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chromatin, epigenomics, machine learning, dynamic Bayesian networks, graphical models, ChIP-seq, DNase-seq, RNA-seq, ENCODE
Canada

Biography

Michael Hoffman creates predictive computational models to understand interactions between genome, epigenome, and phenotype in human cancers. His influential machine learning approaches have reshaped researchers' analysis of gene regulation. These approaches include the genome annotation method Segway, which enables simple interpretation of multivariate genomic data. He is a Senior Scientist at Princess Margaret Cancer Centre and Associate Professor in the Departments of Medical Biophysics and Computer Science, University of Toronto. He was named a CIHR New Investigator and has received several awards for his academic work, including the NIH K99/R00 Pathway to Independence Award, and the Ontario Early Researcher Award.

Activities

Employment (6)

Princess Margaret Cancer Centre: Toronto, ON, CA

2020-09-03 to present | Senior Scientist
Employment
Source: Self-asserted source
Michael M. Hoffman

University of Toronto: Toronto, ON, CA

2020-07-01 to present | Associate Professor (Department of Medical Biophysics)
Employment
Source: Self-asserted source
Michael M. Hoffman

University of Toronto: Toronto, ON, CA

2020-07-01 to present | Associate Professor (Department of Computer Science)
Employment
Source: Self-asserted source
Michael M. Hoffman

Princess Margaret Cancer Centre: Toronto, ON, CA

2013-11-04 to 2020-09-02 | Scientist
Employment
Source: Self-asserted source
Michael M. Hoffman

University of Toronto: Toronto, ON, CA

2014-09-01 to 2020-06-30 | Assistant Professor (Department of Computer Science)
Employment
Source: Self-asserted source
Michael M. Hoffman

University of Toronto: Toronto, ON, CA

2014-04-01 to 2020-06-30 | Assistant Professor (Department of Medical Biophysics)
Employment
Source: Self-asserted source
Michael M. Hoffman

Education and qualifications (4)

University of Washington: Seattle, WA, US

2008-09-01 to 2013-10-01 | Senior Fellow (Department of Genome Sciences)
Education
Source: Self-asserted source
Michael M. Hoffman

University of Cambridge: Cambridge, GB

2003-10-01 to 2008-07-19 | Doctor of Philosophy, Bioinformatics (EMBL-European Bioinformatics Institute)
Education
Source: Self-asserted source
Michael M. Hoffman

University of Texas at Austin: Austin, TX, US

1998-08-26 to 2003-05-17 | Bachelor of Science, Biochemistry (Department of Chemistry and Biochemistry)
Education
Source: Self-asserted source
Michael M. Hoffman

University of Texas at Austin: Austin, TX, US

1998-08-26 to 2003-05-17 | Bachelor of Arts, Plan II Honors (Plan II Honors Program)
Education
Source: Self-asserted source
Michael M. Hoffman

Funding (8)

The expanded epigenetic alphabet: transcription factor binding in methylated DNA and beyond

2016-04 to 2021-03 | Grant
Ministry of Research and Innovation (Toronto, ON, CA)
GRANT_NUMBER:

ER-15-11-223

Source: Self-asserted source
Michael M. Hoffman

Epigenetic DNA modifications as drivers of leukemia gene expression programs

2015-08 to 2017-07 | Grant
Canadian Cancer Society Research Institute (Toronto , ON, CA)
GRANT_NUMBER:

703827

Source: Self-asserted source
Michael M. Hoffman

Interpreting epigenetic DNA modifications in glioblastoma stem cells

2015-05 to 2016-04 | Grant
McLaughlin Centre (Toronto, ON, CA)
Part of GRANT_NUMBER:

MC-2015-06

Source: Self-asserted source
Michael M. Hoffman

Transcription factor recognition models with modified nucleobases

2015-04 to 2021-03 | Grant
Natural Sciences and Engineering Research Council of Canada (Ottawa, ON, CA)
GRANT_NUMBER:

RGPIN-2015-3948

Source: Self-asserted source
Michael M. Hoffman

Cancer Stem Cell Program

2015-04 to 2017-03 | Grant
Ontario Institute for Cancer Research (Toronto, ON, CA)
GRANT_NUMBER:

CSC-PRAR-UHN

Source: Self-asserted source
Michael M. Hoffman

Sequence variation and DNA methylation patterning

2015-01 to 2016-01 | Grant
Natural Sciences and Engineering Research Council of Canada (Ottawa, ON, CA)
GRANT_NUMBER:

RGPIN-2013-435512

Source: Self-asserted source
Michael M. Hoffman

Pattern Discovery for comparative epigenomics

2011-09-13 to 2013-07-31 | Grant
National Human Genome Research Institute (Bethesda, US)
GRANT_NUMBER: 5K99HG006259-02
GRANT_NUMBER: 5K99HG006259-02
Source: Self-asserted source
Michael M. Hoffman via DimensionsWizard

GRADUATE RESEARCH FELLOWSHIPS

2004-09-01 to 2008-08-31 | Grant
National Science Foundation (Airlington, US)
GRANT_NUMBER: 0435785
GRANT_NUMBER: 0435785
Source: Self-asserted source
Michael M. Hoffman via DimensionsWizard

Peer review (1 review for 1 publication/grant)

Review activity for F1000Research. (1)