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Funding (1)

Cell biology of signalling: how members of the rhomboid-like superfamily regulate multiple pathways

2015-01-01 to 2017-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4834245
GRANT_NUMBER: 280679981
Source: Self-asserted source
Stefan Düsterhöft via DimensionsWizard

Works (38)

Investigating plasticity within the interleukin-6 family with AlphaFold-Multimer

Computational and Structural Biotechnology Journal
2025 | Journal article
DOI: 10.1016/j.csbj.2025.02.030
Contributors: Stefan Düsterhöft; Johannes N. Greve; Christoph Garbers
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Crossref

Pathological mutations reveal the key role of the cytosolic iRhom2 N-terminus for phosphorylation-independent 14-3-3 interaction and ADAM17 binding, stability, and activity

Cellular and Molecular Life Sciences
2024-12 | Journal article | Author
DOI: 10.1007/s00018-024-05132-3
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Contributors: Katharina Schun; Lena Ludwig; Sarah Knapp; Charlotte Flaßhove; Friederike Sonnabend; Diandra Keller; Nikola Tacken; Xintong Gao; Selcan Kahveci-Türköz; Caroline Grannemann et al.
Source: Self-asserted source
Stefan Düsterhöft

Modulation of ADAM17 Levels by Pestiviruses Is Species-Specific

Viruses
2024-10-02 | Journal article
DOI: 10.3390/v16101564
Contributors: Hann-Wei Chen; Marianne Zaruba; Aroosa Dawood; Stefan Düsterhöft; Benjamin Lamp; Till Ruemenapf; Christiane Riedel
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Crossref
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Functional characterization of two DYRK1B variants causative of AOMS3

Orphanet Journal of Rare Diseases
2024-06-12 | Journal article
DOI: 10.1186/s13023-024-03183-0
Contributors: Silvia Detro-Dassen; Anna Sternberg; Sonja Maria Lehmann; Katharina Schwandt; Stefan Düsterhöft; Walter Becker
Source: check_circle
Crossref

Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation

Cell Communication and Signaling
2024-06-11 | Journal article
DOI: 10.1186/s12964-024-01690-y
Part of ISSN: 1478-811X
Contributors: Aaron Babendreyer; Julia Kieselhorst; Cindy Rinkens; Anastasia M. Lyashenko; Stefan Düsterhöft; Holger Jahr; Rogerio B. Craveiro; Michael Wolf; Andreas Ludwig
Source: Self-asserted source
Stefan Düsterhöft

Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release

Biomaterials Advances
2023-09 | Journal article
DOI: 10.1016/j.bioadv.2023.213516
Part of ISSN: 2772-9508
Contributors: Caroline Grannemann; Alessa Pabst; Annika Honert; Jana Schieren; Christian Martin; Sophia Hank; Svenja Böll; Katharina Bläsius; Stefan Düsterhöft; Holger Jahr et al.
Source: Self-asserted source
Stefan Düsterhöft

EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2023-06 | Journal article
DOI: 10.1016/j.bbamcr.2023.119489
Part of ISSN: 0167-4889
Contributors: Neele Schumacher; Ilka Thomsen; Florian Brundert; Vaclav Hejret; Stefan Düsterhöft; Boris Tichý; Dirk Schmidt-Arras; Matthias Voss; Stefan Rose-John
Source: Self-asserted source
Stefan Düsterhöft

A structural model of the iRhom–ADAM17 sheddase complex reveals functional insights into its trafficking and activity

Cellular and Molecular Life Sciences
2023-05 | Journal article | Author
DOI: 10.1007/s00018-023-04783-y
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Contributors: Selcan Kahveci-Türköz; Katharina Bläsius; Justyna Wozniak; Cindy Rinkens; Anke Seifert; Petr Kasparek; Henrike Ohm; Shixin Oltzen; Martin Nieszporek; Nicole Schwarz et al.
Source: Self-asserted source
Stefan Düsterhöft

The collectrin‐like part of the SARS‐CoV‐1 and ‐2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17

The FASEB Journal
2022-03 | Journal article
DOI: 10.1096/fj.202101521R
Contributors: Rabea Victoria Niehues; Justyna Wozniak; Florian Wiersch; Eva Lilienthal; Nikola Tacken; Tim Schumertl; Christoph Garbers; Andreas Ludwig; Stefan Düsterhöft
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Crossref

ADAM17 Is an Essential Factor for the Infection of Bovine Cells with Pestiviruses

Viruses
2022-02-13 | Journal article
DOI: 10.3390/v14020381
Contributors: Marianne Zaruba; Hann-Wei Chen; Ole Frithjof Pietsch; Kati Szakmary-Braendle; Angelika Auer; Marlene Mötz; Kerstin Seitz; Stefan Düsterhöft; Aspen M. Workman; Till Rümenapf et al.
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Crossref
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Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells

Scientific Reports
2021-12-20 | Journal article
DOI: 10.1038/s41598-021-03522-2
Part of ISSN: 2045-2322
Contributors: Anja Adelina Giese; Aaron Babendreyer; Peter Krappen; Annika Gross; Pavel Strnad; Stefan Düsterhöft; Andreas Ludwig
Source: Self-asserted source
Stefan Düsterhöft

The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release.

Cellular and molecular life sciences : CMLS
2021-05-05 | Journal article
DOI: 10.1007/s00018-021-03845-3
PMID: 33950315
Source: Self-asserted source
Stefan Düsterhöft
grade
Preferred source (of 2)‎

Interleukin-11 (IL-11) receptor cleavage by the rhomboid protease RHBDL2 induces IL-11 trans-signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2021-03-01 | Journal article
DOI: 10.1096/fj.202002087r
PMID: 33566379
Source: Self-asserted source
Stefan Düsterhöft

Interleukin-6 controls recycling and degradation, but not internalization of its receptors.

The Journal of biological chemistry
2021-02-18 | Journal article
DOI: 10.1016/j.jbc.2021.100434
PMID: 33610555
PMC: PMC8010714
Source: Self-asserted source
Stefan Düsterhöft

Cathepsin S provokes interleukin-6 (IL-6) trans-signaling through cleavage of the IL-6 receptor in vitro

Scientific Reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-77884-4
Part of ISSN: 2045-2322
Source: Self-asserted source
Stefan Düsterhöft

Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells.

Journal of cellular and molecular medicine
2020-12-13 | Journal article
DOI: 10.1111/jcmm.16015
PMID: 33314720
PMC: PMC7882935
Source: Self-asserted source
Stefan Düsterhöft
grade
Preferred source (of 2)‎

Differential Induction of the ADAM17 Regulators iRhom1 and 2 in Endothelial Cells.

Frontiers in cardiovascular medicine
2020-12-01 | Journal article
DOI: 10.3389/fcvm.2020.610344
PMID: 33335915
PMC: PMC7736406
Source: Self-asserted source
Stefan Düsterhöft

The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner.

International journal of molecular sciences
2020-08-19 | Journal article
DOI: 10.3390/ijms21175978
PMID: 32825187
PMC: PMC7503280
Source: Self-asserted source
Stefan Düsterhöft

ADAM 17‐triggered TNF signalling protects the ageing Drosophila retina from lipid droplet‐mediated degeneration

The EMBO Journal
2020-07-26 | Journal article
DOI: 10.15252/embj.2020104415
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Source: Self-asserted source
Stefan Düsterhöft
grade
Preferred source (of 2)‎

Distance dependent shedding of IL-6R

Biochemical and Biophysical Research Communications
2020-05 | Journal article
DOI: 10.1016/j.bbrc.2020.03.093
Part of ISSN: 0006-291X
Source: Self-asserted source
Stefan Düsterhöft

The metalloproteinase ADAM10 requires its activity to sustain surface expression

Cellular and Molecular Life Sciences
2020-05-05 | Journal article
DOI: 10.1007/s00018-020-03507-w
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Source: Self-asserted source
Stefan Düsterhöft

Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and the Bcl-2 Protein Family

Mediators of Inflammation
2019-11-03 | Journal article
DOI: 10.1155/2019/1603131
Part of ISSN: 0962-9351
Part of ISSN: 1466-1861
Source: Self-asserted source
Stefan Düsterhöft

Status update on iRhom and ADAM17: It's still complicated

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2019-10 | Journal article
DOI: 10.1016/j.bbamcr.2019.06.017
Part of ISSN: 0167-4889
Source: Self-asserted source
Stefan Düsterhöft

The metalloprotease ADAM17 in inflammation and cancer

2019-04 | Journal article
DOI: 10.1016/j.prp.2019.04.002
Part of ISSN: 0344-0338
Source: Self-asserted source
Stefan Düsterhöft

The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11.

Biochimica et biophysica acta. Molecular cell research
2017-12 | Journal article
DOI: 10.1016/j.bbamcr.2017.12.003
PMID: 29237553
Contributors: Lokau J; Göttert S; Arnold P; Düsterhöft S; Massa López D; Grötzinger J; Garbers C
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.

FEBS letters
2017-10 | Journal article
DOI: 10.1002/1873-3468.12858
PMID: 28949004
Contributors: Schäfer M; Granato DC; Krossa S; Bartels AK; Yokoo S; Düsterhöft S; Koudelka T; Scheidig AJ; Tholey A; Paes Leme AF et al.
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region.

Biochimica et biophysica acta. Molecular cell research
2017-05 | Journal article
DOI: 10.1016/j.bbamcr.2017.05.024
PMID: 28571693
Contributors: Grötzinger J; Lorenzen I; Düsterhöft S
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Rhomboid proteases in human disease: Mechanisms and future prospects.

Biochimica et biophysica acta. Molecular cell research
2017-04 | Journal article
DOI: 10.1016/j.bbamcr.2017.04.016
PMID: 28460881
Contributors: Düsterhöft S; Künzel U; Freeman M
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

PLoS biology
2017-01 | Journal article
DOI: 10.1371/journal.pbio.2000080
PMID: 28060820
PMC: PMC5218472
Contributors: Riethmueller S; Somasundaram P; Ehlers JC; Hung CW; Flynn CM; Lokau J; Agthe M; Düsterhöft S; Zhu Y; Grötzinger J et al.
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Erratum: Control of ADAM17 activity by regulation of its cellular localisation.

Scientific reports
2016-11 | Journal article
DOI: 10.1038/srep37364
PMID: 27869207
PMC: PMC5116779
Contributors: Lorenzen I; Lokau J; Korpys Y; Oldefest M; Flynn CM; Künzel U; Garbers C; Freeman M; Grötzinger J; Düsterhöft S
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Control of ADAM17 activity by regulation of its cellular localisation.

Scientific reports
2016-10 | Journal article
DOI: 10.1038/srep35067
PMID: 27731361
PMC: PMC5059621
Contributors: Lorenzen I; Lokau J; Korpys Y; Oldefest M; Flynn CM; Künzel U; Garbers C; Freeman M; Grötzinger J; Düsterhöft S
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

Scientific Reports
2016-05 | Journal article
DOI: 10.1038/srep25550
PMID: 27151651
PMC: PMC4858764
Contributors: Riethmueller S; Ehlers JC; Lokau J; Düsterhöft S; Knittler K; Dombrowsky G; Grötzinger J; Rabe B; Rose-John S; Garbers C
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Phosphatidylserine exposure is required for ADAM17 sheddase function.

Nature communications
2016-05 | Journal article
DOI: 10.1038/ncomms11523
PMID: 27161080
PMC: PMC4866515
Contributors: Sommer A; Kordowski F; Büch J; Maretzky T; Evers A; Andrä J; Düsterhöft S; Michalek M; Lorenzen I; Somasundaram P et al.
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity.

Biochemistry
2015-09 | Journal article
DOI: 10.1021/acs.biochem.5b00497
PMID: 26348730
Contributors: Düsterhöft S; Michalek M; Kordowski F; Oldefest M; Sommer A; Röseler J; Reiss K; Grötzinger J; Lorenzen I
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3.

The Biochemical journal
2015-04 | Journal article
DOI: 10.1042/bj20141231
PMID: 25846075
Contributors: Oldefest M; Düsterhöft S; Desel C; Thysen S; Fink C; Rabe B; Lories R; Grötzinger J; Lorenzen I
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.

The Journal of biological chemistry
2014-04 | Journal article
DOI: 10.1074/jbc.M114.557322
PMID: 24790088
PMC: PMC4047402
Contributors: Düsterhöft S; Höbel K; Oldefest M; Lokau J; Waetzig GH; Chalaris A; Garbers C; Scheller J; Rose-John S; Lorenzen I et al.
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.

Journal of the American Chemical Society
2013-04 | Journal article
DOI: 10.1021/ja400340u
PMID: 23521534
Contributors: Düsterhöft S; Jung S; Hung CW; Tholey A; Sönnichsen FD; Grötzinger J; Lorenzen I
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.

FEBS letters
2012-03 | Journal article
DOI: 10.1016/j.febslet.2012.03.012
PMID: 22575642
Contributors: Lorenzen I; Lokau J; Düsterhöft S; Trad A; Garbers C; Scheller J; Rose-John S; Grötzinger J
Source: Self-asserted source
Stefan Düsterhöft via Europe PubMed Central

Peer review (15 reviews for 7 publications/grants)

Review activity for Cellular and molecular life sciences (1)
Review activity for Computers in biology and medicine. (1)
Review activity for Heliyon. (8)
Review activity for International journal of molecular sciences. (1)
Review activity for Journal of molecular liquids. (1)
Review activity for Metabolism, clinical and experimental. (2)
Review activity for Microbial pathogenesis. (1)
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