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ResearcherID: L-7284-2017
Scopus Author ID: 37065033800

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Works (42)

DESIGN, CHEMICAL SYNTHESIS, AND IN VITRO  EVALUATION OF NOVEL UNCHARGED CHOLINESTERASE REACTIVATOR

Military Medical Science Letters
2024-09-18 | Journal article
DOI: 10.31482/mmsl.2024.015
Contributors: Vendula Hepnarova; Martina Hrabinova; Jakub Opravil; Mojmir Vanek; Eva Mezeiova; Lukas Gorecki; Tomas Kucera; Daniel Jun; Ondrej Soukup; Lubica Muckova et al.
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Crossref

A-series agent A-234: initial in vitro and in vivo characterization

Archives of Toxicology
2024-04 | Journal article
DOI: 10.1007/s00204-024-03689-3
Contributors: Martina Hrabinova; Jaroslav Pejchal; Vendula Hepnarova; Lubica Muckova; Lucie Junova; Jakub Opravil; Jana Zdarova Karasova; Tomas Rozsypal; Alzbeta Dlabkova; Helena Rehulkova et al.
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Crossref

A-agents, misleadingly known as “Novichoks”: a narrative review

Archives of Toxicology
2023-10 | Journal article
DOI: 10.1007/s00204-023-03571-8
Contributors: Jakub Opravil; Jaroslav Pejchal; Vladimir Finger; Jan Korabecny; Tomas Rozsypal; Martina Hrabinova; Lubica Muckova; Vendula Hepnarova; Jan Konecny; Ondrej Soukup et al.
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Crossref

Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness

Toxicology Letters
2020-03 | Journal article
DOI: 10.1016/j.toxlet.2019.11.021
Contributors: Jana Zdarova Karasova; Vendula Hepnarova; Rudolf Andrys; Miroslav Lisa; Petr Jost; Lubica Muckova; Jaroslav Pejchal; David Herman; Daniel Jun; Jiri Kassa et al.
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Crossref

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

Journal of Enzyme Inhibition and Medicinal Chemistry
2020-01-01 | Journal article
DOI: 10.1080/14756366.2019.1710501
Contributors: David Malinak; Rafael Dolezal; Vendula Hepnarova; Miroslava Hozova; Rudolf Andrys; Petr Bzonek; Veronika Racakova; Jan Korabecny; Lukas Gorecki; Eva Mezeiova et al.
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Crossref

Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators

Toxicology and Applied Pharmacology
2019-11 | Journal article
DOI: 10.1016/j.taap.2019.114776
Contributors: Vendula Hepnarova; Lubica Muckova; Avi Ring; Jaroslav Pejchal; David Herman; Jan Misik; Martina Hrabinova; Daniel Jun; Ondrej Soukup
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Crossref

Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors

Biomolecules
2019-08-19 | Journal article
DOI: 10.3390/biom9080379
Contributors: Barbora Svobodova; Eva Mezeiova; Vendula Hepnarova; Martina Hrabinova; Lubica Muckova; Tereza Kobrlova; Daniel Jun; Ondrej Soukup; María Luisa Jimeno; José Marco-Contelles et al.
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Crossref

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

European Journal of Medicinal Chemistry
2019-04 | Journal article
DOI: 10.1016/j.ejmech.2019.02.021
Part of ISSN: 0223-5234
Source: Self-asserted source
Vendula Sepsova

N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer’s Disease Therapy

Current Alzheimer Research
2019-04-24 | Journal article
DOI: 10.2174/1567205016666190314163942
Part of ISSN: 1567-2050
Source: Self-asserted source
Vendula Sepsova

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents

ACS Chemical Neuroscience
2018 | Journal article
DOI: 10.1021/acschemneuro.7b00461
EID:

2-s2.0-85047190249
Contributors: Panek, D.; Wiȩckowska, A.; Jończyk, J.; Godyń, J.; Bajda, M.; Wichur, T.; Pasieka, A.; Knez, D.; Pišlar, A.; Korabecny, J. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

Drug Design, Development and Therapy
2018 | Journal article
DOI: 10.2147/DDDT.S133038
EID:

2-s2.0-85044297772
Contributors: Kuca, K.; Karasova, J.Z.; Soukup, O.; Kassa, J.; Novotna, E.; Sepsova, V.; Horova, A.; Pejchal, J.; Hrabinova, M.; Vodakova, E. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Synthesis, Biological Assessment and Molecular Modeling of Racemic QuinoPyranoTacrines for Alzheimer's Disease Therapy

ChemistrySelect
2018 | Journal article
DOI: 10.1002/slct.201702781
EID:

2-s2.0-85044326487
Contributors: Chioua, M.; Serrano, E.; Dgachi, Y.; Martin, H.; Jun, D.; Janockova, J.; Sepsova, V.; Soukup, O.; Moraleda, I.; Chabchoub, F. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Investigation of New Orexin 2 Receptor Modulators Using <i>In Silico</i> and In Vitro Methods

Molecules
2018-11 | Journal article | Author
DOI: 10.3390/molecules23112926
Contributors: Jana Bzdilova Janockova; Rafael Dolezal; Eugenie Nepovimova; Tereza Kobrlova; Marketa Benkova; Kamil Kuca; Jan Konecny; Eva Mezeiova; Michaela Melikova; Vendula Sepsova et al.
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K305, K307) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Journal of Applied Biomedicine
2017 | Journal article
DOI: 10.1016/j.jab.2016.09.008
EID:

2-s2.0-84992313157
Contributors: Kassa, J.; Sepsova, V.; Horova, A.; Musilek, K.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment

Biochimica et Biophysica Acta - Molecular Basis of Disease
2017 | Journal article
DOI: 10.1016/j.bbadis.2016.11.020
EID:

2-s2.0-85005965823
Contributors: Gazova, Z.; Soukup, O.; Sepsova, V.; Siposova, K.; Drtinova, L.; Jost, P.; Spilovska, K.; Korabecny, J.; Nepovimova, E.; Fedunova, D. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Novel tacrine-scutellarin hybrids as multipotent anti-Alzheimer’s agents: Design, synthesis and biological evaluation

Molecules
2017 | Journal article
DOI: 10.3390/molecules22061006
EID:

2-s2.0-85021149055
Contributors: Spilovska, K.; Korabecny, J.; Sepsova, V.; Jun, D.; Hrabinova, M.; Jost, P.; Muckova, L.; Soukup, O.; Janockova, J.; Kucera, T. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier
grade
Preferred source (of 2)‎

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

European Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1016/j.ejmech.2016.12.048
EID:

2-s2.0-85008400066
Contributors: Jeř�bek, J.; Uliassi, E.; Guidotti, L.; Kor�bečn�, J.; Soukup, O.; Sepsova, V.; Hrabinova, M.; Kuča, K.; Bartolini, M.; Pe�a-Altamira, L.E. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203

Molecules (Basel, Switzerland)
2017 | Journal article
DOI: 10.3390/molecules22071152
EID:

2-s2.0-85045085587
Contributors: Kassa, J.; Misik, J.; Hatlapatkova, J.; Zdarova Karasova, J.; Sepsova, V.; Caisberger, F.; Pejchal, J.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy

Molecules
2017-07 | Journal article
DOI: 10.3390/molecules22081265
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

ChemMedChem
2016 | Journal article
DOI: 10.1002/cmdc.201500383
EID:

2-s2.0-84976521292
Contributors: Benek, O.; Soukup, O.; Pasdiorova, M.; Hroch, L.; Sepsova, V.; Jost, P.; Hrabinova, M.; Jun, D.; Kuca, K.; Zala, D. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules

Journal of Inorganic Biochemistry
2016 | Journal article
DOI: 10.1016/j.jinorgbio.2016.05.001
EID:

2-s2.0-84971623020
Contributors: Hamulakova, S.; Poprac, P.; Jomova, K.; Brezova, V.; Lauro, P.; Drostinova, L.; Jun, D.; Sepsova, V.; Hrabinova, M.; Soukup, O. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

Journal of Medicinal Chemistry
2016 | Journal article
DOI: 10.1021/acs.jmedchem.6b01178
EID:

2-s2.0-84994877088
Contributors: Benchekroun, M.; Romero, A.; Egea, J.; León, R.; Michalska, P.; Buendía, I.; Jimeno, M.L.; Jun, D.; Janockova, J.; Sepsova, V. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

7-methoxytacrine-p-anisidine hybrids as novel dual binding site acetylcholinesterase inhibitors for Alzheimer's disease treatment

Molecules
2015 | Journal article
DOI: 10.3390/molecules201219836
EID:

2-s2.0-84954356941
Contributors: Korabecny, J.; Andrs, M.; Nepovimova, E.; Dolezal, R.; Babkova, K.; Horova, A.; Malinak, D.; Mezeiova, E.; Gorecki, L.; Sepsova, V. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice

Basic and Clinical Pharmacology and Toxicology
2015 | Journal article
DOI: 10.1111/bcpt.12327
EID:

2-s2.0-84924666972
Contributors: Kassa, J.; Sepsova, V.; Tumova, M.; Horova, A.; Musilek, K.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice

Toxicology Mechanisms and Methods
2015 | Journal article
DOI: 10.3109/15376516.2015.1036333
EID:

2-s2.0-84930240870
Contributors: Kassa, J.; Sepsova, V.; Matouskova, L.; Horova, A.; Musilek, K.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K920, K923) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Journal of Applied Biomedicine
2015 | Journal article
DOI: 10.1016/j.jab.2015.07.002
EID:

2-s2.0-84969700111
Contributors: Kassa, J.; Sepsova, V.; Horova, A.; Musilek, K.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Cholinergic properties of new 7-methoxytacrine-donepezil derivatives

General physiology and biophysics
2015 | Journal article
DOI: 10.4149/gpb_2014036
EID:

2-s2.0-84931084685
Contributors: Sepsova, V.; Karasova, J.Z.; Tobin, G.; Jun, D.; Korabecny, J.; Cabelova, P.; Janska, K.; Krusek, J.; Skrenkova, K.; Kuca, K. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low in Vivo Toxicity

Journal of Medicinal Chemistry
2015 | Journal article
DOI: 10.1021/acs.jmedchem.5b01325
EID:

2-s2.0-84948807652
Contributors: Nepovimova, E.; Korabecny, J.; Dolezal, R.; Babkova, K.; Ondrejicek, A.; Jun, D.; Sepsova, V.; Horova, A.; Hrabinova, M.; Soukup, O. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies

European Journal of Medicinal Chemistry
2014 | Journal article
DOI: 10.1016/j.ejmech.2014.05.066
EID:

2-s2.0-84902505998
Contributors: Korabecny, J.; Dolezal, R.; Cabelova, P.; Horova, A.; Hruba, E.; Ricny, J.; Sedlacek, L.; Nepovimova, E.; Spilovska, K.; Andrs, M. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A comparison of the reactivating and therapeutic efficacy of two novel oximes K378 and K458 with currently available oximes in rats and mice poisoned with sarin

Journal of Applied Biomedicine
2014 | Journal article
DOI: 10.1016/j.jab.2014.01.007
EID:

2-s2.0-84926040566
Contributors: Kassa, J.; Sepsova, V.; Tumova, M.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine

Expert Opinion on Drug Safety
2014 | Journal article
DOI: 10.1517/14740338.2014.914168
EID:

2-s2.0-84901357991
Contributors: Zemek, F.; Drtinova, L.; Nepovimova, E.; Sepsova, V.; Korabecny, J.; Klimes, J.; Kuca, K.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman-Poisoned Mice - A Comparison with Commonly Used Pyridostigmine

Basic and Clinical Pharmacology and Toxicology
2014 | Journal article
DOI: 10.1111/bcpt.12269
EID:

2-s2.0-84925934689
Contributors: Kassa, J.; Korabecny, J.; Sepsova, V.; Tumova, M.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Toxicology Mechanisms and Methods
2014 | Journal article
DOI: 10.3109/15376516.2013.871766
EID:

2-s2.0-84896886585
Contributors: Kassa, J.; Sepsova, V.; Tumova, M.; Musilek, K.; Horova, A.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinics receptor

Physiological Research
2014 | Journal article
EID:

2-s2.0-84920423555
Contributors: Sepsova, V.; Krusek, J.; Zdarova Karasova, J.; Zemek, F.; Musilek, K.; Kuca, K.; Soukup, O.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A comparison of the reactivating efficacy of a novel bispyridinium oxime K203 with currently available oximes in VX agent-poisoned rats

Journal of Enzyme Inhibition and Medicinal Chemistry
2013 | Journal article
DOI: 10.3109/14756366.2012.681652
EID:

2-s2.0-84880059324
Contributors: Kassa, J.; Zdarova Karasova, J.; Sepsova, V.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A resurrection of 7-MEOTA: A comparison with tacrine

Current Alzheimer Research
2013 | Journal article
DOI: 10.2174/1567205011310080011
EID:

2-s2.0-84888041417
Contributors: Soukup, O.; Jun, D.; Zdarova-Karasova, J.; Patocka, J.; Musilek, K.; Korabecny, J.; Krusek, J.; Kaniakova, M.; Sepsova, V.; Mandikova, J. et al.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): Structural evaluation of human serum albumin binding and absorption kinetics

International Journal of Molecular Sciences
2013 | Journal article
DOI: 10.3390/ijms140816076
EID:

2-s2.0-84881258327
Contributors: Zemek, F.; Zdarova, J.K.; Sepsova, V.; Kuca, K.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

Oximes: Inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study

International Journal of Molecular Sciences
2013 | Journal article
DOI: 10.3390/ijms140816882
EID:

2-s2.0-84882717699
Contributors: Sepsova, V.; Karasova, J.Z.; Korabecny, J.; Dolezal, R.; Zemek, F.; Bennion, B.J.; Kuca, K.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Toxicology Mechanisms and Methods
2013 | Journal article
DOI: 10.3109/15376516.2012.720304
EID:

2-s2.0-84873817038
Contributors: Kassa, J.; Sepsova, V.; Musilek, K.; Horova, A.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice

International Journal of Toxicology
2011 | Journal article
DOI: 10.1177/1091581811415294
EID:

2-s2.0-80054827889
Contributors: Kassa, J.; Karasova, J.Z.; Sepsova, V.; Caisberger, F.; Bajgar, J.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

A comparison of the reactivating and therapeutic efficacy of the newly developed bispyridinium oxime K203 with currently available oximes, in sarin poisoned rats and mice

Journal of Applied Biomedicine
2011 | Journal article
DOI: 10.2478/v10136-011-0011-6
EID:

2-s2.0-80053165223
Contributors: Kassa, J.; Karasová, J.Ž.; Šepsová, V.; Bajgar, J.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier

The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice

Basic and Clinical Pharmacology and Toxicology
2011 | Journal article
DOI: 10.1111/j.1742-7843.2011.00678.x
EID:

2-s2.0-79958842888
Contributors: Kassa, J.; Karasova, J.Z.; Sepsova, V.; Caisberger, F.
Source: Self-asserted source
Vendula Sepsova via Scopus - Elsevier
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