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The Waller Lab
The Cambridge Centre for Proteomics
The Lilley Lab

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Scopus Author ID: 35721579900
Scopus Author ID: 57201895910

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Employment (7)

Karolinska Institutet: Stockholm, SE

(Department of Oncology-Pathology)
Employment
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Karolinska Institutet

Karolinska Institutet: Stockholm, SE

2022-06 to present | Research Specialist (Department of Oncology-Pathology)
Employment
Source: Self-asserted source
Konstantin Barylyuk

University of Cambridge: Cambridge, GB

2022 to present | Visiting Scientist (Department of Biochemistry)
Employment
Source: Self-asserted source
Konstantin Barylyuk

University of Cambridge: Cambridge, Cambridgeshire, GB

2015 to 2022 | Research Associate (Department of Biochemistry)
Employment
Source: Self-asserted source
Konstantin Barylyuk

University of Antwerp: Antwerp, BE

2014 to 2015 | Research Associate (Department of Chemistry)
Employment
Source: Self-asserted source
Konstantin Barylyuk

ETH Zurich: Zurich, CH

2013 to 2014 | Research Associate (Department of Chemistry and Applied Biosciences)
Employment
Source: Self-asserted source
Konstantin Barylyuk

ETH Zurich: Zurich, CH

2009 to 2013 | Research Assistant (Department of Chemistry and Applied Biosciences)
Employment
Source: Self-asserted source
Konstantin Barylyuk

Education and qualifications (2)

ETH Zurich: Zurich, CH

2009 to 2013 | PhD (Department of Chemistry and Applied Biosciences)
Education
Source: Self-asserted source
Konstantin Barylyuk

Moscow State University: Moscow, RU

2003 to 2008 | Diploma in Biochemistry (Faculty of Biology, Department of Bioorganic Chemistry)
Education
Source: Self-asserted source
Konstantin Barylyuk

Funding (1)

High-resolution spatial proteomics of the model apicomplexan Toxoplasma gondii

2017-05 to 2020-05 | Salary award
Leverhulme Trust (London, GB)
GRANT_NUMBER:

ECF-2016-562
Source: Self-asserted source
Konstantin Barylyuk

Works (41)

Mapping diversity in African trypanosomes using high resolution spatial proteomics

Nature Communications
2023-07-21 | Journal article | Author
DOI: 10.1038/s41467-023-40125-z
Part of ISSN: 2041-1723
Contributors: Nicola M Moloney; Konstantin Barylyuk; Eelco C. Tromer; Oliver Crook; Lisa Breckels (Simpson); Kathryn Lilley; Ross Waller; Paula MacGregor
Source: Self-asserted source
Konstantin Barylyuk

Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell

Cell Host & Microbe
2023-04 | Journal article
DOI: 10.1016/j.chom.2023.03.001
Part of ISSN: 1931-3128
Contributors: Amandine Guérin; Katherine M. Strelau; Konstantin Barylyuk; Bethan A. Wallbank; Laurence Berry; Oliver M. Crook; Kathryn S. Lilley; Ross F. Waller; Boris Striepen
Source: Self-asserted source
Konstantin Barylyuk

Stable endocytic structures navigate the complex pellicle of apicomplexan parasites

Nature Communications
2023-04-15 | Journal article | Author
DOI: 10.1038/s41467-023-37431-x
Part of ISSN: 2041-1723
Contributors: Ludek Koreny; Brandon N Mercado-Saavedra; Christen M. Klinger; Konstantin Barylyuk; Simon Butterworth; Jennifer Hirst; Yolanda Rivera-Cuevas; Nathan Zaccai; Victoria J. C. Holzer; Andreas Klingl et al.
Source: Self-asserted source
Konstantin Barylyuk

A Prioritized and Validated Resource of Mitochondrial Proteins in <i>Plasmodium</i> Identifies Unique Biology

mSphere
2021-10-27 | Journal article | Author
DOI: 10.1128/msphere.00614-21
Part of ISSN: 2379-5042
Contributors: Selma van Esveld; Lisette Meerstein; Cas Boshoven; Jochem F. Baaij; Konstantin Barylyuk; JPM Coolen; Joeri van Strien; Ronald A. J. Duim; Bas E. Dutilh; Daniel R. Garza et al.
Source: Self-asserted source
Konstantin Barylyuk

Aptamer-ligand recognition studied by native ion mobility-mass spectrometry

Talanta
2021-03 | Journal article
DOI: 10.1016/j.talanta.2020.121917
Part of ISSN: 0039-9140
Source: Self-asserted source
Konstantin Barylyuk

Molecular characterization of the conoid complex in Toxoplasma reveals its conservation in all apicomplexans, including Plasmodium species

PLOS Biology
2021-03-11 | Journal article | Author
DOI: 10.1371/journal.pbio.3001081
Part of ISSN: 1545-7885
Contributors: Ludek Koreny; Mohammad Zeeshan; Konstantin Barylyuk; Eelco C. Tromer; Jolien J.E. van Hooff; Declan Brady; Huiling Ke; Sara Chelaghma; David Ferguson; Laura Eme et al.
Source: Self-asserted source
Konstantin Barylyuk

A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

Cell Host & Microbe
2020-11 | Journal article
DOI: 10.1016/j.chom.2020.09.011
Part of ISSN: 1931-3128
Source: Self-asserted source
Konstantin Barylyuk

Global mapping of protein subcellular location in apicomplexans: the parasite as we’ve never seen it before

Access Microbiology
2019-03-01 | Conference abstract
DOI: 10.1099/acmi.ac2019.po0252
Part of ISSN: 2516-8290
Source: Self-asserted source
Konstantin Barylyuk

Aryl bis-sulfonamides bind to the active site of a homotrimeric isoprenoid biosynthesis enzyme IspF and extract the essential divalent metal cation cofactor

Chemical Science
2018 | Journal article
DOI: 10.1039/c8sc00814k
Part of ISSN: 2041-6520
Contributors: Katharina Root; Konstantin Barylyuk; Anatol Schwab; Jonas Thelemann; Boris Illarionov; Julie G. Geist; Tobias Gräwert; Adelbert Bacher; Markus Fischer; François Diederich et al.
Source: Self-asserted source
Konstantin Barylyuk via Crossref Metadata Search

Charge-State-Dependent Variation of Signal Intensity Ratio between Unbound Protein and Protein-Ligand Complex in Electrospray Ionization Mass Spectrometry: The Role of Solvent-Accessible Surface Area

Analytical Chemistry
2018 | Journal article
DOI: 10.1021/acs.analchem.7b05349
EID:

2-s2.0-85046431039
Contributors: Chingin, K.; Barylyuk, K.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Native Electrospray Ionization Mass Spectrometry Reveals Multiple Facets of Aptamer-Ligand Interactions: From Mechanism to Binding Constants.

Journal of the American Chemical Society
2018-06 | Journal article
DOI: 10.1021/jacs.7b13044
PMID: 29733584
Contributors: Gülbakan B; Barylyuk K; Schneider P; Pillong M; Schneider G; Zenobi R
Source: Self-asserted source
Konstantin Barylyuk via Europe PubMed Central

Insight into Signal Response of Protein Ions in Native ESI-MS from the Analysis of Model Mixtures of Covalently Linked Protein Oligomers

Journal of the American Society for Mass Spectrometry
2017 | Journal article
DOI: 10.1007/s13361-017-1690-3
EID:

2-s2.0-85027403764
Contributors: Root, K.; Wittwer, Y.; Barylyuk, K.; Anders, U.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Spontaneous non-canonical assembly of CcmK hexameric components from β-carboxysome shells of cyanobacteria

PLoS ONE
2017 | Journal article
DOI: 10.1371/journal.pone.0185109
EID:

2-s2.0-85029747885
Contributors: Garcia-Alles, L.F.; Lesniewska, E.; Root, K.; Aubry, N.; Pocholle, N.; Mendoza, C.I.; Bourillot, E.; Barylyuk, K.; Pompon, D.; Zenobi, R. et al.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils

Journal of the American Chemical Society
2016 | Journal article
DOI: 10.1021/jacs.5b08694
EID:

2-s2.0-84961295404
Contributors: Nespovitaya, N.; Gath, J.; Barylyuk, K.; Seuring, C.; Meier, B.H.; Riek, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

On the preservation of non-covalent protein complexes during electrospray ionization

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
2016 | Journal article
DOI: 10.1098/rsta.2015.0377
EID:

2-s2.0-84988703635
Contributors: Chingin, K.; Barylyuk, K.; Chen, H.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum

ChemMedChem
2015 | Journal article
DOI: 10.1002/cmdc.201500382
EID:

2-s2.0-84949745572
Contributors: Thelemann, J.; Illarionov, B.; Barylyuk, K.; Geist, J.; Kirchmair, J.; Schneider, P.; Anthore, L.; Root, K.; Trapp, N.; Bacher, A. et al.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Determination of thermodynamic and kinetic properties of biomolecules by mass spectrometry

Current Opinion in Biotechnology
2015 | Journal article
DOI: 10.1016/j.copbio.2014.08.003
EID:

2-s2.0-84906761614
Contributors: Gülbakan, B.; Barylyuk, K.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Determination of proteinligand binding constants of a cooperatively regulated tetrameric enzyme using electrospray mass spectrometry

ACS Chemical Biology
2014 | Journal article
DOI: 10.1021/cb4007002
EID:

2-s2.0-84900434296
Contributors: Cubrilovic, D.; Haap, W.; Barylyuk, K.; Ruf, A.; Badertscher, M.; Gubler, M.; Tetaz, T.; Joseph, C.; Benz, J.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Direct monitoring of protein-protein inhibition using nano electrospray ionization mass spectrometry

Chemical Science
2014 | Journal article
DOI: 10.1039/c3sc53360c
EID:

2-s2.0-84901826827
Contributors: Cubrilovic, D.; Barylyuk, K.; Hofmann, D.; Walczak, M.J.; Gräber, M.; Berg, T.; Wider, G.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Fluorescence resonance energy transfer of gas-phase ions under ultra high vacuum and ambient conditions

Physical Chemistry Chemical Physics
2014 | Journal article
DOI: 10.1039/c3cp54521k
EID:

2-s2.0-84898790385
Contributors: Frankevich, V.; Chagovets, V.; Widjaja, F.; Barylyuk, K.; Yang, Z.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Ion mobility spectrometry coupled to laser-induced fluorescence for probing the electronic structure and conformation of gas-phase ions

Journal of Analytical Chemistry
2014 | Journal article
DOI: 10.1134/S106193481413005X
EID:

2-s2.0-84918824402
Contributors: Frankevich, V.E.; Barylyuk, K.V.; Martinez-Lozano Sinues, P.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Mass spectrometry research at the laboratory for organic chemistry, eth zurich

Chimia
2014 | Journal article
DOI: 10.2533/chimia.2014.119
EID:

2-s2.0-84898719506
Contributors: Barylyuk, K.; Frankevich, V.; Ibáñez, A.J.; Sinues, P.M.-L.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

The production of recombinant<sup>15</sup>N,<sup>13</sup>C-labelled somatostatin 14 for NMR spectroscopy

Protein Expression and Purification
2014 | Journal article
DOI: 10.1016/j.pep.2014.03.011
EID:

2-s2.0-84899000074
Contributors: Nespovitaya, N.; Barylyuk, K.; Eichmann, C.; Zenobi, R.; Riek, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

A new, modular mass calibrant for high-mass MALDI-MS

Analytical Chemistry
2013 | Journal article
DOI: 10.1021/ac400129h
EID:

2-s2.0-84875418865
Contributors: Weidmann, S.; Barylyuk, K.; Nespovitaya, N.; Mädler, S.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

DNA oligonucleotides: A model system with tunable binding strength to study monomer-dimer equilibria with electrospray ionization-mass spectrometry

Analytical Chemistry
2013 | Journal article
DOI: 10.1021/ac402669e
EID:

2-s2.0-84890444743
Contributors: Barylyuk, K.; Gülbakan, B.; Xie, X.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Ion mobility spectrometry coupled to laser-induced fluorescence

Analytical Chemistry
2013 | Journal article
DOI: 10.1021/ac303137e
EID:

2-s2.0-84871776957
Contributors: Frankevich, V.; Martinez-Lozano Sinues, P.; Barylyuk, K.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Mass discrimination in high-mass MALDI-MS

Journal of the American Society for Mass Spectrometry
2013 | Journal article
DOI: 10.1007/s13361-013-0686-x
EID:

2-s2.0-84881607678
Contributors: Weidmann, S.; Mikutis, G.; Barylyuk, K.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Native biomolecules in the gas phase? the case of green fluorescent protein

ChemPhysChem
2013 | Journal article
DOI: 10.1002/cphc.201200959
EID:

2-s2.0-84875325385
Contributors: Frankevich, V.; Barylyuk, K.; Chingin, K.; Nieckarz, R.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Compelling advantages of negative ion mode detection in high-mass maldi-ms for homomeric protein complexes

Journal of the American Society for Mass Spectrometry
2012 | Journal article
DOI: 10.1007/s13361-011-0274-x
EID:

2-s2.0-84856274818
Contributors: Mädler, S.; Barylyuk, K.; Boeri Erba, E.; Nieckarz, R.J.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Gas-phase basicity of several common MALDI matrices measured by a simple experimental approach

RSC Advances
2012 | Journal article
DOI: 10.1039/c1ra01117k
EID:

2-s2.0-84859171793
Contributors: Barylyuk, K.; Fritsche, L.; Balabin, R.M.; Nieckarz, R.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Probing the mechanisms of ambient ionization by laser-induced fluorescence spectroscopy

Rapid Communications in Mass Spectrometry
2012 | Journal article
DOI: 10.1002/rcm.6264
EID:

2-s2.0-84861612105
Contributors: Frankevich, V.; Nieckarz, R.J.; Sagulenko, P.N.; Barylyuk, K.; Zenobi, R.; Levitsky, L.I.; Agapov, A.Y.; Perlova, T.Y.; Gorshkov, M.V.; Tarasova, I.A.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Absorption of the green fluorescent protein chromophore anion in the gas phase studied by a combination of FTICR mass spectrometry with laser-induced photodissociation spectroscopy

International Journal of Mass Spectrometry
2011 | Journal article
DOI: 10.1016/j.ijms.2011.01.014
EID:

2-s2.0-80052411057
Contributors: Chingin, K.; Balabin, R.M.; Frankevich, V.; Barylyuk, K.; Nieckarz, R.; Sagulenko, P.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Hexameric supramolecular scaffold orients carbohydrates to sense bacteria

Journal of the American Chemical Society
2011 | Journal article
DOI: 10.1021/ja2036767
EID:

2-s2.0-80052317348
Contributors: Grünstein, D.; Maglinao, M.; Kikkeri, R.; Collot, M.; Barylyuk, K.; Lepenies, B.; Kamena, F.; Zenobi, R.; Seeberger, P.H.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Quantifying protein-protein interactions within noncovalent complexes using electrospray ionization mass spectrometry

Analytical Chemistry
2011 | Journal article
DOI: 10.1021/ac201576e
EID:

2-s2.0-83655192884
Contributors: Boeri Erba, E.; Barylyuk, K.; Yang, Y.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

What happens to hydrophobic interactions during transfer from the solution to the gas phase? The case of electrospray-based soft ionization methods

Journal of the American Society for Mass Spectrometry
2011 | Journal article
DOI: 10.1007/s13361-011-0118-8
EID:

2-s2.0-79960007398
Contributors: Barylyuk, K.; Balabin, R.M.; Grünstein, D.; Kikkeri, R.; Frankevich, V.; Seeberger, P.H.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Direct Access to Isolated Biomolecules under Ambient Conditions

Angewandte Chemie - International Edition
2010 | Journal article
DOI: 10.1002/anie.200906213
EID:

2-s2.0-77952977955
Contributors: Chingin, K.; Frankevich, V.; Balabin, R.M.; Barylyuk, K.; Chen, H.; Wang, R.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Fragmentation of Benzylpyridinium "Thermometer" Ions and Its Effect on the Accuracy of Internal Energy Calibration

Journal of the American Society for Mass Spectrometry
2010 | Journal article
DOI: 10.1016/j.jasms.2009.09.023
EID:

2-s2.0-73449117170
Contributors: Barylyuk, K.V.; Chingin, K.; Balabin, R.M.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Optical properties of protonated Rhodamine 19 isomers in solution and in the gas phase

Physical Chemistry Chemical Physics
2010 | Journal article
DOI: 10.1039/c0cp00482k
EID:

2-s2.0-77958548710
Contributors: Chingin, K.; Balabin, R.M.; Frankevich, V.; Chen, H.; Barylyuk, K.; Nieckarz, R.; Fedorov, A.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Rhodamines in the gas phase: Cations, neutrals, anions, and adducts with metal cations

Physical Chemistry Chemical Physics
2010 | Journal article
DOI: 10.1039/c000807a
EID:

2-s2.0-77956510998
Contributors: Chingin, K.; Balabin, R.M.; Barylyuk, K.; Chen, H.; Frankevich, V.; Zenobi, R.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Proteomic analysis of heart mitochondria from Bos taurus: I. Application of proteomic methods to identification of transmembrane domains of proteins of the internal mitochondrial membrane

Russian Journal of Bioorganic Chemistry
2009 | Journal article
DOI: 10.1134/S1068162009010051
EID:

2-s2.0-59549088204
Contributors: Polyakov, N.B.; Barylyuk, K.V.; Frankevich, V.E.; Grinkevich, V.A.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier

Proteomic analysis of mitochondria from the Bos taurus heart. II. Identification of mitochondrial soluble proteins

Russian Journal of Bioorganic Chemistry
2009 | Journal article
DOI: 10.1134/S1068162009040025
EID:

2-s2.0-67849084757
Contributors: Dainichenko, E.V.; Boldyrev, A.N.; Barylyuk, K.V.; Polyakov, N.B.; Grinkevich, V.A.
Source: Self-asserted source
Konstantin Barylyuk via Scopus - Elsevier
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