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University Zürich: Zürich, ZH, CH

2004-04-01 to present | Professor (Medical Faculty)
Employment
Source: Self-asserted source
Holger Moch

University Hospital Zürich: Zürich, ZH, CH

2004-04-01 to present | Chairman (Pathology and Molecular Pathology)
Employment
Source: Self-asserted source
Holger Moch

Works (39)

DeepSpot: Leveraging Spatial Context for Enhanced Spatial Transcriptomics Prediction from H&E Images

2025-02-12 | Preprint
DOI: 10.1101/2025.02.09.25321567
Contributors: Kalin Nonchev; Sebastian Dawo; Karina Silina; Holger Moch; Sonali Andani; Viktor H Koelzer; Gunnar Rätsch
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Data from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.c.7606528
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

Cancer Research
2025-01-02 | Journal article
DOI: 10.1158/0008-5472.CAN-24-1211
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Figure 1 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122835
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Figure 2 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122832
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Figure 3 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122829
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Figure 4 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122826
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Figure 5 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122823
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Figure 6 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122820
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Figure 7 from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122817
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Supplementary Figures from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122814
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Supplementary Tables from Distant Metastases of Breast Cancer Resemble Primary Tumors in Cancer Cell Composition but Differ in Immune Cell Phenotypes

2025-01-02 | Preprint
DOI: 10.1158/0008-5472.28122811
Contributors: Laura Kuett; Alina Bollhagen; Sandra Tietscher; Bettina Sobottka; Nils Eling; Zsuzsanna Varga; Holger Moch; Natalie de Souza; Bernd Bodenmiller
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Biostatistical Aspects of Whole Genome Sequencing Studies: Preprocessing and Quality Control

Biometrical Journal
2024-07 | Journal article
DOI: 10.1002/bimj.202300278
Contributors: Raphael O. Betschart; Cristian Riccio; Domingo Aguilera‐Garcia; Stefan Blankenberg; Linlin Guo; Holger Moch; Dagmar Seidl; Hugo Solleder; Felix Thalén; Alexandre Thiéry et al.
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Mitochondrial Elongation and ROS-Mediated Apoptosis in Prostate Cancer Cells under Therapy with Apalutamide and Complex I Inhibitor

International Journal of Molecular Sciences
2024-06-25 | Journal article
DOI: 10.3390/ijms25136939
Contributors: Valentin Baumgartner; Dominik Schaer; Holger Moch; Souzan Salemi; Daniel Eberli
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ERBB2‐amplified lobular breast carcinoma exhibits concomitant CDK12 co‐amplification associated with poor prognostic features

The Journal of Pathology: Clinical Research
2024-03 | Journal article
DOI: 10.1002/2056-4538.12362
Contributors: Miriam Forster‐Sack; Martin Zoche; Bernhard Pestalozzi; Isabell Witzel; Esther Irene Schwarz; Joel Julien Herzig; Hisham Fansa; Christoph Tausch; Jeff Ross; Holger Moch et al.
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Genomic alterations and diagnosis of renal cancer

Virchows Archiv
2024-02 | Journal article
DOI: 10.1007/s00428-023-03700-9
Contributors: Xingming Zhang; Hella A. Bolck; Niels J. Rupp; Holger Moch
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Multi-resolution deep learning characterizes tertiary lymphoid structures and their prognostic relevance in solid tumors

Communications Medicine
2024-01-05 | Journal article
DOI: 10.1038/s43856-023-00421-7
Contributors: Mart van Rijthoven; Simon Obahor; Fabio Pagliarulo; Maries van den Broek; Peter Schraml; Holger Moch; Jeroen van der Laak; Francesco Ciompi; Karina Silina
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Pleomorphic adenoma with PLAG1 fusion as an isolated kidney mass: lessons learned from a challenging case

Histopathology
2023-12 | Journal article
DOI: 10.1111/his.15055
Contributors: João Lobo; Markus Rechsteiner; Niels J Rupp; Helmut Ostertag; Holger Moch
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Compressed sensing expands the multiplexity of imaging mass cytometry

2023-11-06 | Preprint
DOI: 10.1101/2023.11.06.565119
Contributors: Tsuyoshi Hosogane; Leonor Schubert Santana; Nils Eling; Holger Moch; Bernd Bodenmiller
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Deletions of CDKN2A and MTAP Detected by Copy-Number Variation Array Are Associated with Loss of p16 and MTAP Protein in Pleural Mesothelioma

Cancers
2023-10-13 | Journal article
DOI: 10.3390/cancers15204978
Contributors: Bart Vrugt; Michaela B. Kirschner; Mayura Meerang; Kathrin Oehl; Ulrich Wagner; Alex Soltermann; Holger Moch; Isabelle Opitz; Peter J. Wild
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Altered cytoplasmic and nuclear ADP‐ribosylation levels analyzed with an improved ADP‐ribose binder are a prognostic factor in renal cell carcinoma

The Journal of Pathology: Clinical Research
2023-07 | Journal article
DOI: 10.1002/cjp2.320
Contributors: Peter Schraml; Fabio Aimi; Martin Zoche; Domingo Aguilera‐Garcia; Fabian Arnold; Holger Moch; Michael O Hottiger
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Next Generation Sequencing of Reactive Stroma and Residual Breast Cancer Cells in Tumor Bed after Neoadjuvant Chemotherapy

Cancers
2022-11-15 | Journal article
DOI: 10.3390/cancers14225609
Contributors: Zsuzsanna Varga; Ailsa Christiansen; Magdalena Lukamowicz-Rajska; Aashil A. Batavia; Adriana von Teichman; Peter Schraml; Holger Moch
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Comparison of calling pipelines for whole genome sequencing: an empirical study demonstrating the importance of mapping and alignment

2022-09-19 | Preprint
DOI: 10.1101/2022.09.18.508404
Contributors: Raphael O. Betschart; Alexandre Thiéry; Domingo Aguilera-Garcia; Martin Zoche; Holger Moch; Raphael Twerenbold; Tanja Zeller; Stefan Blankenberg; Andreas Ziegler
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A systematic comparison of pan-Trk immunohistochemistry assays across multiple cancer types

2022-09-02 | Preprint
DOI: 10.21203/rs.3.rs-1986852/v1
Contributors: Martina Haberecker; Antonia Töpfer; Francesca Malega; Holger Moch; Chantal Pauli
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MTPpilot: An Interactive Software for Visualization of Next-Generation Sequencing Results in Molecular Tumor Boards

JCO Clinical Cancer Informatics
2022-08 | Journal article
DOI: 10.1200/CCI.22.00032
Contributors: Abdullah Kahraman; Fabian M. Arnold; Jacob Hanimann; Marta Nowak; Chantal Pauli; Christian Britschgi; Holger Moch; Martin Zoche
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Modified Immunoscore Improves Prediction of Survival Outcomes in Patients Undergoing Radical Cystectomy for Bladder Cancer—A Retrospective Digital Pathology Study

Diagnostics
2022-06-01 | Journal article
DOI: 10.3390/diagnostics12061360
Contributors: Uwe Bieri; Lorenz Buser; Marian Severin Wettstein; Daniel Eberli; Karim Saba; Holger Moch; Thomas Hermanns; Cédric Poyet
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Validation of a Novel Three-Dimensional (<i>3D Fusion</i>) Gross Sampling Protocol for Clear Cell Renal Cell Carcinoma to Overcome Intratumoral Heterogeneity: The Meet-Uro 18 Study

Journal of Personalized Medicine
2022-04 | Journal article
DOI: 10.3390/jpm12050727
Contributors: Matteo Brunelli; Guido Martignoni; Giorgio Malpeli; Alessandro Volpe; Luca Cima; maria rosaria raspollini; Mattia Barbareschi; Alessandro Tafuri; Giulia Masi; Luisa Barzon et al.
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Multidisciplinary Digital Publishing Institute

MALDI Mass Spectrometry Imaging—Prognostic Pathways and Metabolites for Renal Cell Carcinomas

Cancers
2022-03-30 | Journal article
DOI: 10.3390/cancers14071763
Contributors: Franziska Erlmeier; Na Sun; Jian Shen; Annette Feuchtinger; Achim Buck; Verena M. Prade; Thomas Kunzke; Peter Schraml; Holger Moch; Michael Autenrieth et al.
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MTPpilot: an interactive software for visualization of NGS results in molecular tumor boards

2022-02-10 | Preprint
DOI: 10.1101/2022.02.09.22270751
Contributors: A. Kahraman; F. M. Arnold; J. Hanimann; M. Nowak; C. Pauli; C. Britschgi; H. Moch; M. Zoche
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A novel 5x multiplex immunohistochemical staining reveals PSMA as a helpful marker in prostate cancer with low p504s expression.

Pathology - Research and Practice
2021-12 | Journal article
DOI: 10.1016/j.prp.2021.153667
Contributors: Jan H. Rüschoff; Steven Stratton; Esteban Roberts; Samantha Clark; Noemi Sebastiao; Christian D. Fankhauser; Daniel Eberli; Holger Moch; Peter J. Wild; Niels J. Rupp
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The Morphological Spectrum of Papillary Renal Cell Carcinoma and Prevalence of Provisional/Emerging Renal Tumor Entities with Papillary Growth

Biomedicines
2021-10-09 | Journal article
DOI: 10.3390/biomedicines9101418
Contributors: João Lobo; Riuko Ohashi; Birgit M. Helmchen; Niels J. Rupp; Jan H. Rüschoff; Holger Moch
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CanIsoNet: A Database to Study the Functional Impact of Isoform Switching Events in Diseases

2021-09-18 | Preprint
DOI: 10.1101/2021.09.17.460795
Contributors: Tülay Karakulak; Damian Szklarczyk; Cemil Can Saylan; Holger Moch; Christian von Mering; Abdullah Kahraman
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Cytoplasmic ADP-ribosylation levels correlate with markers of patient outcome in distinct human cancers

Modern Pathology
2021-08 | Journal article
DOI: 10.1038/s41379-021-00788-9
Contributors: Fabio Aimi; Holger Moch; Peter Schraml; Michael O. Hottiger
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Re: Svetlana Avulova, John C. Cheville, Christine M. Lohse, et al. Grading Chromophobe Renal Cell Carcinoma: Evidence for a Four-tiered Classification Incorporating Coagulative Tumor Necrosis. Eur Urol 2021;79:225–31

European Urology
2021-07 | Journal article
DOI: 10.1016/j.eururo.2021.03.025
Contributors: Riuko Ohashi; Arndt Hartmann; Guido Martignoni; Holger Moch
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Spatial Distribution of Private Gene Mutations in Clear Cell Renal Cell Carcinoma

Cancers
2021-04 | Journal article | Author
DOI: 10.3390/cancers13092163
Contributors: Ariane Leoni Moore; Aashil A. Batavia; Jack Kuipers; Jochen Singer; Elodie Burcklen; Peter Schraml; Christian Beisel; Holger Moch; Niko Beerenwinkel
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Multidisciplinary Digital Publishing Institute
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Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Origin: Retrospective Molecular Classification Considering the CUPISCO Study Design

The Oncologist
2021-03 | Journal article
DOI: 10.1002/onco.13597
Contributors: Jeffrey S. Ross; Ethan S. Sokol; Holger Moch; Linda Mileshkin; Giulia Baciarello; Ferran Losa; Andreas Beringer; Marlene Thomas; Julia A. Elvin; Nhu Ngo et al.
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Higher prevalence of pulmonary macrothrombi in SARS‐CoV‐2 than in influenza A: autopsy results from ‘Spanish flu’ 1918/1919 in Switzerland to Coronavirus disease 2019

The Journal of Pathology: Clinical Research
2021-03 | Journal article
DOI: 10.1002/cjp2.189
Contributors: Nina Maria Burkhard‐Koren; Martina Haberecker; Umberto Maccio; Frank Ruschitzka; Reto A Schuepbach; Annelies S Zinkernagel; Thomas Hardmeier; Zsuzsanna Varga; Holger Moch
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Chromophobe renal cell carcinoma: current and controversial issues

Pathology
2021-01 | Journal article
DOI: 10.1016/j.pathol.2020.09.015
Contributors: Holger Moch; Riuko Ohashi
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SAMHD1mutations in mantle cell lymphoma are recurrent and conferin vitroresistance to nucleoside analogues

2020-06-10 | Preprint
DOI: 10.1101/2020.06.09.140376
Contributors: Marco M Bühler; Junyan Lu; Sebastian Scheinost; Ferran Nadeu; Damien Roos-Weil; Manfred Hensel; Tharshika Thavayogarajah; Holger Moch; Markus G Manz; Eugenia Haralambieva et al.
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