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Keywords

Medicinal chemistry, Organic synthesis, Biochemistry

Countries

Czech Republic

Activities

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Employment (1)

University of Chemistry and Technology, Prague: Prague, CZ

2013-08-24 to present
Employment
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OBD VŠCHT

Education and qualifications (1)

University of Chemistry and Technology, Prague: Prague, CZ

2013-08-24 to present
Education
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OBD VŠCHT

Works (7)

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model

Nature Communications
2025-02-06 | Journal article
DOI: 10.1038/s41467-025-56642-y
Contributors: Jan Dusek; Ivana Mejdrová; Klára Dohnalová; Tomas Smutny; Karel Chalupsky; Maria Krutakova; Josef Skoda; Azam Rashidian; Ivona Pavkova; Kryštof Škach et al.
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Crossref

Structure–activity relationship study of small-molecule inhibitor of Atg12-Atg3 protein–protein interaction

Bioorganic & Medicinal Chemistry Letters
2024-11 | Journal article
DOI: 10.1016/j.bmcl.2024.129939
Contributors: Krystof Skach; Jiri Boserle; Gal Chaim Nuta; Petra Břehová; Shani Bialik; Silvia Carvalho; Noga Kozer; Haim Barr; Ema Chaloupecká; Adi Kimchi et al.
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Crossref
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Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping

JOURNAL OF MEDICINAL CHEMISTRY
2023 | Journal article | Author
DOI: 10.1021/acs.jmedchem.3c00575
SOURCE-WORK-ID:

43899554

EID: 2-s2.0-85168369220
WOSUID: 001042199700001
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Petra Břehová; Eva Řezníčková; Krystof Skach; Radek Jorda; Milan Dejmek; Veronika Vojáčková; Michal Šála; Markéta Kovalová; Martin Dračínský; Alexandra Dolníková et al.
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OBD VŠCHT
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Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases

European Journal of Medicinal Chemistry
2023-08 | Journal article
DOI: 10.1016/j.ejmech.2023.115717
Part of ISSN: 0223-5234
Contributors: Mbilo Misehe; Marika Matoušová; Alexandra Dvořáková; Kamil Hercík; Kryštof Škach; Dominika Chalupská; Milan Dejmek; Michal Šála; Miroslav Hájek; Evzen Boura et al.
Source: Self-asserted source
Krystof Skach
grade
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Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure

Journal of Medicinal Chemistry
2023-02-23 | Journal article
DOI: 10.1021/acs.jmedchem.2c01140
Contributors: Ivana Mejdrová; Jan Dušek; Kryštof Škach; Alžbeta Stefela; Josef Skoda; Karel Chalupský; Klára Dohnalová; Ivona Pavkova; Thales Kronenberger; Azam Rashidian et al.
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Crossref
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PF74 and Its Novel Derivatives Stabilize Hexameric Lattice of HIV-1 Mature-Like Particles

Molecules
2020-04-20 | Journal article
DOI: 10.3390/molecules25081895
Part of ISSN: 1420-3049
Source: Self-asserted source
Krystof Skach
grade
Preferred source (of 2)‎

A simple, high-throughput stabilization assay to test HIV-1 uncoating inhibitors

Scientific Reports
2019-12 | Journal article
DOI: 10.1038/s41598-019-53483-w
Part of ISSN: 2045-2322
Source: Self-asserted source
Krystof Skach
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