Federico Forneris (0000-0002-7818-1804)

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Biography

I am responsible for the Armenise-Harvard Laboratory of Structural Biology at the University of Pavia, Italy, Dept. Biology and Biotechnology. Since October 2021, I am also Pro-Rector for Research at the University of Pavia, Italy.

My principal research interest is the elucidation of the intricate mechanisms of protein-protein interaction and signaling. The various processes that fall under the description of "molecular recognition" (ranging from transient inter-molecular interactions, conformational changes, proteolysis-mediated activation and inhibition, to many others) represent for me one of the most fascinating aspects of nature elegance and complexity. I merge structural biology with biochemistry and biophysics to characterize large macromolecular complexes and elucidate their structure-function relationship to put the molecular insights in the proper biological context.

Since October 2021, I am Vice-Rector for Research at the University of Pavia

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University of Pavia: Pavia, IT

2023-08-01 to present | Full Professor of Molecular Biology (Biology and Biotechnology)

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Federico Forneris

https://orcid.org/0000-0002-7818-1804

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Employment (8)

University of Pavia: Pavia, IT

INF-ACT Foundation: Pavia, Italy, IT

University of Pavia: Pavia, Lombardia, IT

Università degli Studi di Pavia: Pavia, Lombardia, IT

Università degli Studi di Pavia: Pavia, Lombardia, IT

Universiteit Utrecht: Utrecht, Utrecht, NL

Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L Spallanzani: Pavia, Lombardia, IT

Università degli Studi di Trieste: Trieste, Friuli-Venezia Giulia, IT

Education and qualifications (2)

Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L Spallanzani: Pavia, Lombardia, IT

Universita degli Studi di Torino: Torino, Piemonte, IT

Professional activities (1)

Policlinico San Matteo Fondazione: Pavia, IT

Funding (12)

AIRC Bridge Grant

Ehlers-Danlos Society Rarer Types EDS Grant

One Health Basic and Translational Actions Addressing Unmet Needs on Emerging Infectious Diseases (INF-ACT)

Immuno-Hub

My First AIRC Grant

Fondazione Cariplo "Rafforzamento"

Fondazione Cariplo "Ricerca Biomedica Condotta da Giovani Ricercatori"

Programma Giovani Ricercatori "Rita Levi-Montalcini"

Armenise-Harvard Career Development Award

Mizutani Foundation for Glycoscience Grant

NATO Science for Peace and Security Programme Multi-Year Project

Velux Stiftung Ophthalmology Grant

Works (50 of 63)

A novel STING variant triggers endothelial toxicity and SAVI disease

Molecular Structure and Enzymatic Mechanism of the Human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1

Identification of Regulatory Molecular “Hot Spots” for LH/PLOD Collagen Glycosyltransferase Activity

A novel targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

Bi-specific AutoAntigen-T cell Engagers as targeted immunotherapy for autoreactive B cell depletion in autoimmune diseases

Deconstruction of Neurotrypsin Reveals a Multi-factorially Regulated Activity Affecting Myotube Formation and Neuronal Excitability

Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent MET receptor agonist

Crystal structure of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (hROR1)

SARS-CoV-2 Spike Affinity and Dynamics Exclude the Strict Requirement of an Intermediate Host

Epidemic preparedness - Leishmania tarentolae as an easy-to-handle tool to produce antigens for viral diagnosis: application to COVID-19

A Pilot Study on Covid and Autism: Prevalence, Clinical Presentation and Vaccine Side Effects

Collagen hydroxylysine glycosylation: non-conventional substrates for atypical glycosyltransferase enzymes

Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers

NT-mini, a recombinant tool for the study of Neurotrypsin functionality

Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent minimal MET receptor agonist

CDH1 Mutation Distribution and Type Suggests Genetic Differences between the Etiology of Orofacial Clefting and Gastric Cancer

A cooperative network of molecular “hot spots” highlights the complexity of LH3 collagen glycosyltransferase activities

Analysis in a murine model points to IgG responses against the 34k2 salivary proteins from Aedes albopictus and Aedes aegypti as novel promising candidate markers of host exposure to Aedes mosquitoes

Structural characterization of the third scavenger receptor cysteine‐rich domain of murine neurotrypsin

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3.

Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study.

Versatile medium-throughput strategies for recombinant expression screening in structural biology

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification.

Expanding the structural biology toolbox with single-molecule holography

Biochemical Characterization of Glutamate Racemase-A New Candidate Drug Target against Burkholderia cenocepacia Infections.

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo.

Identifying and Visualizing Macromolecular Flexibility in Structural Biology.

Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.

Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.

The Crystal Structure of Burkholderia cenocepacia DfsA Provides Insights into Substrate Recognition and Quorum Sensing Fatty Acid Biosynthesis.

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

Structural and biochemical insights into 7β-hydroxysteroid dehydrogenase stereoselectivity.

Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation

The three-dimensional structure of “Lonely Guy” fromClaviceps purpureaprovides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins

Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

Complement Factor D

Large Extent of Disorder in Adenomatous Polyposis Coli Offers a Strategy to Guard Wnt Signalling against Point Mutations

Proteolysis, complex formation and conformational changes drive the complement pathways