Personal information

Websites & social links

My page at Barts Cancer Institute Website

Keywords

DNA damage response, phospho-dependent interactions, signalling

Countries

United Kingdom, Czech Republic

Activities

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Works (20)

Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase.

iScience
2023-02-01 | Journal article
DOI: 10.1016/j.isci.2023.106107
PMID: 36852271
PMC: PMC9958362
Contributors: Dullovi A; Ozgencil M; Rajvee V; Tse WY; Cutillas PR; Martin SA; Hořejší Z
Source: Self-asserted source
Zuzana Hořejší

Nuclear localisation of 53BP1 is regulated by phosphorylation of the nuclear localisation signal.

Biology of the cell
2018-03 | Journal article
DOI: 10.1111/boc.201700067
PMID: 29603287
Contributors: von Morgen P; Lidak T; Horejsi Z; Macurek L
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.

Oncogene
2017-08 | Journal article
DOI: 10.1038/onc.2017.99
PMID: 28436950
PMC: PMC5531254
Contributors: von Morgen P; Burdova K; Flower TG; O'Reilly NJ; Boulton SJ; Smerdon SJ; Macurek L; Hořejší Z
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

The Journal of cell biology
2017-06 | Journal article
DOI: 10.1083/jcb.201701165
PMID: 28515276
PMC: PMC5461031
Contributors: Malinová A; Cvačková Z; Matějů D; Hořejší Z; Abéza C; Vandermoere F; Bertrand E; Staněk D; Verheggen C
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation.

EMBO reports
2017-03 | Journal article
DOI: 10.15252/embr.201641983
PMID: 28077461
PMC: PMC5331243
Contributors: Hiraga SI; Ly T; Garzón J; Hořejší Z; Ohkubo YN; Endo A; Obuse C; Boulton SJ; Lamond AI; Donaldson AD
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Substrate recognition and function of the R2TP complex in response to cellular stress.

Frontiers in genetics
2015 | Journal article
DOI: 10.3389/fgene.2015.00069
PMID: 25767478
PMC: PMC4341119
Contributors: von Morgen P; Hořejší Z; Macurek L
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

Cell reports
2014-04 | Journal article
DOI: 10.1016/j.celrep.2014.03.013
PMID: 24656813
PMC: PMC3989777
Contributors: Hořejší Z; Stach L; Flower TG; Joshi D; Flynn H; Skehel JM; O'Reilly NJ; Ogrodowicz RW; Smerdon SJ; Boulton SJ
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.

The Journal of biological chemistry
2013-11 | Journal article
DOI: 10.1074/jbc.m113.459164
PMID: 23926104
PMC: PMC3820871
Contributors: Kulkarni A; Oza J; Yao M; Sohail H; Ginjala V; Tomas-Loba A; Horejsi Z; Tan AR; Boulton SJ; Ganesan S
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.

Nature
2013-10 | Journal article
DOI: 10.1038/nature12565
PMID: 24005329
PMC: PMC3836231
Contributors: Adelman CA; Lolo RL; Birkbak NJ; Murina O; Matsuzaki K; Horejsi Z; Parmar K; Borel V; Skehel JM; Stamp G et al.
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

Molecular cell
2010-09 | Journal article
DOI: 10.1016/j.molcel.2010.08.037
PMID: 20864032
Contributors: Horejsí Z; Takai H; Adelman CA; Collis SJ; Flynn H; Maslen S; Skehel JM; de Lange T; Boulton SJ
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.

Molecular cell
2010-07 | Journal article
DOI: 10.1016/j.molcel.2010.06.026
PMID: 20598602
Contributors: Adamo A; Collis SJ; Adelman CA; Silva N; Horejsi Z; Ward JD; Martinez-Perez E; Boulton SJ; La Volpe A
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Cytokine expression and signaling in drug-induced cellular senescence.

Oncogene
2010-01 | Journal article
DOI: 10.1038/onc.2009.318
PMID: 19802007
Contributors: Novakova Z; Hubackova S; Kosar M; Janderova-Rossmeislova L; Dobrovolna J; Vasicova P; Vancurova M; Horejsi Z; Hozak P; Bartek J et al.
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

Science (New York, N.Y.)
2009-09 | Journal article
DOI: 10.1126/science.1177321
PMID: 19661379
PMC: PMC3443743
Contributors: Ahel D; Horejsí Z; Wiechens N; Polo SE; Garcia-Wilson E; Ahel I; Flynn H; Skehel M; West SC; Jackson SP et al.
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

FANCM-FAAP24 and HCLK2: roles in ATR signalling and the Fanconi anemia pathway.

Cell cycle (Georgetown, Tex.)
2009-04 | Journal article
DOI: 10.4161/cc.8.8.8204
PMID: 19282663
Contributors: Horejŝí Z; Collis SJ; Boulton SJ
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex.

Molecular cell
2008-11 | Journal article
DOI: 10.1016/j.molcel.2008.10.014
PMID: 18995830
Contributors: Collis SJ; Ciccia A; Deans AJ; Horejsí Z; Martin JS; Maslen SL; Skehel JM; Elledge SJ; West SC; Boulton SJ
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours.

Oncogene
2007-11 | Journal article
DOI: 10.1038/sj.onc.1210553
PMID: 17546051
Contributors: Bartkova J; Horejsí Z; Sehested M; Nesland JM; Rajpert-De Meyts E; Skakkebaek NE; Stucki M; Jackson S; Lukas J; Bartek J
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.

Nature
2005-04 | Journal article
DOI: 10.1038/nature03482
PMID: 15829956
Contributors: Bartkova J; Horejsí Z; Koed K; Krämer A; Tort F; Zieger K; Guldberg P; Sehested M; Nesland JM; Lukas C et al.
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation.

Oncogene
2004-04 | Journal article
DOI: 10.1038/sj.onc.1207447
PMID: 15048089
Contributors: Horejsí Z; Falck J; Bakkenist CJ; Kastan MB; Lukas J; Bartek J
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma.

Oncogene
2003-02 | Journal article
DOI: 10.1038/sj.onc.1206105
PMID: 12569359
Contributors: Pajer P; Pecenka V; Karafiát V; Králová J; Horejsí Z; Dvorák M
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central

The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors.

Blood
2001-12 | Journal article
DOI: 10.1182/blood.v98.13.3668
PMID: 11739171
Contributors: Karafiát V; Dvoráková M; Pajer P; Králová J; Horejsí Z; Cermák V; Bartůnek P; Zenke M; Dvorák M
Source: Self-asserted source
Zuzana Hořejší via Europe PubMed Central
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