Pascal Schlosser (0000-0002-8460-0462)

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The Schlosser lab focusses on statistical genomics and molecular epidemiology. Population-based biomedical science, and in particular statistical genomics, has seen a rapid development in recent years with respect to measurement technologies (omics quantification), data availability (mega biobank-scale datasets such as UK Biobank) and the methods available to analyze at this sample size and resolution. Our group brings together expertise from statistics, bioinformatics, biology and medicine to develop the methods to gain insights into the physiology and pathophysiology of complex traits and diseases, with a particular focus on causal inference, integrative omics, and conducting large-scale meta-analyses of genetic studies. Studying DNA variation, DNA methylation, gene expression, metabolomics, proteomics and across omics data types we contributed especially to our understanding of kidney disease.

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Johns Hopkins University Bloomberg School of Public Health: Baltimore, MD, US

Adjunct Assistant Professor

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Pascal Schlosser

https://orcid.org/0000-0002-8460-0462

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Employment (2)

Johns Hopkins University Bloomberg School of Public Health: Baltimore, MD, US

Faculty of Medicine and Medical Center - University of Freiburg: Freiburg, DE

Education and qualifications (2)

Albert-Ludwigs-Universität Freiburg: Freiburg im Breisgau, Baden-Württemberg, DE

Albert-Ludwigs-Universität Freiburg: Freiburg im Breisgau, Baden-Württemberg, DE

Professional activities (14)

Spemann Graduate School of Biology and Medicine, University of Freiburg: Freiburg, DE

CRC 1453 NephroGenetics: Freiburg, DE

CRC 1597 small data: Freiburg, DE

Cluster of Excellence CIBSS - Centre for Integrative Biological Signalling Studies: Freiburg, DE

International Biometric Society: German Region, DE

Wissenschaftliche Gesellschaft Freiburg: Freiburg, DE

CRC 992 Medical Epigenetics: Freiburg, DE

Deutsche Gesellschaft für Nephrologie: Berlin, DE

Deutsche Gesellschaft für Epidemiologie: Ulm, DE

CHARGE Consortium: Philidelphia, US

International Biometric Society: German Region, DE

Albert-Ludwigs-Universität Freiburg: Freiburg im Breisgau, Baden-Württemberg, DE

International Biometric Society: German Region, DE

German Academic Scolarship Foundation (Studienstiftung des deutschen Volkes): Bonn, DE

Funding (6)

CRC 1453 NephGen Project 13: Deregulation of mTOR signaling pathways and metabolic reprogramming in VHL-dependent clear cell renal cell carcinoma

CRC 1597 Small Data Startup Funding: Extension of tabular Prior-Data Fitted Network transformers in data dimensions for disease classification and risk prediction in context of chronic kidney disease epigenetics

Emmy Noether Programme: Machine learning-aided causal inference – using multi-dimensional omics data for improved understanding of complex diseases

Walter Benjamin Programme: Proteome-wide Association Studies of Metabolites and Kidney Function

CRC 992 Medical Epigenetics Fellowship: Epigenome-based Proteome-wide Association Studies of Kidney Function

Use of (Machine-) Learning to Translate Population Genetics and Biochemistry to Novel Insights into Human Metabolism in Health and Disease

Works (50 of 56)

Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma

Coupling metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and human traits

Sex Differences in Hypertension and Its Management Throughout Life

Plasma proteomics of acute tubular injury

SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans

Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression

Serum and Urine Metabolites and Kidney Function.

Conditional survival to assess prognosis in patients with chronic lymphocytic leukemia

metaGWASmanager: a toolbox for an automated workflow from phenotypes to meta-analysis in GWAS consortia.

Eicosanoids and Related Metabolites Associated with ESKD in a Community-Based Cohort

Advancing proteomics in nephrology: unraveling causal pathways and therapeutic targets

Implication of transcription factor FOXD2 dysfunction in syndromic congenital anomalies of the kidney and urinary tract (CAKUT).

Coupling of metabolomics and exome sequencing reveals graded effects of rare damaging heterozygous variants on gene function and resulting traits and diseases

Circulating Proteins and Mortality in CKD: A Proteomics Study of the AASK and ARIC Cohorts

A genome-wide association study identifies 41 loci associated with eicosanoid levels

Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life

Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine

Proteomics: Progress and Promise of High-Throughput Proteomics in Chronic Kidney Disease

Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage

Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

In vivo kinetics of early, non-random methylome and transcriptome changes induced by DNA-hypomethylating treatment in primary AML blasts

Alterations in the Circulating Proteome Associated with Albuminuria

Proteomic Predictors of Incident Diabetes: Results From the Atherosclerosis Risk in Communities (ARIC) Study

Uromodulin and its association with urinary metabolites: the German Chronic Kidney Disease Study

Integrated proteomic and metabolomic modules identified as biomarkers of mortality in the Atherosclerosis Risk in Communities study and the African American Study of Kidney Disease and Hypertension

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Serum Metabolites and Kidney Outcomes: The Atherosclerosis Risk in Communities Study

Identification of 969 protein quantitative trait loci in an African American population with kidney disease attributed to hypertension.

Epigenome-wide DNA methylation in obsessive-compulsive disorder.

Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies

Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases.

Trans-ethnic genome-wide association study of blood metabolites in the Chronic Renal Insufficiency Cohort (CRIC) study.

Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

Meta-analyses identify DNA methylation associated with kidney function and damage

Netboost: Boosting-Supported Network Analysis Improves High-Dimensional Omics Prediction in Acute Myeloid Leukemia and Huntington’s Disease

Proteins Associated with Risk of Kidney Function Decline in the General Population

pgainsim: an R-package to assess the mode of inheritance for quantitative trait loci in GWAS

Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease

Plasma Proteomics of Renal Function: A Transethnic Meta-Analysis and Mendelian Randomization Study