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Employment (2)

INSERM: Paris, Île-de-France, FR

2023-01-01 to present | Postdoc (Saint Louis Research Institute - INSERM U944)
Employment
Source: Self-asserted source
Dimitrios Topalis

Rega Institute for Medical Research: Leuven, BE

2009-02-01 to 2021-02-21 | Associate researcher (Microbiology, Immunology and Transplantation)
Employment
Source: Self-asserted source
Dimitrios Topalis

Works (40)

Synergistic targeting of the PI3K/mTOR and MAPK/ERK pathways in Merkel cell carcinoma.

Tumour virus research
2022-08-22 | Journal article
DOI: 10.1016/j.tvr.2022.200244
PMID: 36007768
PMC: PMC9449649
Contributors: Temblador A; Topalis D; Graciela Andrei; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance.

Biomedicines
2022-03-01 | Journal article | Author
DOI: 10.3390/biomedicines10030580
PMID: 35327382
PMC: PMC8945813
Contributors: Graciela Andrei; Fiten P; Krečmerová M; Ghislain Opdenakker; Dimitrios Topalis; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis
grade
Preferred source (of 2)‎

Organotypic Epithelial Raft Cultures as a Three-Dimensional In Vitro Model of Merkel Cell Carcinoma.

Cancers
2022-02-21 | Journal article | Author
DOI: 10.3390/cancers14041091
PMID: 35205840
PMC: PMC8870341
Contributors: Arturo Jesus Temblador Perez; Dimitrios Topalis; van den Oord J; Graciela Andrei; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis
grade
Preferred source (of 2)‎

An MHV-68 Mutator Phenotype Mutant Virus, Confirmed by CRISPR/Cas9-Mediated Gene Editing of the Viral DNA Polymerase Gene, Shows Reduced Viral Fitness.

Viruses
2021-05-26 | Journal article
DOI: 10.3390/v13060985
PMID: 34073189
PMC: PMC8227558
Contributors: Erika Trompet; Arturo Jesus Temblador Perez; Gillemot S; Topalis D; Robert Snoeck; Graciela Andrei
Source: Self-asserted source
Dimitrios Topalis

[Herpes simplex virus resistance to antivirals].

Virologie (Montrouge, France)
2020-10-01 | Journal article
DOI: 10.1684/vir.2020.0864
PMID: 33111706
Contributors: Burrel S; Topalis D; Boutolleau D
Source: Self-asserted source
Dimitrios Topalis

Viral fitness of MHV-68 viruses harboring drug resistance mutations in the protein kinase or thymidine kinase.

Antiviral research
2020-08-05 | Journal article
DOI: 10.1016/j.antiviral.2020.104901
PMID: 32763314
Contributors: Erika Trompet; Topalis D; Gillemot S; Robert Snoeck; Graciela Andrei
Source: Self-asserted source
Dimitrios Topalis

BKTyper: Free Online Tool for Polyoma BK Virus VP1 and NCCR Typing.

Viruses
2020-07-31 | Journal article
DOI: 10.3390/v12080837
PMID: 32751885
PMC: PMC7472310
Contributors: Joan Martí-Carreras; Olga Mineeva-Sangwo; Topalis D; Robert Snoeck; Graciela Andrei; Maes P
Source: Self-asserted source
Dimitrios Topalis

CRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In Vitro.

Cancers
2019-08-28 | Journal article
DOI: 10.3390/cancers11091260
PMID: 31466237
PMC: PMC6770690
Contributors: Arturo Jesus Temblador Perez; Topalis D; Graciela Andrei; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Monitoring of phosphorylation using immobilized kinases by on-line enzyme bioreactors hyphenated with High-Resolution Mass Spectrometry.

Talanta
2019-07-05 | Journal article
DOI: 10.1016/j.talanta.2019.120120
PMID: 31450426
Contributors: Ferey J; Da Silva D; Cyril COLAS; Pierre Lafite; Topalis D; Roy V; Agrofoglio LA; Richard Daniellou; Benoit MAUNIT
Source: Self-asserted source
Dimitrios Topalis

Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.

Oncotarget
2018-04-24 | Journal article
DOI: 10.18632/oncotarget.25140
PMID: 29774117
PMC: PMC5955163
Contributors: Mertens B; Cristina de Araujo Nogueira T; Topalis D; Stranska R; Robert Snoeck; Graciela Andrei
Source: Self-asserted source
Dimitrios Topalis

The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase.

The Journal of infectious diseases
2018-02-01 | Journal article
DOI: 10.1093/infdis/jix605
PMID: 29186456
Contributors: Graciela Andrei; Gillemot S; Topalis D; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy
2018-01-31 | Journal article
DOI: 10.1016/j.drup.2018.01.003
PMID: 29548479
Contributors: Topalis D; Gillemot S; Robert Snoeck; Graciela Andrei
Source: Self-asserted source
Dimitrios Topalis

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase.

Nucleic acids research
2016-09-29 | Journal article
DOI: 10.1093/nar/gkw875
PMID: 27694307
PMC: PMC5175367
Contributors: Topalis D; Gillemot S; Robert Snoeck; Graciela Andrei
Source: Self-asserted source
Dimitrios Topalis

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1.

Oncotarget
2016-03-01 | Journal article
DOI: 10.18632/oncotarget.7006
PMID: 26824416
PMC: PMC4891127
Contributors: Topalis D; Nogueira TC; De Schutter T; Chahrazade EL AMRI; Krečmerová M; Lieve Naesens; Balzarini J; Graciela Andrei; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Tenofovir Activating Kinases May Impact the Outcome of HIV Treatment and Prevention.

EBioMedicine
2015-08-03 | Journal article
DOI: 10.1016/j.ebiom.2015.07.042
PMID: 26501093
PMC: PMC4588366
Contributors: Topalis D; Robert Snoeck; Graciela Andrei
Source: Self-asserted source
Dimitrios Topalis

ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping.

The Journal of antimicrobial chemotherapy
2015-01-27 | Journal article
DOI: 10.1093/jac/dku545
PMID: 25630650
PMC: PMC7539645
Contributors: Duraffour S; Maria M. Lorenzo; Zöller G; Topalis D; Grosenbach D; Hruby DE; Graciela Andrei; Rafael Blasco; Meyer H; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Insights into the mechanism of action of cidofovir and other acyclic nucleoside phosphonates against polyoma- and papillomaviruses and non-viral induced neoplasia.

Antiviral research
2014-10-30 | Journal article
DOI: 10.1016/j.antiviral.2014.10.012
PMID: 25446403
Contributors: Graciela Andrei; Topalis D; De Schutter T; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses.

Antimicrobial agents and chemotherapy
2014-09-29 | Journal article
DOI: 10.1128/aac.03957-14
PMID: 25267682
PMC: PMC4249563
Contributors: Coen N; Duraffour S; Topalis D; Robert Snoeck; Graciela Andrei
Source: Self-asserted source
Dimitrios Topalis

Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir.

Molecular cancer
2013-12-10 | Journal article
DOI: 10.1186/1476-4598-12-158
PMID: 24325392
PMC: PMC4029382
Contributors: De Schutter T; Graciela Andrei; Topalis D; Duraffour S; Mitera T; van den Oord J; Patrick Matthys; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.

Antimicrobial agents and chemotherapy
2013-10-14 | Journal article
DOI: 10.1128/aac.01601-13
PMID: 24126587
PMC: PMC3910790
Contributors: Duraffour S; Drillien R; Haraguchi K; Balzarini J; Topalis D; van den Oord JJ; Graciela Andrei; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage.

BMC medical genomics
2013-05-23 | Journal article
DOI: 10.1186/1755-8794-6-18
PMID: 23702334
PMC: PMC3681722
Contributors: De Schutter T; Graciela Andrei; Topalis D; Lieve Naesens; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Heterogeneity and evolution of thymidine kinase and DNA polymerase mutants of herpes simplex virus type 1: implications for antiviral therapy.

The Journal of infectious diseases
2013-01-11 | Journal article
DOI: 10.1093/infdis/jit019
PMID: 23315323
Contributors: Graciela Andrei; Georgala A; Topalis D; Fiten P; Aoun M; Ghislain Opdenakker; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

The large tumor antigen: a "Swiss Army knife" protein possessing the functions required for the polyomavirus life cycle.

Antiviral research
2012-11-28 | Journal article
DOI: 10.1016/j.antiviral.2012.11.007
PMID: 23201316
Contributors: Topalis D; Graciela Andrei; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Cidofovir treatment improves the pathology caused by the growth of human papillomavirus-positive cervical carcinoma xenografts in athymic nude mice.

Cancer letters
2012-11-08 | Journal article
DOI: 10.1016/j.canlet.2012.10.036
PMID: 23142293
Contributors: De Schutter T; Graciela Andrei; Topalis D; Duraffour S; Mitera T; Lieve Naesens; van den Oord J; Patrick Matthys; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Mutations conferring resistance to viral DNA polymerase inhibitors in camelpox virus give different drug-susceptibility profiles in vaccinia virus.

Journal of virology
2012-04-24 | Journal article
DOI: 10.1128/jvi.00355-12
PMID: 22532673
PMC: PMC3416337
Contributors: Duraffour S; Graciela Andrei; Topalis D; Krečmerová M; Crance JM; Garin D; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

In vitro-selected drug-resistant varicella-zoster virus mutants in the thymidine kinase and DNA polymerase genes yield novel phenotype-genotype associations and highlight differences between antiherpesvirus drugs.

Journal of virology
2011-12-21 | Journal article
DOI: 10.1128/jvi.06620-11
PMID: 22190713
PMC: PMC3302250
Contributors: Graciela Andrei; Topalis D; Fiten P; Chris McGuigan; Balzarini J; Ghislain Opdenakker; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Activities of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells.

Antimicrobial agents and chemotherapy
2011-02-22 | Journal article
DOI: 10.1128/aac.01809-10
PMID: 21343444
PMC: PMC3088206
Contributors: Topalis D; Lebeau I; Krecmerová M; Graciela Andrei; Robert Snoeck
Source: Self-asserted source
Dimitrios Topalis

Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.

Journal of medicinal chemistry
2010-12-03 | Journal article
DOI: 10.1021/jm1011462
PMID: 21128666
Contributors: Topalis D; Pradère U; Roy V; Caillat C; Azzouzi A; Broggi J; Robert Snoeck; Graciela Andrei; Lin J; Eriksson S et al.
Source: Self-asserted source
Dimitrios Topalis

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.

Biochemical and biophysical research communications
2009-07-23 | Journal article
DOI: 10.1016/j.bbrc.2009.07.089
PMID: 19631609
Contributors: Auvynet C; Topalis D; Caillat C; Hélène Munier-Lehmann; Seclaman E; Balzarini J; Luigi AGROFOGLIO; Pierre Alexandre Kaminski; Philippe Meyer; Deville-Bonne D et al.
Source: Self-asserted source
Dimitrios Topalis

Structural basis for the specificity of thymidylate kinases from human pathogens: implications for nucleotide analogues activation.

Nucleic acids symposium series (2004)
2009-01-01 | Journal article
DOI: 10.1093/nass/nrp021
PMID: 19749250
Contributors: Philippe Meyer; Caillat C; Topalis D; Balzarini J; Deville-Bonne D
Source: Self-asserted source
Dimitrios Topalis

Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy.

Proceedings of the National Academy of Sciences of the United States of America
2008-10-29 | Journal article
DOI: 10.1073/pnas.0804525105
PMID: 18971333
PMC: PMC2579350
Contributors: Caillat C; Topalis D; Luigi AGROFOGLIO; Pochet S; Balzarini J; Deville-Bonne D; Philippe Meyer
Source: Self-asserted source
Dimitrios Topalis

Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.

Protein science : a publication of the Protein Society
2008-06-03 | Journal article
DOI: 10.1110/ps.034199.107
PMID: 18523102
PMC: PMC2525521
Contributors: Carnrot C; Wang L; Topalis D; Eriksson S
Source: Self-asserted source
Dimitrios Topalis

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

Nucleosides, nucleotides & nucleic acids
2008-04-01 | Journal article
DOI: 10.1080/15257770801941952
PMID: 18404568
Contributors: Topalis D; Alvarez K; Barral K; Hélène Munier-Lehmann; Benoit Schneider; Véron M; Guerreiro C; Mulard L; Chahrazade EL AMRI; Bruno Canard et al.
Source: Self-asserted source
Dimitrios Topalis

Enantioselectivity of human AMP, dTMP and UMP-CMP kinases.

Nucleic acids research
2007-07-10 | Journal article
DOI: 10.1093/nar/gkm479
PMID: 17626051
PMC: PMC1950558
Contributors: Julie Alexandre; Béatrice ROY; Topalis D; Pochet S; Christian Périgaud; Deville-Bonne D
Source: Self-asserted source
Dimitrios Topalis

Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.

The FEBS journal
2007-07-02 | Journal article
DOI: 10.1111/j.1742-4658.2007.05902.x
PMID: 17608725
Contributors: Topalis D; Kumamoto H; Amaya Velasco MF; Dugué L; Ahmed HAOUZ; Julie Alexandre; Sarah Gallois-Montbrun; Pedro Alzari; Pochet S; Luigi AGROFOGLIO et al.
Source: Self-asserted source
Dimitrios Topalis

Alkyne-azide click chemistry mediated carbanucleosides synthesis.

Nucleosides, nucleotides & nucleic acids
2007-01-01 | Journal article
DOI: 10.1080/15257770701534139
PMID: 18066789
Contributors: Broggi J; Joubert N; Vincent Aucagne; Sabine Berteina-Raboin; Diez-Gonzalez S; Steven Nolan; Topalis D; Deville-Bonne D; Balzarini J; Johan NEYTS et al.
Source: Self-asserted source
Dimitrios Topalis

Cross-metathesis mediated synthesis of new acyclic nucleoside phosphonates.

Nucleosides, nucleotides & nucleic acids
2007-01-01 | Journal article
DOI: 10.1080/15257770701534196
PMID: 18066791
Contributors: Roy V; Kumamoto H; Sabine Berteina-Raboin; Steven Nolan; Topalis D; Deville-Bonne D; Balzarini J; Johan NEYTS; Graciela Andrei; Robert Snoeck et al.
Source: Self-asserted source
Dimitrios Topalis

Enantio-selectivity of human nucleoside monophosphate kinases.

Nucleosides, nucleotides & nucleic acids
2007-01-01 | Journal article
DOI: 10.1080/15257770701534014
PMID: 18066786
Contributors: Julie Alexandre; Béatrice ROY; Topalis D; Christian Périgaud; Deville-Bonne D
Source: Self-asserted source
Dimitrios Topalis

Looking for new pyrimidine acyclic nucleotide analogues designed for phosphorylation by human UMP-CMP kinase.

Nucleosides, nucleotides & nucleic acids
2007-01-01 | Journal article
DOI: 10.1080/15257770701533982
PMID: 18066785
Contributors: Topalis D; Kumamoto H; Julie Alexandre; Dugué L; Pochet S; Sabine Berteina-Raboin; Luigi AGROFOGLIO; Deville-Bonne D
Source: Self-asserted source
Dimitrios Topalis

Substrate specificity of vaccinia virus thymidylate kinase.

The FEBS journal
2005-12-01 | Journal article
DOI: 10.1111/j.1742-4658.2005.05006.x
PMID: 16336263
Contributors: Topalis D; Collinet B; Gasse C; Dugué L; Balzarini J; Pochet S; Deville-Bonne D
Source: Self-asserted source
Dimitrios Topalis
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