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Works (41)

Explainable machine learning identifies features and thresholds predictive of immunotherapy response

2025-03-25 | Preprint
DOI: 10.1101/2025.03.23.643560
Contributors: Khoa A. Tran; Venkateswar Addala; Lambros T. Koufariotis; Jia Zhang; Scott Wood; Conrad Leonard; Lotte L. Hoeijmakers; Christian U. Blank; Mireia Crispin-Ortuzar; Elizabeth D. Williams et al.
Source: check_circle
Crossref

Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) Samples from Advanced Non-Small Cell Lung Cancer for Whole Genome, Whole Exome and Comprehensive Panel Sequencing

Cancers
2024-02-15 | Journal article | Author
DOI: 10.3390/cancers16040785
Part of ISSN: 2072-6694
Contributors: David Fielding; Vanessa Lakis; Andrew J. Dalley; Haarika Chittoory; Felicity Newell; Lambros T. Koufariotis; Ann-Marie Patch; Stephen Kazakoff; Farzad Bashirzadeh; Jung hwa Son et al.
Source: Self-asserted source
Conrad Leonard

The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study

Genome Medicine
2023-09-19 | Journal article
DOI: 10.1186/s13073-023-01223-1
Part of ISSN: 1756-994X
Contributors: Aimee Davidson; Uwe Dressel; Sarah Norris; Daffodil M. Canson; Dylan M. Glubb; Cristina Fortuno; Georgina E. Hollway; Michael T. Parsons; Miranda E. Vidgen; Oliver Holmes et al.
Source: Self-asserted source
Conrad Leonard

Multi-omic features of oesophageal adenocarcinoma in patients treated with preoperative neoadjuvant therapy

Nature Communications
2023-05-31 | Journal article | Author
DOI: 10.1038/s41467-023-38891-x
Part of ISSN: 2041-1723
Contributors: Dr. Marjan M. Naeini; Felicity Newell; Lauren G. Aoude; Vanessa F. Bonazzi; Kalpana Patel; Guy Lampe; Lambros T. Koufariotis; Vanessa Lakis; Venkateswar; Olga Kondrashova et al.
Source: Self-asserted source
Conrad Leonard

streammd: fast low-memory duplicate marking using a Bloom filter

Bioinformatics
2023-04-03 | Journal article
DOI: 10.1093/bioinformatics/btad181
Contributors: Conrad Leonard; Peter Robinson
Source: check_circle
Crossref

Analysis of hereditary cancer gene variant classifications from ClinVar indicates a need for regular reassessment of clinical assertions

Human Mutation
2022-12 | Journal article
DOI: 10.1002/humu.24468
Part of ISSN: 1059-7794
Part of ISSN: 1098-1004
Contributors: Aimee Davidson; Olga Kondrashova; Conrad Leonard; Scott Wood; Emma Tudini; Georgina E. Hollway; John V. Pearson; Felicity Newell; Amanda Spurdle; Nicola Waddell
Source: Self-asserted source
Conrad Leonard

Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

Genome Medicine
2022-12 | Journal article
DOI: 10.1186/s13073-022-01060-8
Part of ISSN: 1756-994X
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes

Cancer Discovery
2022-12-02 | Journal article | Author
DOI: 10.1158/2159-8290.cd-22-0603
Part of ISSN: 2159-8274
Part of ISSN: 2159-8290
Contributors: Felicity Newell; Peter Johansson; James Wilmott; Katia Nones; Vanessa Lakis; Antonia Pritchard; Serigne N Lo; Robert V Rawson; Stephen Kazakoff; Andrew Colebatch et al.
Source: Self-asserted source
Conrad Leonard

Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels

ESMO Open
2022-08 | Journal article
DOI: 10.1016/j.esmoop.2022.100540
Part of ISSN: 2059-7029
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

Gastroenterology
2022-01 | Journal article
DOI: 10.1053/j.gastro.2021.09.022
Part of ISSN: 0016-5085
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance

Cancer Cell
2022-01 | Journal article
DOI: 10.1016/j.ccell.2021.11.012
Part of ISSN: 1535-6108
Contributors: Felicity Newell; Ines Pires da Silva; Peter Johansson; Alexander M. Menzies; James Wilmott; Venkateswar; Matteo S. Carlino; Helen Rizos; Katia Nones; Jarem J. Edwards et al.
Source: Self-asserted source
Conrad Leonard

qmotif: determination of telomere content from whole-genome sequence data

Bioinformatics Advances
2022-01-10 | Journal article
DOI: 10.1093/bioadv/vbac005
Part of ISSN: 2635-0041
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association

Communications Biology
2021-12 | Journal article
DOI: 10.1038/s42003-020-01469-0
Part of ISSN: 2399-3642
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard
grade
Preferred source (of 2)‎

Considerations for using population frequency data in germline variant interpretation: Cancer syndrome genes as a model

Human Mutation
2021-05 | Journal article
DOI: 10.1002/humu.24183
Part of ISSN: 1059-7794
Part of ISSN: 1098-1004
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Gastroenterology
2021-01 | Journal article
DOI: 10.1053/j.gastro.2020.09.043
Part of ISSN: 0016-5085
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Using whole-genome sequencing data to derive the homologous recombination deficiency scores

npj Breast Cancer
2020-12 | Journal article
DOI: 10.1038/s41523-020-0172-0
Part of ISSN: 2374-4677
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard
grade
Preferred source (of 2)‎

Whole genome landscapes of uveal melanoma show an ultraviolet radiation signature in iris tumours

Nature Communications
2020-12 | Journal article
DOI: 10.1038/s41467-020-16276-8
Part of ISSN: 2041-1723
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity

Nature Communications
2020-12 | Journal article
DOI: 10.1038/s41467-020-18988-3
Part of ISSN: 2041-1723
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer

Cell Reports
2020-05 | Journal article
DOI: 10.1016/j.celrep.2020.107625
Part of ISSN: 2211-1247
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs

Biomaterials
2020-05 | Journal article
DOI: 10.1016/j.biomaterials.2019.119742
Part of ISSN: 0142-9612
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Complex structural rearrangements are present in high-grade dysplastic Barrett’s oesophagus samples

BMC Medical Genomics
2019-12 | Journal article
DOI: 10.1186/s12920-019-0476-9
Part of ISSN: 1755-8794
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets

Nature Communications
2019-12 | Journal article
DOI: 10.1038/s41467-019-11107-x
Part of ISSN: 2041-1723
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Running Genomic Analyses in the Cloud

Digital Health: Changing the Way Healthcare is Conceptualised and Delivered
2019-08 | Book chapter | Writing - original draft
DOI: 10.3233/SHTI190787
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers

Annals of Oncology
2019-07 | Journal article
DOI: 10.1093/annonc/mdz132
Part of ISSN: 0923-7534
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole genome sequencing of melanomas in adolescent and young adults reveals distinct mutation landscapes and the potential role of germline variants in disease susceptibility

International Journal of Cancer
2019-03-01 | Journal article
DOI: 10.1002/ijc.31791
Part of ISSN: 0020-7136
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications

The Journal of Pathology
2019-02 | Journal article
DOI: 10.1002/path.5184
Part of ISSN: 0022-3417
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Germline and somatic variant identification using BGISEQ-500 and HiSeq X Ten whole genome sequencing

PLOS ONE
2018-01-10 | Journal article
DOI: 10.1371/journal.pone.0190264
Part of ISSN: 1932-6203
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Lost in translation: returning germline genetic results in genome-scale cancer research

Genome Medicine
2017-12 | Journal article
DOI: 10.1186/s13073-017-0430-4
Part of ISSN: 1756-994X
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole-genome landscapes of major melanoma subtypes

Nature
2017-05 | Journal article
DOI: 10.1038/nature22071
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole-genome landscape of pancreatic neuroendocrine tumours

Nature
2017-03-02 | Journal article
DOI: 10.1038/nature21063
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Hypermutation In Pancreatic Cancer

Gastroenterology
2017-01 | Journal article
DOI: 10.1053/j.gastro.2016.09.060
Part of ISSN: 0016-5085
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Genomic analyses identify molecular subtypes of pancreatic cancer

Nature
2016-03 | Journal article
DOI: 10.1038/nature16965
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Integrated genomic and transcriptomic analysis of human brain metastases identifies alterations of potential clinical significance

The Journal of Pathology
2015-11 | Journal article
DOI: 10.1002/path.4583
Part of ISSN: 0022-3417
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole–genome characterization of chemoresistant ovarian cancer

Nature
2015-05-28 | Journal article
DOI: 10.1038/nature14410
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Whole genomes redefine the mutational landscape of pancreatic cancer

Nature
2015-02-26 | Journal article
DOI: 10.1038/nature14169
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis

Nature Communications
2014-12 | Journal article
DOI: 10.1038/ncomms6224
Part of ISSN: 2041-1723
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling

International Journal of Cancer
2014-09-01 | Journal article
DOI: 10.1002/ijc.28765
Part of ISSN: 0020-7136
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

A workflow to increase verification rate of chromosomal structural rearrangements using high-throughput next-generation sequencing

BioTechniques
2014-07 | Journal article
DOI: 10.2144/000114189
Part of ISSN: 0736-6205
Part of ISSN: 1940-9818
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Somatic Point Mutation Calling in Low Cellularity Tumors

PLoS ONE
2013-11-08 | Journal article
DOI: 10.1371/journal.pone.0074380
Part of ISSN: 1932-6203
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Nature
2012-11 | Journal article
DOI: 10.1038/nature11547
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard

qpure: A Tool to Estimate Tumor Cellularity from Genome-Wide Single-Nucleotide Polymorphism Profiles

PLoS ONE
2012-09-25 | Journal article
DOI: 10.1371/journal.pone.0045835
Part of ISSN: 1932-6203
Contributors: Conrad Leonard
Source: Self-asserted source
Conrad Leonard
How many people are using ORCID?