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Apoptosis, Mitochondria, Melatonin, Calcium signalling, Chemotherapy
Spain

Biography

BSc in Biology (2007) from University of Extremadura (Spain)
Extraordinary Award of Bachelor (2008) from University of Extremadura (Spain)
MSc in Physiology (2008) from University of Extremadura (Spain)
PhD in Physiology (2014) from University of Extremadura (Spain)
Extraordinary PhD Award (2014) from University of Extremadura (Spain)
Post-doc fellow (2015-2017) at University of Padova (Italy)
Post-doc fellow ("Juan de la Cierva" programme; 2018-2019) at University of Extremadura (Spain)
Post-doc fellow ("Talento Investigador del SECTI" programme; 2019-2023) at University of Extremadura (Spain)
Associate Professor (Profesor Contratado Doctor; 2023-present) at University of Extremadura (Spain)

Activities

Employment (4)

University of Extremadura: Badajoz, ES

2023-03-15 to present | Associate Professor (Physiology)
Employment
Source: Self-asserted source
Espino J

University of Extremadura: Badajoz, ES

2018-07-09 to 2023-03-14 | Post-doc fellow (Physiology)
Employment
Source: Self-asserted source
Espino J

University of Padova: Padova, IT

2015-05-27 to 2017-05-31 | Post-doc fellow (Biomedical Sciences)
Employment
Source: Self-asserted source
Espino J

University of Extremadura: Badajoz, ES

2014-05-27 to 2015-05-26 | PhD (Physiology)
Employment
Source: Self-asserted source
Espino J

Education and qualifications (2)

University of Extremadura: Badajoz, ES

2008 to 2014 | PhD (Physiology)
Education
Source: Self-asserted source
Espino J

University of Extremadura: Badajoz, ES

2002-09-20 to 2007-07-05 | BSc in Biology
Education
Source: Self-asserted source
Espino J

Funding (2)

New strategies for the treatment of tumors of the female genital tract: usefulness of melatonin as a chemotherapeutic agent

2019-09 to 2023-03 | Award
Consejería de Empleo Empresa e Innovación del Gobierno de Extremadura (Badajoz, ES)
GRANT_NUMBER:

TA18002

Source: Self-asserted source
Espino J

Melatonin and apoptosis in human leukocytes

2010-10 to 2014-10 | Grant
Ministerio de Educación, Cultura y Deporte (Tarragona, ES)
GRANT_NUMBER:

AP2009-0753

Source: Self-asserted source
Espino J

Works (50 of 53)

Items per page:
Page 1 of 2

Melatonin Derivative-Conjugated Formulations of Pd(II) and Pt(II) Thiazoline Complexes on Mesoporous Silica to Enhance Cytotoxicity and Apoptosis against HeLa Cells

Pharmaceutics
2024-01 | Journal article | Author
Contributors: Samuel Estirado Rivera; Diana Díaz; Elena Fernández Delgado; Emilio Viñuelas-Zahinos; Santiago Gómez-Ruiz; Sanjiv Prashar; Ana B. Rodríguez; Francisco Luna-Giles; JOSÉ ANTONIO PARIENTE; Espino J
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Selenium Protects ARPE-19 and ACBRI 181 Cells against High Glucose-Induced Oxidative Stress

Molecules
2023-08-09 | Journal article
Contributors: Handan Bardak; Abdülhadi Cihangir Uğuz; Yavuz Bardak; Javier Rocha-Pimienta; Jonathan Delgado-Adámez; Javier Espino
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Chlorophyll Pigments of Olive Leaves and Green Tea Extracts Differentially Affect Their Antioxidant and Anticancer Properties

Molecules
2023-03-20 | Journal article
Contributors: Abdülhadi Cihangir Uğuz; Javier Rocha-Pimienta; Sara Martillanes; María Garrido; Javier Espino; Jonathan Delgado-Adámez
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines

Pharmaceutics
2023-02-18 | Journal article
Contributors: Elena Fernández-Delgado; Samuel Estirado; Ana B. Rodríguez; Francisco Luna-Giles; Emilio Viñuelas-Zahínos; Javier Espino; José Antonio Pariente
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Coping with Oxidative Stress in Reproductive Pathophysiology and Assisted Reproduction: Melatonin as an Emerging Therapeutical Tool

Antioxidants
2022-12-30 | Journal article
Contributors: Patricia Cosme; Ana B. Rodríguez; María Garrido; Javier Espino
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Pro-Apoptotic and Anti-Migration Properties of a Thiazoline-Containing Platinum(II) Complex in MDA-MB-231 Breast Cancer Cells: The Role of Melatonin as a Synergistic Agent

Antioxidants
2022-10 | Journal article | Author
Contributors: Samuel Estirado Rivera; Elena Fernández Delgado; Emilio Viñuelas-Zahinos; Francisco Luna-Giles; Ana B. Rodríguez; JOSÉ ANTONIO PARIENTE; Espino J
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Synthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand

Pharmaceuticals
2021-04-22 | Journal article
Contributors: Silvia Gutiérrez-Tarriño; Javier Espino; Francisco Luna-Giles; Ana B. Rodríguez; José A. Pariente; Emilio Viñuelas-Zahínos
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Plant Phenolics: Bioavailability as a Key Determinant of Their Potential Health-Promoting Applications

Antioxidants
2020-12-12 | Journal article
Contributors: Patricia Cosme; Ana B. Rodríguez; Javier Espino; María Garrido
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Impact of Melatonin Supplementation in Women with Unexplained Infertility Undergoing Fertility Treatment

Antioxidants
2019-08-23 | Journal article
Contributors: Javier Espino; María Macedo; Graciela Lozano; Águeda Ortiz; Carmina Rodríguez; Ana B. Rodríguez; Ignacio Bejarano
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake

Cell Death & Differentiation
2019-01-03 | Journal article
Contributors: Maria Patron; Veronica Granatiero; Javier Espino; Rosario Rizzuto; Diego De Stefani
Source: check_circle
Crossref

Melatonin increases the effect of 5-fluorouracil-based chemotherapy in human colorectal adenocarcinoma cells in vitro

Molecular and Cellular Biochemistry
2018-03-17 | Journal article
Contributors: Roberto Pariente; Ignacio Bejarano; Ana Beatriz Rodríguez; José Antonio Pariente; Javier Espino
Source: check_circle
Crossref

Chemical composition and bioactivity of essential oils from flower and fruit of Thymbra capitata and Thymus species

Journal of Food Science and Technology
2017 | Journal article
EID:

2-s2.0-85017237781

Contributors: Delgado-Adámez, J.; Garrido, M.; Bote, M.E.; Fuentes-Pérez, M.C.; Espino, J.; Martín-Vertedor, D.
Source: Self-asserted source
Espino J via Scopus - Elsevier
grade
Preferred source (of 2)‎

Participation of MT3 melatonin receptors in the synergistic effect of melatonin on cytotoxic and apoptotic actions evoked by chemotherapeutics

Cancer Chemotherapy and Pharmacology
2017 | Journal article
EID:

2-s2.0-85030085298

Contributors: Pariente, R.; Bejarano, I.; Espino, J.; Rodríguez, A.B.; Pariente, J.A.
Source: Self-asserted source
Espino J via Scopus - Elsevier

The MCU complex in cell death

Cell Calcium
2017 | Journal article
EID:

2-s2.0-85028530578

Contributors: Penna, E.; Espino, J.; De Stefani, D.; Rizzuto, R.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility

Scientific Reports
2016 | Journal article
WOSUID:

WOS:000383651600001

Contributors: Aparicio, I. M.; Espino, J.; Bejarano, I.; Gallardo-Soler, A.; Campo, M. L.; Salido, G. M.; Pariente, J. A.; Pena, F. J.; Tapia, J. A.
Source: Self-asserted source
Espino J via ResearcherID

Bioavailability of Bioactive Molecules from Olive Leaf Extracts and its Functional Value

Phytotherapy Research
2016 | Journal article
WOSUID:

WOS:000379945200014

Contributors: Martin-Vertedor, Daniel; Garrido, Maria; Antonio Pariente, Jose; Espino, Javier; Delgado-Adamez, Jonathan
Source: Self-asserted source
Espino J via ResearcherID

Extracellular heat shock proteins protect U937 cells from H2O2-induced apoptotic cell death

Molecular and Cellular Biochemistry
2016 | Journal article
WOSUID:

WOS:000369943600003

Contributors: Franco, Lourdes; Terrinca, Jorge; Rodriguez, Ana B.; Espino, Javier; Pariente, Jose A.
Source: Self-asserted source
Espino J via ResearcherID

Melatonin sensitizes human cervical cancer HeLa cells to cisplatin-induced cytotoxicity and apoptosis: effects on oxidative stress and DNA fragmentation

Journal of Pineal Research
2016 | Journal article
WOSUID:

WOS:000366405700006

Contributors: Pariente, Roberto; Pariente, Jose A.; Rodriguez, Ana B.; Espino, Javier
Source: Self-asserted source
Espino J via ResearcherID

The importance of melatonin and mitochondria interaction in mood disorders and schizophrenia: A current assessment

Current Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84983661931

Contributors: Uguz, A.C.; Demirci, K.; Espino, J.
Source: Self-asserted source
Espino J via Scopus - Elsevier

The efficiency of Poly(ADP-Ribose) Polymerase (PARP) cleavage on detection of apoptosis in an experimental model of testicular torsion

International Journal of Experimental Pathology
2015 | Journal article
EID:

2-s2.0-84983201129

Contributors: Aslan Koşar, P.; Tuncer, H.; Cihangir Uğuz, A.; Espino Palma, J.; Darici, H.; Onaran, I.; Çiğ, B.; Koşar, A.; Rodriguez Moratinos, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa

Journal of Pineal Research
2014 | Journal article
EID:

2-s2.0-84922328489

Contributors: Bejarano, I.; Monllor, F.; Marchena, A.M.; Ortiz, A.; Lozano, G.; Jiménez, M.I.; Gaspar, P.; García, J.F.; Pariente, J.A.; Rodríguez, A.B. et al.
Source: Self-asserted source
Espino J via Scopus - Elsevier

FMLP-, thapsigargin-, and H2O2-evoked changes in intracellular free calcium concentration in lymphocytes and neutrophils of type 2 diabetic patients

2014 | Journal article
EID:

2-s2.0-84893821786

Contributors: Kappala, S.S.; Espino, J.; Pariente, J.A.; Rodriguez, A.B.; Rajbhandari, S.; Iyengar, A.; Bidasee, K.R.; Singh, J.
Source: Self-asserted source
Espino J via Scopus - Elsevier

A jerte valley cherry-based product as a supply of tryptophan

International Journal of Tryptophan Research
2013 | Journal article
Contributors: Barriga, C.; Cubero, J.; Espino, J.; Garrido, M.; Maynar-Mariño, J.I.; Paredes, S.D.; Rodríguez, A.B.; Toribio-Delgado, A.F.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Metabolic syndrome, its pathophysiology and the role of melatonin

Recent Patents on Endocrine, Metabolic and Immune Drug Discovery
2013 | Journal article
Contributors: Espino, J.; Mohamed, M.; Ohta, Y.; Pariente, J.A.; Rodríguez, A.B.; Srinivasan, V.; Zakaria, R.
Source: Self-asserted source
Espino J via Scopus - Elsevier
grade
Preferred source (of 2)‎

Tempranillo-derived grape seed extract induces apoptotic cell death and cell growth arrest in human promyelocytic leukemia HL-60 cells

2013 | Journal article
EID:

2-s2.0-84888139563

Contributors: Espino, J.; González-Gómez, D.; Moreno, D.; Fernández-León, M.F.; Rodríguez, A.B.; Pariente, J.A.; Delgado-Adámez, J.
Source: Self-asserted source
Espino J via Scopus - Elsevier

The inhibition of TNF-α-induced leucocyte apoptosis by melatonin involves membrane receptor MT1/MT2 interaction

Journal of Pineal Research
2013 | Journal article
Contributors: Espino, J.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves

Journal of Applied Biomedicine
2012 | Journal article
Contributors: Barriga, C.; Delgado, J.; Espino, J.; Garrido, M.; Paredes, S.D.; Rodríguez, A.B.; del Pilar Terrón, M.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells

Journal of Pineal Research
2012 | Journal article
Contributors: Bejarano, I.; Cig, B.; Espino, J.; Naziroglu, M.; Pariente, J.A.; Rodríguez, A.B.; Uguz, A.C.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Oxidative stress and immunosenescence: Therapeutic effects of melatonin

Oxidative Medicine and Cellular Longevity
2012 | Journal article
Contributors: Espino, J.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Systemic inflammatory load in young and old ringdoves is modulated by consumption of a Jerte Valley cherry-based product

Journal of Medicinal Food
2012 | Journal article
Contributors: Barriga, C.; Del Pilar Terrón, M.; Delgado, J.; Espino, J.; Garrido, M.; Paredes, S.D.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

The consumption of a Jerte Valley cherry product in humans enhances mood, and increases 5-hydroxyindoleacetic acid but reduces cortisol levels in urine

Experimental Gerontology
2012 | Journal article
Contributors: Barriga, C.; Espino, J.; Garrido, M.; González-Gómez, D.; Lozano, M.; Paredes, S.D.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Apoptosis, ROS and calcium signaling in human spermatozoa: Relationship to infertility

2012-04-20 | Book | Author
Contributors: Espino J
Source: Self-asserted source
Espino J

High endogenous melatonin concentrations enhance sperm quality and short-term in vitro exposure to melatonin improves aspects of sperm motility

Journal of Pineal Research
2011 | Journal article
Contributors: Bejarano, I.; Espino, J.; García, J.F.; Lozano, G.M.; Monllor, F.; Ortiz, A.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells

Molecular and Cellular Biochemistry
2011 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; Marchena, A.M.; Paredes, S.D.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin is able to delay endoplasmic reticulum stress-induced apoptosis in leukocytes from elderly humans

Age
2011 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; Paredes, S.D.; Pariente, J.A.; Reiter, R.J.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways

Fertility and Sterility
2011 | Journal article
Contributors: Bejarano, I.; Espino, J.; García, J.F.; Lozano, G.M.; Monllor, F.; Ortiz, A.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Pro-oxidant effect of melatonin in tumour leucocytes: Relation with its cytotoxic and pro-apoptotic effects

Basic and Clinical Pharmacology and Toxicology
2011 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; Pariente, J.A.; Reiter, R.J.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: Relation with its antioxidant actions

Journal of Pineal Research
2011 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; Paredes, S.D.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Zinc(II) complexes with novel 1,3-thiazine/pyrazole derivative ligands: Synthesis, structural characterization and effect of coordination on the phagocytic activity of human neutrophils

Polyhedron
2011 | Journal article
Contributors: Barros-García, F.J.; Espino, J.; Luna-Giles, F.; Torres-García, P.; Viñuelas-Zahínos, E.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Role of melatonin on diabetes-related metabolic disorders

2011-06-15 | Book review | Author
Contributors: Espino J
Source: Self-asserted source
Espino J

Caspase-3 and -9 are activated in human myeloid HL-60 cells by calcium signal

Molecular and Cellular Biochemistry
2010 | Journal article
Contributors: Bejarano, I.; Espino, J.; González, D.; López, J.J.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa

Fertility and Sterility
2010 | Journal article
Contributors: Bejarano, I.; Espino, J.; García, J.F.; Lozano, G.M.; Ortiz, A.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin counteracts alterations in oxidative metabolism and cell viability induced by intracellular calcium overload in human leucocytes: Changes with age

Basic and Clinical Pharmacology and Toxicology
2010 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; González, D.; Paredes, S.D.; Pariente, J.A.; Reiter, R.J.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: Evidence for the involvement of mitochondria and bax activation

Journal of Membrane Biology
2010 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; Pariente, J.A.; Redondo, P.C.; Reiter, R.J.; Rodríguez, A.B.; Rosado, J.A.
Source: Self-asserted source
Espino J via Scopus - Elsevier

The correlation between urinary 5-hydroxyindoleacetic acid and sperm quality in infertile men and rotating shift workers

Reproductive Biology and Endocrinology
2010 | Journal article
Contributors: Bejarano, I.; Espino, J.; García, J.F.; Lozano, G.M.; Monllor, F.; Ortiz, Á.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

A nutraceutical product based on Jerte Valley cherries improves sleep and augments the antioxidant status in humans

e-SPEN
2009 | Journal article
Contributors: Barriga, C.; Cubero, J.; Espino, J.; Garrido, M.; González-Gómez, D.; Lozano, M.; Maynar-Mariño, J.I.; Muñoz, J.L.; Paredes, S.D.; Pariente, J.A. et al.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: Changes with age

Journals of Gerontology - Series A Biological Sciences and Medical Sciences
2009 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; Marchena, A.Ma.; Paredes, S.D.; Reiter, R.J.; Rial, R.V.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells

Journal of Pineal Research
2009 | Journal article
Contributors: Barriga, C.; Bejarano, I.; Espino, J.; Paredes, S.D.; Pariente, J.A.; Redondo, P.C.; Reiter, R.J.; Rodríguez, A.B.; Rosado, J.A.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Reduced levels of intracellular calcium releasing in spermatozoa from asthenozoospermic patients

Reproductive Biology and Endocrinology
2009 | Journal article
Contributors: Bejarano, I.; Espino, J.; García, J.F.; Lozano, G.M.; Mediero, M.; Ortiz, Á.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier

Relationship between caspase activity and apoptotic markers in human sperm in response to hydrogen peroxide and progesterone

Journal of Reproduction and Development
2009 | Journal article
Contributors: Bejarano, I.; Espino, J.; García, J.F.; González, D.; Lozano, G.M.; Ortiz, A.; Pariente, J.A.; Rodríguez, A.B.
Source: Self-asserted source
Espino J via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (31 reviews for 27 publications/grants)

Review activity for Andrologia. (2)
Review activity for Antioxidants. (1)
Review activity for Biomolecules. (2)
Review activity for Bipolar disorders. (1)
Review activity for British journal of pharmacology. (1)
Review activity for Cell biochemistry and biophysics. (1)
Review activity for Cell biochemistry and function. (2)
Review activity for Cells. (2)
Review activity for Cellular and molecular neurobiology. (1)
Review activity for Clinical nutrition. (1)
Review activity for Experimental and molecular medicine (1)
Review activity for Experimental and toxicologic pathology. (1)
Review activity for Food research international. (1)
Review activity for Hepatobiliary & pancreatic diseases international. (1)
Review activity for Journal of medicinal food. (1)
Review activity for Journal of personalized medicine. (1)
Review activity for Journal of pineal research. (1)
Review activity for Molecular and cellular biochemistry. (1)
Review activity for Molecular nutrition & food research. (1)
Review activity for Molecules. (1)
Review activity for Photonics & lasers in medicine. (1)
Review activity for Redox biology. (1)
Review activity for Reproductive biology and endocrinology (1)
Review activity for Reproductive Biology. (1)
Review activity for Scientific reports. (1)
Review activity for Trends in food science & technology. (1)
Review activity for World journal of experimental medicine. (1)