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Works (21)

YAK577 Attenuates Cardiac Remodeling and Fibrosis in Isoproterenol-Infused Heart Failure Mice by Downregulating MMP12

Korean Circulation Journal
2025 | Journal article
DOI: 10.4070/kcj.2024.0093
Contributors: Hongyan Zhou; Hae Jin Kee; Le Wan; Yodita Asfaha; Fabian Fischer; Matthias U Kassack; Thomas Kurz; Seong Hoon Kim; Seung-Jung Kee; Young Joon Hong et al.
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Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water

Beilstein Journal of Organic Chemistry
2025-03-14 | Journal article
DOI: 10.3762/bjoc.21.46
Contributors: Wei-Jin Chang; Sook Yee Liew; Thomas Kurz; Siow-Ping Tan
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Pharmacological Inhibition of MDM2 Induces Apoptosis in p53-Mutated Triple-Negative Breast Cancer

International Journal of Molecular Sciences
2025-01 | Journal article | Author
DOI: 10.3390/ijms26031078
Contributors: Jasmin L. On; Sahel Ghaderi; Carina Rittmann; Greta Elena Hoffmann; Franziska Gier; Vitalij Woloschin; Jia-Wey Tu; Sanil Bhatia; Andrea Kulik; Dieter Niederacher et al.
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Multidisciplinary Digital Publishing Institute

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents

Molecules
2024-12-28 | Journal article
DOI: 10.3390/molecules30010072
Contributors: Sana Takada; Mona A. Abdullaziz; Stefan Höfmann; Talea Knak; Shin-ichiro Ozawa; Yasumitsu Sakamoto; Thomas Kurz; Nobutada Tanaka
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Novel Histone Deacetylase (HDAC) Inhibitor Induces Apoptosis and Suppresses Invasion via E-Cadherin Upregulation in Pancreatic Ductal Adenocarcinoma (PDAC)

Pharmaceuticals
2024-06-07 | Journal article
DOI: 10.3390/ph17060752
Contributors: Katja Schiedlauske; Alina Deipenbrock; Marc Pflieger; Alexandra Hamacher; Jan Hänsel; Matthias U. Kassack; Thomas Kurz; Nicole E. Teusch
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Over 40 Years of Fosmidomycin Drug Research: A Comprehensive Review and Future Opportunities

Pharmaceuticals
2022-12-14 | Journal article
DOI: 10.3390/ph15121553
Contributors: Talea Knak; Mona A. Abdullaziz; Stefan Höfmann; Leandro A. Alves Avelar; Saskia Klein; Matthew Martin; Markus Fischer; Nobutada Tanaka; Thomas Kurz
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The Novel Class IIa Selective Histone Deacetylase Inhibitor YAK540 Is Synergistic with Bortezomib in Leukemia Cell Lines

International Journal of Molecular Sciences
2022-11-02 | Journal article
DOI: 10.3390/ijms232113398
Contributors: Lukas M. Bollmann; Alexander J. Skerhut; Yodita Asfaha; Nadine Horstick; Helmut Hanenberg; Alexandra Hamacher; Thomas Kurz; Matthias U. Kassack
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Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed <i>ortho</i>-C(sp<sup>2</sup>)-H-Hydroxylation

Pharmaceuticals
2022-08 | Journal article | Author
DOI: 10.3390/ph15080984
Contributors: Alexander Berger; Dr. Talea Knak; Anna-Lene Kiffe-Delf; Korana Mudrovcic; Vinayak Singh; Mathew Njoroge; Bjoern B Burckhardt; Mohanraj Gopalswamy; Beate Lungerich; Lutz Ackermann et al.
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Multidisciplinary Digital Publishing Institute

Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation

Pharmaceutics
2022-03-30 | Journal article
DOI: 10.3390/pharmaceutics14040754
Contributors: Markéta Zajíčková; Lukáš Prchal; Ivan Vokřál; Linh Thuy Nguyen; Thomas Kurz; Robin Gasser; Klára Bednářová; Magdalena Mičundová; Beate Lungerich; Oliver Michel et al.
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Designing HDAC-PROTACs: Lessons Learned So Far

Future Medicinal Chemistry
2022-02 | Journal article
DOI: 10.4155/fmc-2021-0206
Contributors: Fabian Fischer; Leandro A Alves Avelar; Laoise Murray; Thomas Kurz
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QSAR Classification Models for Prediction of Hydroxamate Histone Deacetylase Inhibitor Activity against Malaria Parasites

ACS Infectious Diseases
2022-01-14 | Journal article
DOI: 10.1021/acsinfecdis.1c00355
Contributors: Eva Hesping; Ming Jang Chua; Marc Pflieger; Yunan Qian; Lilong Dong; Prabhakar Bachu; Ligong Liu; Thomas Kurz; Gillian M. Fisher; Tina S. Skinner-Adams et al.
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Three Small Molecule Entities (MPK18, MPK334 and YAK308) with Activity against Haemonchus contortus In Vitro

Molecules
2021-05-10 | Journal article
DOI: 10.3390/molecules26092819
Contributors: Aya C. Taki; Abdul Jabbar; Thomas Kurz; Beate Lungerich; Guangxu Ma; Joseph J. Byrne; Marc Pflieger; Yodita Asfaha; Fabian Fischer; Bill C. H. Chang et al.
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Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors

International Journal of Molecular Sciences
2020-11-05 | Journal article
DOI: 10.3390/ijms21218300
Contributors: Ana J. Rodrigues Moita; Jan J. Bandolik; Finn K. Hansen; Thomas Kurz; Alexandra Hamacher; Matthias U. Kassack
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In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi)

International Journal of Molecular Sciences
2020-07-03 | Journal article
DOI: 10.3390/ijms21134747
Contributors: Annabelle Friedrich; Ann-Sophie Assmann; Lena Schumacher; Jana v. Stuijvenberg; Matthias U. Kassack; Wolfgang A. Schulz; Wynand P. Roos; Finn K. Hansen; Marc Pflieger; Thomas Kurz et al.
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Synthesis of Peptoid-Based Class I-Selective Histone Deacetylase Inhibitors with Chemosensitizing Properties

Journal of Medicinal Chemistry
2019-12-26 | Journal article
DOI: 10.1021/acs.jmedchem.9b01489
Contributors: Viktoria Krieger; Alexandra Hamacher; Fangyuan Cao; Katharina Stenzel; Christoph G. W. Gertzen; Linda Schäker-Hübner; Thomas Kurz; Holger Gohlke; Frank J. Dekker; Matthias U. Kassack et al.
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Discovery of the First-in-Class Dual Histone Deacetylase–Proteasome Inhibitor

Journal of Medicinal Chemistry
2018-11-21 | Journal article
DOI: 10.1021/acs.jmedchem.8b01487
Contributors: Sanil Bhatia; Viktoria Krieger; Michael Groll; Jeremy D. Osko; Nina Reßing; Heinz Ahlert; Arndt Borkhardt; Thomas Kurz; David W. Christianson; Julia Hauer et al.
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Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity

Journal of Medicinal Chemistry
2018-09-13 | Journal article
DOI: 10.1021/acs.jmedchem.8b01013
Contributors: Nicholas J. Porter; Jeremy D. Osko; Daniela Diedrich; Thomas Kurz; Jacob M. Hooker; Finn K. Hansen; David W. Christianson
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3-Hydroxy-N′-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally

Journal of Medicinal Chemistry
2017-07-27 | Journal article
DOI: 10.1021/acs.jmedchem.7b00140
Contributors: Michael Leven; Tanja C. Knaab; Jana Held; Sandra Duffy; Stephan Meister; Christoph Fischli; Diane Meitzner; Ursula Lehmann; Beate Lungerich; Krystina Kuna et al.
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Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

Journal of Medicinal Chemistry
2017-07-13 | Journal article
DOI: 10.1021/acs.jmedchem.6b01538
Contributors: Katharina Stenzel; Alexandra Hamacher; Finn K. Hansen; Christoph G. W. Gertzen; Johanna Senger; Viktoria Marquardt; Linda Marek; Martin Marek; Christophe Romier; Marc Remke et al.
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Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

Journal of Medicinal Chemistry
2017-07-13 | Journal article
DOI: 10.1021/acs.jmedchem.7b00197
Contributors: Viktoria Krieger; Alexandra Hamacher; Christoph G. W. Gertzen; Johanna Senger; Martijn R. H. Zwinderman; Martin Marek; Christophe Romier; Frank J. Dekker; Thomas Kurz; Manfred Jung et al.
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Design and Synthesis of Novel Anti‐Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit

Archiv der Pharmazie
2017-04 | Journal article
DOI: 10.1002/ardp.201600347
Contributors: Leandro A. Alves Avelar; Jana Held; Jessica A. Engel; Parichat Sureechatchaiyan; Finn K. Hansen; Alexandra Hamacher; Matthias U. Kassack; Benjamin Mordmüller; Katherine T. Andrews; Thomas Kurz
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Peer review (56 reviews for 7 publications/grants)

Review activity for ACS infectious diseases. (2)
Review activity for ACS medicinal chemistry letters. (9)
Review activity for ACS omega. (2)
Review activity for ChemMedChem. (4)
Review activity for European journal of medicinal chemistry. (9)
Review activity for Journal of medicinal chemistry. (29)
Review activity for PloS one. (1)
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