Personal information

chemistry, medicinal chemistry, heterocyclic chemistry, history of chemistry, organic chemistry

Biography

Assoc. Prof. STANISLAV RADL, PhD
A versatile chemist with research, teaching, writing, and editing skills combined with industrial applied research experience
CAREER HISTORY
2013-to date Scientific Development Expert, Zentiva – A Sanofi company
2010 Assoc. Prof. of Organic Chemistry, Prague Institute of Chemical Technology
2006-to date Visiting lecturer (Medicinal Chemistry) at the Prague Institute of Chemical Technology
2005-2013 Head of the API Synthesis Development I Department, Zentiva, Prague
1995- 2005: Head of the Department of Organic Synthesis I of the Reseach Institute of Pharmacy and Biochemistry, Prague
1993-1994: Senior Research Scientist, Research Institute of Pharmacy and Biochemistry, Prague
1992-1993: Visiting Scientist, Hoffmann-La Roche, Nutley, U.S.A.
1990-1991: Senior Research Scientist, Research Institute of Pharmacy and Biochemistry, Prague
1987-1990: Head, Organic Synthesis-I department, Research Institute of Pharmacy and Biochemistry, Prague
1983-1986: Research Scientist, Research Institute of Pharmacy and Biochemistry, Prague
1978-1982: Postgraduate student, Research Institute of Pharmacy and Biochemistry (PhD Dissertation: Synthesis of new antiviral agents)
1970-1976: Student, Prague Institute of Chemical Technology, Faculty of Chemical Technology, Department of Organic Chemistry

PERSONAL DETAILS
Address: Zentiva, U kabelovny 130, 102 37, Prague 10. Czech Republic
Tel : 0420 2 67243741 Fax: 0420 2 67243741 Email: stanislav.radl@zentiva.cz
Date of Birth: 21 July 1951
RESEARCH PUBLICATIONS AND EDITING ACTIVITIES
Publications:
70 Original articles (Collect. Czech. Chem. Commun., Heterocycles, J. Heterocycl. Chem., Arch. Pharm.-Pharm. Med. Chem., Bioorg.Med. Chem. Lett., Gen. Physiol. Biophys., Cesk. Farm., Electronic Conference on Heterocyclic Chemistry '98, Org. Proc. Res. Dev., Synthesis, Tetrahedron Lett.)
38 Review articles (Advances in Heterocyclic Chemistry, Heterocycles, Current Medicinal Chemistry, Cesk. Farm., Drugs of the Future, Pharmacology and Therapeutics, Arch. Pharm.-Pharm. Med. Chem., Chem. Listy, Aldrichimica Acta, Janssen Chimica Acta, Vesmir)
1 Section in Comprehensive Heterocyclic Chemistry II (A. R. Katritzky, C. W. Rees, Eds)
1 Section in Comprehensive Heterocyclic Chemistry III (A. R. Katritzky, C. W. Rees, Eds)
1 Section in Comprehensive Functional Groups Transformations II (A. R. Katritzky, C. W. Rees, Eds)
1 Chapter in Science of Synthesis (Thieme)
1 Chapter in Selected Methods for Synthesis and Modification of Heterocycles (Kartsev V.G., Ed.).
5 Short monographs (Drugs of the Future)
4 Meeting Reports (Drugs of the Future, Drug News & Perspectives)
Textbook „Chemie léčiv“ (Cz), i.e. Medicinal Chemistry
Book „Farmakochemie“ (Cz), i.e. Pharmacochemistry,
2nd edition 2005 (cca 450 pages),
3rd edition is scheduled for Jan 2015 (cca 650 pages).
Section of Pharmacochemistry (480 entries) in „Encykopedický farmaceutický slovník“ (Cz), i.e. Encyclopedia of Pharmacy (cca 800 pages).
Co-author of more than 100 Czech Patent Applications, most of them also as WO, EP and/or US patents.
Editorial Boards:
Contributing Editor of Drugs of the Future (published by Prous Science Publishers, Barcelona, Spain, currently by Thompson Reuters)
Reviewer of ARKAT (an electronic publication published by Arkivoc)
1995-2012 Scientific editor of the Collection of Czechoslovak Chemical Communications (published by Czech Academy of Sciences, in 2012 transformed into ChemPlusChem)
Professional memberships:
Czech Chemical Society
International Society of Heterocyclic Chemistry
Fields of special interest:
Medicinal chemistry (especially antibacterial chemotherapy)
Heterocyclic chemistry (especially nitrogen-containing heterocycles)
Denitrocyclization reactions
Awards:
The Karel Preiss Annual Award of the Czech Chemical Society for 2004
Personality of Zentiva 2007
Gold Badge of the International Scientific Partnership Foundation, 2010

Activities

Employment (8)

Zentiva ks: Praha, CZ

2018-01-01 to present | Consultant (Development)
Employment
Source: Self-asserted source
Stanislav Radl

Zentiva - A Sanofi Company: Prague, CZ

2013 to 2017-12-31 | Scientific Development Expert (Chemistry Office)
Employment
Source: Self-asserted source
Stanislav Radl

Zentiva - A Sanofi Company: Prague, CZ

2005 to 2012 | Head (API DEvelopment I)
Employment
Source: Self-asserted source
Stanislav Radl

Research Institute of Pharmacy and Biochemistry: Prague, CZ

1995 to 2005 | Department Head (Organic Synthesis I)
Employment
Source: Self-asserted source
Stanislav Radl

Research Institute of Pharmacy and Biochemistry: Prague, CZ

1993-10-01 to 1994-12-31 | Senior Research Scientist (Organic Synthesis)
Employment
Source: Self-asserted source
Stanislav Radl

Hoffmann-La Roche Inc: Nutley, NJ, US

1992-01-01 to 1993-09-31 | Visiting Scientist (Medicinal Chemistry)
Employment
Source: Self-asserted source
Stanislav Radl

Research Institute of Pharmacy and Biochemistry: Prague, CZ

1987 to 1990 | Department Head (Organic Synthesis)
Employment
Source: Self-asserted source
Stanislav Radl

Research Institute of Pharmacy and Biochemistry: Prague, CZ

1983 to 1986 | Research Scientist (Organic Sznthesis)
Employment
Source: Self-asserted source
Stanislav Radl

Education and qualifications (2)

Research Institute of Pharmacy and Biochemistry: Prague, CZ

1978-09-01 to 1982-12-31 | CSc./PhD (Organic Synthesis)
Education
Source: Self-asserted source
Stanislav Radl

Prague Institute of Chemical Technology, Faculty of Chemical Technology[: Prague, CZ

1970-09-30 to 1976-06-31 | Ing/Mgr (Organic Chemistry)
Education
Source: Self-asserted source
Stanislav Radl

Works (50 of 73)

Items per page:
Page 1 of 2

Will the Drugs of the Future Be Small Molecules or Biological Drugs?

Chemické listy
2022-08-15 | Journal article
Contributors: Stanislav Rádl; Ondřej Dammer; Luděk Ridvan
Source: check_circle
Crossref

Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold

ACS Medicinal Chemistry Letters
2022-06-09 | Journal article
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Source: Self-asserted source
Stanislav Radl

A Scalable Synthesis of Roxadustat (FG-4592)

Organic Process Research & Development
2022-03-18 | Journal article
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Source: Self-asserted source
Stanislav Radl

Synthesis of Fingolimod Employing Regioselective Aziridine Ring-Opening Reaction as a Key Step

Organic Process Research & Development
2022-03-18 | Journal article
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Source: Self-asserted source
Stanislav Radl

An Improved Synthesis of Elvitegravir

Journal of Heterocyclic Chemistry
2015 | Journal article
EID:

2-s2.0-84940951180

Contributors: Rádl, S.; Stach, J.; Píša, O.; Cinibulk, J.; Havlíček, J.; Zajícová, M.; Pekárek, T.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Deuterated compounds as potential drugs | Deuterované sloučeniny jako potenciální léčiva

Chemicke Listy
2015 | Journal article
EID:

2-s2.0-84946089850

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

To err is human | Mýliti se je lidské

Chemicke Listy
2015 | Journal article
EID:

2-s2.0-84923036668

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Identification, characterization, synthesis and HPLC quantification of new process-related impurities and degradation products in retigabine

Journal of Pharmaceutical and Biomedical Analysis
2014 | Journal article
EID:

2-s2.0-84894119470

Contributors: Douša, M.; Srbek, J.; Rádl, S.; Černý, J.; Klecán, O.; Havlíček, J.; Tkadlecová, M.; Pekárek, T.; Gibala, P.; Nováková, L.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis of 2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-ol; A quinoline building block for simeprevir synthesis

Synthesis (Germany)
2014 | Journal article
EID:

2-s2.0-84897051897

Contributors: Rádl, S.; Rezková, H.; Obadalová, I.; Srbek, J.; Břicháč, J.; Pekárek, T.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

The Bosutinib Case - Trust but Check Out | Případ bosutinib aneb důvěřuj, ale prověřuj

Chemicke Listy
2014 | Journal article
EID:

2-s2.0-84892972285

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Improved process for azilsartan medoxomil: A new angiotensin receptor blocker

Organic Process Research and Development
2013 | Journal article
EID:

2-s2.0-84872703178

Contributors: Rádl, S.; Černý, J.; Stach, J.; Gablíková, Z.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Suvorexant: Dual orexin OX<inf>1</inf>/OX<inf>2</inf> receptor antagonist treatment of sleep disorders

Drugs of the Future
2013 | Journal article
EID:

2-s2.0-84930539587

Contributors: Radl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis of azilsartan and its selected potential impurities

Journal of Heterocyclic Chemistry
2013 | Journal article
EID:

2-s2.0-84880959455

Contributors: Rádl, S.; Černý, J.; Stach, J.; Holec, J.; Píša, O.; Gablíková, Z.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Utilization of studies of drug side effects in development of modern drugs | Využití výsledků studií vedlejších účinků léčiv při vývoji moderních léčiv

Chemicke Listy
2013 | Journal article
EID:

2-s2.0-84883219766

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Identification, preparation and UHPLC determination of process-related impurity in zolmitriptan

Journal of Pharmaceutical and Biomedical Analysis
2012 | Journal article
EID:

2-s2.0-80255133187

Contributors: Douša, M.; Gibala, P.; Rádl, S.; Klecán, O.; Mandelová, Z.; Břicháč, J.; Pekárek, T.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis of some impurities and/or degradation products of zaleplon

Journal of Heterocyclic Chemistry
2010 | Journal article
EID:

2-s2.0-77950336038

Contributors: Rádl, S.; Blahovcová, M.; Plaček, L.; Pekárek, T.; Havlíček, J.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthetic studies connected with the preparation of N-[3-(3- cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide, a zaleplon regioisomer

Heterocycles
2010 | Journal article
EID:

2-s2.0-77955675196

Contributors: Rádl, S.; Blahovcová, M.; Tkadlecová, M.; Havlíček, J.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

An efficient synthesis of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3- dihydro-lh-pyrrolizine, a key intermediate in the licofelone synthesis

Collection of Czechoslovak Chemical Communications
2009 | Journal article
EID:

2-s2.0-69549135348

Contributors: Rádl, S.; Stach, J.; Černy, J.; Klecán, O.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Bicyclic Systems with Two Ring Junction Nitrogen Atoms

Comprehensive Heterocyclic Chemistry II: A Review of the Literature 1982-1995
2009 | Book
EID:

2-s2.0-84944076141

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Identification, synthesis and structural determination of some impurities of candesartan cilexetil

Collection of Czechoslovak Chemical Communications
2009 | Journal article
EID:

2-s2.0-63849261479

Contributors: Havlĺček, J.; Mandelová, Z.; Weisemann, R.; Střelec, I.; Plaček, L.; Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and identification of some impurities of irbesartan

Acta Chimica Slovenica
2009 | Journal article
EID:

2-s2.0-70349427214

Contributors: Rádl, S.; Stach, J.; Havlíček, J.; Tkadlecová, M.; Plaček, L.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

A new synthesis of rizatriptan based on radical cyclization

Collection of Czechoslovak Chemical Communications
2008 | Journal article
EID:

2-s2.0-41949115584

Contributors: Rádl, S.; Klecán, O.; Klvaňa, R.; Havlíček, J.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

A synthesis of licofelone using Fenton's reagent

Tetrahedron Letters
2008 | Journal article
EID:

2-s2.0-47549094297

Contributors: Rádl, S.; Černý, J.; Klecán, O.; Stach, J.; Plaček, L.; Mandelová, Z.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Bicyclic systems with two bridgehead (ring junction) nitrogen atoms

Comprehensive Heterocyclic Chemistry III
2008 | Book
EID:

2-s2.0-84906420362

Contributors: Radl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis of some impurities and/or degradation products of atorvastatin

Collection of Czechoslovak Chemical Communications
2008 | Journal article
EID:

2-s2.0-43049146571

Contributors: Stach, J.; Havlíček, J.; Plaček, L.; Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthetic studies connected with the preparation of H+/K +-ATPase inhibitors rabeprazole and lansoprazole

Journal of Heterocyclic Chemistry
2006 | Journal article
EID:

2-s2.0-33845457970

Contributors: Rádl, S.; Klecán, O.; Havlíček, J.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Modification of the Gewald methodology for the synthesis of 3-amino-2-(1H-1,2,3-benzotriazol-1-yl) substituted benzofurans, benzothiophenes and 1H-indoles

Arkivoc
2005 | Journal article
EID:

2-s2.0-23744510681

Contributors: Rádl, S.; Obadalová, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

The origin of a drug - Selected aspects of the research and development of synthetic drugs | Jak se rodí lék, aneb vybrané aspekty výzkumu a vývoje chemických léčiv

Chemicke Listy
2004 | Journal article
EID:

2-s2.0-11444250502

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Utilization of aromatic denitrocyclization reaction for the synthesis of 3-unsubstituted 1,4-dihydroquinolin-4-one derivatives

Collection of Czechoslovak Chemical Communications
2004 | Journal article
EID:

2-s2.0-2442583473

Contributors: Rádl, S.; Obadalová, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

A new way to tert-Butyl [(4R,6R)-6-aminoethyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate, a key intermediate of atorvastatin synthesis

Synthetic Communications
2003 | Journal article
EID:

2-s2.0-17944402728

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

An improved synthesis of 1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for atorvastatin synthesis

Tetrahedron Letters
2002 | Journal article
EID:

2-s2.0-0037060950

Contributors: Rádl, S.; Stach, J.; Hajicek, J.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Aromatic nucleophilic denitrocyclization reactions

Advances in Heterocyclic Chemistry
2002 | Book
EID:

2-s2.0-0036440946

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Aromatic nucleophilic denitrocyclization reactions

Chemicke Listy
2001 | Journal article
EID:

2-s2.0-0041410296

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

A new approach to the synthesis of benzofuro[3,2-b]quinolines, benzothieno[3,2-b]quinolines and indolo[3,2-b]quinolines

Journal of Heterocyclic Chemistry
2000 | Journal article
EID:

2-s2.0-0033786416

Contributors: Radl, S.; Konvicka, P.; Vachal, P.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and analgesic activity of some 1-benzofurans, 1-benzothiophenes and indoles

Collection of Czechoslovak Chemical Communications
2000 | Journal article
EID:

2-s2.0-0034344030

Contributors: Rádl, S.; Hezký, P.; Urbánková, J.; Váchal, P.; Krejčí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and analgesic activity of some quinazoline analogs of anpirtoline

Archiv der Pharmazie
2000 | Journal article
EID:

2-s2.0-0033651738

Contributors: Rádl, S.; Hezky, P.; Proka, J.; Krejc, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and analgesic activity of some side-chain modified anpirtoline derivatives

Archiv der Pharmazie
2000 | Journal article
EID:

2-s2.0-0343729420

Contributors: Rádl, S.; Hezky, P.; Proška, J.; Hejnová, L.; Krejcí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and analgesic activity of some substituted 1-benzofurans and 1-benzothiophenes

Collection of Czechoslovak Chemical Communications
2000 | Journal article
EID:

2-s2.0-0034340219

Contributors: Rádl, S.; Hezký, P.; Konvička, P.; Krejčí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and binding studies of some epibatidine analogues

Bioorganic and Medicinal Chemistry Letters
2000 | Journal article
EID:

2-s2.0-0342948833

Contributors: Rádl, S.; Hezký, P.; Hafner, W.; Buděšínský, M.; Hejnová, L.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis, analgesic activity, and binding properties of some epibatidine analogs with a tropine skeleton

Archiv der Pharmazie
2000 | Journal article
EID:

2-s2.0-0343457949

Contributors: Rádl, S.; Hafner, W.; Budešínsky, M.; Hejnová, L.; Krejcí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Molecular modification of anpirtoline, a non-opioid centrally acting analgesic

Collection of Czechoslovak Chemical Communications
1999 | Journal article
EID:

2-s2.0-0033241277

Contributors: Rádl, S.; Hafner, W.; Hezký, P.; Krejčí, I.; Proška, J.; Taimr, J.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and analgesic activity of some condensed analogs of anpirtoline

Archiv der Pharmazie
1999 | Journal article
EID:

2-s2.0-0342956832

Contributors: Rádl, S.; Kovárová, L.; Hezky, P.; Vosátka, V.; Königová, O.; Proǎka, J.; Krejcí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and analgesic activity of some deaza derivatives of anpirtoline

Archiv der Pharmazie
1999 | Journal article
EID:

2-s2.0-0343413562

Contributors: Rádl, S.; Hezky, P.; Proška, J.; Krejcí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis and antinociceptive activity of some 3-chlorophenyl-and 6-chloropyridin-2-yl derivatives

Collection of Czechoslovak Chemical Communications
1999 | Journal article
EID:

2-s2.0-0033241280

Contributors: Rádl, S.; Hafner, W.; Hezký, P.; Krejčí, I.; Proška, J.; Hájíček, J.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthesis of piperidine analogs of 1-(3- chlorophenyl)piperazine, a well known serotonin ligand

Journal of Heterocyclic Chemistry
1999 | Journal article
EID:

2-s2.0-0032853485

Contributors: Rádl, S.; Hezký, P.; Taimr, J.; Proška, J.; Krejčí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Analgetically active substances derived from structures of anpirtoline and epibatidine

General Physiology and Biophysics
1998 | Journal article
EID:

2-s2.0-0031814202

Contributors: Rádl, S.; Hezký, P.; Proška, J.; Krejčí, I.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

1,2,4-triazoIine-3,5-diones

Advances in Heterocyclic Chemistry
1997 | Book
EID:

2-s2.0-0343537654

Contributors: Radl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Crisscross cycloaddition reactions

Aldrichimica Acta
1997 | Journal article
EID:

2-s2.0-0040651627

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

Synthetic studies connected with the preparation of 4-cyclopropyl-7-fluoro-6-(4-methylpiperazin-1-yl)-1,2,4,9-tetrahydrothiazolo[5, 4-b]quinoline-2,9-dione

Collection of Czechoslovak Chemical Communications
1997 | Journal article
EID:

2-s2.0-0040689312

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier

From chloroquine to antineoplastic drugs? The story of antibacterial quinolones

Archiv der Pharmazie
1996 | Journal article
EID:

2-s2.0-5844386254

Contributors: Rádl, S.
Source: Self-asserted source
Stanislav Radl via Scopus - Elsevier
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