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Employment (2)

University of Pennsylvania: Philadelphia, PA, US

PI
Employment
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University of Pennsylvania via ORCID Member Portal

University of California San Diego: La Jolla, CA, US

2016-08-01 to present | Professor (Skaggs School of Pharmacy and Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Carlo Ballatore

Works (50 of 74)

Items per page:
Page 1 of 2

A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury

Science translational medicine
2023 | Journal article
EID:

2-s2.0-85171230625

Part of ISSN: 19466242
Contributors: Zhao, X.; Zeng, W.; Xu, H.; Sun, Z.; Hu, Y.; Peng, B.; McBride, J.D.; Duan, J.; Deng, J.; Zhang, B. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Protein–protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies

Trends in Pharmacological Sciences
2023 | Journal article
EID:

2-s2.0-85160532958

Part of ISSN: 18733735 01656147
Contributors: Lucero, B.; Francisco, K.R.; Liu, L.J.; Caffrey, C.R.; Ballatore, C.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis**

ChemMedChem
2023 | Journal article
EID:

2-s2.0-85165471049

Part of ISSN: 18607187 18607179
Contributors: Monti, L.; Liu, L.J.; Varricchio, C.; Lucero, B.; Alle, T.; Yang, W.; Bem-Shalom, I.; Gilson, M.; Brunden, K.R.; Brancale, A. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Structure-property relationships of fluorinated carboxylic acid bioisosteres

Bioorganic and Medicinal Chemistry Letters
2023 | Journal article
EID:

2-s2.0-85163143151

Part of ISSN: 14643405 0960894X
Contributors: Alle, T.; Joyasawal, S.; Oukoloff, K.; Long, K.; Owyang, Z.; Francisco, K.R.; Cahard, D.; Huryn, D.M.; Ballatore, C.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Hydrogen Bonding Parameters by Rapid Colorimetric Assessment: Evaluation of Structural Components Found in Biological Ligands and Organocatalysts.

Chemistry (Weinheim an der Bergstrasse, Germany)
2023-03 | Journal article
Contributors: Roenfanz HF; Paniak TJ; Berlin CB; Tran V; Francisco KR; Lassalas P; Devas A; Landes O; Rosenberger A; Rotella ME et al.
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Microtubule-Stabilizing 1,2,4-Triazolo[1,5-<i>a</i>]pyrimidines as Candidate Therapeutics for Neurodegenerative Disease: Matched Molecular Pair Analyses and Computational Studies Reveal New Structure-Activity Insights.

Journal of medicinal chemistry
2022-12 | Journal article
Contributors: Alle T; Varricchio C; Yao Y; Lucero B; Nzou G; Demuro S; Muench M; Vuong KD; Oukoloff K; Cornec AS et al.
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay.

Communications biology
2022-02 | Journal article
Contributors: Narayanan A; Narwal M; Majowicz SA; Varricchio C; Toner SA; Ballatore C; Brancale A; Murakami KS; Jose J
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Thietanes and Derivatives thereof in Medicinal Chemistry.

Current topics in medicinal chemistry
2022-01 | Journal article
Contributors: Francisco KR; Ballatore C
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Corrigendum to “structure property relationships of N-Acylsulfonamides and related bioisosteres” (European Journal of Medicinal Chemistry (2021) 218 (113399)(S0223523421002488), (10.1016/j.ejmech.2021.113399))

European Journal of Medicinal Chemistry
2021 | Journal article
EID:

2-s2.0-85117307987

Part of ISSN: 17683254 02235234
Contributors: Francisco, K.R.; Varricchio, C.; Paniak, T.J.; Kozlowski, M.C.; Brancale, A.; Ballatore, C.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection

bioRxiv
2021 | Other
EID:

2-s2.0-85105370769

Part of ISSN: 26928205
Contributors: Sandoval, D.R.; Clausen, T.M.; Nora, C.; Magida, J.A.; Cribbs, A.P.; Denardo, A.; Clark, A.E.; Garretson, A.F.; Coker, J.K.C.; Narayanan, A. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

New Heights for ProTides?

Journal of medicinal chemistry
2021-11 | Journal article
Contributors: Ballatore C
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Evaluation of log P, pK<sub>a</sub>, and log D predictions from the SAMPL7 blind challenge.

Journal of computer-aided molecular design
2021-06 | Journal article
Contributors: Bergazin TD; Tielker N; Zhang Y; Mao J; Gunner MR; Francisco K; Ballatore C; Kast SM; Mobley DL
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Structure property relationships of N-acylsulfonamides and related bioisosteres.

European journal of medicinal chemistry
2021-03 | Journal article
Contributors: Francisco KR; Varricchio C; Paniak TJ; Kozlowski MC; Brancale A; Ballatore C
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells.

FASEB bioAdvances
2021-02 | Journal article
Contributors: Lopez-Ramirez MA; McCurdy S; Li W; Haynes MK; Hale P; Francisco K; Oukoloff K; Bautista M; Choi CHJ; Sun H et al.
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-<i>a</i>]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies.

Journal of medicinal chemistry
2021-01 | Journal article
Contributors: Oukoloff K; Nzou G; Varricchio C; Lucero B; Alle T; Kovalevich J; Monti L; Cornec AS; Yao Y; James MJ et al.
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of <i>Schistosoma mansoni</i> In Vitro.

ACS infectious diseases
2020-10 | Journal article
Contributors: Monti L; Cornec AS; Oukoloff K; Kovalevich J; Prijs K; Alle T; Brunden KR; Smith AB; El-Sakkary N; Liu LJ et al.
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2020-09 | Journal article
Contributors: Yao Y; Nzou G; Alle T; Tsering W; Maimaiti S; Trojanowski JQ; Lee VM; Ballatore C; Brunden KR
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.

The Journal of biological chemistry
2020-02 | Journal article
Contributors: Gorecki L; Gerlits O; Kong X; Cheng X; Blumenthal DK; Taylor P; Ballatore C; Kovalevsky A; Radić Z
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant.

ACS omega
2019-10 | Journal article
Contributors: Meewan I; Zhang X; Roy S; Ballatore C; O'Donoghue AJ; Schooley RT; Abagyan R
Source: Self-asserted source
Carlo Ballatore via Europe PubMed Central
grade
Preferred source (of 2)‎

1,2,4-Triazolo[1,5-a]pyrimidines in drug design.

European journal of medicinal chemistry
2019-01-14 | Journal article
Source: Self-asserted source
Carlo Ballatore
grade
Preferred source (of 2)‎

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model.

Molecular neurodegeneration
2018-11-07 | Journal article
Source: Self-asserted source
Carlo Ballatore
grade
Preferred source (of 2)‎

Brain-Penetrant Triazolopyrimidine and Phenylpyrimidine Microtubule Stabilizers as Potential Leads to Treat Human African Trypanosomiasis.

ChemMedChem
2018-08-07 | Journal article
Source: Self-asserted source
Carlo Ballatore
grade
Preferred source (of 2)‎

Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.

Bioorganic & medicinal chemistry letters
2018-05-05 | Journal article
Source: Self-asserted source
Carlo Ballatore
grade
Preferred source (of 2)‎

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies

ACS Chemical Neuroscience
2017 | Journal article
EID:

2-s2.0-85013664843

Contributors: Ballatore, C.; Brunden, K.R.; Trojanowski, J.Q.; Lee, V.M.-Y.; Smith, A.B.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group.

ACS medicinal chemistry letters
2017-07-05 | Journal article
Source: Self-asserted source
Carlo Ballatore
grade
Preferred source (of 2)‎

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases.

Journal of medicinal chemistry
2017-06-08 | Journal article
Source: Self-asserted source
Carlo Ballatore
grade
Preferred source (of 2)‎

Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes

Human Molecular Genetics
2016 | Journal article
EID:

2-s2.0-84962145270

Contributors: Delépine, C.; Meziane, H.; Nectoux, J.; Opitz, M.; Smith, A.B.; Ballatore, C.; Saillour, Y.; Bennaceur-Griscelli, A.; Chang, Q.; Williams, E.C. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D

Neuropharmacology
2016 | Journal article
EID:

2-s2.0-84955161706

Contributors: Penazzi, L.; Tackenberg, C.; Ghori, A.; Golovyashkina, N.; Niewidok, B.; Selle, K.; Ballatore, C.; Smith, A.B.; Bakota, L.; Brandt, R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer's disease and related tauopathies

Journal of Pharmacology and Experimental Therapeutics
2016 | Journal article
EID:

2-s2.0-85011973296

Contributors: Kovalevich, J.; Cornec, A.-S.; Yao, Y.; James, M.; Crowe, A.; Lee, V.M.-Y.; John, T.Q.; Smith, A.B.; Ballatore, C.; Brunden, K.R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Microtubule Stabilization

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges
2016 | Book
EID:

2-s2.0-85011900251

Contributors: Ballatore, C.; Smith, A.B.; Lee, V.M.-Y.; Trojanowski, J.Q.; Brunden, K.R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Microtubule-stabilizing agents for Alzheimer’s and other tauopathies

Topics in Medicinal Chemistry
2016 | Book chapter
EID:

2-s2.0-85019636733

Part of ISSN: 1862247X 18622461
Contributors: Ballatore, C.; Smith, A.B.; Lee, V.M.-Y.; Trojanowski, J.Q.; Brunden, K.R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Structure Property Relationships of Carboxylic Acid Isosteres

Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84966333678

Contributors: Lassalas, P.; Gay, B.; Lasfargeas, C.; James, M.J.; Tran, V.; Vijayendran, K.G.; Brunden, K.R.; Kozlowski, M.C.; Thomas, C.J.; Smith, A.B. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.

Neurobiology of disease
2016-12-22 | Journal article
Source: Self-asserted source
Carlo Ballatore
grade
Preferred source (of 2)‎

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

Bioorganic and Medicinal Chemistry
2015 | Journal article
EID:

2-s2.0-84925883347

Contributors: Brunden, K.R.; Trojanowski, J.Q.; Smith, A.B.; Lee, V.M.-Y.; Ballatore, C.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine

Bioorganic and Medicinal Chemistry Letters
2015 | Journal article
EID:

2-s2.0-84944173890

Contributors: Cornec, A.-S.; James, M.J.; Kovalevich, J.; Trojanowski, J.Q.; Lee, V.M.-Y.; Smith, A.B.; Ballatore, C.; Brunden, K.R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Region-specific dendritic simplification induced by Aβ, mediated by tau via dysregulation of microtubule dynamics: A mechanistic distinct event from other neurodegenerative processes

Molecular Neurodegeneration
2015 | Journal article
EID:

2-s2.0-84960089794

Contributors: Golovyashkina, N.; Penazzi, L.; Ballatore, C.; Smith, A.B.; Bakota, L.; Brandt, R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Aminothienopyridazines as imaging probes of tau pathology: A patent evaluation of WO2013090497

Expert Opinion on Therapeutic Patents
2014 | Journal article
EID:

2-s2.0-84896734490

Contributors: Ballatore, C.; Smith III, A.B.; Lee, V.M.-Y.; Trojanowski, J.Q.; Brunden, K.R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies

Journal of Medicinal Chemistry
2014 | Journal article
EID:

2-s2.0-84905012180

Contributors: Lou, K.; Yao, Y.; Hoye, A.T.; James, M.J.; Cornec, A.-S.; Hyde, E.; Gay, B.; Lee, V.M.-Y.; Trojanowski, J.Q.; Smith, A.B. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group

Bioorganic and Medicinal Chemistry Letters
2014 | Journal article
EID:

2-s2.0-84906939078

Contributors: Ballatore, C.; Gay, B.; Huang, L.; Robinson, K.H.; James, M.J.; Trojanowski, J.Q.; Lee, V.M.-Y.; Brunden, K.R.; Smith, A.B.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Potent, long-acting cyclopentane-1,3-dione thromboxane (A<sub>2</sub>)-receptor antagonists

ACS Medicinal Chemistry Letters
2014 | Journal article
EID:

2-s2.0-84907527298

Contributors: Wang, X.; Liu, L.; Huang, L.; Herbst-Robinson, K.; Cornec, A.-S.; James, M.J.; Sugiyama, S.; Bassetto, M.; Brancale, A.; Trojanowski, J.Q. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

Journal of Biological Chemistry
2013 | Journal article
EID:

2-s2.0-84876588286

Contributors: Crowe, A.; James, M.J.; Virginia M.-Y. Lee; Smith III, A.B.; Trojanowski, J.Q.; Ballatore, C.; Brunden, K.R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Carboxylic Acid (Bio)Isosteres in Drug Design

ChemMedChem
2013 | Journal article
EID:

2-s2.0-84874353612

Contributors: Ballatore, C.; Huryn, D.M.; Smith III, A.B.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4- e ]pyrrolo[3,4- G ]indolizine-4,6(1 H,5 h)-diones as new glycogen synthase kinase-3β inhibitors

Journal of Medicinal Chemistry
2013 | Journal article
EID:

2-s2.0-84891341466

Contributors: La Pietra, V.; La Regina, G.; Coluccia, A.; Famiglini, V.; Pelliccia, S.; Plotkin, B.; Eldar-Finkelman, H.; Brancale, A.; Ballatore, C.; Crowe, A. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

MT-stabilizer, dictyostatin, exhibits prolonged brain retention and activity: Potential therapeutic implications

ACS Medicinal Chemistry Letters
2013 | Journal article
EID:

2-s2.0-84884220993

Contributors: Brunden, K.R.; Gardner, N.M.; James, M.J.; Yao, Y.; Trojanowski, J.Q.; Lee, V.M.-Y.; Paterson, I.; Ballatore, C.; Smith, A.B.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties

Bioorganic and Medicinal Chemistry
2012 | Journal article
EID:

2-s2.0-84863202528

Contributors: Ballatore, C.; Crowe, A.; Piscitelli, F.; James, M.; Lou, K.; Rossidivito, G.; Yao, Y.; Trojanowski, J.Q.; Lee, V.M.-Y.; Brunden, K.R. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies

Biochemical Society Transactions
2012 | Journal article
EID:

2-s2.0-84864395349

Contributors: Brunden, K.R.; Ballatore, C.; Lee, V.M.-Y.; Smith III, A.B.; Trojanowski, J.Q.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimers disease

ACS Chemical Neuroscience
2012 | Journal article
EID:

2-s2.0-84869753420

Contributors: Soper, J.H.; Sugiyama, S.; Herbst-Robinson, K.; James, M.J.; Wang, X.; Trojanowski, J.Q.; Smith, A.B.; Lee, V.M.-Y.; Ballatore, C.; Brunden, K.R.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Microtubule stabilizing agents as potential treatment for alzheimers disease and related neurodegenerative tauopathies

Journal of Medicinal Chemistry
2012 | Journal article
EID:

2-s2.0-84868514765

Contributors: Ballatore, C.; Brunden, K.R.; Huryn, D.M.; Trojanowski, J.Q.; Lee, V.M.-Y.; Smith, A.B.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and alzheimer-like pathology in an interventional study with aged tau transgenic mice

Journal of Neuroscience
2012 | Journal article
EID:

2-s2.0-84863230105

Contributors: Zhang, B.; Carroll, J.; Trojanowski, J.Q.; Yao, Y.; Iba, M.; Potuzak, J.S.; Hogan, A.-M.L.; Xie, S.X.; Ballatore, C.; Smith III, A.B. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier

Cyclopentane-1,3-dione: A novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists

Journal of Medicinal Chemistry
2011 | Journal article
EID:

2-s2.0-80053922655

Contributors: Ballatore, C.; Soper, J.H.; Piscitelli, F.; James, M.; Huang, L.; Atasoylu, O.; Huryn, D.M.; Trojanowski, J.Q.; Lee, V.M.-Y.; Brunden, K.R. et al.
Source: Self-asserted source
Carlo Ballatore via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (34 reviews for 7 publications/grants)

Review activity for ACS chemical neuroscience. (3)
Review activity for ACS medicinal chemistry letters. (4)
Review activity for ACS omega. (1)
Review activity for Journal of agricultural and food chemistry. (2)
Review activity for Journal of medicinal chemistry. (16)
Review activity for Journal of organic chemistry. (3)
Review activity for Organic letters. (5)