštěk, J.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

A novel poly(A) binding protein interacts with ATP synthase β subunit mRNA via an element in the 3′-untranslated region

1998 | Journal article
EID:

2-s2.0-19044399635
Contributors: Antonická, H.; Andersson, U.; Cannon, B.; Houštěk, J.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Fluorometric studies of mitochondrial membrane potential in mitochondrial diseases

1998 | Journal article
EID:

2-s2.0-0345148071
Contributors: Floryk, D.; Heřmanská, J.; Antonická, H.; Houštěk, J.
Source: Self-asserted source
Hana Antonicka via Scopus - Elsevier

Peer review (6 reviews for 4 publications/grants)

Review activity for Biochimica et biophysica acta. Molecular cell research (2)
Review activity for Journal of cell science (1)
Review activity for Nature communications (1)
Review activity for PLOS genetics. (2)
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