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Works (22)

Senataxin RNA/DNA helicase promotes replication restart at co-transcriptional R-loops to prevent MUS81-dependent fork degradation

Nucleic Acids Research
2024-09-23 | Journal article
DOI: 10.1093/nar/gkae673
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Satyajeet Rao; Martin Andrs; Kaustubh Shukla; Esin Isik; Christiane König; Stefan Schneider; Michael Bauer; Vinicio Rosano; Jiri Prokes; Anne Müller et al.
Source: Self-asserted source
Martin Andrs

IN SILICO LIBRARY SCREENING TO FIND NOVEL ANTICANCER AGENT WITH CHEMOSENSITIZING PROPERTIES: FOCUS ON TARGETING ATAXIA TELANGIECTASIA AND Rad3 RELATED KINASE

Military Medical Science Letters
2024-03-01 | Journal article
DOI: 10.31482/mmsl.2023.009
Contributors: Darina Muthna; Tomas Kucera; Zbynek Vecera; Lukas Gorecki; Martin Andrs; Martina Rezacova; Jan Korabecny
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Crossref

MutSβ-MutLβ-FANCJ axis mediates the restart of DNA replication after fork stalling at cotranscriptional G4/R-loops

Science Advances
2024-02-09 | Journal article
DOI: 10.1126/sciadv.adk2685
Contributors: Esin Isik; Kaustubh Shukla; Michaela Pospisilova; Christiane König; Martin Andrs; Satyajeet Rao; Vinicio Rosano; Jana Dobrovolna; Lumir Krejci; Pavel Janscak
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Crossref

2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1

European Journal of Medicinal Chemistry
2023-10 | Journal article
DOI: 10.1016/j.ejmech.2023.115611
Part of ISSN: 0223-5234
Contributors: Vladimir Finger; Tomas Kucera; Radka Kafkova; Lubica Muckova; Rafael Dolezal; Jan Kubes; Martin Novak; Lukas Prchal; Levente Lakatos; Martin Andrs et al.
Source: Self-asserted source
Martin Andrs

Excessive reactive oxygen species induce transcription-dependent replication stress

Nature Communications
2023-03-30 | Journal article
DOI: 10.1038/s41467-023-37341-y
Part of ISSN: 2041-1723
Contributors: Martin Andrs; Henriette Stoy; Barbora Boleslavska; Nagaraja Chappidi; Radhakrishnan Kanagaraj; Zuzana Nascakova; Shruti Menon; Satyajeet Rao; Anna Oravetzova; Jana Dobrovolna et al.
Source: Self-asserted source
Martin Andrs

The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress

Nucleic Acids Research
2023-03-21 | Journal article
DOI: 10.1093/nar/gkad085
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Zhe Han; Martin Andrš; Bindhu K Madhavan; Serap Kaymak; Alba Sulaj; Zoltan Kender; Stefan Kopf; Lars Kihm; Rainer Pepperkok; Pavel Janscak et al.
Source: Self-asserted source
Martin Andrs

DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells

Nucleic Acids Research
2022-11-28 | Journal article
DOI: 10.1093/nar/gkac1116
Contributors: Barbora Boleslavska; Anna Oravetzova; Kaustubh Shukla; Zuzana Nascakova; Oluwakemi Ngozi Ibini; Zdenka Hasanova; Martin Andrs; Radhakrishnan Kanagaraj; Jana Dobrovolna; Pavel Janscak
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Crossref

7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties

European Journal of Medicinal Chemistry
2022-10 | Journal article
DOI: 10.1016/j.ejmech.2022.114580
Part of ISSN: 0223-5234
Contributors: Lukas Gorecki; Darina Muthna; Sara Merdita; Martin Andrs; Tomas Kucera; Radim Havelek; Lubica Muckova; Tereza Kobrlova; Jiri Soukup; Petr Krupa et al.
Source: Self-asserted source
Martin Andrs

Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer

Cancers
2021-02-14 | Journal article
DOI: 10.3390/cancers13040795
Part of ISSN: 2072-6694
Contributors: Lukas Gorecki; Martin Andrs; Jan Korabecny
Source: Self-asserted source
Martin Andrs

Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy

Pharmacology & Therapeutics
2020-06 | Journal article
DOI: 10.1016/j.pharmthera.2020.107518
Part of ISSN: 0163-7258
Contributors: Lukas Gorecki; Martin Andrs; Martina Rezacova; Jan Korabecny
Source: Self-asserted source
Martin Andrs

Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops

Molecular Cell
2020-02 | Journal article
DOI: 10.1016/j.molcel.2019.10.026
Part of ISSN: 1097-2765
Contributors: Nagaraja Chappidi; Zuzana Nascakova; Barbora Boleslavska; Ralph Zellweger; Esin Isik; Martin Andrs; Shruti Menon; Jana Dobrovolna; Chiara Balbo Pogliano; Joao Matos et al.
Source: Self-asserted source
Martin Andrs

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

Genes
2020-02-21 | Journal article
DOI: 10.3390/genes11020232
Part of ISSN: 2073-4425
Contributors: Martin Andrs; Zdenka Hasanova; Anna Oravetzova; Jana Dobrovolna; Pavel Janscak
Source: Self-asserted source
Martin Andrs

Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity

Bioorganic Chemistry
2019-02 | Journal article
DOI: 10.1016/j.bioorg.2018.10.001
Contributors: Monika Pospisilova; Martin Andrs; Martina Seifrtova; Radim Havelek; Daniel Jun; Pavel Tomsik; Lukas Prchal; Rafael Dolezal; Ales Tichy; Tomas Kucera et al.
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Crossref

Purin-6-One and Pyrrolo[2,3-d]Pyrimidin-4-One Derivatives As Potentiating Agents of Doxorubicin Cytotoxicity

Future Medicinal Chemistry
2018-09 | Journal article
DOI: 10.4155/fmc-2018-0086
Part of ISSN: 1756-8919
Part of ISSN: 1756-8927
Contributors: Martin Andrs; Monika Pospisilova; Martina Seifrtova; Radim Havelek; Ales Tichy; Katerina Vejrychova; Michaela Polednikova; Lukas Gorecki; Daniel Jun; Jan Korabecny et al.
Source: Self-asserted source
Martin Andrs

Novel caffeine derivatives with antiproliferative activity

RSC Advances
2016 | Journal article
DOI: 10.1039/c5ra22889a
Part of ISSN: 2046-2069
Contributors: Martin Andrs; Darina Muthna; Martina Rezacova; Martina Seifrtova; Pavel Siman; Jan Korabecny; Ondrej Benek; Rafael Dolezal; Ondrej Soukup; Daniel Jun et al.
Source: Self-asserted source
Martin Andrs

Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy.

Current cancer drug targets
2016 | Journal article
DOI: 10.2174/156800961603160206122927
PMID: 26882028
Contributors: Andrs M; Korabecny J; Nepovimova E; Jun D; Hodny Z; Kuca K
Source: Self-asserted source
Martin Andrs via Europe PubMed Central

7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.

Molecules (Basel, Switzerland)
2015-12 | Journal article
DOI: 10.3390/molecules201219836
PMID: 26690394
Contributors: Korabecny J; Andrs M; Nepovimova E; Dolezal R; Babkova K; Horova A; Malinak D; Mezeiova E; Gorecki L; Sepsova V et al.
Source: Self-asserted source
Martin Andrs via Europe PubMed Central

Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.

Journal of medicinal chemistry
2015-11 | Journal article
DOI: 10.1021/acs.jmedchem.5b01325
PMID: 26503905
Contributors: Nepovimova E; Korabecny J; Dolezal R; Babkova K; Ondrejicek A; Jun D; Sepsova V; Horova A; Hrabinova M; Soukup O et al.
Source: Self-asserted source
Martin Andrs via Europe PubMed Central

Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.

Journal of medicinal chemistry
2015-01 | Journal article
DOI: 10.1021/jm501026z
PMID: 25387153
Contributors: Andrs M; Korabecny J; Jun D; Hodny Z; Bartek J; Kuca K
Source: Self-asserted source
Martin Andrs via Europe PubMed Central

From pyridinium-based to centrally active acetylcholinesterase reactivators.

Mini reviews in medicinal chemistry
2014 | Journal article
DOI: 10.2174/1389557514666140219103138
PMID: 24552265
Contributors: Korabecny J; Soukup O; Dolezal R; Spilovska K; Nepovimova E; Andrs M; Nguyen TD; Jun D; Musilek K; Kucerova-Chlupacova M et al.
Source: Self-asserted source
Martin Andrs via Europe PubMed Central

The development of ataxia telangiectasia mutated kinase inhibitors.

Mini reviews in medicinal chemistry
2014 | Journal article
PMID: 25138084
Contributors: Andrs M; Korabecny J; Nepovimova E; Jun D; Hodny Z; Moravcova S; Hanzlikova H; Kuca K
Source: Self-asserted source
Martin Andrs via Europe PubMed Central

7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.

European journal of medicinal chemistry
2014-07 | Journal article
DOI: 10.1016/j.ejmech.2014.05.066
PMID: 24929293
Contributors: Korabecny J; Dolezal R; Cabelova P; Horova A; Hruba E; Ricny J; Sedlacek L; Nepovimova E; Spilovska K; Andrs M et al.
Source: Self-asserted source
Martin Andrs via Europe PubMed Central
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