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ResearcherID: C-2619-2012
ResearcherID: C-2619-2012

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Czech Republic

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Employment (1)

Institute of Physiology of the Czech Academy of Sciences: Prague , CZ

Senior Researcher (Laboratory of Biomathematics)
Employment
Source: Self-asserted source
Petr Svoboda

Education and qualifications (2)

Charles University Faculty of Sciences: Prague, CZ

Associated Professor (Animal Physiology and Developmental Biology)
Education
Source: Self-asserted source
Petr Svoboda

Charles University 1st Faculty of Medicine: Prague, CZ

DSc degree in Medicine
Education
Source: Self-asserted source
Petr Svoboda

Works (50 of 128)

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Page 1 of 3

The Dose-Dependent Effects of Multifunctional Enkephalin Analogs on the Protein Composition of Rat Spleen Lymphocytes, Cortex, and Hippocampus; Comparison with Changes Induced by Morphine

Biomedicines
2022-08-14 | Journal article
DOI: 10.3390/biomedicines10081969
Part of ISSN: 2227-9059
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Time-Dependent Changes in Protein Composition of Medial Prefrontal Cortex in Rats with Neuropathic Pain

International Journal of Molecular Sciences
2022-01-16 | Journal article
DOI: 10.3390/ijms23020955
Part of ISSN: 1422-0067
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Therapeutic lithium alters polar head-group region of lipid bilayer and prevents lipid peroxidation in forebrain cortex of sleep-deprived rats

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
2021 | Journal article
DOI: 10.1016/J.BBALIP.2021.158962
WOSUID: WOS:000665526800001
Contributors: Vosahlikova, Miroslava; Roubalova, Lenka; Brejchova, Jana; Alda, Martin; Svoboda, Petr
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Alterations in the Proteome and Phosphoproteome Profiles of Rat Hippocampus after Six Months of Morphine Withdrawal: Comparison with the Forebrain Cortex

Biomedicines
2021-12-31 | Journal article
DOI: 10.3390/biomedicines10010080
Part of ISSN: 2227-9059
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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The Altered Migration and Distribution of Systemically Administered Mesenchymal Stem Cells in Morphine-Treated Recipients

Stem Cell Reviews and Reports
2021-08 | Journal article
DOI: 10.1007/s12015-021-10126-w
Part of ISSN: 2629-3269
Part of ISSN: 2629-3277
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Tissue-specific protective properties of lithium: comparison of rat kidney, erythrocytes and brain

Naunyn-Schmiedeberg's Archives of Pharmacology
2021-05 | Journal article
DOI: 10.1007/s00210-020-02036-4
Part of ISSN: 0028-1298
Part of ISSN: 1432-1912
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Impact of three-month morphine withdrawal on rat brain cortex, hippocampus, striatum and cerebellum: proteomic and phosphoproteomic studies

Neurochemistry International
2021-03 | Journal article
DOI: 10.1016/j.neuint.2021.104975
Part of ISSN: 0197-0186
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Expression of Opioid Receptors in Cells of the Immune System

International Journal of Molecular Sciences
2020-12-30 | Journal article
DOI: 10.3390/ijms22010315
Part of ISSN: 1422-0067
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Na+/K+-ATPase and lipid peroxidation in forebrain cortex and hippocampus of sleep-deprived rats treated with therapeutic lithium concentration for different periods of time

Progress in Neuro-Psychopharmacology and Biological Psychiatry
2020-08 | Journal article
DOI: 10.1016/j.pnpbp.2020.109953
Part of ISSN: 0278-5846
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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The high-resolution proteomic analysis of protein composition of rat spleen lymphocytes stimulated by Concanavalin A; a comparison with morphine-treated cells

Journal of Neuroimmunology
2020-04 | Journal article
DOI: 10.1016/j.jneuroim.2020.577191
Part of ISSN: 0165-5728
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Proteomic analysis of protein composition of rat hippocampus exposed to morphine for 10 days; comparison with animals after 20 days of morphine withdrawal

PLOS ONE
2020-04-15 | Journal article
DOI: 10.1371/journal.pone.0231721
Part of ISSN: 1932-6203
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Concurrent Compression of Phospholipid Membranes by Calcium and Cholesterol

Langmuir
2019 | Journal article
DOI: 10.1021/ACS.LANGMUIR.9B00477
WOSUID: WOS:000484644000015
Contributors: Melcrova, Adela; Pokorna, Sarka; Vosahlikova, Miroslava; Sykora, Jan; Svoboda, Petr; Hof, Martin; Cwiklik, Lukasz; Jurkiewicz, Piotr
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Na+/K+-ATPase level and products of lipid peroxidation in live cells treated with therapeutic lithium for different periods in time (1, 7, and 28 days); studies of Jurkat and HEK293 cells

Naunyn-Schmiedeberg's Archives of Pharmacology
2019 | Journal article
DOI: 10.1007/S00210-019-01631-4
WOSUID: WOS:000470688700003
Contributors: Miroslava Vosahlikova; Lenka Roubalova; Hana Ujcikova; Martina Hlouskova; Stanislav Musil; Martin Alda; Petr Svoboda
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Determination of δ-opioid receptor molecules mobility in living cells plasma membrane by novel method of FRAP analysis

Biochimica et Biophysica Acta (BBA) - Biomembranes
2019-07 | Journal article
DOI: 10.1016/j.bbamem.2019.04.012
Part of ISSN: 0005-2736
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Induction of oxidative stress by long-term treatment of live HEK293 cells with therapeutic concentration of lithium is associated with down-regulation of δ-opioid receptor amount and function

Biochem Pharmacol
2018 | Journal article
DOI: 10.1016/j.bcp.2018.06.004
Contributors: Vosahlikova, M.; Ujcikova, H.; Hlouskova, M.; Musil, S.; Roubalova, L.; Alda, M.; Svoboda, P.
Source: Self-asserted source
Petr Svoboda via ResearcherID
grade
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The Impact of Morphine on the Characteristics and Function Properties of Human Mesenchymal Stem Cells

Stem Cell Rev
2018 | Journal article
DOI: 10.1007/s12015-018-9843-8
Contributors: Holan, V.; Cechova, K.; Zajicova, A.; Kossl, J.; Hermankova, B.; Bohacova, P.; Hajkova, M.; Krulova, M.; Svoboda, P.; Javorkova, E.
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Up-regulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes

Journal of Neuroimmunology
2018-08 | Journal article
DOI: 10.1016/j.jneuroim.2018.05.008
Part of ISSN: 0165-5728
Contributors: Petr Svoboda
Source: Self-asserted source
Petr Svoboda
grade
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Determination of μ-, δ- and κ-opioid receptors in forebrain cortex of rats exposed to morphine for 10 days: Comparison with animals after 20 days of morphine withdrawal

PLoS One
2017 | Journal article
DOI: 10.1371/journal.pone.0186797
Contributors: Ujcikova, H.; Hlouskova, M.; Cechova, K.; Stolarova, K.; Roubalova, L.; Svoboda, P.
Source: Self-asserted source
Petr Svoboda via ResearcherID
grade
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Effect of therapeutic concentration of lithium on live HEK293 cells; increase of Na+/K+-ATPase, change of overall protein composition and alteration of surface layer of plasma membrane

Biochimica et biophysica acta
2017 | Journal article
DOI: 10.1016/j.bbagen.2017.02.011
WOSUID:

MEDLINE:28215700
Contributors: Vosahlikova, Miroslava; Ujcikova, Hana; Chernyavskiy, Oleksandr; Brejchova, Jana; Roubalova, Lenka; Alda, Martin; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
grade
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Lithium - therapeutic tool endowed with multiple beneficiary effects caused by multiple mechanisms

Acta Neurobiologiae Experimentalis
2016 | Journal article
WOSUID:

WOS:000375636700001
Contributors: Vosahlikova, Miroslava; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
grade
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Plasma membrane cholesterol level and agonist-induced internalization of delta-opioid receptors; colocalization study with intracellular membrane markers of Rab family

Journal of Bioenergetics and Biomembranes
2016 | Journal article
DOI: 10.1007/s10863-016-9667-7
WOSUID:

WOS:000384436600004
Contributors: Brejchova, Jana; Vosahlikova, Miroslava; Roubalova, Lenka; Parenti, Marco; Mauri, Mario; Chernyavskiy, Oleksandr; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Proteomic analysis of protein composition of rat forebrain cortex exposed to morphine for 10 days; comparison with animals exposed to morphine and subsequently nurtured for 20 days in the absence of this drug

Journal of Proteomics
2016 | Journal article
DOI: 10.1016/j.jprot.2016.02.019
WOSUID:

WOS:000383931000003
Contributors: Ujcikova, Hana; Vosahlikova, Miroslava; Roubalova, Lenka; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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High Efficacy but Low Potency of delta-Opioid Receptor-G Protein Coupling in Brij-58-Treated, Low-Density Plasma Membrane Fragments

Plos One
2015 | Journal article
DOI: 10.1371/journal.pone.0135664
WOSUID:

WOS:000359666100055
Contributors: Roubalova, Lenka; Vosahlikova, Miroslava; Brejchova, Jana; Sykora, Jan; Rudajev, Vladimir; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
grade
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TRH-receptor mobility and function in intact and cholesterol-depleted plasma membrane of HEK293 cells stably expressing TRH-R-eGFP

Biochimica Et Biophysica Acta-Biomembranes
2015 | Journal article
DOI: 10.1016/j.bbamem.2014.11.029
WOSUID:

WOS:000349582500005
Contributors: Brejchova, Jana; Sykora, Jan; Ostasov, Pavel; Merta, Ladislav; Roubalova, Lenka; Janacek, Jiri; Hof, Martin; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Biguanides Inhibit Complex I, II and IV of Rat Liver Mitochondria and Modify Their Functional Properties

Physiological Research
2014 | Journal article
WOSUID:

WOS:000333406000002
Contributors: Drahota, Z.; Palenickova, E.; Endlicher, R.; Milerova, M.; Brejchova, J.; Vosahlikova, M.; Svoboda, P.; Kazdova, L.; Kalous, M.; Cervinkova, Z. et al.
Source: Self-asserted source
Petr Svoboda via ResearcherID
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High- and low-affinity sites for sodium in delta-OR-Gi1alpha (Cys (351)-Ile (351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane.

Naunyn-Schmiedeberg's archives of pharmacology
2014 | Journal article
DOI: 10.1007/s00210-014-0962-8
WOSUID:

MEDLINE:24577425
Contributors: Vosahlikova, Miroslava; Jurkiewicz, Piotr; Roubalova, Lenka; Hof, Martin; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
grade
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Methodological Aspects of In Vitro Assessment of Bio-accessible Risk Element Pool in Urban Particulate Matter

Biological Trace Element Research
2014 | Journal article
DOI: 10.1007/s12011-014-0101-x
WOSUID:

WOS:000344084800009
Contributors: Sysalova, Jirina; Szakova, Jirina; Tremlova, Jana; Kasparovska, Katerina; Kotlik, Bohumil; Tlustos, Pavel; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Opioid-Receptor (OR) Signaling Cascades in Rat Cerebral Cortex and Model Cell Lines: the Role of Plasma Membrane Structure

Physiological Research
2014 | Journal article
WOSUID:

WOS:000332073100014
Contributors: Ujcikova, H.; Brejchova, J.; Vosahlikova, M.; Kagan, D.; Dlouha, K.; Sykora, J.; Merta, L.; Drastichova, Z.; Novotny, J.; Ostasov, P. et al.
Source: Self-asserted source
Petr Svoboda via ResearcherID
grade
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Proteomic analysis of post-nuclear supernatant fraction and percoll-purified membranes prepared from brain cortex of rats exposed to increasing doses of morphine

Proteome Science
2014 | Journal article
DOI: 10.1186/1477-5956-12-11
WOSUID:

WOS:000332800900002
Contributors: Ujcikova, Hana; Eckhardt, Adam; Kagan, Dmytro; Roubalova, Lenka; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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FLIM studies of 22-and 25-NBD-cholesterol in living HEK293 cells: Plasma membrane change induced by cholesterol depletion

Chemistry and Physics of Lipids
2013 | Journal article
DOI: 10.1016/j.chemphyslip.2013.02.006
WOSUID:

WOS:000318137600008
Contributors: Ostasov, Pavel; Sykora, Jan; Brejchova, Jana; Olzynska, Agnieszka; Hof, Martin; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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In-vitro Bioavailability of Hazardous Elements from Inhaled Urban Particulate Matter

Chemicke Listy
2013 | Journal article
WOSUID:

WOS:000322269400009
Contributors: Kasparovska, Katerina; Szakova, Jirina; Sysalova, Jirina; Tlustos, Pavel; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Plasma Membrane Density of GABA(B)-R1a, GABA(B)-R1b, GABA-R2 and Trimeric G-proteins in the Course of Postnatal Development of Rat Brain Cortex

Physiological Research
2013 | Journal article
WOSUID:

WOS:000327444700009
Contributors: Dlouha, K.; Kagan, D.; Roubalova, L.; Ujcikova, H.; Svoboda, P.
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Ontogenetic Development of GABA(B)-Receptor Signaling Cascade in Plasma Membranes Isolated From Rat Brain Cortex; the Number of GABA(B)-Receptors Is High Already Shortly After the Birth

Physiological Research
2012 | Journal article
WOSUID:

WOS:000314138600008
Contributors: Kagan, D.; Dlouha, K.; Roubalova, L.; Svoboda, P.
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Early postnatal development of rat brain is accompanied by generation of lipofuscin-like pigments

Molecular and Cellular Biochemistry
2011 | Journal article
DOI: 10.1007/s11010-010-0623-2
WOSUID:

WOS:000285421500017
Contributors: Wilhelm, Jiri; Ivica, Josko; Kagan, Dmytro; Svoboda, Petr
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Petr Svoboda via ResearcherID
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Fluorescence spectroscopy studies of HEK293 cells expressing DOR-G(i)1 alpha fusion protein; the effect of cholesterol depletion

Biochimica Et Biophysica Acta-Biomembranes
2011 | Journal article
DOI: 10.1016/j.bbamem.2011.08.010
WOSUID:

WOS:000296938600006
Contributors: Brejchova, Jana; Sykora, Jan; Dlouha, Katerina; Roubalova, Lenka; Ostasov, Pavel; Vosahlikova, Miroslava; Hof, Martin; Svoboda, Petr
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Petr Svoboda via ResearcherID
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The Influence of Monovalent Cations on Trimeric G Protein G(i)1 alpha Activity in HEK293 Cells Stably Expressing DOR-G(i)1 alpha (Cys(351)-Ile(351)) Fusion Protein

Physiological Research
2011 | Journal article
WOSUID:

WOS:000293138600015
Contributors: Vosahlikova, M.; Svoboda, P.
Source: Self-asserted source
Petr Svoboda via ResearcherID
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Up-regulation of adenylylcyclases I and II induced by long-term adaptation of rats to morphine fades away 20 days after morphine withdrawal

Biochimica Et Biophysica Acta-General Subjects
2011 | Journal article
DOI: 10.1016/j.bbagen.2011.09.017
WOSUID:

WOS:000297885300011
Contributors: Ujcikova, Hana; Dlouha, Katerina; Roubalova, Lenka; Vosahlikova, Miroslava; Kagan, Dmytro; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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14-3-3 protein interacts with and affects the structure of RGS domain of regulator of G protein signaling 3 (RGS3)

Journal of Structural Biology
2010 | Journal article
DOI: 10.1016/j.jsb.2010.03.009
WOSUID:

WOS:000277946200003
Contributors: Rezabkova, Lenka; Boura, Evzen; Herman, Petr; Vecer, Jaroslav; Bourova, Lenka; Sulc, Miroslav; Svoboda, Petr; Obsilova, Veronika; Obsil, Tomas
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Long-term adaptation to high doses of morphine causes desensitization of mu-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits

Medical Science Monitor
2010 | Journal article
WOSUID:

WOS:000280762400008
Contributors: Bourova, Lenka; Vosahlikova, Miroslava; Kagan, Dmytro; Dlouha, Katerina; Novotny, Jiri; Svoboda, Petr
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Petr Svoboda via ResearcherID
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Protein Alterations Induced by Long-Term Agonist Treatment of HEK293 Cells Expressing Thyrotropin-Releasing Hormone Receptor and G(11)alpha Protein

Journal of Cellular Biochemistry
2010 | Journal article
DOI: 10.1002/jcb.22409
WOSUID:

WOS:000273339200027
Contributors: Drastichova, Zdenka; Bourova, Lenka; Hejnova, Lucie; Jedelsky, Petr; Svoboda, Petr; Novotny, Jiri
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Petr Svoboda via ResearcherID
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Stress Proteins in the Cytoplasmic Membrane Fraction of Bacillus subtilis

Folia Microbiologica
2010 | Journal article
DOI: 10.1007/s12223-010-0072-z
WOSUID:

WOS:000282873200004
Contributors: Petrackova, D.; Semberova, L.; Halada, P.; Svoboda, P.; Svobodova, J.
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Petr Svoboda via ResearcherID
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G-protein activity in percoll-purified plasma membranes, bulk plasma membranes, and low-density plasma membranes isolated from rat cerebral cortex

Medical Science Monitor
2009 | Journal article
WOSUID:

WOS:000266193900005
Contributors: Bourova, Lenka; Stohr, Jiri; Lisy, Vaclav; Rudajev, Vladimir; Novotny, Jiri; Svoboda, Petr
Source: Self-asserted source
Petr Svoboda via ResearcherID
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The effect of detergents on trimeric G-protein activity in isolated plasma membranes from rat brain cortex: Correlation with studies of DPH and Laurdan fluorescence

Biochimica Et Biophysica Acta-Biomembranes
2009 | Journal article
DOI: 10.1016/j.bbamem.2008.11.008
WOSUID:

WOS:000263794700004
Contributors: Sykora, J.; Bourova, L.; Hof, M.; Svoboda, P.
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Petr Svoboda via ResearcherID
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Ca2+ responses to thyrotropin-releasing hormone and angiotensin II: the role of plasma membrane integrity and effect of G(11)alpha protein overexpression on homologous and heterologous desensitization

Cell Biochemistry and Function
2008 | Journal article
DOI: 10.1002/cbf.1453
WOSUID:

WOS:000254679300019
Contributors: Ostasov, Pavel; Krusek, Jan; Durchankova, Dana; Svoboda, Petr; Novotny, Jiri
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Petr Svoboda via ResearcherID
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Subcellular Redistribution of Trimeric G-Proteins - Potential Mechanism of Desensitization of Hormone Response: Internalization, Solubilization, Down-regulation

Physiological Research
2008 | Journal article
WOSUID:

WOS:000262473500002
Contributors: Drastichova, Z.; Bourova, L.; Lisy, V.; Hejnova, L.; Rudajev, V.; Stohr, J.; Durchankova, D.; Ostasov, P.; Teisinger, J.; Soukup, T. et al.
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Petr Svoboda via ResearcherID
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The time-course of agonist-induced solubilization of trimeric G(q)alpha/G(11)alpha proteins resolved by two-dimensional electrophoresis

Physiological Research
2008 | Journal article
WOSUID:

WOS:000257270700006
Contributors: Durchankova, D.; Novotny, J.; Svoboda, P.
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Petr Svoboda via ResearcherID
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Disruption of the plasma membrane integrity by cholesterol depletion impairs effectiveness of TRH receptor-mediated signal transduction via G(q)/G(11)alpha proteinse

Journal of Receptors and Signal Transduction
2007 | Journal article
DOI: 10.1080/10799890701684142
WOSUID:

WOS:000252089800001
Contributors: Ostasov, Pavel; Bourova, Lenka; Hejnova, Lucie; Novotny, Jiri; Svoboda, Petr
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Petr Svoboda via ResearcherID
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Functional interactions between the alpha(1b)-adrenoceptor and G alpha(11) are compromised by de-palmitoylation of the G protein but not of the receptor

Cellular Signalling
2006 | Journal article
DOI: 10.1016/j.cellsig.2005.10.004
WOSUID:

WOS:000238002700016
Contributors: Novotny, J; Durchankova, D; Ward, RJ; Carrillo, JJ; Svoboda, P; Milligan, G
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Petr Svoboda via ResearcherID
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Agonist-induced tyrosine phosphorylation of Gq/G(11)alpha requires the intact structure of membrane domains

Biochemical and Biophysical Research Communications
2005 | Journal article
DOI: 10.1016/j.bbrc.2005.01.020
WOSUID:

WOS:000227075700023
Contributors: Matousek, P; Durchankova, D; Svandova, I; Novotny, J; Svoboda, P
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Petr Svoboda via ResearcherID
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Characterization of [H-3]-forskolin binding sites in young and adult rat brain cortex: identification of suramin as a competitive inhibitor of [H-3]-forskolin binding

Canadian Journal of Physiology and Pharmacology
2005 | Journal article
DOI: 10.1139/y05-048
WOSUID:

WOS:000231262900005
Contributors: Stohr, J; Novotny, J; Svoboda, P
Source: Self-asserted source
Petr Svoboda via ResearcherID
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