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Works (26)

Phenotype of a transient neonatal diabetes point mutation (SUR1-R1183W) in mice [version 2; peer review: 3 approved]

2021-03-15 | Journal article
DOI: 10.12688/wellcomeopenres.15529.2
Part of ISSN: 2398-502X
Contributors: Gregor Sachse; Elizabeth Haythorne; Peter Proks; Michelle Stewart; Heather Cater; Sian Ellard; Ben Davies; Frances M. Ashcroft
Source: check_circle
Wellcome Open Research

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Nature communications
2019-01 | Journal article
DOI: 10.1038/s41467-018-08193-8
PMID: 30635569
PMC: PMC6329806
Contributors: Vergari E; Knudsen JG; Ramracheya R; Salehi A; Zhang Q; Adam J; Asterholm IW; Benrick A; Briant LJB; Chibalina MV et al.
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production.

Cell metabolism
2018-11 | Journal article
DOI: 10.1016/j.cmet.2018.10.003
PMID: 30415925
Contributors: Knudsen JG; Hamilton A; Ramracheya R; Tarasov AI; Brereton M; Haythorne E; Chibalina MV; Spégel P; Mulder H; Zhang Q et al.
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2.

Diabetologia
2018-11 | Journal article
DOI: 10.1007/s00125-018-4771-3
PMID: 30426168
PMC: PMC6323097
Contributors: Kurstjens S; de Baaij JHF; Overmars-Bos C; van den Munckhof ICL; Garzero V; de Vries MA; Burggraaf B; van Diepen JA; Riksen NP; Rutten JHW et al.
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac KATP channels by MgADP and metabolism.

The Journal of physiology
2018-10 | Journal article
DOI: 10.1113/JP276708
PMID: 30179258
PMC: PMC6292810
Contributors: Vedovato N; Rorsman O; Hennis K; Ashcroft FM; Proks P
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis.

Lab on a chip
2018-09 | Journal article
DOI: 10.1039/c8lc00417j
PMID: 30083680
PMC: PMC6250124
Contributors: Tarasov AI; Galvanovskis J; Rorsman O; Hamilton A; Vergari E; Johnson PRV; Reimann F; Ashcroft FM; Rorsman P
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding

2018-08 | Other
DOI: 10.1101/402206
OTHER-ID:

PPR54305
Contributors: Puljung M; Vedovato N; Usher S; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Magnesium deficiency prevents high-fat-diet-induced obesity in mice.

Diabetologia
2018-07 | Journal article
DOI: 10.1007/s00125-018-4680-5
PMID: 29987474
PMC: PMC6096631
Contributors: Kurstjens S; van Diepen JA; Overmars-Bos C; Alkema W; Bindels RJM; Ashcroft FM; Tack CJJ; Hoenderop JGJ; de Baaij JHF
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Influences: Find a friend.

The Journal of general physiology
2018-06 | Journal article
DOI: 10.1085/jgp.201812123
PMID: 29930195
PMC: PMC6028500
Contributors: Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment.

Diabetic medicine : a journal of the British Diabetic Association
2018-06 | Journal article
DOI: 10.1111/dme.13758
PMID: 29896782
Contributors: Misra S; Vedovato N; Cliff E; De Franco E; Hattersley AT; Ashcroft FM; Oliver NS
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

PloS one
2018-05 | Journal article
DOI: 10.1371/journal.pone.0197634
PMID: 29772022
PMC: PMC5957440
Contributors: Proks P; Kramer H; Haythorne E; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Diabetes
2018-04 | Journal article
DOI: 10.2337/db17-1195
PMID: 29610263
Contributors: Rohm M; Savic D; Ball V; Curtis MK; Bonham S; Fischer R; Legrave N; MacRae JI; Tyler DJ; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

Physiological reviews
2018-01 | Journal article
DOI: 10.1152/physrev.00008.2017
PMID: 29212789
PMC: PMC5866358
Contributors: Rorsman P; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.

Biochimica et biophysica acta. Molecular basis of disease
2017-12 | Journal article
DOI: 10.1016/j.bbadis.2017.11.027
PMID: 29203346
PMC: PMC5798602
Contributors: Sachse G; Church C; Stewart M; Cater H; Teboul L; Cox RD; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes.

Cell reports
2017-09 | Journal article
DOI: 10.1016/j.celrep.2017.08.093
PMID: 28954230
PMC: PMC5637167
Contributors: Adam J; Ramracheya R; Chibalina MV; Ternette N; Hamilton A; Tarasov AI; Zhang Q; Rebelato E; Rorsman NJG; Martín-Del-Río R et al.
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

Cell metabolism
2017-07 | Journal article
DOI: 10.1016/j.cmet.2017.05.014
PMID: 28683284
PMC: PMC5890904
Contributors: Ashcroft FM; Rohm M; Clark A; Brereton MF
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression.

Journal of clinical research in pediatric endocrinology
2017-06 | Journal article
DOI: 10.4274/jcrpe.4624
PMID: 28663158
PMC: PMC5596808
Contributors: Flanagan SE; Dũng VC; Houghton JAL; De Franco E; Ngoc CTB; Damhuis A; Ashcroft FM; Harries LW; Ellard S
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Functional identification of islet cell types by electrophysiological fingerprinting.

Journal of the Royal Society, Interface
2017-03 | Journal article
DOI: 10.1098/rsif.2016.0999
PMID: 28275121
PMC: PMC5378133
Contributors: Briant LJ; Zhang Q; Vergari E; Kellard JA; Rodriguez B; Ashcroft FM; Rorsman P
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Neonatal Diabetes and the KATP Channel: From Mutation to Therapy.

Trends in endocrinology and metabolism: TEM
2017-03 | Journal article
DOI: 10.1016/j.tem.2017.02.003
PMID: 28262438
PMC: PMC5582192
Contributors: Ashcroft FM; Puljung MC; Vedovato N
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.

Nature communications
2016-11 | Journal article
DOI: 10.1038/ncomms13496
PMID: 27882918
PMC: PMC5123088
Contributors: Brereton MF; Rohm M; Shimomura K; Holland C; Tornovsky-Babeay S; Dadon D; Iberl M; Chibalina MV; Lee S; Glaser B et al.
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes.

Diabetes
2016-11 | Journal article
DOI: 10.2337/db16-0641
PMID: 27864307
PMC: PMC5248995
Contributors: Dahan T; Ziv O; Horwitz E; Zemmour H; Lavi J; Swisa A; Leibowitz G; Ashcroft FM; In't Veld P; Glaser B et al.
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Correction to 'Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels'.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2016-09 | Journal article
DOI: 10.1098/rstb.2016.0330
PMID: 27481794
PMC: PMC4971194
Contributors: Proks P; Puljung MC; Vedovato N; Sachse G; Mulvaney R; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

β-Cell dysfunction in diabetes: a crisis of identity?

Diabetes, obesity & metabolism
2016-09 | Journal article
DOI: 10.1111/dom.12732
PMID: 27615138
PMC: PMC5890905
Contributors: Brereton MF; Rohm M; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2016-08 | Journal article
DOI: 10.1098/rstb.2015.0426
PMID: 27377720
PMC: PMC4938026
Contributors: Proks P; Puljung MC; Vedovato N; Sachse G; Mulvaney R; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk.

Diabetologia
2016-04 | Journal article
DOI: 10.1007/s00125-016-3964-x
PMID: 27118464
PMC: PMC4901145
Contributors: Vedovato N; Cliff E; Proks P; Poovazhagi V; Flanagan SE; Ellard S; Hattersley AT; Ashcroft FM
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central

Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.

Diabetologia
2016-03 | Journal article
DOI: 10.1007/s00125-016-3921-8
PMID: 27033559
PMC: PMC4869695
Contributors: Babiker T; Vedovato N; Patel K; Thomas N; Finn R; Männikkö R; Chakera AJ; Flanagan SE; Shepherd MH; Ellard S et al.
Source: Self-asserted source
Frances Ashcroft via Europe PubMed Central
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