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Scopus Author ID: 6602573582

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Ilia State University: Tbilisi, GE

2008 to present | Director (School of Natural Sciences and Medicine, Institute of Chemical Biology)
Employment
Source: Self-asserted source
David Mikeladze

I. Beritashvili Center of Experimental Biomedicine: Tbilisi, GE

1986 to present | Head (Department of Biochemistry)
Employment
Source: Self-asserted source
David Mikeladze

Works (50 of 68)

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Page 1 of 2

Novel PCR-Based Technology for the Detection of Sunflower in Edible and Used Cooking Oils

Foods
2024-11-24 | Journal article
DOI: 10.3390/foods13233760
Contributors: Tamara Kutateladze; Kakha Karchkhadze; Kakha Bitskinashvili; Boris Vishnepolsky; Tata Ninidze; David Mikeladze; Nelly Datukishvili
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Novel PCR-Based Technology for the Detection of Sunflower in Edible and Used Cooking Oils

2024-09-30 | Preprint
DOI: 10.20944/preprints202409.2270.v1
Contributors: Tamara Kutateladze; Kakha Karchkhadze; Kakha Bitskinashvili; Boris Vishnepolsky; Tata Ninidze; David Mikeladze; Nelly Datukishvili
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Sodium nitroprusside induces H‐Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells

Cell Biochemistry and Function
2019-10 | Journal article
DOI: 10.1002/cbf.3431
Contributors: Galina Goloshvili; Tamar Barbakadze; David Mikeladze
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Saccharomyces cerevisiae, key role of MIG1 gene in metabolic switching: putative fermentation/oxidation.

Journal of biological regulators and homeostatic agents
2018-05 | Journal article
PMID: 29921394
Contributors: Alipourfard I; Bakhtiyari S; Datukishvili N; Haghani K; Di Renzo L; De Miranda RC; Cioccoloni G; Basiratyan Yazdi P; Mikeladze D
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress.

Neurotoxicity research
2017-11 | Journal article
DOI: 10.1007/s12640-017-9838-2
PMID: 29127580
Contributors: Goguadze N; Zhuravliova E; Morin D; Mikeladze D; Maurice T
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia.

Cell journal
2017-08 | Journal article
DOI: 10.22074/cellj.2017.4546
PMID: 28836406
PMC: PMC5570409
Contributors: Barbakadze T; Goloshvili G; Narmania N; Zhuravliova E; Mikeladze D
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Erratum to: Metabotropic glutamate receptor 5 may be involved in macrophage plasticity.

Biological research
2017-03 | Journal article
DOI: 10.1186/s40659-017-0118-7
PMID: 28347317
PMC: PMC5368921
Contributors: Shanshiashvili L; Tsitsilashvili E; Dabrundashvili N; Kalandadze I; Mikeladze D
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Mitochondrial activity detected by cantilever based sensor

Mechanical Sciences
2017-03 | Journal article
DOI: 10.5194/ms-8-23-2017
Part of ISSN: 2191-916X
Contributors: Petar Stupar; Wojciech Chomicki; Caroline Maillard; David Mikeladze; Aleksandar Kalauzi; Ksenija Radotić; Giovanni Dietler; Sandor Kasas
Source: Self-asserted source
David Mikeladze via Crossref Metadata Search

EFFECTS OF MEDIAL SEPTAL LESION ON HIPPOCAMPAL EXTRACELLULAR GLUTAMATE AND GABA LEVELS DURING SPATIAL ALTERNATION TESTING.

Georgian medical news
2016-10 | Journal article
PMID: 27845295
Contributors: Mataradze S; Naneishvili T; Sephashvili M; Mikeladze D; Dashniani M
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria.

2015 | Journal article
DOI: 10.1186/s12858-015-0040-y
PMID: 25924612
PMC: PMC4430930
Contributors: Natsvlishvili N; Goguadze N; Zhuravliova E; Mikeladze D
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons

Biological Research
2015-12 | Journal article
DOI: 10.1186/s40659-015-0048-1
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Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation.

2015-07 | Journal article
DOI: 10.1179/1476830514Y.0000000120
PMID: 24627959
Contributors: Jojua N; Sharikadze N; Zhuravliova E; Zaalishvili E; Mikeladze DG
Source: Self-asserted source
David Mikeladze via Europe PubMed Central
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IL-10 Gene Knockout Reduces the Expression of mGlu Receptor 1a/b and Decreases the Glutamate-Dependent Production of Nitric Oxide

Journal of Biomedical Science and Engineering
2014 | Journal article
DOI: 10.4236/jbise.2014.713099
Part of ISSN: 1937-6871
Contributors: Sopiko Koriauli; Tamar Barbakadze; Nino Natsvlishvili; Nino Dabrundashvili; Eka Kvaratskhelia; David Mikeladze
Source: Self-asserted source
David Mikeladze via Crossref Metadata Search

Different isoforms of deiminated myelin basic protein have different adsorption capacities to the myelin lipids

Journal of Biological Physics and Chemistry
2014-09 | Journal article
DOI: 10.4024/11sh14a.jbpc.14.03
Part of ISSN: 1512-0856
Contributors: L.V. Shanshiasvili; J.J. Ramsden; D.G. Mikeladze
Source: Self-asserted source
David Mikeladze via Crossref Metadata Search

Possible improvement of neuronal mitochondrial bioenergetics by nobiletin involves activation of matrix substrate-level phosphorylation

Biochimica et Biophysica Acta (BBA) - Bioenergetics
2014-07 | Journal article
DOI: 10.1016/j.bbabio.2014.05.029
Part of ISSN: 0005-2728
Contributors: Elene Zhuravliova; Natia Jojua; Nino Sharikadze; Elnari Zaalishvili; David G. Mikeladze
Source: Self-asserted source
David Mikeladze via Crossref Metadata Search

Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin αvβ3 receptor in undifferentiated and differentiated PC-12 cells

Cell Biochemistry and Function
2013 | Journal article
DOI:

10.1002/cbf.3013
Contributors: Barbakadze, T.; Natsvlishvili, N.; Mikeladze, D.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

MGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes

Molecular Immunology
2012 | Journal article
DOI:

10.1016/j.molimm.2012.03.029
Contributors: Shanshiashvili, L.V.; Dabrundashvili, N.; Natsvlishvili, N.; Kvaratskhelia, E.; Zhuravliova, E.; Barbakadze, T.; Koriauli, S.; Maisuradze, E.; Topuria, T.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein

Cellular and Molecular Biology Letters
2012 | Journal article
DOI:

10.2478/s11658-012-0013-8
Contributors: Bátor, J.; Varga, J.; Berta, G.; Barbakadze, T.; Mikeladze, D.; Ramsden, J.; Szeberényi, J.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism

Cellular and Molecular Neurobiology
2012 | Journal article
DOI:

10.1007/s10571-012-9857-8
Contributors: Zhuravliova, E.; Barbakadze, T.; Jojua, N.; Zaalishvili, E.; Shanshiashvili, L.; Natsvlishvili, N.; Kalandadze, I.; Narmania, N.; Chogovadze, I.; Mikeladze, D.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Adhesive properties and inflammatory potential of citrullinated myelin basic protein peptide 45-89.

2012-09 | Journal article
DOI:

10.1007/s11064-012-0816-z

PMID:

22678722
Contributors: Shanshiashvili LV; Kalandadze IV; Ramsden JJ; Mikeladze DG
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

NObiletin transiently increases the production of nitric oxide and changes the activity of succinate dehydrogenase in human blood lymphocytes

Journal of Food Biochemistry
2011 | Journal article
DOI:

10.1111/j.1745-4514.2010.00407.x
Contributors: Dabrundashvili, N.G.; Kvaratskhelia, E.B.; Gagua, M.; Maisuradze, E.; Chkhikvishvili, I.; Zhuravliova, E.I.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

S-Nitrosylation Decreases the Adsorption of H-Ras in Lipid Bilayer and Changes Intrinsic Catalytic Activity

Cell Biochemistry and Biophysics
2011 | Journal article
DOI:

10.1007/s12013-010-9132-x
Contributors: Shanshiashvili, L.; Narmania, N.; Barbakadze, T.; Zhuravliova, E.; Natsvlishvili, N.; Ramsden, J.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Hypoinsulinemia alleviates the Grf1/Ras/Akt anti-apoptotic pathway and induces alterations of mitochondrial Ras trafficking in neuronal cells

Neurochemical Research
2009 | Journal article
DOI:

10.1007/s11064-008-9877-4
Contributors: Zhuravliova, E.; Barbakadze, T.; Narmania, N.; Sepashvili, M.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

N-methyl-D-aspartate and σ-ligands change the production of interleukins 8 and 10 in lymphocytes through modulation of the NMDA glutamate receptor

NeuroImmunoModulation
2009 | Journal article
DOI:

10.1159/000204234
Contributors: Kvaratskhelia, E.; Maisuradze, E.; Dabrundashvili, N.G.; Natsvlishvili, N.; Zhuravliova, E.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase.

2009-12 | Journal article
DOI:

10.1016/j.bbr.2009.07.009

PMID:

19616040
Contributors: Zhuravliova E; Barbakadze T; Zaalishvili E; Chipashvili M; Koshoridze N; Mikeladze D
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Action of various peptide fragments of MBP on a viability and production of nitric oxide in glial cells

2008 | Journal article
DOI:

10.1186/1753-6561-2-s1-p64

Part of ISSN:

1753-6561
Source: Self-asserted source
David Mikeladze via Crossref Metadata Search

Glutamate decreases the secretion of IL-10 by peripheral blood lymphocytes in persons with autoimmune thyroiditis.

Georgian medical news
2008 | Journal article
EID: 2-s2.0-65849373146
Contributors: Kvaratskhelia, E.; Dabrundashvili, N.; Gagua, M.; Maisuradze, E.; Mikeladze, D.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

P.1.c.013 Some molecular aspects of haloperidol's neurotoxicity

2008 | Journal article
DOI:

10.1016/s0924-977x(08)70277-3

Part of ISSN:

0924-977X
Source: Self-asserted source
David Mikeladze via Crossref Metadata Search

Ras proteins, nitrosylation and homocysteine metabolism.

Georgian medical news
2008 | Journal article
EID: 2-s2.0-58149214366
Contributors: Mikeladze, D.; Zhuravliova, E.; Barbakadze, T.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Glutamate decreases the secretion of IL-10 by peripheral blood lymphocytes in persons with autoimmune thyroiditis.

2008-11 | Journal article
PMID: 19075349
Contributors: Kvaratskhelia E; Dabrundashvili N; Gagua M; Maisuradze E; Mikeladze D
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Ras proteins, nitrosylation and homocysteine metabolism.

2008-09 | Journal article
PMID: 18830027
Contributors: Mikeladze D; Zhuravliova E; Barbakadze T
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity

Neurochemistry International
2007 | Journal article
DOI:

10.1016/j.neuint.2006.09.015
Contributors: Zhuravliova, E.; Barbakadze, T.; Natsvlishvili, N.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Inhibition of nitric oxide synthase and farnesyltransferase change the activities of several transcription factors

Journal of Molecular Neuroscience
2007 | Journal article
EID: 2-s2.0-34548313708
Contributors: Zhuravliova, E.; Barbakadze, T.; Narmania, N.; Ramsden, J.; Mikeladze, D.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Inhibition of nitric oxide synthase and farnesyltransferase change the activities of several transcription factors.

2007 | Journal article
PMID: 17726232
Contributors: Zhuravliova E; Barbakadze T; Narmania N; Ramsden J; Mikeladze D
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Concentrational changes of mannose-binding proteins in blood plasma during noncomplicated pregnancy and in blood plasma of pregnant women with some infections

Georgian medical news.
2006 | Journal article
EID: 2-s2.0-33744971195
Contributors: Khotivari, N.A.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-Ras pheochromocytoma cells.

2006-10 | Journal article
DOI:

10.1007/s11064-006-9148-1

PMID:

17004132
Contributors: Sephashvili M; Zhuravliova E; Barbakadze T; Khundadze M; Narmania N; Mikeladze DG
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

[Concentrational changes of mannose-binding proteins in blood plasma during noncomplicated pregnancy and in blood plasma of pregnant women with some infections]

2006-02 | Journal article
PMID: 16575126
Contributors: Khotivari NA; Mikeladze DG
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Creatine enhances survival of glutamate-treated neuronal/glial cells, modulates Ras/NF-κB signaling, and increases the generation of reactive oxygen species

Journal of Neuroscience Research
2005 | Journal article
DOI:

10.1002/jnr.20291
Contributors: Juravleva, E.; Barbakadze, T.; Mikeladze, D.; Kekelidze, T.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Production of homocysteine in serum-starved apoptotic PC12 cells depends on the activation and modification of Ras

Neuroscience Letters
2005 | Journal article
DOI:

10.1016/j.neulet.2005.08.039
Contributors: Barbakadze, T.; Zhuravliova, E.; Sepashvili, M.; Zaalishvili, E.; Ramsden, J.J.; Bátor, J.; Szeberényi, J.; Mikeladze, D.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

The action of dextrorphan and sigma ligands on the spontaneous secretion of interleukins by jurkat cell line

Georgian medical news.
2005 | Journal article
EID: 2-s2.0-33644874092
Contributors: Kvaratskheliia, E.B.; Dabrundashvili, N.G.; Maǐsuradze, E.B.; Kadzhaia, L.N.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

[The action of dextrorphan and sigma ligands on the spontaneous secretion of interleukins by jurkat cell line]

2005-10 | Journal article
PMID: 16308450
Contributors: Kvaratskheliia EB; Dabrundashvili NG; Maĭsuradze EB; Kadzhaia LN; Mikeladze DG
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Action of a Novel Pyrrolo[1,2-c][1.3]benzodiazepine on the Viability of Jurkat and Neuronal/Glial Cells.

ChemInform
2005-10 | Journal article
DOI: 10.1002/chin.200543182
Part of ISSN: 0931-7597
Contributors: Georgios Rotas; Ketevan Natchkebia; Nino Natsvlishvili; Merab Kekelidze; Athanasios Kimbaris; George Varvounis; David Mikeladze
Source: Self-asserted source
David Mikeladze via Crossref Metadata Search

Adhesion and clustering of charge isomers of myelin basic protein at model myelin membranes

Archives of Biochemistry and Biophysics
2003 | Journal article
DOI:

10.1016/j.abb.2003.09.020
Contributors: Shanshiashvili, L.V.; Suknidze, N.Ch.; Machaidze, G.G.; Mikeladze, D.G.; Ramsden, J.J.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Different effects of lectins on the ligand binding of the NMDA receptors and sigma sites in rat brain hippocampus synaptic membranes

Neurochemical Research
2001 | Journal article
DOI:

10.1023/A:1010961808570
Contributors: Machaidze, G.G.; Mikeladze, D.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Isolation and purification of protein responsible for the conversion of dimethylallylpyrophosphate from poplar leaves into isoprene

Russian Journal of Plant Physiology
2001 | Journal article
DOI:

10.1023/A:1009008318764
Contributors: Datukishvili, N.T.; Tarkhnishvili, G.M.; Mikeladze, D.G.; Beridze, T.G.; Sanadze, G.A.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Dextrorphan-binding proteins in the hippocampus of audiosensitive genetically epilepsy-prone rats | Dekstrorfan-sviazyvaiushchie belki gippokampa audiosensitivnykh krys, geneticheski predraspolozhennykh k épilepsii.

Biulleten' eksperimental'noi biologii i meditsiny
1997 | Journal article
EID: 2-s2.0-0031203792
Contributors: Natsvlishvili, N.I.; Abutidze, K.D.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Dextrorphan-binding proteins in the hippocampus of audiosensitized rats genetically predisposed to epilepsy

Bulletin of Experimental Biology and Medicine
1997 | Journal article
EID: 2-s2.0-26944469361
Contributors: Natsvlishvili, N.I.; Abutidze, K.D.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

[Dextrorphan-binding proteins in the hippocampus of audiosensitive genetically epilepsy-prone rats]

1997-08 | Journal article
PMID: 9410201
Contributors: Natsvlishvili NI; Abutidze KD; Mikeladze DG
Source: Self-asserted source
David Mikeladze via Europe PubMed Central

Purification and properties of brain neuroleptic-binding proteins

Journal of Protein Chemistry
1989 | Journal article
EID: 2-s2.0-0024380816
Contributors: Sartania, N.A.; Abutidze, K.D.; Mikeladze, D.G.
Source: Self-asserted source
David Mikeladze via Scopus - Elsevier

Purification and properties of brain neuroleptic-binding proteins.

1989-06 | Journal article
DOI: 10.1007/BF01674269
PMID: 2571344
Contributors: Sartania NA; Abutidze KD; Mikeladze DG
Source: Self-asserted source
David Mikeladze via Europe PubMed Central
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