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Employment (3)

LOB - Laboratoire d’Optique et Biosciences CNRS UMR7645 – INSERM U1182: Palaiseau, FR

2022-01-01 to present (Laboratoire d'Optique et Biosciences, CNRS, INSERM)
Employment
Source: Self-asserted source
Lionel Guittat

Université Sorbonne Paris Nord: Bobigny, Ile de France, FR

2020-01 to present | Assistant professor (Laboratoire d'Optique et Biosciences, CNRS, INSERM, Ecole Polytechnique)
Employment
Source: Self-asserted source
Lionel Guittat

Université Sorbonne Paris Nord: Bobigny, Île-de-France, FR

2010-01 to 2019-12 | Assistant professor (Unité INSERM U978)
Employment
Source: Self-asserted source
Lionel Guittat

Education and qualifications (2)

Université Sorbonne Paris Nord: Villetaneuse, Ile de France, FR

2024-01-26 to present | Habilitation à Diriger des Recherches (HDR)
Qualification
Source: Self-asserted source
Lionel Guittat

Muséum National d'Histoire Naturelle: Paris, Île-de-France, FR

2000-09 to 2004-10 | Docteur
Education
Source: Self-asserted source
Lionel Guittat

Works (32)

G-quadruplex ligands as potent regulators of lysosomes

Autophagy
2023-07-03 | Journal article | Author
DOI: 10.1080/15548627.2023.2170071
Part of ISSN: 1554-8627
Part of ISSN: 1554-8635
Contributors: Lucille Ferret; Karla Alvarez-Valadez; Jennifer Rivière; Alexandra Muller; Natalia Bohálová; Luo Yu; Lionel Guittat; Václav Brázda; Guido Kroemer; Mergny JL et al.
Source: Self-asserted source
Lionel Guittat

G-quadruplexes in helminth parasites

Nucleic Acids Research
2022-03-21 | Newspaper article
DOI: 10.1093/nar/gkac129
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Alessio Cantara; Yu Luo; Michaela Dobrovolná; Natalia Bohalova; Miroslav Fojta; Daniela Verga; Lionel Guittat; Anne Cucchiarini; Solène Savrimoutou; Cécile Häberli et al.
Source: Self-asserted source
Lionel Guittat

Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells

Cellular Signalling
2021-10 | Journal article
DOI: 10.1016/j.cellsig.2021.110079
Part of ISSN: 0898-6568
Contributors: Rofia Boudria; Vanessa Laurienté; Antonin Oudar; Souleymane Harouna-Rachidi; Elisabetta Dondi; Christine Le Roy; Laura Gardano; Nadine Varin-Blank; Lionel Guittat
Source: Self-asserted source
Lionel Guittat

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

Nucleic Acids Research
2021-07-21 | Journal article
DOI: 10.1093/nar/gkab571
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Marc LAVIGNE; Olivier Helynck; Pascal Rigolet; Rofia Boudria-Souilah; Mireille Nowakowski; Bruno Baron; Sébastien Brülé; Sylviane Hoos; Bertrand Raynal; Lionel Guittat et al.
Source: Self-asserted source
Lionel Guittat

Télomères et télomérase : des cibles toujours pertinentes en oncologie ?

Bulletin du Cancer
2021-01 | Journal article
DOI: 10.1016/j.bulcan.2020.10.007
Part of ISSN: 0007-4551
Contributors: Jean-Louis Mergny; Lionel Guittat; Évelyne Ségal-Bendirdjian
Source: Self-asserted source
Lionel Guittat

Protein kinase D-dependent CXCR4 down-regulation upon BCR triggering is linked to lymphadenopathy in chronic lymphocytic leukaemia

Oncotarget
2016-04 | Journal article
DOI: 10.18632/oncotarget.9031
Part of ISSN: 1949-2553
Contributors: Stéphane Saint-Georges; Maude Quettier; Marouane Bouyaba; Stéphanie Le Coquil; Vanessa Laurienté; Lionel Guittat; Vincent Lévy; Florence Ajchenbaum-Cymbalista; Nadine Varin-Blank; Christine Le Roy et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Mutation of Vav1 adaptor region reveals a new oncogenic activation

Oncotarget
2014-10 | Journal article
DOI: 10.18632/oncotarget.2629
Part of ISSN: 1949-2553
Contributors: Lyra Razanadrakoto; Françoise Cormier; Vanessa Laurienté; Elisabetta Dondi; Laura Gardano; Shulamit Katzav; Lionel Guittat; Nadine Varin-Blank
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Cancer translocations in human cells induced by zinc finger and TALE nucleases

Genome Research
2013-04-08 | Journal article
DOI: 10.1101/gr.147314.112
Part of ISSN: 1088-9051
Contributors: M. Piganeau; H. Ghezraoui; A. De Cian; L. Guittat; M. Tomishima; L. Perrouault; O. Rene; G. E. Katibah; L. Zhang; M. C. Holmes et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Telomere Targeting with a New G4 Ligand Enhances Radiation-Induced Killing of Human Glioblastoma Cells

Molecular Cancer Therapeutics
2011-10-01 | Journal article
DOI: 10.1158/1535-7163.mct-10-0664
Part of ISSN: 1535-7163
Contributors: P. Merle; B. Evrard; A. Petitjean; J.-M. Lehn; M.-P. Teulade-Fichou; E. Chautard; A. De Cian; L. Guittat; P. L. T. Tran; J.-L. Mergny et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Revealing Novel Telomere Proteins Usingin VivoCross-linking, Tandem Affinity Purification, and Label-free Quantitative LC-FTICR-MS

Molecular & Cellular Proteomics
2010-01 | Journal article
DOI: 10.1074/mcp.m900490-mcp200
Part of ISSN: 1535-9476
Contributors: Thalia Nittis; Lionel Guittat; Richard D. LeDuc; Ben Dao; Julien P. Duxin; Henry Rohrs; R. Reid Townsend; Sheila A. Stewart
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

PLoS ONE
2009-09-09 | Journal article
DOI: 10.1371/journal.pone.0006919
Part of ISSN: 1932-6203
Contributors: Nassima Temime-Smaali; Lionel Guittat; Assitan Sidibe; Kazuo Shin-ya; Chantal Trentesaux; Jean-François Riou; Alfred Lewin
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

Molecular and Cellular Biology
2009-06-01 | Journal article
DOI: 10.1128/mcb.01834-08
Part of ISSN: 0270-7306
Contributors: J. P. Duxin; B. Dao; P. Martinsson; N. Rajala; L. Guittat; J. L. Campbell; J. N. Spelbrink; S. A. Stewart
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

DNA and RNA Quadruplex ligands

Nucleic Acids Symposium Series
2008-09-01 | Journal article
DOI: 10.1093/nass/nrn004
Part of ISSN: 0261-3166
Contributors: A. De Cian; J. Gros; A. Guedin; M. Haddi; S. Lyonnais; L. Guittat; J.-F. Riou; C. Trentesaux; B. Sacca; L. Lacroix et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Telomerase Inhibition: Strategies and Protocols. Edited by Lucy G. Andrews and Trygve O. Tollefsbol.

ChemMedChem
2008-07 | Journal article
DOI: 10.1002/cmdc.200800107
Part of ISSN: 1860-7179
Contributors: Lionel Guittat; Jean‐Louis Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Flap Endonuclease 1 Contributes to Telomere Stability

Current Biology
2008-04 | Journal article
DOI: 10.1016/j.cub.2008.02.071
Part of ISSN: 0960-9822
Contributors: Abhishek Saharia; Lionel Guittat; Sandra Crocker; Adeline Lim; Martin Steffen; Shashikant Kulkarni; Sheila A. Stewart
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Topoisomerase IIIα is required for normal proliferation and telomere stability in alternative lengthening of telomeres

The EMBO Journal
2008-04 | Journal article
DOI: 10.1038/emboj.2008.74
Part of ISSN: 0261-4189
Contributors: Nassima Temime-Smaali; Lionel Guittat; Thomas Wenner; Emilie Bayart; Céline Douarre; Dennis Gomez; Marie-Josèphe Giraud-Panis; Arturo Londono-Vallejo; Eric Gilson; Mounira Amor-Guéret et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Alternative lengthening of telomeres (ALT) and chromatin: Is there a connection?

Biochimie
2008-01 | Journal article
DOI: 10.1016/j.biochi.2007.08.009
Part of ISSN: 0300-9084
Contributors: Thalia Nittis; Lionel Guittat; Sheila A. Stewart
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Telomerase and Telomere Interacting Agents

Targeted Therapies in Oncology
2007-09 | Other
DOI: 10.3109/9781420020588-22
Part of ISBN: 9780849393716
Contributors: Jean-François Riou; Anne de Cian; Lionel Guittat; Dennis Gomez; Céline Douarre; Laurent Lacroix; Chantal Trentesaux; Jean-Louis Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Fluorescence-based melting assays for studying quadruplex ligands

Methods
2007-06 | Journal article
DOI: 10.1016/j.ymeth.2006.10.004
Part of ISSN: 1046-2023
Contributors: A DECIAN; L GUITTAT; M KAISER; B SACCA; S AMRANE; A BOURDONCLE; P ALBERTI; M TEULADEFICHOU; L LACROIX; J MERGNY
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study

ChemMedChem
2007-05 | Journal article
DOI: 10.1002/cmdc.200600286
Part of ISSN: 1860-7179
Contributors: Candide Hounsou; Lionel Guittat; David Monchaud; Muriel Jourdan; Nicolas Saettel; Jean-Louis Mergny; Marie-Paule Teulade-Fichou
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Affinity and selectivity of G4 ligands measured by FRET

Nucleic Acids Symposium Series
2005-09-01 | Journal article
DOI: 10.1093/nass/49.1.235
Part of ISSN: 1746-8272
Contributors: Anne De Cian; Lionel Guittat; Kazuo Shin-ya; Jean-François Riou; Jean-Louis Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro

Biochimica et Biophysica Acta (BBA) - General Subjects
2005-08 | Journal article
DOI: 10.1016/j.bbagen.2005.04.023
Part of ISSN: 0304-4165
Contributors: Lionel Guittat; Anne De Cian; Frédéric Rosu; Valérie Gabelica; Edwin De Pauw; Evelyne Delfourne; Jean-Louis Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Molecular Recognition of Quadruplex DNA by Quinacridine Derivatives

Nucleosides, Nucleotides and Nucleic Acids
2003-10 | Journal article
DOI: 10.1081/ncn-120023016
Part of ISSN: 1525-7770
Contributors: M.-P. Teulade-Fichou; C. Hounsou; L. Guittat; J.-L. Mergny; P. Alberti; C. Carrasco; C. Bailly; J.-M. Lehn; W. D. Wilson
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Selective Interaction of Ethidium Derivatives with Quadruplexes:  An Equilibrium Dialysis and Electrospray Ionization Mass Spectrometry Analysis†

Biochemistry
2003-09 | Journal article
DOI: 10.1021/bi034531m
Part of ISSN: 0006-2960
Contributors: Frederic Rosu; Edwin De Pauw; Lionel Guittat; Patrizia Alberti; Laurent Lacroix; Patrick Mailliet; Jean-François Riou; Jean-Louis Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Interactions of cryptolepine and neocryptolepine with unusual DNA structures

Biochimie
2003-05 | Journal article
DOI: 10.1016/s0300-9084(03)00035-x
Part of ISSN: 0300-9084
Contributors: Lionel Guittat; Patrizia Alberti; Frédéric Rosu; Sabine Van Miert; Emilie Thetiot; Luc Pieters; Valérie Gabelica; Edwin De Pauw; Alexandre Ottaviani; Jean-François Riou et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Selective Recognition of G-Quadruplex Telomeric DNA by a Bis(quinacridine) Macrocycle

Journal of the American Chemical Society
2003-04 | Journal article
DOI: 10.1021/ja021299j
Part of ISSN: 0002-7863
Contributors: Marie-Paule Teulade-Fichou; Carolina Carrasco; Lionel Guittat; Christian Bailly; Patrizia Alberti; Jean-Louis Mergny; Arnaud David; Jean-Marie Lehn; W. David Wilson
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Nucleic Acids as Targets for Antitelomerase Agents

Mini-Reviews in Medicinal Chemistry
2003-02-01 | Journal article
DOI: 10.2174/1389557033405485
Part of ISSN: 1389-5575
Contributors: Patrizia Alberti; Laurent Lacroix; Lionel Guittat; Claude Helene; Jean-Louis Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands

Proceedings of the National Academy of Sciences
2002-02 | Journal article
DOI: 10.1073/pnas.052698099
Part of ISSN: 0027-8424
Contributors: J. F. Riou; L. Guittat; P. Mailliet; A. Laoui; E. Renou; O. Petitgenet; F. Megnin-Chanet; C. Helene; J. L. Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Inhibiteurs de la télomérase : conséquences pour la thérapeutique anticancéreuse.

médecine/sciences
2001 | Journal article
DOI: 10.4267/10608/1826
Part of ISSN: 1958-5381
Contributors: L Guittat; P Alberti; JL Mergny; JF Riou; MP Teulade-Fichou; P Mailliet
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Interaction of an Acridine Dimer with DNA Quadruplex Structures

Journal of Biomolecular Structure and Dynamics
2001 | Journal article
DOI: 10.1080/07391102.2001.10506758
Part of ISSN: 0739-1102
Contributors: Patrizia Alberti; Jinsong Ren; Marie Paule Teulade-Fichou; Lionel Guittat; Jean-François Riou; Jonathan B. Chaires; Claude Hélène; Jean-Pierre Vigneron; Jean-Marie Lehn; Jean-Louis Mergny
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

Proceedings of the National Academy of Sciences
2001-03 | Journal article
DOI: 10.1073/pnas.051620698
Part of ISSN: 0027-8424
Contributors: J.-L. Mergny; L. Lacroix; M.-P. Teulade-Fichou; C. Hounsou; L. Guittat; M. Hoarau; P. B. Arimondo; J.-P. Vigneron; J.-M. Lehn; J.-F. Riou et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Triplex- versus Quadruplex-Specific Ligands and Telomerase Inhibition

Small Molecule DNA and RNA Binders
Other
DOI: 10.1002/3527601783.ch12
Part of ISBN: 3527305955
Contributors: Patrizia Alberti; Magali Hoarau; Lionel Guittat; Masashi Takasugi; Paola B. Arimondo; Laurent Lacroix; Martin Mills; Marie-Paule Teulade-Fichou; Jean-Pierre Vigneron; Jean-Marie Lehn et al.
Source: Self-asserted source
Lionel Guittat via Crossref Metadata Search

Peer review (2 reviews for 2 publications/grants)

Review activity for Chemical engineering journal. (1)
Review activity for Heliyon. (1)
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