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Frequency of targetable genetic alterations in resectable lung adenocarcinoma: Results from the LORD project

Lung Cancer
2025-04 | Journal article
DOI: 10.1016/j.lungcan.2025.108530
Contributors: Yohan Bossé; Dominique Boudreau; Victoria Saavedra Armero; Zhonglin Li; Élody Tremblay; Nathalie Gaudreault; Andréanne Gagné; Patrice Desmeules; Philippe Joubert
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Mapping the Monogenic and Polygenic Architecture of Mitral Valve Prolapse

Canadian Journal of Cardiology
2025-01 | Journal article
DOI: 10.1016/j.cjca.2025.01.022
Contributors: Yohan Bossé; Sébastien Thériault; Patrick Mathieu
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Alpha-1-Antitrypsin Deficiency Targeted Testing and Augmentation Therapy: A Canadian Thoracic Society Meta-analysis and Clinical Practice Guideline

Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
2025-01-27 | Journal article
DOI: 10.1080/24745332.2024.2443178
Contributors: Paul Hernandez; Yohan Bossé; Pam Bush; Kenneth R. Chapman; François Maltais; Erika D. Penz; Brandie L. Walker; Avtar Lal; Darcy D. Marciniuk
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Circulating Autoantibodies Targeting TREK-1 in Patients With Short-Coupled Ventricular Fibrillation

Circulation
2024-12-10 | Journal article
DOI: 10.1161/CIRCULATIONAHA.124.070284
Contributors: Jin Li; Alexandre Janin; Mona Patoughi; Nathalie Gaudreault; Lenke Kis; Hamid Moha Ou Maati; Yohan Bossé; Christian Steinberg
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Metabolomic Profiling of Pulmonary Neuroendocrine Neoplasms

Cancers
2024-09-17 | Journal article
DOI: 10.3390/cancers16183179
Contributors: Clémence Boullier; Fabien C. Lamaze; Jean-François Haince; Rashid Ahmed Bux; Michèle Orain; Jiamin Zheng; Lun Zhang; David S. Wishart; Yohan Bossé; Venkata S. K. Manem et al.
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Efficient molecular mendelian randomization screens with LaScaMolMR.jl

2024-08-30 | Preprint
DOI: 10.1101/2024.08.29.24312805
Contributors: Samuel Mathieu; Louis-Hippolyte Minvielle Moncla; Mewen Briend; Valentine Duclos; Anne Rufiange; Yohan Bossé; Patrick Mathieu
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Lung Tissue Transcriptomics Reveal Associations between Thymic Stromal Lymphopoietin Signaling, Mast Cells, and Airway Obstruction in Active Smokers

American Journal of Respiratory Cell and Molecular Biology
2024-07 | Journal article
DOI: 10.1165/rcmb.2023-0416LE
Contributors: Nadia Milad; Sophie Aubin; Christine Racine; François Maltais; Yohan Bossé; Mathieu C. Morissette
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Prognostic implication of methylation-based circulating tumor DNA detection prior to surgery in stage I non-small cell lung cancer

Cancer Letters
2024-07 | Journal article
DOI: 10.1016/j.canlet.2024.216984
Contributors: Yohan Bossé; Abhijit Dasgupta; Michael Abadier; Violeta Guthrie; Florian Song; Victoria Saavedra Armero; Nathalie Gaudreault; Michèle Orain; Fabien C. Lamaze; Collin Melton et al.
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A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology
2024-06 | Journal article
DOI: 10.1165/rcmb.2024-0009MA
Contributors: Judith Villeneuve; Élody Tremblay; Nathalie Gaudreault; Victoria Saavedra Armero; Dominique K. Boudreau; Zhonglin Li; Sébastien Renaut; Geneviève Dion; Yohan Bossé
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Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse

Communications Medicine
2024-06-06 | Journal article
DOI: 10.1038/s43856-024-00530-x
Contributors: Louis-Hippolyte Minvielle Moncla; Mewen Briend; Mame Sokhna Sylla; Samuel Mathieu; Anne Rufiange; Yohan Bossé; Patrick Mathieu
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Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights

PLOS Genetics
2024-05-30 | Journal article
DOI: 10.1371/journal.pgen.1011301
Contributors: Sébastien Renaut; Yan Tang; Victoria Saavedra Armero; Dominique K. Boudreau; Nathalie Gaudreault; Patrice Desmeules; Sébastien Thériault; Patrick Mathieu; Philippe Joubert; Yohan Bossé
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Cardiac reverse remodeling in a mouse model with many phenotypical features of heart failure with preserved ejection fraction: effects of modifying lifestyle

American Journal of Physiology-Heart and Circulatory Physiology
2024-04-01 | Journal article
DOI: 10.1152/ajpheart.00462.2023
Contributors: Mohamed Lamine Aidara; Élisabeth Walsh-Wilkinson; Sara-Ève Thibodeau; Emylie-Ann Labbé; Audrey Morin-Grandmont; Geneviève Gagnon; Dominique K. Boudreau; Marie Arsenault; Yohan Bossé; Jacques Couët
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Calcific aortic valve disease: mechanisms, prevention and treatment

Nature Reviews Cardiology
2023-08 | Journal article
DOI: 10.1038/s41569-023-00845-7
Contributors: Louis-Hippolyte Minvielle Moncla; Mewen Briend; Yohan Bossé; Patrick Mathieu
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Integrative Analysis of the Blood Proteome by Mendelian Randomization Reveals Regulatory Networks in Calcific Aortic Valve Disease

2023-07-28 | Preprint
DOI: 10.1101/2023.07.26.23293222
Contributors: Mewen Briend; Louis-Hippolyte Minvielle Moncla; Valentine Duclos; Samuel Mathieu; Anne Rufiange; Sébastien Thériault; Benoit Arsenault; Yohan Bossé; Patrick Mathieu
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A Simplified Version of the IASLC Grading System for Invasive Pulmonary Adenocarcinomas With Improved Prognosis Discrimination

American Journal of Surgical Pathology
2023-06 | Journal article
DOI: 10.1097/PAS.0000000000002040
Contributors: Yohan Bossé; Andréanne Gagné; Wajd A. Althakfi; Michèle Orain; Christian Couture; Sylvain Trahan; Sylvain Pagé; David Joubert; Pierre O. Fiset; Patrice Desmeules et al.
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The journey towards identification of actionable molecular pathways in calcific aortic valve stenosis

European Heart Journal
2023-06-01 | Journal article
DOI: 10.1093/eurheartj/ehad134
Contributors: Sébastien Thériault; Patrick Mathieu; Yohan Bossé
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Leucocyte-Derived Micro-RNAs as Candidate Biomarkers in Brugada Syndrome

2023-05-25 | Other
DOI: 10.1093/europace/euad145
Contributors: Christian Steinberg; Alan Spatz; François Philippon; Yohan Bossé
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Prognostic value of complex glandular patterns in invasive pulmonary adenocarcinomas

Human Pathology
2022-10 | Journal article
DOI: 10.1016/j.humpath.2022.07.007
Contributors: Yohan Bossé; Andréanne Gagné; Wajd Althakfi; Michèle Orain; Pierre Olivier Fiset; Patrice Desmeules; Philippe Joubert
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The Null Q0Ourém Variant within a Copy-Neutral Loss-of-Heterozygosity Event Causing Alpha-1 Antitrypsin Deficiency

American Journal of Respiratory Cell and Molecular Biology
2022-06 | Journal article
DOI: 10.1165/rcmb.2021-0564LE
Contributors: Nathalie Gaudreault; Claudia Blouin; Annie Haillot; Julie Milot; François Maltais; Yohan Bossé
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Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve

PLOS Genetics
2022-01-18 | Journal article
DOI: 10.1371/journal.pgen.1010010
Contributors: Arnaud Chignon; Jeannie T. Lee; Déborah Argaud; Marie-Chloé Boulanger; Ghada Mkannez; Valentin Bon-Baret; Zhonglin Li; Sébastien Thériault; Yohan Bossé; Patrick Mathieu
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Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men

Circulation: Genomic and Precision Medicine
2021-12 | Journal article
DOI: 10.1161/CIRCGEN.121.003452
Contributors: Hasanga D. Manikpurage; Aida Eslami; Nicolas Perrot; Zhonglin Li; Christian Couture; Patrick Mathieu; Yohan Bossé; Benoit J. Arsenault; Sébastien Thériault
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SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues

International Journal of Molecular Sciences
2021-08-26 | Journal article
DOI: 10.3390/ijms22179228
Contributors: Guoshuai Cai; Mulong Du; Yohan Bossé; Helmut Albrecht; Fei Qin; Xizhi Luo; Xiao Michelle Androulakis; Chao Cheng; Mitzi Nagarkatti; Prakash Nagarkatti et al.
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Sex-Specific Associations of Genetically-Predicted Circulating Lipoprotein(a) and Hepatic LPA Gene Expression Levels with Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses

Circulation: Genomic and Precision Medicine
2021-07-19 | Journal article
DOI: 10.1161/CIRCGEN.120.003271
Contributors: Jakie Guertin; Yannick Kaiser; Hasanga Manikpurage; Nicolas Perrot; Raphaëlle Bourgeois; Christian Couture; Nicholas J. Wareham; Yohan Bossé; Philippe Pibarot; Erik S.G. Stroes et al.
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Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk

2021-07-13 | Preprint
DOI: 10.21203/rs.3.rs-647012/v1
Contributors: Yafang Li; Xiangjun Xiao; Jianrong Li; Jinyoung Byun; Chao Cheng; Yohan Bossé; James McKay; Demetrius Albanes; Stephen Lam; Adonina Tardon et al.
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System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan

Circulation: Genomic and Precision Medicine
2021-04 | Journal article
DOI: 10.1161/CIRCGEN.120.003196
Contributors: Valentin Bon-Baret; Arnaud Chignon; Marie-Chloé Boulanger; Zhonglin Li; Deborah Argaud; Benoit J. Arsenault; Sébastien Thériault; Yohan Bossé; Patrick Mathieu
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A Polygenic Risk Score for Coronary Artery Disease Improves the Prediction of Early-Onset Myocardial Infarction and Mortality in Men

2021-04-27 | Other
DOI: 10.1101/2021.04.25.21256083
Contributors: Hasanga D. Manikpurage; Aida Eslami; Nicolas Perrot; Zhonglin Li; Christian Couture; Patrick Mathieu; Yohan Bossé; Benoit J. Arsenault; Sébastien Thériault
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Crossref

Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers

PLOS Genetics
2021-03-05 | Journal article
DOI: 10.1371/journal.pgen.1009254
Contributors: Corina Lesseur; Stephen J. Chanock; Aida Ferreiro-Iglesias; James D. McKay; Yohan Bossé; Mattias Johansson; Valerie Gaborieau; Maria Teresa Landi; David C. Christiani; Neil C. Caporaso et al.
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Oxyphospholipids in Cardiovascular Calcification

Arteriosclerosis, Thrombosis, and Vascular Biology
2021-01 | Journal article
DOI: 10.1161/ATVBAHA.120.313790
Contributors: Arnaud Chignon; Valentin Bon-Baret; Marie-Chloé Boulanger; Yohan Bossé; Patrick Mathieu
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Electronic Health Record-Based Genome-Wide Meta-Analysis and Mendelian Randomization Identify Metabolic and Phenotypic Consequences of Non-Alcoholic Fatty Liver Disease

2020-11-04 | Other
DOI: 10.21203/rs.3.rs-97977/v1
Contributors: Nooshin Ghodsian; Erik Abner; Émilie Gobeil; Nele Taba; Alexis St-Amand; Nicolas Perrot; Christian Couture; Patricia Mitchell; Yohan Bossé; Patrick Mathieu et al.
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Granularity ofSERPINA1alleles by DNA sequencing in CanCOLD

European Respiratory Journal
2020-10 | Journal article
DOI: 10.1183/13993003.00958-2020
Contributors: Nisha Gupta; Nathalie Gaudreault; Sébastien Thériault; Pei Zhi Li; Cyndi Henry; Miranda Kirby; François Maltais; Wan Tan; Jean Bourbeau; Yohan Bossé
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Transcriptomic data helps refining classification of pulmonary carcinoid tumors with increased mitotic counts

Modern Pathology
2020-09 | Journal article
DOI: 10.1038/s41379-020-0538-8
Contributors: Olga Sazonova; Venkata Manem; Michèle Orain; Babak Khoshkrood-Mansoori; Nathalie Gaudreault; Patrice Desmeules; Yohan Bossé; Philippe Joubert
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Phenome-wide analyses establish a specific association between aortic valve PALMD expression and calcific aortic valve stenosis

Communications Biology
2020-08-28 | Journal article
DOI: 10.1038/s42003-020-01210-x
Contributors: Zhonglin Li; Nathalie Gaudreault; Benoit J. Arsenault; Patrick Mathieu; Yohan Bossé; Sébastien Thériault
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Reply to Polverino: Cigarette Smoking and COVID-19: A Complex Interaction

American Journal of Respiratory and Critical Care Medicine
2020-08-01 | Journal article
DOI: 10.1164/rccm.202005-1807LE
Contributors: Guoshuai Cai; Yohan Bossé; Feifei Xiao; Farrah Kheradmand; Christopher I. Amos
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A Trans-Omic Mendelian Randomization Study of Parental Lifespan Uncovers Novel Aging Biology and Drug Candidates for Human Healthspan Extension

2020-07-10 | Other
DOI: 10.1101/2020.07.06.20147520
Contributors: Nicolas Perrot; William Pelletier; Jerome Bourgeault; Christian Couture; Zhonglin Li; Patricia Mitchell; Nooshin Ghodsian; Yohan Bosse; Sebastien Theriault; Patrick Mathieu et al.
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Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2

American Journal of Respiratory and Critical Care Medicine
2020-06-15 | Journal article
DOI: 10.1164/rccm.202003-0693LE
Contributors: Guoshuai Cai; Yohan Bossé; Feifei Xiao; Farrah Kheradmand; Christopher I. Amos
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Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]

2020-06-01 | Journal article
DOI: 10.12688/wellcomeopenres.15846.1
Part of ISSN: 2398-502X
Contributors: Katherine A. Fawcett; Ma'en Obeidat; Carl Melbourne; Nick Shrine; Anna L. Guyatt; Catherine John; Jian'an Luan; Anne Richmond; Marta R. Moksnes; Raquel Granell et al.
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Wellcome Open Research

Protein-altering germline mutations implicate novel genes related to lung cancer development

Nature Communications
2020-05-11 | Journal article
DOI: 10.1038/s41467-020-15905-6
Contributors: Xuemei Ji; Semanti Mukherjee; Maria Teresa Landi; Yohan Bosse; Philippe Joubert; Dakai Zhu; Ivan Gorlov; Xiangjun Xiao; Younghun Han; Olga Gorlova et al.
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Single-cell expression and Mendelian randomization analyses identify blood genes associated with lifespan and chronic diseases

Communications Biology
2020-05-01 | Journal article
DOI: 10.1038/s42003-020-0937-x
Contributors: Arnaud Chignon; Valentin Bon-Baret; Marie-Chloé Boulanger; Zhonglin Li; Deborah Argaud; Yohan Bossé; Sébastien Thériault; Benoit J. Arsenault; Patrick Mathieu
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Transcriptome‐wide association study reveals candidate causal genes for lung cancer

International Journal of Cancer
2020-04 | Journal article
DOI: 10.1002/ijc.32771
Contributors: Yohan Bossé; Zhonglin Li; Jun Xia; Venkata Manem; Robert Carreras‐Torres; Aurélie Gabriel; Nathalie Gaudreault; Demetrius Albanes; Melinda C. Aldrich; Angeline Andrew et al.
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Whole Exome Sequencing of Highly Aggregated Lung Cancer Families Reveals Linked Loci for Increased Cancer Risk on Chromosomes 12q, 7p, and 4q

Cancer Epidemiology, Biomarkers & Prevention
2020-02-01 | Journal article
DOI: 10.1158/1055-9965.EPI-19-0887
Contributors: Anthony M. Musolf; Bilal A. Moiz; Haiming Sun; Claudio W. Pikielny; Yohan Bossé; Diptasri Mandal; Mariza de Andrade; Colette Gaba; Ping Yang; Yafang Li et al.
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Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

Nature Communications
2020-01-07 | Journal article
DOI: 10.1038/s41467-019-13855-2
Contributors: Linda Kachuri; Mattias Johansson; Sara R. Rashkin; Rebecca E. Graff; Yohan Bossé; Venkata Manem; Neil E. Caporaso; Maria Teresa Landi; David C. Christiani; Paolo Vineis et al.
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High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma

Journal of Lipid Research
2019-10-13 | Journal article
DOI: 10.1194/jlr.M093955
Contributors: Anne-Marie Lemay; Olivier Courtemanche; Timothy A. Couttas; Giuleta Jamsari; Andréanne Gagné; Yohan Bossé; Philippe Joubert; Anthony S. Don; David Marsolais
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A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity

npj Genomic Medicine
2019-09-20 | Journal article
DOI: 10.1038/s41525-019-0097-4
Contributors: Mickael Rosa; Arnaud Chignon; Zhonglin Li; Marie-Chloé Boulanger; Benoit J. Arsenault; Yohan Bossé; Sébastien Thériault; Patrick Mathieu
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Benefits and limitations of genome-wide association studies

Nature Reviews Genetics
2019-08-08 | Journal article
DOI: 10.1038/s41576-019-0127-1
Contributors: Vivian Tam; Nikunj Patel; Michelle Turcotte; Yohan Bossé; Guillaume Paré; David Meyre
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Differential lung tissue gene expression in males and females: implications for the susceptibility to develop COPD

European Respiratory Journal
2019-07 | Journal article
DOI: 10.1183/13993003.02567-2017
Contributors: Maarten van den Berge; Corry-Anke Brandsma; Alen Faiz; Maaike de Vries; Senani N.H. Rathnayake; Peter D. Paré; Don D. Sin; Yohan Bossé; Michel Laviolette; David C. Nickle et al.
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UCP1 expression–associated gene signatures of human epicardial adipose tissue

JCI Insight
2019-04-18 | Journal article
DOI: 10.1172/jci.insight.123618
Contributors: Kanta Chechi; Jinchu Vijay; Pierre Voisine; Patrick Mathieu; Yohan Bossé; Andre Tchernof; Elin Grundberg; Denis Richard
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Crossref

Tumor-based gene expression biomarkers to predict survival following curative intent resection for stage I lung adenocarcinoma

PLOS ONE
2018-11-20 | Journal article
DOI: 10.1371/journal.pone.0207513
Contributors: Alisson Clemenceau; Alfons Navarro; Nathalie Gaudreault; Cyndi Henry; Paula A. Ugalde; Catherine Labbé; Michel Laviolette; Philippe Joubert; Yohan Bossé
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Crossref

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Nature Communications
2018-08-13 | Journal article
DOI: 10.1038/s41467-018-05074-y
Contributors: Xuemei Ji; Yohan Bossé; Maria Teresa Landi; Jiang Gui; Xiangjun Xiao; David Qian; Philippe Joubert; Maxime Lamontagne; Yafang Li; Ivan Gorlov et al.
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Crossref

The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD

Scientific Reports
2018-08-08 | Journal article
DOI: 10.1038/s41598-018-30313-z
Contributors: Ma’en Obeidat; Anna Dvorkin-Gheva; Xuan Li; Yohan Bossé; Corry-Anke Brandsma; David C. Nickle; Philip M. Hansbro; Rosa Faner; Alvar Agusti; Peter D. Paré et al.
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Crossref

Meta-analysis of exome array data identifies six novel genetic loci for lung function [version 3; referees: 2 approved]

2018-08-07 | Journal article
DOI: 10.12688/wellcomeopenres.12583.3
Part of ISSN: 2398-502X
Contributors: Victoria E. Jackson; Jeanne C. Latourelle; Louise V. Wain; Albert V. Smith; Megan L. Grove; Traci M. Bartz; Ma'en Obeidat; Michael A. Province; Wei Gao; Beenish Qaiser et al.
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Wellcome Open Research
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Peer review (10 reviews for 7 publications/grants)

Review activity for American journal of human genetics. (1)
Review activity for European heart journal. (2)
Review activity for Nature communications (1)
Review activity for Nature genetics. (1)
Review activity for Nature reviews. (1)
Review activity for The Canadian journal of cardiology. (2)
Review activity for The Lancet. (2)
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