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Proteomics, Mass Spectrometry, BioChemistry, Cross-linking, Posttranslational Modifications, Proteome Bio-Informatics
Austria

Activities

Employment (1)

Research Institute of Molecular Pathology: Vienna, Austria, AT

1989-01-01 to present | Head of Facility (Protein Chemistry Facility)
Employment
Source: Self-asserted source
Karl Mechtler

Education and qualifications (1)

HTBLVA: Vienna, Vienna, AT

(Biochemistry)
Education
Source: Self-asserted source
Karl Mechtler

Funding (2)

Delineating the crossover control networks in plants

Source: Self-asserted source
Karl Mechtler via DimensionsWizard

SFB F3402-B03: Chromosome dynamics - unraveling the function of chromosomal domains

Grant
FWF (Vienna, Vienna, AT)
GRANT_NUMBER:

SFB F3402-B03:

Source: Self-asserted source
Karl Mechtler

Works (50 of 262)

Items per page:
Page 1 of 6

Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity

Nature Methods
2025-03 | Journal article
Contributors: Julia A. Bubis; Tabiwang N. Arrey; Eugen Damoc; Bernard Delanghe; Jana Slovakova; Theresa M. Sommer; Harunobu Kagawa; Peter Pichler; Nicolas Rivron; Karl Mechtler et al.
Source: check_circle
Crossref

In vivocrosslinking and effective 2D enrichment for interactome studies of the nucleosome

2025-02-28 | Preprint
Contributors: Philipp Bräuer; Laszlo Tirian; Fränze Müller; Karl Mechtler; Manuel Matzinger
Source: check_circle
Crossref

Author Correction: Proteome-wide non-cleavable crosslink identification with MS Annika 3.0 reveals the structure of the C. elegans Box C/D complex

Communications Chemistry
2025-02-27 | Journal article
Contributors: Micha J. Birklbauer; Fränze Müller; Sowmya Sivakumar Geetha; Manuel Matzinger; Karl Mechtler; Viktoria Dorfer
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Crossref

Cohesin positions the epigenetic reader Phf2 within the genome

The EMBO Journal
2025-01-02 | Journal article
Contributors: Wen Tang; Lorenzo Costantino; Roman Stocsits; Gordana Wutz; Rene Ladurner; Otto Hudecz; Karl Mechtler; Jan-Michael Peters
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Crossref

Breaking Barriers in Crosslinking Mass Spectrometry: Enhanced Throughput and Sensitivity with the Orbitrap Astral Mass Analyzer

2024-12-21 | Preprint
Contributors: Fränze Müller; Karel Stejskal; Karl Mechtler
Source: check_circle
Crossref

Proteome-wide non-cleavable crosslink identification with MS Annika 3.0 reveals the structure of the C. elegans Box C/D complex

Communications Chemistry
2024-12-19 | Journal article
Contributors: Micha J. Birklbauer; Fränze Müller; Sowmya Sivakumar Geetha; Manuel Matzinger; Karl Mechtler; Viktoria Dorfer
Source: check_circle
Crossref

Proteome-wide non-cleavable crosslink identification with MS Annika 3.0 reveals the structure of theC. elegansBox C/D complex

2024-09-05 | Preprint
Contributors: Micha J. Birklbauer; Fränze Müller; Sowmya Sivakumar Geetha; Manuel Matzinger; Karl Mechtler; Viktoria Dorfer
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Crossref

Identification of Pathogenic Pathways for Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation

Diagnostics
2024-07-24 | Journal article
Contributors: Sahra Pajenda; Daniela Gerges; Ludwig Wagner; David O’Connell; Monika Aiad; Richard Imre; Karl Mechtler; Alexander Zimprich; Alice Schmidt; Guerkan Sengoelge et al.
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Crossref
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Preferred source (of 2)‎

Micropillar arrays, wide window acquisition and AI-based data analysis improve comprehensiveness in multiple proteomic applications

Nature Communications
2024-02-03 | Journal article
Contributors: Manuel Matzinger; Anna Schmücker; Ramesh Yelagandula; Karel Stejskal; Gabriela Krššáková; Frédéric Berger; Karl Mechtler; Rupert L. Mayer
Source: check_circle
Crossref

Challenging the Astral™mass analyzer - up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneity

2024-02-01 | Preprint
Contributors: Julia A. Bubis; Tabiwang N. Arrey; Eugen Damoc; Bernard Delanghe; Jana Slovakova; Theresa M. Sommer; Harunobu Kagawa; Peter Pichler; Nicolas Rivron; Karl Mechtler et al.
Source: check_circle
Crossref

A Causal Model of Ion Interference Enables Assessment and Correction of Ratio Compression in Multiplex Proteomics

Molecular & Cellular Proteomics
2024-01 | Journal article
Contributors: Moritz Madern; Wolfgang Reiter; Florian Stanek; Natascha Hartl; Karl Mechtler; Markus Hartl
Source: check_circle
Crossref

A High-Sensitivity Low-Nanoflow LC-MS Configuration for High-Throughput Sample-Limited Proteomics

Analytical Chemistry
2023-12-26 | Journal article
Contributors: Runsheng Zheng; Manuel Matzinger; Rupert L. Mayer; Alec Valenta; Xuefei Sun; Karl Mechtler
Source: check_circle
Crossref

Immunopeptidomics in the Era of Single-Cell Proteomics

Biology
2023-12-12 | Journal article
Contributors: Rupert L. Mayer; Karl Mechtler
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Crossref
grade
Preferred source (of 2)‎

MS Annika 2.0 Identifies Cross-Linked Peptides in MS2–MS3-Based Workflows at High Sensitivity and Specificity

Journal of Proteome Research
2023-09-01 | Journal article
Contributors: Micha J. Birklbauer; Manuel Matzinger; Fränze Müller; Karl Mechtler; Viktoria Dorfer
Source: check_circle
Crossref

Label‐free single cell proteomics utilizing ultrafast LC and MS instrumentation: A valuable complementary technique to multiplexing

PROTEOMICS
2023-07 | Journal article
Contributors: Manuel Matzinger; Rupert L. Mayer; Karl Mechtler
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Crossref

A method for deep and quantitative protein profiling of urine sediment, soluble and exosome fractions for biomarker research

2023-06-28 | Preprint
Contributors: Peter Pichler; Amelie Kurnikowski; Manuel Matzinger; Karl Mechtler
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Crossref

Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns

The EMBO Journal
2023-05-15 | Journal article
Contributors: Leonid Serebreni; Lisa‐Marie Pleyer; Vanja Haberle; Oliver Hendy; Anna Vlasova; Vincent Loubiere; Filip Nemčko; Katharina Bergauer; Elisabeth Roitinger; Karl Mechtler et al.
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Crossref

The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate

Nature Communications
2023-05-04 | Journal article
Contributors: Andreas Lackner; Michael Müller; Magdalena Gamperl; Delyana Stoeva; Olivia Langmann; Henrieta Papuchova; Elisabeth Roitinger; Gerhard Dürnberger; Richard Imre; Karl Mechtler et al.
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Crossref

A high-sensitivity low-nanoflow LC-MS configuration for high-throughput sample-limited proteomics

2023-04-27 | Preprint
Contributors: Runsheng Zheng; Manuel Matzinger; Rupert Mayer; Alec Valenta; Xuefei Sun; Karl Mechtler
Source: check_circle
Crossref

Data from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Data from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Figures S1-S9 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Figures S1-S9 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S1 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S1 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S10 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S10 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S11 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S11 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S12 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S12 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S13 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S13 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S14 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S14 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S2 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S2 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S3 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S3 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S4 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S4 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S5 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S5 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S6 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S6 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S7 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S7 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S8 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S8 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref

Supplementary Table S9 from Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

2023-04-04 | Preprint
Contributors: Lukas Leiendecker; Tobias Neumann; Pauline S. Jung; Shona M. Cronin; Thomas L. Steinacker; Alexander Schleiffer; Michael Schutzbier; Karl Mechtler; Thibault Kervarrec; Estelle Laurent et al.
Source: check_circle
Crossref
Items per page:
Page 1 of 6

Peer review (58 reviews for 14 publications/grants)

Review activity for Analytical chemistry. (17)
Review activity for Bioinformatics (3)
Review activity for Brain pathology. (2)
Review activity for Cell reports. (1)
Review activity for Cell. (1)
Review activity for Communications biology. (2)
Review activity for Czech Science Foundation (1)
Review activity for Journal of proteome research. (23)
Review activity for Journal of proteomics. (1)
Review activity for Molecular systems biology. (1)
Review activity for Molecules. (1)
Review activity for Nature biotechnology. (1)
Review activity for Nature communications (3)
Review activity for Nature methods. (1)