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Works (28)

Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

International Journal of Molecular Sciences
2024-05 | Journal article | Author
DOI: 10.3390/ijms25105324
Contributors: Garrett Schey; Emily R Hildebrandt; You Wang; Safwan Diwan; Holly Passetti; Gavin W. Potts; Andrea M. Sprague-Getsy; Ethan Roman Leoni; Taylor S. Kuebler; Yuk Sham et al.
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Multidisciplinary Digital Publishing Institute

Targeted Drug Delivery by MMAE Farnesyl-Bioconjugated Multivalent Chemically Self-Assembled Nanorings Induces Potent Receptor-Dependent Immunogenic Cell Death

Bioconjugate Chemistry
2024-05-15 | Journal article
DOI: 10.1021/acs.bioconjchem.4c00004
Contributors: Yiao Wang; Ozgun Kilic; Lakmal Rozumalski; Mark D. Distefano; Carston R. Wagner
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Crossref

Multivalent Fluorinated Nanorings for On-Cell 19F NMR

Biomacromolecules
2024-02-12 | Journal article
DOI: 10.1021/acs.biomac.3c01391
Contributors: Jiaqian Li; Yiao Wang; Mark. D. Distefano; Carston R. Wagner; William C. K. Pomerantz
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Crossref

Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1

RSC Chemical Biology
2023 | Journal article
DOI: 10.1039/D3CB00089C
Contributors: Kiall F. Suazo; Jakub Bělíček; Garrett L. Schey; Shelby A. Auger; Alexandru M. Petre; Ling Li; Katarzyna M. Błażewska; David Kopečný; Mark D. Distefano
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Crossref

Orthogonal Enzyme–Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates

Journal of the American Chemical Society
2023-10-18 | Journal article
DOI: 10.1021/jacs.3c04359
Contributors: Robbins Puthenveetil; Shelby A. Auger; Natalia Gómez-Navarro; Mitra Shumsher Rana; Riki Das; Liam Brendan Healy; Kiall F. Suazo; Zhen-Dan Shi; Rolf E. Swenson; Mark D. Distefano et al.
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Crossref

GTPase splice variants RAC1 and RAC1B display isoform-specific differences in localization, prenylation, and interaction with the chaperone protein SmgGDS

Journal of Biological Chemistry
2023-06 | Journal article
DOI: 10.1016/j.jbc.2023.104698
Contributors: Olivia J. Koehn; Ellen Lorimer; Bethany Unger; Ra’Mal Harris; Akansha S. Das; Kiall F. Suazo; Shelby A. Auger; Mark D. Distefano; Jeremy W. Prokop; Carol L. Williams
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Crossref

Engineering Biomimetic Trogocytosis with Farnesylated Chemically Self-Assembled Nanorings

Biomacromolecules
2022-12-12 | Journal article
DOI: 10.1021/acs.biomac.2c00837
Contributors: Yiao Wang; Lakmal Rozumalski; Ozgun Kilic; Caitlin Lichtenfels; Jacob Petersberg; Mark D. Distefano; Carston R. Wagner
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Crossref

Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase

Journal of Medicinal Chemistry
2022-10-27 | Journal article
DOI: 10.1021/acs.jmedchem.2c00902
Contributors: You Wang; Feng Xu; Connie B. Nichols; Yuqian Shi; Homme W. Hellinga; J. Andrew Alspaugh; Mark D. Distefano; Lorena S. Beese
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Crossref

In Vivo Prenylomic Profiling in the Brain of a Transgenic Mouse Model of Alzheimer’s Disease Reveals Increased Prenylation of a Key Set of Proteins

ACS Chemical Biology
2022-10-21 | Journal article
DOI: 10.1021/acschembio.2c00486
Contributors: Angela Jeong; Shelby A. Auger; Sanjay Maity; Kristina Fredriksen; Rui Zhong; Ling Li; Mark D. Distefano
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Crossref

Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation

ACS Chemical Biology
2022-10-21 | Journal article
DOI: 10.1021/acschembio.2c00645
Contributors: Johannes Morstein; Taysir Bader; Ariana L. Cardillo; Julian Schackmann; Sudhat Ashok; James L. Hougland; Christine A. Hrycyna; Dirk H. Trauner; Mark D. Distefano
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Crossref

Manipulating Cell Fates with Protein Conjugates

Bioconjugate Chemistry
2022-10-19 | Journal article
DOI: 10.1021/acs.bioconjchem.2c00226
Contributors: Yiao Wang; Carston R. Wagner; Mark D. Distefano
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Crossref

Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy

International Journal of Molecular Sciences
2022-09-29 | Journal article
DOI: 10.3390/ijms231911537
Contributors: Yi Zhang; Yiao Wang; Safak Uslu; Sneha Venkatachalapathy; Mohammad Rashidian; Jonas V. Schaefer; Andreas Plückthun; Mark D. Distefano
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Crossref

Mevalonate metabolites contribute to granulocyte chemotaxis and mortality in murine endotoxemia

2022-09-15 | Preprint
DOI: 10.1101/2022.09.13.507840
Contributors: Jamal Hussain; Carey G. Ousley; Steven A. Krauklis; Evan L. Dray; Jenny Drnevich; Katarzyna Justyna; Mark D. Distefano; Daniel B. McKim
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Crossref

Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1

2022-08-30 | Preprint
DOI: 10.1101/2022.08.29.505770
Contributors: Kiall F. Suazo; Garrett L. Schey; Shelby A. Auger; Ling Li; Mark Distefano
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Crossref

Combining Isoprenoid Probes with Antibody Markers for Mass Cytometric Analysis of Prenylation in Single Cells

Analytical Chemistry
2022-08-23 | Journal article
DOI: 10.1021/acs.analchem.2c01509
Contributors: Zoë A. Maxwell; Kiall F. Suazo; Heather M.G. Brown; Mark D. Distefano; Edgar A. Arriaga
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Crossref

In vivo prenylomic profiling in the brain of a transgenic mouse model of Alzheimer’s disease reveals increased prenylation of a key set of proteins

2022-04-01 | Preprint
DOI: 10.1101/2022.04.01.486487
Contributors: Angela Jeong; Shelby A. Auger; Sanjay Maity; Ling Li; Mark D. Distefano
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Crossref

Engineering reversible cell–cell interactions using enzymatically lipidated chemically self-assembled nanorings

Chemical Science
2021 | Journal article
DOI: 10.1039/D0SC03194A
Contributors: Yiao Wang; Ozgun Kilic; Clifford M. Csizmar; Sudhat Ashok; James L. Hougland; Mark D. Distefano; Carston R. Wagner
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Crossref

Two-photon uncaging of bioactive thiols in live cells at wavelengths above 800 nm

Organic & Biomolecular Chemistry
2021 | Journal article
DOI: 10.1039/d0ob01986k
Part of ISSN: 1477-0520
Part of ISSN: 1477-0539
Source: Self-asserted source
Mark Distefano

MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase

International Journal of Molecular Sciences
2021-11-07 | Journal article
DOI: 10.3390/ijms222112042
Contributors: Garrett L. Schey; Peter H. Buttery; Emily R. Hildebrandt; Sadie X. Novak; Walter K. Schmidt; James L. Hougland; Mark D. Distefano
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Crossref
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Preferred source (of 2)‎

A Not-So-Ancient Grease History: Click Chemistry and Protein Lipid Modifications

Chemical Reviews
2021-06-23 | Journal article
DOI: 10.1021/acs.chemrev.0c01108
Contributors: Kiall F. Suazo; Keun-Young Park; Mark D. Distefano
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Crossref

Neuronal Protein Farnesylation Regulates Hippocampal Synaptic Plasticity and Cognitive Function

Molecular Neurobiology
2021-03-24 | Journal article
DOI: 10.1007/s12035-020-02169-w
Contributors: Wenhui Qu; Kiall F. Suazo; Wenfeng Liu; Shaowu Cheng; Angela Jeong; David Hottman; Li-Lian Yuan; Mark D. Distefano; Ling Li
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Crossref

Metabolic labeling with an alkyne probe reveals similarities and differences in the prenylomes of several brain-derived cell lines and primary cells

Scientific Reports
2021-02-23 | Journal article
DOI: 10.1038/s41598-021-83666-3
Contributors: Kiall F. Suazo; Angela Jeong; Mina Ahmadi; Caroline Brown; Wenhui Qu; Ling Li; Mark D. Distefano
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Crossref

Red-shifted backbone N–H photocaging agents

Organic & Biomolecular Chemistry
2020 | Journal article
DOI: 10.1039/D0OB00923G
Contributors: Alicia E. Mangubat-Medina; Hallie O. Trial; Reyner D. Vargas; Mekedlawit T. Setegne; Taysir Bader; Mark D. Distefano; Zachary T. Ball
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Crossref

Anti-EGFR Fibronectin Bispecific Chemically Self-Assembling Nanorings (CSANs) Induce Potent T Cell-Mediated Antitumor Responses and Downregulation of EGFR Signaling and PD-1/PD-L1 Expression

Journal of Medicinal Chemistry
2020-09-24 | Journal article
DOI: 10.1021/acs.jmedchem.0c00489
Contributors: Ozgun Kilic; Marcos R. Matos de Souza; Abdulaziz A. Almotlak; Yiao Wang; Jill M. Siegfried; Mark D. Distefano; Carston R. Wagner
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Crossref

Methoxy-Substituted Nitrodibenzofuran-Based Protecting Group with an Improved Two-Photon Action Cross-Section for Thiol Protection in Solid Phase Peptide Synthesis

The Journal of Organic Chemistry
2020-02-07 | Journal article
DOI: 10.1021/acs.joc.9b02751
Contributors: Taysir K. Bader; Feng Xu; Michael H. Hodny; David A. Blank; Mark D. Distefano
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Crossref

Recent progress in enzymatic protein labelling techniques and their applications

Chemical Society Reviews
2018 | Journal article
DOI: 10.1039/C8CS00537K
Contributors: Yi Zhang; Keun-Young Park; Kiall F. Suazo; Mark D. Distefano
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Crossref

Efficient farnesylation of an extended C-terminal C(x)3X sequence motif expands the scope of the prenylated proteome

Journal of Biological Chemistry
2018-02-23 | Journal article
DOI: 10.1074/jbc.M117.805770
Contributors: Melanie J. Blanden; Kiall F. Suazo; Emily R. Hildebrandt; Daniel S. Hardgrove; Meet Patel; William P. Saunders; Mark D. Distefano; Walter K. Schmidt; James L. Hougland
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Crossref

a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity

Bioconjugate Chemistry
2018-02-21 | Journal article
DOI: 10.1021/acs.bioconjchem.7b00648
Contributors: Veronica Diaz-Rodriguez; Erh-Ting Hsu; Elena Ganusova; Elena R. Werst; Jeffrey M. Becker; Christine A. Hrycyna; Mark D. Distefano
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Crossref
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