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Precise Control of Molecular Weight Characteristics of Charge‐Shifting Poly(2‐(N,N‐Dimethylamino)Ethylacrylate) Synthesized by Reversible Addition‐Fragmentation Chain Transfer Polymerization

Macromolecular Rapid Communications
2025-01 | Journal article
DOI: 10.1002/marc.202400640
Contributors: Radoslava Sivkova; Rafal Konefal; Libor Kostka; Richard Laga; Gabriela S. García‐Briones; Olga Kočková; Ognen Pop‐Georgievski; Dana Kubies
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Polymer-based antibody mimetics (iBodies) target human PD-L1 and function as a potent immune checkpoint blocker

Journal of Biological Chemistry
2024 | Journal article
DOI: 10.1016/J.JBC.2024.107325
WOSUID: WOS:001345352100001
Contributors: Zamani, Mohammad Reza; Hadzima, Martin; Blazkova, Kristyna; Subr, Vladimir; Ormsby, Tereza; Celis-Gutierrez, Javier; Malissen, Bernard; Kostka, Libor; Etrych, Tomas; Sacha, Pavel et al.
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Polymer-Tethered Quenched Fluorescent Probes for Enhanced Imaging of Tumor-Associated Proteases

ACS Sensors
2024 | Journal article
DOI: 10.1021/ACSSENSORS.4C00912
WOSUID: WOS:001260906200001
Contributors: Hadzima, Martin; Faucher, Franco F.; Blazkova, Kristyna; Yim, Joshua J.; Guerra, Matteo; Chen, Shiyu; Woods, Emily C.; Park, Ki Wan; Sacha, Pavel; Subr, Vladimir et al.
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Step‐By‐Step Standardization of the Bottom‐Up Semi‐Automated Nanocrystallization of Pharmaceuticals: A Quality By Design and Design of Experiments Joint Approach

Small
2024-06 | Journal article
DOI: 10.1002/smll.202306054
Contributors: Luis Castillo Henríquez; Badr Bahloul; Khair Alhareth; Feras Oyoun; Markéta Frejková; Libor Kostka; Tomáš Etrych; Luc Kalshoven; Alain Guillaume; Nathalie Mignet et al.
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Iridium‐based Polymeric Multifunctional Imaging Tools for Biochemistry

ChemPlusChem
2024-05 | Journal article
DOI: 10.1002/cplu.202300647
Contributors: Anuson Sansee; Libor Kostka; Adéla Marcalíková; Júlia Kudláčová; František Sedlák; Lenka Kotrchová; Pavel Šácha; Tomáš Etrych; Filip Kielar
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Highly Effective Synthetic Polymer-Based Blockers of Non-Specific Interactions in Immunochemical Analyses

Polymers
2024-03-10 | Journal article
DOI: 10.3390/polym16060758
Contributors: Vladimír Šubr; Libor Kostka; Jan Plicka; Ondřej Sedláček; Tomáš Etrych
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Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation

Nanomedicine: Nanotechnology, Biology and Medicine
2024-02 | Journal article
DOI: 10.1016/j.nano.2023.102730
Contributors: M. Kovář; V. Šubr; K. Běhalová; M. Studenovský; D. Starenko; J. Kovářová; P. Procházková; T. Etrych; L. Kostka
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Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry

Macromolecular Bioscience
2024-02 | Journal article
DOI: 10.1002/mabi.202300306
Contributors: Júlia Kudláčová; Daniela Kužílková; František Bárta; Naděžda Brdičková; Adéla Vávrová; Libor Kostka; Ondřej Hovorka; Tomáš Kalina; Tomáš Etrych
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Comparison of linear and star-like polymeric nanomedicines on biodistribution,pharmacologic properties and anti-tumor activity in mice

Journal of Nuclear Medicine
2023 | Journal article
WOSUID: WOS:001109210200162
Contributors: Li, Xiaoyan; Kostka, Libor; Kotrchova, Lenka; Randarova, Eva; Ferreira, Carolina; Lee, Hye Jin; Olson, Aeli P.; Engle, Jonathan; Kovar, Marek; Sirova, Milada et al.
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Evaluation of linear<i> versus</i><i> star</i>-like polymer anti-cancer nanomedicines in mouse models

Journal of Controlled Release
2023 | Journal article
DOI: 10.1016/J.JCONREL.2022.11.060
WOSUID: WOS:000992308100001
Contributors: Kostka, Libor; Kotrchova, Lenka; Randarova, Eva; Ferreira, Carolina A.; Malatova, Iva; Lee, Hye Jin; Olson, Aeli P.; Engle, Jonathan W.; Kovar, Marek; Cai, Weibo et al.
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Ritonavir derivate bound to HPMA copolymer carrier has potent antitumor activity which synergizes with IL-2 based immunotherapy

European Journal of Immunology
2023 | Journal article
WOSUID: WOS:001058863800061
Contributors: Sivak, Ladislav; Subr, Vladimir; Kovarova, Jirina; Dvorakova, Barbora; Sirova, Milada; Rihova, Blanka; Randarova, Eva; Kraus, Michal; Tomala, Jakub; Studenovsky, Martin et al.
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Tumor-specific targeting of polymer drug delivery systems with recombinant proteins bound via tris(nitrilotriacetic acid)

International Journal of Pharmaceutics
2023-12 | Journal article
DOI: 10.1016/j.ijpharm.2023.123619
Contributors: Michal Pechar; Vlastimil Král; Lucie Kracíková; Ladislav Androvič; Eliška Hrdá; Robert Pola; Sára Pytlíková; Martin Studenovský; Libor Kostka; Vladimír Šubr et al.
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Adaptable polymerization platform for therapeutics with tunable biodegradability

Acta Biomaterialia
2023-11 | Journal article
DOI: 10.1016/j.actbio.2023.09.004
Contributors: M. Hrochová; L. Kotrchová; M. Frejková; R. Konefał; S. Gao; J. Fang; L. Kostka; T. Etrych
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Tumor-Specific Targeting of Polymer Drug Delivery Systems with Recombinant Proteins Bound via Tris(Nitrilotriacetic Acid)

2023-07-04 | Preprint
DOI: 10.20944/preprints202307.0133.v1
Contributors: Michal Pechar; Vlastimil Král; Lucie Woldřichová; Ladislav Androvič; Eliška Hrdá; Robert Pola; Sára Pytlíková; Martin Studenovský; Libor Kostka; Vladimír Šubr et al.
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Metastatic spread inhibition of cancer cells through stimuli-sensitive HPMA copolymer-bound actinonin nanomedicines

Nanomedicine: Nanotechnology, Biology, and Medicine
2022 | Journal article
DOI: 10.1016/J.NANO.2022.102578
WOSUID: WOS:000830513600002
Contributors: Kousalova, Jana; Sirova, Milada; Kostka, Libor; Subr, Vladimir; Kovarova, Jirina; Behalova, Katerina; Studenovsky, Martin; Kovar, Marek; Etrych, Tomas
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Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance

Biomacromolecules
2022-06-13 | Journal article
DOI: 10.1021/acs.biomac.2c00256
Contributors: Libor Kostka; Ladislav Sivák; Vladimír Šubr; Jiřina Kovářová; Milada Šírová; Blanka Říhová; Radislav Sedlacek; Tomáš Etrych; Marek Kovář
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HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo

Pharmaceutics
2022-06-04 | Journal article
DOI: 10.3390/pharmaceutics14061201
Contributors: Martin Studenovský; Anna Rumlerová; Jiřina Kovářová; Barbora Dvořáková; Ladislav Sivák; Libor Kostka; Daniel Berdár; Tomáš Etrych; Marek Kovář
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Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity<i> in</i><i> vivo</i><i> via</i> inhibition of proteasome and STAT3 signaling

Journal of Controlled Release
2021 | Journal article
DOI: 10.1016/J.JCONREL.2021.03.015
WOSUID: WOS:000646224400003
Contributors: Sivak, Ladislav; Subr, Vladimir; Kovarova, Jirina; Dvorakova, Barbora; Sirova, Milada; Sihova, Blanka; Randarova, Eva; Kraus, Michal; Tomala, Jakub; Studenovsky, Martin et al.
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The role of the biotin linker in polymer antibody mimetics, iBodies, in biochemical assays

Polymer Chemistry
2021 | Journal article
DOI: 10.1039/D1PY00707F
Contributors: Vladimír Šubr; Tereza Ormsby; Pavel Šácha; Jan Konvalinka; Tomáš Etrych; Libor Kostka
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The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody)

Journal of Biological Chemistry
2021-11 | Journal article
DOI: 10.1016/j.jbc.2021.101342
Contributors: Kristyna Blažková; Jana Beranová; Martin Hradilek; Libor Kostka; Vladimír Šubr; Tomáš Etrych; Pavel Šácha; Jan Konvalinka
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HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics

Polymers
2021-07-30 | Journal article
DOI: 10.3390/polym13152530
Contributors: Martin Studenovský; Anna Rumlerová; Libor Kostka; Tomáš Etrych
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HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery

Journal of Personalized Medicine
2021-02-10 | Journal article
DOI: 10.3390/jpm11020115
Contributors: Petr Chytil; Libor Kostka; Tomáš Etrych
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Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study

Pharmaceutics
2020-12-20 | Journal article
DOI: 10.3390/pharmaceutics12121242
Contributors: Júlia Kudláčová; Lenka Kotrchová; Libor Kostka; Eva Randárová; Marcela Filipová; Olga Janoušková; Jun Fang; Tomáš Etrych
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HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours

Biomaterials
2020-03 | Journal article | Investigation
DOI: 10.1016/j.biomaterials.2019.119728
Part of ISSN: 0142-9612
Contributors: Libor Kostka
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Libor Kostka
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From bioactive small molecule to an identified protein target: A new method combining stochastic photomodification with a synthetic antibody mimetic

Cancer Immunology Research
2019 | Journal article
DOI: 10.1158/2326-6074.CRICIMTEATIAACR18-B147
WOSUID: WOS:000557035600341
Contributors: Blazkova, Kristyna; Simon, Petr; Knedlik, Tomas; Dvorakova, Petra; Brezinova, Anna; Kostka, Libor; Subr, Vladimir; Konvalinka, Jan; Sacha, Pavel
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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

PLoS Biology
2019 | Journal article
DOI: 10.1371/JOURNAL.PBIO.3000354
WOSUID: WOS:000496470000025
Contributors: Vande Walle, Lieselotte; Stowe, Irma B.; Sacha, Pavel; Lee, Bettina L.; Demon, Dieter; Fossoul, Amelie; Van Hauwermeiren, Filip; Saavedra, Pedro H., V; Simon, Petr; Subrt, Vladimir et al.
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MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition (vol 17, e3000354, 2019)

PLoS Biology
2019 | Journal article
DOI: 10.1371/JOURNAL.PBIO.3000529
WOSUID: WOS:000505712400056
Contributors: Vande Walle, Lieselotte; Stowe, Irma B.; Sacha, Pavel; Lee, Bettina L.; Demon, Dieter; Fossoul, Amelie; Van Hauwermeiren, Filip; Saavedra, Pedro H. V.; Simon, Petr; Subr, Vladimir et al.
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Optimizing the Cu-RDRP of N-(2-hydroxypropyl) methacrylamide toward biomedical applications

Polymer Chemistry
2019 | Journal article
DOI: 10.1039/C8PY01569D
Contributors: Vladimír Raus; Libor Kostka
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Tris-(Nitrilotriacetic Acid)-Decorated Polymer Conjugates as Tools for Immobilization and Visualization of His-Tagged Proteins

Catalysts
2019-12-01 | Journal article
DOI: 10.3390/catal9121011
Contributors: Jana Beranová; Tomáš Knedlík; Adéla Šimková; Vladimír Šubr; Libor Kostka; Tomáš Etrych; Pavel Šácha; Jan Konvalinka
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Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

Pharmaceutics
2019-11-05 | Journal article
DOI: 10.3390/pharmaceutics11110579
Contributors: Alena Braunová; Martin Kaňa; Júlia Kudláčová; Libor Kostka; Jan Bouček; Jan Betka; Milada Šírová; Tomáš Etrych
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Inhibitor–Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms

ACS Omega
2019-04-30 | Journal article
DOI: 10.1021/acsomega.9b00596
Contributors: Klára Pospíšilová; Tomáš Knedlík; Pavel Šácha; Libor Kostka; Jiří Schimer; Jiří Brynda; Vlastimil Král; Petr Cígler; Václav Navrátil; Tomáš Etrych et al.
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Drug Carriers With Star Polymer Structures

Physiological Research
2018 | Journal article
WOSUID: WOS:000450606900004
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Inhibitor-GCPII Interaction: Selective and Robust System for Targeting Cancer Cells with Structurally Diverse Nanoparticles

Molecular Pharmaceutics
2018 | Journal article
DOI: 10.1021/acs.molpharmaceut.7b00889
EID:

2-s2.0-85051209704
Contributors: Neburkova, J.; Sedlak, F.; Zackova Suchanova, J.; Kostka, L.; Sacha, P.; Subr, V.; Etrych, T.; Simon, P.; Barinkova, J.; Krystufek, R. et al.
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Libor Kostka via Scopus - Elsevier
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Identification of Protein Targets of Bioactive Small Molecules Using Randomly Photomodified Probes

ACS Chemical Biology
2018-12-21 | Journal article
DOI: 10.1021/acschembio.8b00791
Contributors: Petr Šimon; Tomáš Knedlík; Kristýna Blažková; Petra Dvořáková; Anna Březinová; Libor Kostka; Vladimír Šubr; Jan Konvalinka; Pavel Šácha
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N-(2-Hydroxypropyl)methacrylamide-Based Linear, Diblock, and Starlike Polymer Drug Carriers: Advanced Process for Their Simple Production

Biomacromolecules
2018-10-08 | Journal article
DOI: 10.1021/acs.biomac.8b00973
Contributors: Eva Koziolová; Libor Kostka; Lenka Kotrchová; Vladimír Šubr; Rafal Konefal; Benjamin Nottelet; Tomáš Etrych
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Drug Carriers With Star Polymer Structures

Physiological Research
2018-09-27 | Journal article
DOI: 10.33549/physiolres.933978
Part of ISSN: 1802-9973
Part of ISSN: 0862-8408
Contributors: Libor Kostka
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Libor Kostka

Corrigendum to “Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo” [Euro. J. Pharm. Biopharm. 105 (2016) 85–96] (S0939641116301849) (10.1016/j.ejpb.2016.05.019)

European Journal of Pharmaceutics and Biopharmaceutics
2017 | Journal article
DOI: 10.1016/j.ejpb.2017.01.010
EID:

2-s2.0-85011015026
Contributors: Beckert, L.; Kostka, L.; Kessel, E.; Krhac Levacic, A.; Kostkova, H.; Etrych, T.; Lächelt, U.; Wagner, E.
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Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein

Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1021/acs.jmedchem.7b00767
EID:

2-s2.0-85032436419
Contributors: Dvořáková, P.; Bušek, P.; Knedlík, T.; Schimer, J.; Etrych, T.; Kostka, L.; Stollinová Šromová, L.; Šubr, V.; Šácha, P.; Šedo, A. et al.
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Polymers as tools for studying the internalization of membrane protein glutamate carboxypeptidase II

Journal of Controlled Release
2017 | Journal article
DOI: 10.1016/J.JCONREL.2017.03.180
WOSUID: WOS:000407591400139
Contributors: Kostka, Libor; Sedlak, Frantisek; Blazkova, Kristyna; Etrych, Tomas; Sacha, Pavel; Subr, Vladimir; Konvalinka, Jan
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Star Polymer-Drug Conjugates with pH-Controlled Drug Release and Carrier Degradation

Journal of Nanomaterials
2017 | Journal article
DOI: 10.1155/2017/8675435
EID:

2-s2.0-85010402888
Contributors: Kostková, H.; Schindler, L.; Kotrchová, L.; Kovář, M.; Šírová, M.; Kostka, L.; Etrych, T.
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Structural Design and Synthesis of Polymer Prodrugs

Polymers for Biomedicine
2017 | Book chapter
DOI: 10.1002/9781118967904.ch13
Source: Self-asserted source
Libor Kostka
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Tumor-targeted micelle-forming block copolymers for overcoming of multidrug resistance

Journal of Controlled Release
2017 | Journal article
DOI: 10.1016/j.jconrel.2016.11.020
EID:

2-s2.0-84997107109
Contributors: Braunová, A.; Kostka, L.; Sivák, L.; Cuchalová, L.; Hvězdová, Z.; Laga, R.; Filippov, S.; Černoch, P.; Pechar, M.; Janoušková, O. et al.
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Libor Kostka via Scopus - Elsevier
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Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo

European Journal of Pharmaceutics and Biopharmaceutics
2016 | Journal article
DOI: 10.1016/j.ejpb.2016.05.019
EID:

2-s2.0-84975042083
Contributors: Beckert, L.; Kostka, L.; Kessel, E.; Krhac Levacic, A.; Kostkova, H.; Etrych, T.; Lächelt, U.; Wagner, E.
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High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor

Physiological Research
2016 | Journal article
WOSUID: WOS:000386686800004
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High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor

Physiological Research
2016 | Journal article
EID:

2-s2.0-84997221443
Contributors: Kostka, L.; Etrych, T.
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Libor Kostka via Scopus - Elsevier

Passive Tumor Targeting of Polymer Therapeutics: In Vivo Imaging of Both the Polymer Carrier and the Enzymatically Cleavable Drug Model

Macromolecular Bioscience
2016 | Journal article
DOI: 10.1002/mabi.201600273
EID:

2-s2.0-84994501796
Contributors: Pola, R.; Heinrich, A.-K.; Mueller, T.; Kostka, L.; Mäder, K.; Pechar, M.; Etrych, T.
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Antioxidant properties of 2-hydroxyethyl methacrylate-based copolymers with incorporated sterically hindered amine

Biomacromolecules
2015 | Journal article
DOI: 10.1021/acs.biomac.5b00599
EID:

2-s2.0-84941655387
Contributors: Poláková, L.; Raus, V.; Kostka, L.; Braunová, A.; Pilař, J.; Lobaz, V.; Pánek, J.; Sedláková, Z.
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Nanotherapeutics shielded with a pH responsive polymeric layer

Physiological Research
2015 | Journal article
WOSUID: WOS:000365010700005
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Nanotherapeutics shielded with a pH responsive polymeric layer

Physiological Research
2015 | Journal article
EID:

2-s2.0-84952656462
Contributors: Kostka, L.; Šubr, V.; Laga, R.; Chytil, P.; Ulbrich, K.; Seymour, L.W.; Etrych, T.
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Nanotherapeutics with anthracyclines: Methods of determination and quantification of anthracyclines in biological samples

Physiological Research
2015 | Journal article
EID:

2-s2.0-84952655699
Contributors: Koziolova, E.; Janouskova, O.; Chytil, P.; Studenovsky, M.; Kostka, L.; Etrych, T.
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Peer review (24 reviews for 7 publications/grants)

Review activity for Journal of nanotheranostics. (2)
Review activity for Membranes. (2)
Review activity for Micro. (1)
Review activity for Molecules. (3)
Review activity for Pharmaceutical research. (1)
Review activity for Pharmaceutics. (11)
Review activity for Polymers. (4)
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