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Works (23)

A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase

Chemical Science
2023 | Journal article
DOI: 10.1039/D3SC03331G
Contributors: Teodors Pantelejevs; Pedro Zuazua-Villar; Oliwia Koczy; Andrew J. Counsell; Stephen J. Walsh; Naomi S. Robertson; David R. Spring; Jessica A. Downs; Marko Hyvönen
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Disulfide re-bridging reagents for single-payload antibody-drug conjugates

Chemical Communications
2023 | Journal article
DOI: 10.1039/D3CC02980H
Contributors: Thomas A. King; Stephen J. Walsh; Mia Kapun; Thomas Wharton; Sona Krajcovicova; Melanie S. Glossop; David R. Spring
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Peroxide-cleavable linkers for antibody–drug conjugates

Chemical Communications
2023 | Journal article
DOI: 10.1039/D2CC06677G
Contributors: Nicola Ashman; Jonathan D. Bargh; Stephen J. Walsh; Ryan D. Greenwood; Arnaud Tiberghien; Jason S. Carroll; David R. Spring
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A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase

2023-02-24 | Preprint
DOI: 10.1101/2023.02.24.529929
Contributors: Teodors Pantelejevs; Pedro Zuazua-Villar; Oliwia Koczy; Andrew Counsell; Stephen J. Walsh; Naomi S. Robertson; David R. Spring; Jessica Downs; Marko Hyvönen
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All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

Chemical Science
2022 | Journal article
DOI: 10.1039/D2SC02198F
Contributors: Friederike M. Dannheim; Stephen J. Walsh; Carolina T. Orozco; Anders Højgaard Hansen; Jonathan D. Bargh; Sophie E. Jackson; Nicholas J. Bond; Jeremy S. Parker; Jason S. Carroll; David R. Spring
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Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy

Chemical Communications
2022 | Journal article
DOI: 10.1039/D2CC02515A
Contributors: Abigail R. Hanby; Stephen J. Walsh; Andrew J. Counsell; Nicola Ashman; Kim T. Mortensen; Jason S. Carroll; David R. Spring
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Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability

Chemical Communications
2022 | Journal article
DOI: 10.1039/D1CC06766D
Contributors: Stephen J. Walsh; Soleilmane Omarjee; Friederike M. Dannheim; Dominique-Laurent Couturier; Dorentina Bexheti; Lee Mendil; Gemma Cronshaw; Toby Fewster; Charlotte Gregg; Cara Brodie et al.
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A dual-enzyme cleavable linker for antibody–drug conjugates

Chemical Communications
2021 | Journal article
DOI: 10.1039/D1CC00957E
Contributors: Jonathan D. Bargh; Stephen J. Walsh; Nicola Ashman; Albert Isidro-Llobet; Jason S. Carroll; David R. Spring
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Photocatalytic methods for amino acid modification

Chemical Society Reviews
2021 | Journal article
DOI: 10.1039/D0CS00344A
Contributors: Thomas A. King; Jiyan Mandrup Kandemir; Stephen J. Walsh; David R. Spring
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Rapid and robust cysteine bioconjugation with vinylheteroarenes

Chemical Science
2021 | Journal article
DOI: 10.1039/D1SC02722K
Contributors: Hikaru Seki; Stephen J. Walsh; Jonathan D. Bargh; Jeremy S. Parker; Jason Carroll; David R. Spring
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Site-selective modification strategies in antibody–drug conjugates

Chemical Society Reviews
2021 | Journal article
DOI: 10.1039/D0CS00310G
Contributors: Stephen J. Walsh; Jonathan D. Bargh; Friederike M. Dannheim; Abigail R. Hanby; Hikaru Seki; Andrew J. Counsell; Xiaoxu Ou; Elaine Fowler; Nicola Ashman; Yuri Takada et al.
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Efficient and selective antibody modification with functionalised divinyltriazines

Organic & Biomolecular Chemistry
2020 | Journal article
DOI: 10.1039/D0OB01002B
Contributors: Andrew J. Counsell; Stephen J. Walsh; Naomi S. Robertson; Hannah F. Sore; David R. Spring
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General dual functionalisation of biomacromolecules via a cysteine bridging strategy

Organic & Biomolecular Chemistry
2020 | Journal article
DOI: 10.1039/D0OB00907E
Contributors: Stephen J. Walsh; Jessica Iegre; Hikaru Seki; Jonathan D. Bargh; Hannah F. Sore; Jeremy S. Parker; Jason S. Carroll; David R. Spring
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Sulfatase-cleavable linkers for antibody-drug conjugates

Chemical Science
2020 | Journal article
DOI: 10.1039/C9SC06410A
Contributors: Jonathan D. Bargh; Stephen J. Walsh; Albert Isidro-Llobet; Soleilmane Omarjee; Jason S. Carroll; David R. Spring
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Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents

Chemical Communications
2020 | Journal article
DOI: 10.1039/C9CC09050A
Contributors: Talia R. Pettigrew; Rachel J. Porter; Stephen J. Walsh; Michael P. Housden; Nelson Y. S. Lam; Jason S. Carroll; Jeremy S. Parker; David R. Spring; Ian Paterson
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Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics

Angewandte Chemie
2020-12-14 | Journal article
DOI: 10.1002/ange.202010090
Contributors: Jiraborrirak Charoenpattarapreeda; Stephen J. Walsh; Jason S. Carroll; David R. Spring
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Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics

Angewandte Chemie International Edition
2020-12-14 | Journal article
DOI: 10.1002/anie.202010090
Contributors: Jiraborrirak Charoenpattarapreeda; Stephen J. Walsh; Jason S. Carroll; David R. Spring
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A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Chemical Science
2019 | Journal article
DOI: 10.1039/C8SC04645J
Contributors: Stephen J. Walsh; Soleilmane Omarjee; Warren R. J. D. Galloway; Terence T.-L. Kwan; Hannah F. Sore; Jeremy S. Parker; Marko Hyvönen; Jason S. Carroll; David R. Spring
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Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Chemical Science
2019 | Journal article
DOI: 10.1039/C8SC90248H
Contributors: Stephen J. Walsh; Soleilmane Omarjee; Warren R. J. D. Galloway; Terence T.-L. Kwan; Hannah F. Sore; Jeremy S. Parker; Marko Hyvönen; Jason S. Carroll; David R. Spring
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Crossref

Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling

Chemical Communications
2019 | Journal article
DOI: 10.1039/C9CC05042F
Contributors: Naomi S. Robertson; Stephen J. Walsh; Elaine Fowler; Masao Yoshida; Sam M. Rowe; Yuteng Wu; Hannah F. Sore; Jeremy S. Parker; David R. Spring
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Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides

Chemical Communications
2019 | Journal article
DOI: 10.1039/C9CC04022F
Contributors: Jiraborrirak Charoenpattarapreeda; Yaw Sing Tan; Jessica Iegre; Stephen J. Walsh; Elaine Fowler; Rohan S. Eapen; Yuteng Wu; Hannah F. Sore; Chandra S. Verma; Laura Itzhaki et al.
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Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides

ACS Chemical Biology
2019-01 | Journal article
DOI: 10.1021/acschembio.9b00063
Part of ISSN: 1554-8929
Contributors: Yuteng Wu; Amandeep Kaur; Elaine Fowler; Mareike M. Wiedmann; Reginald Young; Warren R. J. D. Galloway; Lasse Olsen; Hannah F. Sore; Anasuya Chattopadhyay; Terence T.-L. Kwan et al.
Source: Self-asserted source
Stephen J Walsh via Crossref Metadata Search

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst

Chemical Science
2017 | Journal article
DOI: 10.1039/c6sc05313k
Part of ISSN: 2041-6520
Contributors: Terence T.-L. Kwan; Omar Boutureira; Elizabeth C. Frye; Stephen J. Walsh; Moni K. Gupta; Stephen Wallace; Yuteng Wu; Fengzhi Zhang; Hannah F. Sore; Warren R. J. D. Galloway et al.
Source: Self-asserted source
Stephen J Walsh via Crossref Metadata Search
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