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Works (18)

Cdc2-like kinases: structure, biological function and therapeutic targets for diseases

Signal Transduction and Targeted Therapy
2023-04-07 | Journal article
DOI: 10.1038/s41392-023-01409-4
Contributors: Mengqiu Song; Luping Pang; Mengmeng Zhang; Yingzi Qu; Kyle Vaughn Laster; Zigang Dong
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Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides

International Journal of Molecular Sciences
2022-12-01 | Journal article
DOI: 10.3390/ijms232315095
Contributors: Luping Pang; Stijn Lenders; Evgenii M. Osipov; Stephen D. Weeks; Jef Rozenski; Tatiana Piller; Davie Cappoen; Sergei V. Strelkov; Arthur Van Aerschot
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Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip

Communications Biology
2022-08-29 | Journal article
DOI: 10.1038/s42003-022-03825-8
Contributors: Luping Pang; Vladimir Zanki; Sergei V. Strelkov; Arthur Van Aerschot; Ita Gruic-Sovulj; Stephen D. Weeks
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Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

International Journal of Molecular Sciences
2021-07-21 | Journal article
DOI: 10.3390/ijms22157793
Contributors: Luping Pang; Stephen D. Weeks; Martin Juhás; Sergei V. Strelkov; Jan Zitko; Arthur Van Aerschot
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Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery

International Journal of Molecular Sciences
2021-02-10 | Journal article
DOI: 10.3390/ijms22041750
Contributors: Luping Pang; Stephen D. Weeks; Arthur Van Aerschot
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Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase

Bioorganic & Medicinal Chemistry
2020-09 | Journal article
Part of DOI: 10.1016/j.bmc.2020.115645
Part of ISSN: 0968-0896
Source: Self-asserted source
Luping Pang

Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase

Bioorganic & Medicinal Chemistry
2020-08 | Journal article
DOI: 10.1016/j.bmc.2020.115580
Part of ISSN: 0968-0896
Source: Self-asserted source
Luping Pang

Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases

ACS Chemical Biology
2020-02-21 | Journal article
DOI: 10.1021/acschembio.9b00887
Contributors: Luping Pang; Manesh Nautiyal; Steff De Graef; Bharat Gadakh; Valentina Zorzini; Anastassios Economou; Sergei V. Strelkov; Arthur Van Aerschot; Stephen D. Weeks
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Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases.

Antibiotics (Basel, Switzerland)
2019-10-09 | Journal article
DOI: 10.3390/antibiotics8040180
PMID: 31600972
Source: Self-asserted source
Luping Pang

Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.

European journal of medicinal chemistry
2019-04-17 | Journal article
DOI: 10.1016/j.ejmech.2019.04.045
PMID: 31048140
Source: Self-asserted source
Luping Pang

Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.

European journal of medicinal chemistry
2019-04-05 | Journal article
DOI: 10.1016/j.ejmech.2019.04.003
PMID: 30995568
Source: Self-asserted source
Luping Pang

Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases.

European journal of medicinal chemistry
2018-02-14 | Journal article
DOI: 10.1016/j.ejmech.2018.02.013
PMID: 29477072
Source: Self-asserted source
Luping Pang

Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance

European Journal of Medicinal Chemistry
2018-01 | Journal article
DOI: 10.1016/j.ejmech.2017.10.041
Part of ISSN: 0223-5234
Source: Self-asserted source
Luping Pang

LPE-1, an orally active pyrimidine derivative, inhibits growth and mobility of human esophageal cancers by targeting LSD1

Pharmacological Research
2017-08 | Journal article
DOI: 10.1016/j.phrs.2017.05.025
Part of ISSN: 1043-6618
Source: Self-asserted source
Luping Pang

Design and synthesis of novel 1,2,3-triazole–pyrimidine–urea hybrids as potential anticancer agents

Bioorganic & Medicinal Chemistry Letters
2015-03 | Journal article
DOI: 10.1016/j.bmcl.2014.12.087
Part of ISSN: 0960-894X
Source: Self-asserted source
Luping Pang

Design, Synthesis, and Structure–Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine–Thiourea Hybrids As Potent, Orally Active Antitumor Agents

Journal of Medicinal Chemistry
2015-02-26 | Journal article
DOI: 10.1021/acs.jmedchem.5b00037
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Luping Pang

Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents

European Journal of Medicinal Chemistry
2014-10 | Journal article
DOI: 10.1016/j.ejmech.2014.08.010
Part of ISSN: 0223-5234
Source: Self-asserted source
Luping Pang

Design and synthesis of novel D-ring fused steroidal heterocycles

Steroids
2013-12 | Journal article
Part of DOI: 10.1016/j.steroids.2013.07.006
Part of ISSN: 0039-128X
Source: Self-asserted source
Luping Pang

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)
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