Personal information

Emails & domains

Verified email addresses

Verified email domains

Activities

Collapse all

Education and qualifications (1)

University of Oxford: Oxford, Oxfordshire, GB

1992-10-01 to 1996-10-01 | D.Phil (Biochemistry)
Education
Source: Self-asserted source
Peter McHugh

Works (50 of 63)

Items per page:
Page 1 of 2

The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks

2024-11-26 | Preprint
DOI: 10.1101/2024.11.26.625361
Contributors: Wei Song; Yichen Zhao; Annamaria Ruggiano; Christina Redfield; Joseph A Newman; Xiaosheng Zhu; Abimael Cruz-Migoni; Rebecca Roddan; Peter McHugh; Paul Elliott et al.
Source: check_circle
Crossref

Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing

2024-09-06 | Preprint
DOI: 10.1101/2024.09.05.611390
Contributors: Rebecca Roddan; William J. Nathan; Joseph A. Newman; Afaf El-Sagheer; David M. Wilson, III; Tom Brown; Christopher J. Schofield; Peter J. McHugh
Source: check_circle
Crossref

N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells

Chemical Science
2023 | Journal article
DOI: 10.1039/D3SC02867D
Contributors: Vicki L. Emms; Liam A. Lewis; Lilla Beja; Natasha F. A. Bulman; Elisabete Pires; Frederick W. Muskett; James S. O. McCullagh; Lonnie. P. Swift; Peter J. McHugh; Richard J. Hopkinson
Source: check_circle
Crossref

SNM1A (DCLRE1A) is crucial for efficient repair of complex DNA breaks in human cells

2023-08-04 | Preprint
DOI: 10.21203/rs.3.rs-3169914/v1
Contributors: Peter McHugh; Lonnie Swift; B. Christoffer Lagerholm; Hannah Baddock; Lucy Henderson; Malitha Ratnaweera; Blanka Sengerova; Sook Lee; Abimael Cruz-Migoni; Dominic Waithe et al.
Source: check_circle
Crossref

WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures

The EMBO Journal
2023-02 | Journal article
DOI: 10.15252/embj.2022111998
Contributors: Valentina Mengoli; Ilaria Ceppi; Aurore Sanchez; Elda Cannavo; Swagata Halder; Sarah Scaglione; Pierre‐Henri Gaillard; Peter J McHugh; Nathalie Riesen; Piergiorgio Pettazzoni et al.
Source: check_circle
Crossref

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

Nucleic Acids Research
2021-09-20 | Journal article
DOI: 10.1093/nar/gkab692
Contributors: Hannah T Baddock; Joseph A Newman; Yuliana Yosaatmadja; Marcin Bielinski; Christopher J Schofield; Opher Gileadi; Peter J McHugh
Source: check_circle
Crossref

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

Nucleic Acids Research
2021-09-20 | Journal article
DOI: 10.1093/nar/gkab693
Contributors: Yuliana Yosaatmadja; Hannah T Baddock; Joseph A Newman; Marcin Bielinski; Angeline E Gavard; Shubhashish M M Mukhopadhyay; Adam A Dannerfjord; Christopher J Schofield; Peter J McHugh; Opher Gileadi
Source: check_circle
Crossref

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core

NAR Cancer
2021-01-12 | Journal article
DOI: 10.1093/narcan/zcaa043
Contributors: Tabitha Jenkins; Sarah J Northall; Denis Ptchelkine; Rebecca Lever; Andrew Cubbon; Hannah Betts; Vincenzo Taresco; Christopher D O Cooper; Peter J McHugh; Panos Soultanas et al.
Source: check_circle
Crossref

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

2021-01-08 | Preprint
DOI: 10.1101/2021.01.08.423993
Contributors: Yuliana Yosaatmadja; Hannah T Baddock; Joseph A Newman; Marcin Bielinski; Angeline E Gavard; Shubhashish M M Mukhopadhyay; Adam A Dannerfjord; Christopher J Schofield; Peter J McHugh; Opher Gileadi
Source: check_circle
Crossref

XPF–ERCC1: Linchpin of DNA crosslink repair

PLOS Genetics
2020-04-09 | Journal article
DOI: 10.1371/journal.pgen.1008616
Contributors: Peter J. McHugh; Nancy Maizels
Source: check_circle
Crossref

Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors

Chemical Communications
2019 | Journal article
DOI: 10.1039/C9CC05476F
Contributors: Adam M. Thomas; Sanja Brolih; Joanna F. McGouran; Afaf H. El-Sagheer; Denis Ptchelkine; Morgan Jones; Neil Q. McDonald; Peter J. McHugh; Tom Brown
Source: check_circle
Crossref

Microhomologies are prevalent at Cas9-induced larger deletions

Nucleic Acids Research
2019-08-22 | Journal article
DOI: 10.1093/nar/gkz459
Contributors: Dominic D G Owens; Adam Caulder; Vincent Frontera; Joe R Harman; Alasdair J Allan; Akin Bucakci; Lucas Greder; Gemma F Codner; Philip Hublitz; Peter J McHugh et al.
Source: check_circle
Crossref

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors.

Journal of medicinal chemistry
2018-01 | Journal article
DOI: 10.1021/acs.jmedchem.7b01728
PMID: 29271657
Contributors: Cain R; Brem J; Zollman D; McDonough MA; Johnson RM; Spencer J; Makena A; Abboud MI; Cahill S; Lee SY et al.
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

PloS one
2017 | Journal article
DOI: 10.1371/journal.pone.0179278
PMID: 28628639
PMC: PMC5476263
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

RPA activates the XPF ‐ ERCC 1 endonuclease to initiate processing of DNA interstrand crosslinks

The EMBO Journal
2017-07-14 | Journal article
DOI: 10.15252/embj.201796664
Contributors: Ummi B Abdullah; Joanna F McGouran; Sanja Brolih; Denis Ptchelkine; Afaf H El‐Sagheer; Tom Brown; Peter J McHugh
Source: check_circle
Crossref

A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1

Genes & Development
2017-02-15 | Journal article
DOI: 10.1101/gad.289769.116
Contributors: Erkin Erdal; Syed Haider; Jan Rehwinkel; Adrian L. Harris; Peter J. McHugh
Source: check_circle
Crossref

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

Chemical Communications
2016 | Journal article
DOI: 10.1039/C6CC00529B
Contributors: Sook Y. Lee; Jürgen Brem; Ilaria Pettinati; Timothy D. W. Claridge; Opher Gileadi; Christopher J. Schofield; Peter J. McHugh
Source: check_circle
Crossref

Mgm101: A double-duty Rad52-like protein.

Cell cycle (Georgetown, Tex.)
2016-12 | Journal article
DOI: 10.1080/15384101.2016.1231288
PMID: 27636878
PMC: PMC5176325
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins.

Trends in biochemical sciences
2016-04 | Journal article
DOI: 10.1016/j.tibs.2015.12.007
PMID: 26805042
PMC: PMC4819959
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

EXD2 promotes homologous recombination by facilitating DNA end resection.

Nature cell biology
2016-03 | Journal article
DOI: 10.1038/ncb3303
PMID: 26807646
PMC: PMC4829102
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

The structures of the SNM1A and SNM1B/Apollo nuclease domains reveal a potential basis for their distinct DNA processing activities.

Nucleic acids research
2015-12 | Journal article
DOI: 10.1093/nar/gkv1256
PMID: 26582912
PMC: PMC4678830
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers.

Antimicrobial agents and chemotherapy
2015-10 | Journal article
DOI: 10.1128/aac.01335-15
PMID: 26482303
PMC: PMC4704194
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.

Nucleic acids research
2015-01 | Journal article
DOI: 10.1093/nar/gku1279
PMID: 25505141
PMC: PMC4288174
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

XPF protein levels determine sensitivity of malignant melanoma cells to oxaliplatin chemotherapy: suitability as a biomarker for patient selection.

International journal of cancer
2014-03 | Journal article
DOI: 10.1002/ijc.28454
PMID: 23982883
PMC: PMC4233955
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

Cell reports
2013-12 | Journal article
DOI: 10.1016/j.celrep.2013.11.035
PMID: 24360959
PMC: PMC4136507
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

Chemistry & biology
2013-01 | Journal article
DOI: 10.1016/j.chembiol.2012.10.016
PMID: 23352139
PMC: PMC3558928
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.

PLoS genetics
2012 | Journal article
DOI: 10.1371/journal.pgen.1002884
PMID: 22912599
PMC: PMC3415447
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Quantitative analysis of survivin protein expression and its therapeutic depletion by an antisense oligonucleotide in human lung tumors.

Molecular therapy. Nucleic acids
2012 | Journal article
DOI: 10.1038/mtna.2012.19
PMID: 23344082
PMC: PMC3390226
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

A prototypical Fanconi anemia pathway in lower eukaryotes?

Cell cycle (Georgetown, Tex.)
2012-10 | Journal article
DOI: 10.4161/cc.21727
PMID: 22895051
PMC: PMC3495816
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases.

The Journal of biological chemistry
2012-07 | Journal article
DOI: 10.1074/jbc.m112.367243
PMID: 22692201
PMC: PMC3406710
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.

Cell cycle (Georgetown, Tex.)
2011-12 | Journal article
DOI: 10.4161/cc.10.23.18385
PMID: 22101340
PMC: PMC3272282
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

Genes & development
2011-09 | Journal article
DOI: 10.1101/gad.15699211
PMID: 21896658
PMC: PMC3175721
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures.

The Journal of biological chemistry
2011-05 | Journal article
DOI: 10.1074/jbc.m111.228189
PMID: 21398521
PMC: PMC3091193
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.

Molecular and cellular biology
2011-05 | Journal article
DOI: 10.1128/mcb.01130-10
PMID: 21343337
PMC: PMC3133222
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair.

The Journal of Cell Biology
2010-12 | Journal article
DOI: 10.1083/jcb.201006178
PMID: 21135142
PMC: PMC3002029
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study.

Clinical cancer research : an official journal of the American Association for Cancer Research
2010-12 | Journal article
DOI: 10.1158/1078-0432.ccr-10-1932
PMID: 21041181
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

The SNM1/Pso2 family of ICL repair nucleases: from yeast to man.

Environmental and molecular mutagenesis
2010-07 | Journal article
DOI: 10.1002/em.20556
PMID: 20175117
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.

Molecular and cellular biology
2009-12 | Journal article
DOI: 10.1128/mcb.00086-09
PMID: 19805513
PMC: PMC2786876
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Apollo: a healer of the genome?

Cell cycle (Georgetown, Tex.)
2009-07 | Journal article
PMID: 19550156
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.

DNA repair
2008-02 | Journal article
DOI: 10.1016/j.dnarep.2007.09.013
PMID: 18006388
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.

Molecular cancer therapeutics
2007-10 | Journal article
DOI: 10.1158/1535-7163.mct-07-0294
PMID: 17938264
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

DNA interstrand cross-link repair in Saccharomyces cerevisiae.

FEMS microbiology reviews
2007-03 | Journal article
DOI: 10.1111/j.1574-6976.2006.00046.x
PMID: 17096663
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

DNA interstrand cross-link repair in the cell cycle: a critical role for polymerase zeta in G1 phase.

Cell cycle (Georgetown, Tex.)
2006-05 | Journal article
DOI: 10.4161/cc.5.10.2763
PMID: 16687932
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta.

The EMBO journal
2006-03 | Journal article
DOI: 10.1038/sj.emboj.7600993
PMID: 16482220
PMC: PMC1422152
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136.

Nucleic acids research
2005 | Journal article
DOI: 10.1093/nar/gki639
PMID: 15944449
PMC: PMC1145189
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair.

Molecular cell
2005-09 | Journal article
DOI: 10.1016/j.molcel.2005.08.018
PMID: 16168378
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase.

Molecular and cellular biology
2005-03 | Journal article
DOI: 10.1128/mcb.25.6.2297-2309.2005
PMID: 15743825
PMC: PMC1061624
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

Cancer research
2004-09 | Journal article
DOI: 10.1158/0008-5472.can-03-2941
PMID: 15374986
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis.

Human molecular genetics
2003-09 | Journal article
DOI: 10.1093/hmg/ddg225
PMID: 12915468
Source: Self-asserted source
Peter McHugh via Europe PubMed Central

Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links.

Molecular and cellular biology
2003-07 | Journal article
DOI: 10.1128/mcb.23.13.4728-4737.2003
PMID: 12808110
PMC: PMC164842
Source: Self-asserted source
Peter McHugh via Europe PubMed Central
Items per page:
Page 1 of 2
How many people are using ORCID?