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Keywords

Bordetella pertussis, Adenylate cyclase toxin, Pertussis toxin, RTX Toxins, Host immune response, Immune cell migration

Countries

Czech Republic, France, United Kingdom

Activities

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Employment (2)

University of Oxford: Oxford, GB

2024-01-01 to present | Postdoctoral Research Assistant in Immunology (Kennedy Institute of Rheumatology)
Employment
Source: Self-asserted source
Nela Klimova

Czech Academy of Sciences: Prague, CZ

2015-07 to 2022-11-13 | PhD Student (Institute of Microbiology)
Employment
Source: Self-asserted source
Nela Klimova

Education and qualifications (2)

Charles University: Prague, CZ

2015-10 to 2022-11-13 | PhD (Faculty of Science)
Education
Source: Self-asserted source
Nela Klimova

Charles University: Prague, CZ

2013-10 to 2015-06 | Master (Faculty of Science)
Education
Source: Self-asserted source
Nela Klimova

Funding (1)

The role of the adenylate cyclase toxin of Bordetella pertussis in subversion of host defense

2016 to 2018 | Grant
The Charles University Grant Agency (Prague, CZ)
GRANT_NUMBER:

507116
Source: Self-asserted source
Nela Klimova

Works (7)

Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes

PLOS Pathogens
2022-06-06 | Journal article
DOI: 10.1371/journal.ppat.1010577
Part of ISSN: 1553-7374
Source: Self-asserted source
Nela Klimova

Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein

International Journal of Molecular Sciences
2021-08-23 | Journal article
DOI: 10.3390/ijms22169064
Contributors: Anna Malandra; Waheed Ur Rahman; Nela Klimova; Gaia Streparola; Jana Holubova; Adriana Osickova; Simone Bariselli; Peter Sebo; Radim Osicka
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Binding of Kingella kingae RtxA Toxin Depends on Cell Surface Oligosaccharides, but Not on β2 Integrins

International Journal of Molecular Sciences
2020-11-29 | Journal article
DOI: 10.3390/ijms21239092
Part of ISSN: 1422-0067
Source: Self-asserted source
Nela Klimova

Continuous Assembly of β-Roll Structures Is Implicated in the Type I-Dependent Secretion of Large Repeat-in-Toxins (RTX) Proteins

Journal of Molecular Biology
2020-09 | Journal article
DOI: 10.1016/j.jmb.2020.08.020
Part of ISSN: 0022-2836
Source: Self-asserted source
Nela Klimova

Retargeting from the CR3 to the LFA-1 receptor uncovers the adenylyl cyclase enzyme–translocating segment of Bordetella adenylate cyclase toxin

Journal of Biological Chemistry
2020-07 | Journal article
DOI: 10.1074/jbc.RA120.013630
Contributors: Jiri Masin; Adriana Osickova; David Jurnecka; Nela Klimova; Humaira Khaliq; Peter Sebo; Radim Osicka
Source: check_circle
Crossref

Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity

Toxins
2017-09-21 | Journal article
DOI: 10.3390/toxins9100293
Part of ISSN: 2072-6651
Source: Self-asserted source
Nela Klimova

Calcium-Driven Folding of RTX Domain β-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts

Molecular Cell
2016-04 | Journal article
DOI: 10.1016/j.molcel.2016.03.018
Part of ISSN: 1097-2765
Source: Self-asserted source
Nela Klimova
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