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UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill: Chapel Hill, NC, US

2022-06-27 to present | Project Manager (Structural Genomics Consortium)
Employment
Source: Self-asserted source
Peter J. Brown

Works (50 of 115)

Items per page:
Page 1 of 3

Identification of Direct-acting nsP2 Helicase Inhibitors with Antialphaviral Activity

2025-03-10 | Preprint
DOI: 10.1101/2025.03.04.641060
Contributors: Muthu Ramalingam Bose; John D. Sears; Kacey M. Talbot; Yuan-Wei Norman Su; Scott Houliston; Mohammed Anwar Hossain; Zachary W. Davis-Gilbert; Chunqing Zhao; Hans J. Oh; Peter J. Brown et al.
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Crossref

Exploring the Ligandability of 53BP1 Through Fragment-Based Approaches

2024-12-04 | Preprint
DOI: 10.26434/chemrxiv-2024-lng9q
Contributors: Beatrice Chiew; Menachem J. Gunzburg; Caroline A. Foley; Hong Zeng; Aiping Dong; Peter J. Brown; Juliana The; Jacqueline L. Noris; Stephanie H. Cholensky; Biswaranjan Mohanty et al.
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Crossref

Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

Proceedings of the National Academy of Sciences
2024-10-15 | Journal article
DOI: 10.1073/pnas.2409166121
Contributors: Eric M. Merten; John D. Sears; Tina M. Leisner; P. Brian Hardy; Anirban Ghoshal; Mohammad Anwar Hossain; Kesatebrhan Haile Asressu; Peter J. Brown; Edwin G. Tse; Michael A. Stashko et al.
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Crossref

Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors ofChikungunyansP2 Cysteine Protease with Anti-alphavirus Activity

2024-06-13 | Preprint
DOI: 10.1101/2024.06.12.598722
Contributors: Anirban Ghoshal; Kesatebrhan Haile Asressu; Mohammad Anwar Hossain; Peter J. Brown; Eric M. Merten; John D. Sears; Sumera Perveen; Kenneth H. Pearce; Konstantin I. Popov; Nathaniel J. Moorman et al.
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Crossref

Target 2035 – an update on private sector contributions

RSC Medicinal Chemistry
2023 | Journal article
DOI: 10.1039/D2MD00441K
Contributors: Suzanne Ackloo; Albert A. Antolin; Jose Manuel Bartolome; Hartmut Beck; Alex Bullock; Ulrich A. K. Betz; Jark Böttcher; Peter J. Brown; Menorca Chaturvedi; Alisa Crisp et al.
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Crossref

Discovery of a Novel DCAF1 Ligand Using a Drug–Target Interaction Prediction Model: Generalizing Machine Learning to New Drug Targets

Journal of Chemical Information and Modeling
2023-07-10 | Journal article
DOI: 10.1021/acs.jcim.3c00082
Contributors: Serah W. Kimani; Julie Owen; Stuart R. Green; Fengling Li; Yanjun Li; Aiping Dong; Peter J. Brown; Suzanne Ackloo; David Kuter; Cindy Yang et al.
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Crossref

A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.

Journal of medicinal chemistry
2021-02-16 | Journal article
DOI: 10.1021/acs.jmedchem.0c02160
PMID: 33591753
Source: Self-asserted source
Peter J. Brown

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.

Journal of medicinal chemistry
2021-02-01 | Journal article
DOI: 10.1021/acs.jmedchem.0c01768
PMID: 33522809
Source: Self-asserted source
Peter J. Brown

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain.

Biochimie
2021-01-18 | Journal article
DOI: 10.1016/j.biochi.2021.01.007
PMID: 33476699
Source: Self-asserted source
Peter J. Brown

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.

Nature communications
2020-05-14 | Journal article
DOI: 10.1038/s41467-020-16271-z
PMID: 32409666
PMC: PMC7224190
Source: Self-asserted source
Peter J. Brown

Discovery of a chemical probe for PRDM9.

Nature communications
2019-12-17 | Journal article
DOI: 10.1038/s41467-019-13652-x
PMID: 31848333
PMC: PMC6917776
Source: Self-asserted source
Peter J. Brown

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.

eLife
2019-10-28 | Journal article
DOI: 10.7554/eLife.47110
PMID: 31657716
PMC: PMC6917500
Source: Self-asserted source
Peter J. Brown

Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.

Journal of medicinal chemistry
2019-09-03 | Journal article
DOI: 10.1021/acs.jmedchem.9b00112
PMID: 31415173
Source: Self-asserted source
Peter J. Brown

Identification and characterization of the first fragment hits for SETDB1 Tudor domain.

Bioorganic & medicinal chemistry
2019-07-12 | Journal article
DOI: 10.1016/j.bmc.2019.07.020
PMID: 31327677
Source: Self-asserted source
Peter J. Brown

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Nature chemical biology
2019-07-08 | Journal article
DOI: 10.1038/s41589-019-0310-x
PMID: 31285596
Source: Self-asserted source
Peter J. Brown

Structural and functional consequences of the STAT5BN642H driver mutation.

Nature communications
2019-06-07 | Journal article
DOI: 10.1038/s41467-019-10422-7
PMID: 31175292
PMC: PMC6555848
Source: Self-asserted source
Peter J. Brown

The dynamic conformational landscape of the protein methyltransferase SETD8.

eLife
2019-05-13 | Journal article
DOI: 10.7554/eLife.45403
PMID: 31081496
PMC: PMC6579520
Source: Self-asserted source
Peter J. Brown

Discovery of selective activators of PRC2 mutant EED-I363M

Scientific Reports
2019-04-25 | Journal article
DOI: 10.1038/s41598-019-43005-z
Contributors: Junghyun L. Suh; Kimberly D. Barnash; Tigran M. Abramyan; Fengling Li; Juliana The; Isabelle A. Engelberg; Masoud Vedadi; Peter J. Brown; Dmitri B. Kireev; Cheryl H. Arrowsmith et al.
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Crossref

AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation.

Oncogene
2019-03-20 | Journal article
DOI: 10.1038/s41388-019-0790-x
PMID: 30894683
Source: Self-asserted source
Peter J. Brown

A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.

Nature communications
2019-01-03 | Journal article
DOI: 10.1038/s41467-018-07905-4
PMID: 30604761
PMC: PMC6318333
Source: Self-asserted source
Peter J. Brown

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.

ChemMedChem
2018-06-01 | Journal article
DOI: 10.1002/cmdc.201800193
PMID: 29856130
PMC: PMC6126618
Source: Self-asserted source
Peter J. Brown

LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.

ACS medicinal chemistry letters
2018-04-23 | Journal article
DOI: 10.1021/acsmedchemlett.8b00014
PMID: 30034588
PMC: PMC6047023
Source: Self-asserted source
Peter J. Brown

Donated chemical probes for open science.

eLife
2018-04-20 | Journal article
DOI: 10.7554/eLife.34311
PMID: 29676732
PMC: PMC5910019
Source: Self-asserted source
Peter J. Brown

TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.

Oncotarget
2018-04-06 | Journal article
DOI: 10.18632/oncotarget.24883
PMID: 29719619
PMC: PMC5915086
Source: Self-asserted source
Peter J. Brown

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.

SLAS discovery : advancing life sciences R & D
2018-03-21 | Journal article
DOI: 10.1177/2472555218766278
PMID: 29562800
Source: Self-asserted source
Peter J. Brown

Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).

Journal of medicinal chemistry
2018-02 | Journal article
DOI: 10.1021/acs.jmedchem.7b01674
PMID: 29244490
Contributors: Kaniskan HÜ; Eram MS; Zhao K; Szewczyk MM; Yang X; Schmidt K; Luo X; Xiao S; Dai M; He F et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first).

The Journal of biological chemistry
2018-01-10 | Journal article
DOI: 10.1074/jbc.RA117.000529
PMID: 29321206
PMC: PMC5836141
Source: Self-asserted source
Peter J. Brown
grade
Preferred source (of 2)‎

Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.

The Journal of biological chemistry
2017-12 | Journal article
DOI: 10.1074/jbc.m117.799700
PMID: 29074623
PMC: PMC5743070
Contributors: Houliston RS; Lemak A; Iqbal A; Ivanochko D; Duan S; Kaustov L; Ong MS; Fan L; Senisterra G; Brown PJ et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.

Nature communications
2017-11 | Journal article
DOI: 10.1038/s41467-017-01657-3
PMID: 29142305
PMC: PMC5688144
Contributors: Dahlin JL; Nelson KM; Strasser JM; Barsyte-Lovejoy D; Szewczyk MM; Organ S; Cuellar M; Singh G; Shrimp JH; Nguyen N et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Structure-activity relationship studies of G9a-like protein (GLP) inhibitors.

Bioorganic & medicinal chemistry
2017-08 | Journal article
DOI: 10.1016/j.bmc.2017.06.021
PMID: 28662962
Contributors: Xiong Y; Li F; Babault N; Wu H; Dong A; Zeng H; Chen X; Arrowsmith CH; Brown PJ; Liu J et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Chemical probes targeting epigenetic proteins: Applications beyond oncology.

Epigenetics
2017-05 | Journal article
DOI: 10.1080/15592294.2017.1279371
PMID: 28080202
PMC: PMC5453191
Contributors: Ackloo S; Brown PJ; Müller S
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2.

ACS combinatorial science
2017-03 | Journal article
DOI: 10.1021/acscombsci.6b00174
PMID: 28165227
Contributors: Barnash KD; The J; Norris-Drouin JL; Cholensky SH; Worley BM; Li F; Stuckey JI; Brown PJ; Vedadi M; Arrowsmith CH et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.

Journal of medicinal chemistry
2017-03 | Journal article
DOI: 10.1021/acs.jmedchem.6b01645
PMID: 28135087
Contributors: Xiong Y; Li F; Babault N; Dong A; Zeng H; Wu H; Chen X; Arrowsmith CH; Brown PJ; Liu J et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Nature chemical biology
2017-03 | Journal article
DOI: 10.1038/nchembio.2282
PMID: 28114273
Contributors: Bromberg KD; Mitchell TR; Upadhyay AK; Jakob CG; Jhala MA; Comess KM; Lasko LM; Li C; Tuzon CT; Dai Y et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.

2016 | Journal article
DOI: 10.7554/elife.17101
PMID: 27595565
PMC: PMC5012860
Contributors: Harrison JS; Cornett EM; Goldfarb D; DaRosa PA; Li ZM; Yan F; Dickson BM; Guo AH; Cantu DV; Kaustov L et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.

ACS medicinal chemistry letters
2016-12 | Journal article
DOI: 10.1021/acsmedchemlett.6b00303
PMID: 27994746
PMC: PMC5150682
Contributors: Judge RA; Zhu H; Upadhyay AK; Bodelle PM; Hutchins CW; Torrent M; Marin VL; Yu W; Vedadi M; Li F et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.

2016-11 | Journal article
PMID: 27804297
Contributors: Butler KV; Ma A; Yu W; Li F; Tempel W; Babault N; Pittella-Silva F; Shao J; Wang J; Luo M et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6.

2016-10 | Journal article
PMID: 27584694
Contributors: Shen Y; Szewczyk MM; Eram MS; Smil D; Kaniskan HÜ; Ferreira de Freitas R; Senisterra G; Li F; Schapira M; Brown PJ et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Structural basis of arginine asymmetrical dimethylation by PRMT6.

2016-10 | Journal article
DOI: 10.1042/bcj20160537
PMID: 27480107
Contributors: Wu H; Zheng W; Eram MS; Vhuiyan M; Dong A; Zeng H; He H; Brown P; Frankel A; Vedadi M et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Design and synthesis of selective, small molecule inhibitors of coactivator-associated arginine methyltransferase 1 (CARM1).

MedChemComm
2016-09 | Journal article
DOI: 10.1039/c6md00342g
PMID: 28042453
PMC: PMC5198778
Contributors: Kaniskan HÜ; Eram MS; Liu J; Smil D; Martini ML; Shen Y; Santhakumar V; Brown PJ; Arrowsmith C; Vedadi M et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors.

2016-08 | Journal article
DOI: 10.1021/acs.jmedchem.6b00855
PMID: 27468126
Contributors: Yang X; Li F; Konze KD; Meslamani J; Ma A; Brown PJ; Zhou MM; Arrowsmith CH; Kaniskan HÜ; Vedadi M et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening.

2016-07 | Journal article
DOI: 10.1021/acs.jmedchem.6b00668
PMID: 27390919
Contributors: Ferreira de Freitas R; Eram MS; Smil D; Szewczyk MM; Kennedy S; Brown PJ; Santhakumar V; Barsyte-Lovejoy D; Arrowsmith CH; Vedadi M et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Functional interdependence of BRD4 and DOT1L in MLL leukemia.

2016-07 | Journal article
DOI: 10.1038/nsmb.3249
PMID: 27294782
Contributors: Gilan O; Lam EY; Becher I; Lugo D; Cannizzaro E; Joberty G; Ward A; Wiese M; Fong CY; Ftouni S et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.

2016-06 | Journal article
DOI: 10.1016/j.celrep.2016.05.051
PMID: 27292644
PMC: PMC4920893
Contributors: Elkouris M; Kontaki H; Stavropoulos A; Antonoglou A; Nikolaou KC; Samiotaki M; Szantai E; Saviolaki D; Brown PJ; Sideras P et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.

2016-05 | Journal article
DOI: 10.1021/acs.jmedchem.5b01890
PMID: 27075367
PMC: PMC4917279
Contributors: Eggert E; Hillig RC; Koehr S; Stöckigt D; Weiske J; Barak N; Mowat J; Brumby T; Christ CD; Ter Laak A et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling.

2016-04 | Journal article
DOI: 10.1016/j.devcel.2016.03.002
PMID: 27046831
Contributors: Oudhoff MJ; Braam MJ; Freeman SA; Wong D; Rattray DG; Wang J; Antignano F; Snyder K; Refaeli I; Hughes MR et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.

2016-03 | Journal article
DOI: 10.1038/nchembio.2007
PMID: 26807715
PMC: PMC4755828
Contributors: Stuckey JI; Dickson BM; Cheng N; Liu Y; Norris JL; Cholensky SH; Tempel W; Qin S; Huber KG; Sagum C et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

2016-03 | Journal article
DOI: 10.1021/acschembio.5b00839
PMID: 26598975
Contributors: Eram MS; Shen Y; Szewczyk MM; Wu H; Senisterra G; Li F; Butler KV; Kaniskan HÜ; Speed BA; dela Seña C et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

2016-03 | Journal article
DOI: 10.1021/acs.jmedchem.5b01630
PMID: 26958703
Contributors: Getlik M; Smil D; Zepeda-Velázquez C; Bolshan Y; Poda G; Wu H; Dong A; Kuznetsova E; Marcellus R; Senisterra G et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central

Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.

2016-02 | Journal article
DOI: 10.1021/acs.jmedchem.5b01772
PMID: 26824386
Contributors: Ferreira de Freitas R; Eram MS; Szewczyk MM; Steuber H; Smil D; Wu H; Li F; Senisterra G; Dong A; Brown PJ et al.
Source: Self-asserted source
Peter J. Brown via Europe PubMed Central
Items per page:
Page 1 of 3

Peer review (25 reviews for 7 publications/grants)

Review activity for ACS medicinal chemistry letters. (2)
Review activity for ACS omega. (1)
Review activity for Communications chemistry. (1)
Review activity for European journal of medicinal chemistry. (2)
Review activity for Journal of chemical information and modeling. (1)
Review activity for Journal of medicinal chemistry. (17)
Review activity for PloS one. (1)
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