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Works (14)

Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention

Proceedings of the National Academy of Sciences
2023-03-28 | Journal article
DOI: 10.1073/pnas.2300054120
Contributors: Stefan G. Krimmer; Nicole Bertoletti; Yoshihisa Suzuki; Luka Katic; Jyotidarsini Mohanty; Sheng Shu; Sangwon Lee; Irit Lax; Wei Mi; Joseph Schlessinger
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Crossref

Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability

Proceedings of the National Academy of Sciences
2023-02-14 | Journal article
DOI: 10.1073/pnas.2219128120
Contributors: Seong J. An; Jyotidarsini Mohanty; Francisco Tome; Yoshihisa Suzuki; Irit Lax; Joseph Schlessinger
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Unveiling molecular insights into the mechanism of activation of oncogenic phosphoinositide 3-kinase mutants

Proceedings of the National Academy of Sciences
2022-12-13 | Journal article
DOI: 10.1073/pnas.2218237119
Contributors: Stefan G. Krimmer; Joseph Schlessinger
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Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

Proceedings of the National Academy of Sciences
2022-11-29 | Journal article
DOI: 10.1073/pnas.2208947119
Contributors: Seong J. An; Alexander Anneken; Zhiqun Xi; Changseon Choi; Joseph Schlessinger; Derek Toomre
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Crossref

Covalent Modification of the JH2 Domain of Janus Kinase 2

ACS Medicinal Chemistry Letters
2022-11-10 | Journal article
DOI: 10.1021/acsmedchemlett.2c00414
Contributors: Sean P. Henry; Maria-Elena Liosi; Joseph A. Ippolito; Fabian Menges; Ana S. Newton; Joseph Schlessinger; William L. Jorgensen
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Cryo-EM analyses of wild-type and oncogenic KIT mutants reveal structural oncogenic plasticity and a novel “Achilles heel” for therapeutic intervention

2022-09-08 | Preprint
DOI: 10.1101/2022.09.08.506998
Contributors: Stefan G. Krimmer; Nicole Bertoletti; Yoshihisa Suzuki; Luka Katic; Jyotidarsini Mohanty; Sheng Shu; Sangwon Lee; Irit Lax; Wei Mi; Joseph Schlessinger
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Crossref

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands

Journal of Medicinal Chemistry
2022-06-23 | Journal article
DOI: 10.1021/acs.jmedchem.2c00283
Contributors: Maria-Elena Liosi; Joseph A. Ippolito; Sean P. Henry; Stefan G. Krimmer; Ana S. Newton; Kara J. Cutrona; Rene A. Olivarez; Jyotidarsini Mohanty; Joseph Schlessinger; William L. Jorgensen
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Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies

ACS Medicinal Chemistry Letters
2022-05-12 | Journal article
DOI: 10.1021/acsmedchemlett.2c00051
Contributors: Sean P. Henry; Maria-Elena Liosi; Joseph A. Ippolito; Kara J. Cutrona; Stefan G. Krimmer; Ana S. Newton; Joseph Schlessinger; William L. Jorgensen
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A hypothalamic pathway for Augmentor α–controlled body weight regulation

Proceedings of the National Academy of Sciences
2022-04-19 | Journal article
DOI: 10.1073/pnas.2200476119
Contributors: Mansoor Ahmed; Navjot Kaur; Qianni Cheng; Marya Shanabrough; Evgenii O. Tretiakov; Tibor Harkany; Tamas L. Horvath; Joseph Schlessinger
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Mechanism for the activation of the anaplastic lymphoma kinase receptor

Nature
2021-12-02 | Journal article
DOI: 10.1038/s41586-021-04140-8
Contributors: Andrey V. Reshetnyak; Paolo Rossi; Alexander G. Myasnikov; Munia Sowaileh; Jyotidarsini Mohanty; Amanda Nourse; Darcie J. Miller; Irit Lax; Joseph Schlessinger; Charalampos G. Kalodimos
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FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho

Proceedings of the National Academy of Sciences
2020-12-15 | Journal article
DOI: 10.1073/pnas.2018554117
Contributors: Yoshihisa Suzuki; Ekaterina Kuzina; Seong J. An; Francisco Tome; Jyotidarsini Mohanty; Wenxue Li; Sangwon Lee; Yansheng Liu; Irit Lax; Joseph Schlessinger
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Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

Journal of Medicinal Chemistry
2020-05-28 | Journal article
DOI: 10.1021/acs.jmedchem.0c00192
Contributors: Maria-Elena Liosi; Stefan G. Krimmer; Ana S. Newton; Thomas K. Dawson; David E. Puleo; Kara J. Cutrona; Yoshihisa Suzuki; Joseph Schlessinger; William L. Jorgensen
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Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders

ACS Medicinal Chemistry Letters
2017-06-08 | Journal article
DOI: 10.1021/acsmedchemlett.7b00153
Contributors: David E. Puleo; Kaury Kucera; Henrik M. Hammarén; Daniela Ungureanu; Ana S. Newton; Olli Silvennoinen; William L. Jorgensen; Joseph Schlessinger
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Crossref

JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules

ACS Medicinal Chemistry Letters
2017-06-08 | Journal article
DOI: 10.1021/acsmedchemlett.7b00154
Contributors: Ana S. Newton; Luca Deiana; David E. Puleo; José A. Cisneros; Kara J. Cutrona; Joseph Schlessinger; William L. Jorgensen
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Peer review (8 reviews for 4 publications/grants)

Review activity for Cell. (1)
Review activity for Journal of medicinal chemistry. (2)
Review activity for Molecular cell. (3)
Review activity for Nature communications (2)
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