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The Krasny Lab

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ResearcherID: H-2429-2014

Keywords

bacteria, RNA polymerase, control of transcription, antibiotics & resistance

Countries

Czech Republic, United States

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Employment (1)

Czech Academy of Sciences, Institute of Microbiology: Prague, CZ

PI
Employment
Source: Self-asserted source
Libor Krasny

Education and qualifications (1)

Charles University: Prague, CZ

Education
Source: Self-asserted source
Libor Krasny

Works (50 of 78)

Items per page:
Page 1 of 2

MoaB2, a newly identified transcription factor, binds to σ<sup>A</sup> in <i>Mycobacterium smegmatis</i>.

Journal of bacteriology
2024-11-05 | Journal article | Author
DOI: 10.1128/jb.00066-24
PMID: 39499088
Contributors: Barbora Brezovska; Narasimhan S; Šiková M; Šanderová H; Kovaľ T; Borah N; Shoman M; Pospíšilová D; Vaňková Hausnerová V; Tužinčin D et al.
Source: Self-asserted source
Libor Krasny

Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.

Nature communications
2024-10-09 | Journal article | Author
DOI: 10.1038/s41467-024-52891-5
PMID: 39384756
PMC: PMC11464796
Contributors: Tomáš Kovaľ; Borah N; Petra Sudzinová; Brezovská B; Hana Šanderová; Vaňková Hausnerová V; Křenková A; Hubálek M; Trundová M; Adámková K et al.
Source: Self-asserted source
Libor Krasny

Whole proteome analysis of germinating and outgrowing Bacillus subtilis 168.

Proteomics
2024-07-23 | Journal article
DOI: 10.1002/pmic.202400031
PMID: 39044338
Contributors: Jiri Pospisil; Sax A; Hubálek M; Krásný L; Jiri Vohradsky
Source: Self-asserted source
Libor Krasny

Spatio-temporal control of asymmetric septum positioning during sporulation in Bacillus subtilis

Journal of Biological Chemistry
2024-06 | Journal article
DOI: 10.1016/j.jbc.2024.107339
Part of ISSN: 0021-9258
Contributors: Katarína Muchová; Jiří Pospíšil; Evelína Kalocsaiová; Zuzana Chromiková; Silvia Žarnovičanová; Hana Šanderová; Libor Krásný; Imrich Barák
Source: Self-asserted source
Libor Krasny

Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function

Nucleic Acids Research
2024-06-06 | Journal article | Author
DOI: 10.1093/nar/gkae434
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Markéta Šoltysová; Jana Skerlova; Petr Pachl; Karel Škubník; Milan Fábry; Irena Sieglová; Martina Farolfi; Irina Grishkovskaya; Michal Babiak; Jiri Novacek et al.
Source: Self-asserted source
Libor Krasny

RIP-seq reveals RNAs that interact with RNA polymerase and primary sigma factors in bacteria

Nucleic Acids Research
2024-02-13 | Journal article | Author
DOI: 10.1093/nar/gkae081
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Viola Vaňková Hausnerová; Mahmoud Shoman; Dilip Kumar; Marek Schwarz; Martin Modrák; Jitka Jirát Matějčková; Eliška Mikesková; Silvia Neva; Anna Herrmannová; Michaela Šiková et al.
Source: Self-asserted source
Libor Krasny

σE of Streptomyces coelicolor can function both as a direct activator or repressor of transcription

Communications Biology
2024-01-06 | Journal article | Author
DOI: 10.1038/s42003-023-05716-y
Part of ISSN: 2399-3642
Contributors: Jiri Pospisil; Marek Schwarz; Alice Ziková; Dragana Vítovská; Miluše Hradilová; Michal Kolář; Alena Křenková; Martin Hubálek; Libor Krasny; Jiri Vohradsky
Source: Self-asserted source
Libor Krasny

Characterization of a transitionally occupied state and thermal unfolding of domain 1.1 of σA factor of <scp>RNA</scp> polymerase from <i>Bacillus subtilis</i>

Proteins: Structure, Function, and Bioinformatics
2023-09 | Journal article
DOI: 10.1002/prot.26531
Part of ISSN: 0887-3585
Part of ISSN: 1097-0134
Contributors: Dávid Tužinčin; Petr Padrta; Hana Šanderová; Alžběta Rabatinová; Kateřina Bendová; Libor Krásný; Lukáš Žídek; Pavel Kadeřávek
Source: Self-asserted source
Libor Krasny

The alternative sigma factor SigN of <i>Bacillus subtilis</i> is intrinsically toxic

Journal of Bacteriology
2023-09-20 | Journal article | Author
DOI: 10.1128/jb.00112-23
Part of ISSN: 0021-9193
Part of ISSN: 1098-5530
Contributors: Aisha T Burton; Debora Pospíšilová; Petra Sudzinova; Elizabeth V. Snider; Andrew M. Burrage; Libor Krasny; Daniel B. Kearns
Source: Self-asserted source
Libor Krasny

What the Hel: recent advances in understanding rifampicin resistance in bacteria.

FEMS microbiology reviews
2022-12-22 | Journal article | Author
DOI: 10.1093/femsre/fuac051
PMID: 36549665
Contributors: Sudzinová P; Šanderová H; Kovaľ T; Skálová T; Borah N; Hnilicová J; Kouba T; Dohnálek J; Libor Krasny
Source: Self-asserted source
Libor Krasny

LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.

Journal of medicinal chemistry
2022-07-15 | Journal article
DOI: 10.1021/acs.jmedchem.2c00684
PMID: 35839126
PMC: PMC9580004
Contributors: Duy Dinh Do Pham; Mojr V; Helusová M; Gabriela Mikušová; Radek Pohl; Eva Davidova; Šanderová H; Vítovská D; Bogdanová K; Večeřová R et al.
Source: Self-asserted source
Libor Krasny

Homologues of epigenetic pyrimidines: 5-alkyl-, 5-hydroxyalkyl and 5-acyluracil and -cytosine nucleotides: synthesis, enzymatic incorporation into DNA and effect on transcription with bacterial RNA polymerase.

RSC chemical biology
2022-06-30 | Journal article
DOI: 10.1039/d2cb00133k
PMID: 35975001
PMC: PMC9347353
Contributors: Gracias F; Ruiz-Larrabeiti O; Vaňková Hausnerová V; Radek Pohl; Klepetářová B; Sýkorová V; Krásný L; Michal Hocek
Source: Self-asserted source
Libor Krasny

Epigenetic Pyrimidine Nucleotides in Competition with Natural dNTPs as Substrates for Diverse DNA Polymerases.

ACS chemical biology
2022-06-09 | Journal article
DOI: 10.1021/acschembio.2c00342
PMID: 35679536
PMC: PMC9594043
Contributors: Pospíšil Š; Panattoni A; Gracias F; Sýkorová V; Hausnerová VV; Vítovská D; Šanderová H; Krásný L; Michal Hocek
Source: Self-asserted source
Libor Krasny

Ms1 RNA Interacts With the RNA Polymerase Core in <i>Streptomyces coelicolor</i> and Was Identified in Majority of <i>Actinobacteria</i> Using a Linguistic Gene Synteny Search.

Frontiers in microbiology
2022-05-11 | Journal article
DOI: 10.3389/fmicb.2022.848536
PMID: 35633709
PMC: PMC9130861
Contributors: Vaňková Hausnerová V; Marvalová O; Šiková M; Shoman M; Havelková J; Kambová M; Janoušková M; Kumar D; Halada P; Schwarz M et al.
Source: Self-asserted source
Libor Krasny

Glucosylated 5-Hydroxymethylpyrimidines as Epigenetic DNA Bases Regulating Transcription and Restriction Cleavage.

Chemistry (Weinheim an der Bergstrasse, Germany)
2022-04-13 | Journal article
DOI: 10.1002/chem.202200911
PMID: 35355345
Contributors: Chakrapani A; Ruiz-Larrabeiti O; Radek Pohl; Svoboda M; Krásný L; Michal Hocek
Source: Self-asserted source
Libor Krasny

β-CASP proteins removing RNA polymerase from DNA: when a torpedo is needed to shoot a sitting duck.

Nucleic acids research
2021-10-01 | Journal article | Author
DOI: 10.1093/nar/gkab803
PMID: 34551438
PMC: PMC8501993
Contributors: Jana Wiedermannová; Libor Krasny
Source: Self-asserted source
Libor Krasny

Novel lipophosphonoxin-loaded polycaprolactone electrospun nanofiber dressing reduces Staphylococcus aureus induced wound infection in mice.

Scientific reports
2021-09-03 | Journal article
DOI: 10.1038/s41598-021-96980-7
PMID: 34480072
PMC: PMC8417216
Contributors: Duy Dinh Do Pham; Jenčová Věra; Kaňuchová M; Bayram J; Grossová I; Šuca H; Urban L; Kristyna Havlickova; Novotný V; Mikeš P et al.
Source: Self-asserted source
Libor Krasny

Quasi-essentiality of RNase Y in Bacillus subtilis is caused by its critical role in the control of mRNA homeostasis.

Nucleic acids research
2021-07-01 | Journal article | Author
DOI: 10.1093/nar/gkab528
PMID: 34157109
PMC: PMC8266666
Contributors: Benda M; Woelfel S; Faßhauer P; Gunka K; Klumpp S; Anja Poehlein; Kálalová D; Šanderová H; Daniel R; Libor Krasny et al.
Source: Self-asserted source
Libor Krasny

Effects of DNA Topology on Transcription from rRNA Promoters in <i>Bacillus subtilis</i>

Microorganisms
2021-01 | Journal article | Author
DOI: 10.3390/microorganisms9010087
Contributors: Petra Sudzinová; Milada Kambová; Marvalová; Martin Benda; Hana Šanderová; Libor Krasny
Source: check_circle
Multidisciplinary Digital Publishing Institute

Kinetic Modeling and Meta-Analysis of the <i>Bacillus subtilis</i> SigB Regulon during Spore Germination and Outgrowth

Microorganisms
2021-01 | Journal article | Author
DOI: 10.3390/microorganisms9010112
Contributors: Jiri Vohradsky; Marek Schwarz; Marvalová; Olatz Ruiz Larrabeiti; Viola Vaňková Hausnerová; Hana Šanderová; Libor Krasny
Source: check_circle
Multidisciplinary Digital Publishing Institute

Photocaged 5-(Hydroxymethyl)pyrimidine Nucleoside Phosphoramidites for Specific Photoactivatable Epigenetic Labeling of DNA.

Organic letters
2020-11-06 | Journal article
DOI: 10.1021/acs.orglett.0c03462
PMID: 33156631
Source: Self-asserted source
Libor Krasny

Author Correction: Bacterial nanotubes as a manifestation of cell death.

Nature communications
2020-11-03 | Journal article
DOI: 10.1038/s41467-020-19618-8
PMID: 33144574
PMC: PMC7609721
Source: Self-asserted source
Libor Krasny

Bacterial nanotubes as a manifestation of cell death.

Nature communications
2020-10-02 | Journal article
DOI: 10.1038/s41467-020-18800-2
PMID: 33009406
PMC: PMC7532143
Source: Self-asserted source
Libor Krasny

The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis.

PLoS genetics
2020-03-16 | Journal article
DOI: 10.1371/journal.pgen.1008275
PMID: 32176689
PMC: PMC7098656
Source: Self-asserted source
Libor Krasny

Dinucleoside polyphosphates act as 5'-RNA caps in bacteria.

Nature communications
2020-02-26 | Journal article
DOI: 10.1038/s41467-020-14896-8
PMID: 32103016
PMC: PMC7044304
Source: Self-asserted source
Libor Krasny

Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement.

ACS omega
2020-02-12 | Journal article
DOI: 10.1021/acsomega.9b03072
PMID: 32118132
PMC: PMC7045315
Source: Self-asserted source
Libor Krasny

The torpedo effect in Bacillus subtilis: RNase J1 resolves stalled transcription complexes.

The EMBO journal
2019-12-16 | Journal article
DOI: 10.15252/embj.2019102500
PMID: 31840842
Source: Self-asserted source
Libor Krasny

Quantitative Conformational Analysis of Functionally Important Electrostatic Interactions in the Intrinsically Disordered Region of Delta Subunit of Bacterial RNA Polymerase.

Journal of the American Chemical Society
2019-10-10 | Journal article
DOI: 10.1021/jacs.9b07837
PMID: 31550880
Source: Self-asserted source
Libor Krasny

Analysis of nucleotide pools in bacteria using HPLC-MS in HILIC mode.

Talanta
2019-07-18 | Journal article
DOI: 10.1016/j.talanta.2019.120161
PMID: 31450400
Source: Self-asserted source
Libor Krasny

Domain structure of HelD, an interaction partner of Bacillus subtilis RNA polymerase.

FEBS letters
2019-04-23 | Journal article
DOI: 10.1002/1873-3468.13385
PMID: 30972737
Source: Self-asserted source
Libor Krasny

Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA.

Chemical science
2019-03-04 | Journal article
DOI: 10.1039/c9sc00205g
PMID: 31015933
PMC: PMC6457204
Source: Self-asserted source
Libor Krasny

The Core and Holoenzyme Forms of RNA Polymerase from Mycobacterium smegmatis.

Journal of bacteriology
2019-01-28 | Journal article
DOI: 10.1128/jb.00583-18
PMID: 30478083
PMC: PMC6351736
Source: Self-asserted source
Libor Krasny

Ms1 RNA increases the amount of RNA polymerase in Mycobacterium smegmatis.

Molecular microbiology
2018-12-11 | Journal article
DOI: 10.1111/mmi.14159
PMID: 30427073
Source: Self-asserted source
Libor Krasny

Spx, the central regulator of the heat and oxidative stress response in B. subtilis, can repress transcription of translation-related genes.

Molecular microbiology
2018-12-11 | Journal article
DOI: 10.1111/mmi.14171
PMID: 30480837
Source: Self-asserted source
Libor Krasny

Transcription apparatus of the yeast virus-like elements: Architecture, function, and evolutionary origin.

PLoS pathogens
2018-10-22 | Journal article
DOI: 10.1371/journal.ppat.1007377
PMID: 30346988
PMC: PMC6211774
Source: Self-asserted source
Libor Krasny

σI from Bacillus subtilis: Impact on Gene Expression and Characterization of σI-Dependent Transcription That Requires New Types of Promoters with Extended -35 and -10 Elements.

Journal of bacteriology
2018-08-10 | Journal article
DOI: 10.1128/jb.00251-18
PMID: 29914988
PMC: PMC6088155
Source: Self-asserted source
Libor Krasny

Turning Off Transcription with Bacterial RNA Polymerase through CuAAC Click Reactions of DNA Containing 5-Ethynyluracil.

Chemistry (Weinheim an der Bergstrasse, Germany)
2018-05-17 | Journal article
DOI: 10.1002/chem.201801757
PMID: 29655191
Source: Self-asserted source
Libor Krasny

CapZyme-Seq Comprehensively Defines Promoter-Sequence Determinants for RNA 5' Capping with NAD<sup/>.

Molecular cell
2018-04-19 | Journal article
DOI: 10.1016/j.molcel.2018.03.014
PMID: 29681497
PMC: PMC5935523
Source: Self-asserted source
Libor Krasny

Kinetic modelling and meta-analysis of the B. subtilis SigA regulatory network during spore germination and outgrowth

Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms
2017 | Journal article
DOI: 10.1016/j.bbagrm.2017.06.003
WOSUID:

WOS:000407658800008
Contributors: Ramaniuk, O.; Cerny, M.; Krasny, L.; Vohradsky, J.
Source: Self-asserted source
Libor Krasny via ResearcherID

Lipophosphonoxins II: Design, Synthesis, and Properties of Novel Broad Spectrum Antibacterial Agents

Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1021/acs.jmedchem.7b00355
WOSUID:

WOS:000406727700011
Contributors: Seydlova, Gabriela; Pohl, Radek; Zbornikova, Eva; Ehn, Marcel; Simak, Ondrej; Panova, Natalya; Kolar, Milan; Bogdanova, Katerina; Vecerova, Renata; Fiser, Radovan et al.
Source: Self-asserted source
Libor Krasny via ResearcherID

Non-canonical transcription initiation: the expanding universe of transcription initiating substrates

Fems Microbiology Reviews
2017 | Journal article
DOI: 10.1093/femsre/fuw041
WOSUID:

WOS:000396366700002
Contributors: Barvik, Ivan; Rejman, Dominik; Panova, Natalya; Sanderova, Hana; Krasny, Libor
Source: Self-asserted source
Libor Krasny via ResearcherID

Solution structure of domain 1.1 of the sigma(A) factor from Bacillus subtilis is preformed for binding to the RNA polymerase core

Journal of Biological Chemistry
2017 | Journal article
DOI: 10.1074/jbc.M117.784074
WOSUID:

WOS:000405485600002
Contributors: Zachrdla, Milan; Padrta, Petr; Rabatinova, Alzbeta; Sanderova, Hana; Barvik, Ivan; Krasny, Libor; Zidek, Lukas
Source: Self-asserted source
Libor Krasny via ResearcherID

5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase.

Chemical communications (Cambridge, England)
2017-12-01 | Journal article
DOI: 10.1039/c7cc08053k
PMID: 29184924
Source: Self-asserted source
Libor Krasny

Triple resonance ¹⁵Ν NMR relaxation experiments for studies of intrinsically disordered proteins.

Journal of biomolecular NMR
2017-10-25 | Journal article
DOI: 10.1007/s10858-017-0138-1
PMID: 29071460
Source: Self-asserted source
Libor Krasny

Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases

Nucleic Acids Research
2016 | Journal article
DOI: 10.1093/nar/gkw171
WOSUID:

WOS:000375800200013
Contributors: Raindlova, Veronika; Janouskova, Martina; Slavickova, Michaela; Perlikova, Pavla; Bohacova, Sona; Milisavljevic, Nemanja; Sanderova, Hana; Benda, Martin; Barvik, Ivan; Krasny, Libor et al.
Source: Self-asserted source
Libor Krasny via ResearcherID

The mechanism of RNA 5 ' capping with NAD(+), NADH and desphospho-CoA

Nature
2016 | Journal article
DOI: 10.1038/nature18622
WOSUID:

WOS:000380344200045
Contributors: Bird, Jeremy G.; Zhang, Yu; Tian, Yuan; Panova, Natalya; Barvik, Ivan; Greene, Landon; Liu, Min; Buckley, Brian; Krasny, Libor; Lee, Jeehiun K. et al.
Source: Self-asserted source
Libor Krasny via ResearcherID

Insights into the Mechanism of Action of Bactericidal Lipophosphonoxins

Plos One
2015 | Journal article
DOI: 10.1371/journal.pone.0145918
WOSUID:

WOS:000367510500095
Contributors: Panova, Natalya; Zbornikova, Eva; Simak, Ondrej; Pohl, Radek; Kolar, Milan; Bogdanova, Katerina; Vecerova, Renata; Seydlova, Gabriela; Fiser, Radovan; Hadravova, Romana et al.
Source: Self-asserted source
Libor Krasny via ResearcherID

Characterization of HelD, an interacting partner of RNA polymerase from Bacillus subtilis

Nucleic Acids Research
2014 | Journal article
DOI: 10.1093/nar/gku113
WOSUID:

WOS:000336092300042
Contributors: Wiedermannova, Jana; Sudzinova, Petra; Koval, Tomas; Rabatinova, Alzbeta; Sanderova, Hana; Ramaniuk, Olga; Rittich, Simon; Dohnalek, Jan; Fu, Zhihui; Halada, Petr et al.
Source: Self-asserted source
Libor Krasny via ResearcherID

epsilon, a New Subunit of RNA Polymerase Found in Gram-Positive Bacteria

Journal of Bacteriology
2014 | Journal article
DOI: 10.1128/JB.02020-14
WOSUID:

WOS:000342367700011
Contributors: Keller, Andrew N.; Yang, Xiao; Wiedermannova, Jana; Delumeau, Olivier; Krasny, Libor; Lewis, Peter J.
Source: Self-asserted source
Libor Krasny via ResearcherID

Ms1, a novel sRNA interacting with the RNA polymerase core in mycobacteria

Nucleic Acids Research
2014 | Journal article
DOI: 10.1093/nar/gku793
WOSUID:

WOS:000347687100047
Contributors: Hnilicova, Jarmila; Matejckova, Jitka Jirat; Sikova, Michaela; Pospisil, Jiri; Halada, Petr; Panek, Josef; Krasny, Libor
Source: Self-asserted source
Libor Krasny via ResearcherID
Items per page:
Page 1 of 2

Peer review (4 reviews for 3 publications/grants)

Review activity for Genes. (2)
Review activity for Nature communications (1)
Review activity for Nature microbiology. (1)
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