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ResearcherID: G-3442-2012
Scopus Author ID: 6508128302

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Czech Republic

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Charles University, Faculty of Pharmacy in Hradec Kralove: Hradec Kralove, CZ

2012-01-01 to present | Academic Researcher (Dpt. of Pharmaceutical Chemistry and Pharmaceutical Analysis)
Employment
Source: Self-asserted source
Jan Zitko

Works (46)

Antimicrobial and Antiproliferative Properties of 2‐Phenyl‐N‐(Pyridin‐2‐yl)acetamides

Chemical Biology & Drug Design
2025-01 | Journal article
DOI: 10.1111/cbdd.70030
Contributors: Daria Nawrot; Barbora Koutníková; Ondřej Janďourek; Klára Konečná; Martin Novák; Pavla Paterová; Pavel Bárta; Ghada Bouz; Jan Zitko; Martin Doležal
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Crossref

The discovery of a new nonbile acid modulator of Takeda G protein‐coupled receptor 5: An integrated computational approach

Archiv der Pharmazie
2025-01 | Journal article
DOI: 10.1002/ardp.202400423
Contributors: Rudy Salam; Michael Bakker; Mária Krutáková; Alžbeta Štefela; Petr Pávek; Jurjen Duintjer Tebbens; Jan Zitko
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Crossref

N -Pyrazinylhydroxybenzamides As Biologically Active Compounds: A Hit-Expansion Study and Antimicrobial Evaluation

Future Medicinal Chemistry
2023-10 | Journal article
DOI: 10.4155/fmc-2023-0189
Contributors: Marek Kerda; Petr Šlechta; Ondrej Jand'ourek; Klara Konečná; Paulina Hatoková; Pavla Paterová; Jan Zitko
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Crossref

Adenosine-Mimicking Derivatives of 3-Aminopyrazine-2-Carboxamide: Towards Inhibitors of Prolyl-tRNA Synthetase with Antimycobacterial Activity

Biomolecules
2022-10-26 | Journal article
DOI: 10.3390/biom12111561
Contributors: Vinod Sukanth Kumar Pallabothula; Marek Kerda; Martin Juhás; Ondřej Janďourek; Klára Konečná; Pavel Bárta; Pavla Paterová; Jan Zitko
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Crossref
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Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole

Pharmaceuticals
2022-05 | Journal article | Author
DOI: 10.3390/ph15050580
Contributors: Martin Juhás; Andrea Bachtíková; Daria Nawrot; Paulína Hatoková; Vinod Sukanth Kumar Pallabothula; Adéla Diepoltová; Ondřej Janďourek; Pavel Barta; Klára Konečná; Pavla Paterová et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides

Pharmaceuticals
2021-08-04 | Journal article
DOI: 10.3390/ph14080768
Contributors: Ghada Bouz; Sarah Bouz; Ondřej Janďourek; Klára Konečná; Pavel Bárta; Jarmila Vinšová; Martin Doležal; Jan Zitko
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Crossref
grade
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Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies

International Journal of Molecular Sciences
2021-07-21 | Journal article
DOI: 10.3390/ijms22157793
Contributors: Luping Pang; Stephen D. Weeks; Martin Juhás; Sergei V. Strelkov; Jan Zitko; Arthur Van Aerschot
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Crossref
grade
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N‐pyridinylbenzamides: an isosteric approach towards new antimycobacterial compounds

Chemical Biology & Drug Design
2021-03 | Journal article
DOI: 10.1111/cbdd.13804
Contributors: Daria Nawrot; Eliška Suchánková; Ondřej Janďourek; Klára Konečná; Pavel Bárta; Martin Doležal; Jan Zitko
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Crossref

Molecular Interactions of Pyrazine-Based Compounds to Proteins

Journal of Medicinal Chemistry
2020-09-10 | Journal article
DOI: 10.1021/acs.jmedchem.9b02021
Contributors: Martin Juhás; Jan Zitko
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Crossref

5-Alkylamino-<i>N</i>-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation

Molecules
2020-03 | Journal article | Author
DOI: 10.3390/molecules25071561
Contributors: Weronika Ambrożkiewicz; Marta Kučerová-Chlupáčová; Ondřej Janďourek; Klára Konečná; Pavla Paterová; Pavel Barta; Jarmila Vinšová; Martin Dolezal; Jan Zitko
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Multidisciplinary Digital Publishing Institute
grade
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<em>N</em>-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents—The Synthesis and Biological Evaluation of Enantiomers

Molecules
2020-03 | Journal article | Author
DOI: 10.3390/molecules25071518
Contributors: Martin Juhás; Lucie Kučerová; Ondřej Horáček; Ondřej Janďourek; Vladimír Kubíček; Klára Konečná; Radim Kučera; Pavel Barta; Jiří Janoušek; Pavla Paterová et al.
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Multidisciplinary Digital Publishing Institute

Exploring the detailed spectroscopic characteristics, chemical and biological activity of two cyanopyrazine-2-carboxamide derivatives using experimental and theoretical tools

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
2020-01 | Journal article
DOI: 10.1016/j.saa.2019.117414
Contributors: Shargina Beegum; Y. Sheena Mary; Y. Shyma Mary; Renjith Thomas; Stevan Armaković; Sanja J. Armaković; Jan Zitko; Martin Dolezal; C. Van Alsenoy
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Crossref

Substituted <i>N</i>-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies

Molecules
2019-12 | Journal article | Author
DOI: 10.3390/molecules25010138
Contributors: Ghada Bouz; Martin Juhás; Lluis Pausas Otero; Cristina Paredes de la Red; Ondřej Janďourek; Klára Konečná; Pavla Paterová; Vladimír Kubíček; Jiří Janoušek; Martin Dolezal et al.
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Multidisciplinary Digital Publishing Institute

Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity

Molecules
2019-03-28 | Journal article
DOI: 10.3390/molecules24071212
Contributors: Ghada Bouz; Lucia Semelková; Ondřej Janďourek; Klára Konečná; Pavla Paterová; Lucie Navrátilová; Vladimír Kubíček; Jiří Kuneš; Martin Doležal; Jan Zitko
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Crossref
grade
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Design, synthesis and antimycobacterial activity of hybrid molecules combining pyrazinamide with a 4-phenylthiazol-2-amine scaffold

MedChemComm
2018 | Journal article
DOI: 10.1039/C8MD00056E
Contributors: Jan Zitko; Ondřej Jand'ourek; Pavla Paterová; Lucie Navrátilová; Jiří Kuneš; Jarmila Vinšová; Martin Doležal
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Crossref

Design, Synthesis and Evaluation of <i>N</i>-pyrazinylbenzamides as Potential Antimycobacterial Agents

Molecules
2018-09 | Journal article | Author
DOI: 10.3390/molecules23092390
Contributors: Jan Zitko; Alžběta Mindlová; Ondřej Valášek; Ondřej Janďourek; Pavla Paterová; Jiří Janoušek; Klára Konečná; Martin Dolezal
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Design, synthesis, antimycobacterial evaluation, and in silico studies of 3-(phenylcarbamoyl)-pyrazine-2-carboxylic acids

Molecules
2017 | Journal article
DOI: 10.3390/molecules22091491
EID:

2-s2.0-85029660516
Contributors: Semelková, L.; Janošcová, P.; Fernandes, C.; Bouz, G.; Jand’Ourek, O.; Konečná, K.; Paterová, P.; Navrátilová, L.; Kuneš, J.; Doležal, M. et al.
Source: Self-asserted source
Jan Zitko via Scopus - Elsevier

Synthesis of novel pyrazinamide derivatives based on 3-chloropyrazine-2-carboxamide and their antimicrobial evaluation

Molecules
2017 | Journal article
DOI: 10.3390/molecules22020223
EID:

2-s2.0-85013997060
Contributors: Jandourek, O.; Tauchman, M.; Paterova, P.; Konecna, K.; Navratilova, L.; Kubicek, V.; Holas, O.; Zitko, J.; Dolezal, M.
Source: Self-asserted source
Jan Zitko via Scopus - Elsevier
grade
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Vibrational spectroscopic analysis of cyanopyrazine-2-carboxamide derivatives and investigation of their reactive properties by DFT calculations and molecular dynamics simulations

Journal of Molecular Structure
2017 | Journal article
DOI: http://dx.doi.org/10.1016/j.molstruc.2016.11.044
Contributors: Beegum, Shargina; Mary, Y. Sheena; Varghese, Hema Tresa; Panicker, C. Yohannan; Armaković, Stevan; Armaković, Sanja J.; Zitko, Jan; Dolezal, Martin; Van Alsenoy, C.
Source: Self-asserted source
Jan Zitko via ResearcherID
grade
Preferred source (of 2)‎

The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot <sup>†</sup>

Molecules
2017-10 | Journal article
DOI: 10.3390/molecules22111848
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Multidisciplinary Digital Publishing Institute

Ureidopyrazine Derivatives: Synthesis and Biological Evaluation as Anti-Infectives and Abiotic Elicitors

Molecules
2017-10 | Journal article
DOI: 10.3390/molecules22101797
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

FT-IR and FT-Raman characterization and investigation of reactive properties of N-(3-iodo-4-methylphenyl)pyrazine-2-carboxamide by molecular dynamics simulations and DFT calculations

Journal of Molecular Structure
2017-05 | Journal article
DOI: 10.1016/j.molstruc.2017.01.079
Contributors: P.K. Ranjith; Ebtehal S. Al-Abdullah; Fatmah A.M. Al-Omary; Ali A. El-Emam; P.L. Anto; Mary Y. Sheena; Stevan Armaković; Sanja J. Armaković; Jan Zitko; Martin Dolezal et al.
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Crossref

3-Substituted <em>N</em>-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation

Molecules
2017-03 | Journal article
DOI: 10.3390/molecules22030495
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Design, synthesis and anti-mycobacterial evaluation of some new N-phenylpyrazine-2-carboxamides

Chemical Papers
2016 | Journal article
DOI: 10.1515/chempap-2015-0246
WOSUID:

WOS:000376512000014
Contributors: Zitko, J.; Servusova-Vanaskova, B.; Paterova, P.; Navratilova, L.; Trejtnar, F.; Kunes, J.; Dolezal, M.
Source: Self-asserted source
Jan Zitko via ResearcherID

Enoyl acyl carrier protein reductase inhibitors: an updated patent review (2011 - 2015)

Expert Opin Ther Pat
2016 | Journal article
DOI: 10.1080/13543776.2016.1211112
Contributors: Zitko, J.; Dolezal, M.
Source: Self-asserted source
Jan Zitko via ResearcherID

Spectroscopic, quantum chemical studies, Fukui functions, in vitro antiviral activity and molecular docking of 5-chloro-N-(3-nitrophenyl) pyrazine-2-carboxamide

Journal of Molecular Structure
2016 | Journal article
DOI: 10.1016/j.molstruc.2016.04.088
WOSUID:

WOS:000378360000022
Contributors: Sebastian, S. H. R.; Al-Alshaikh, M. A.; El-Emam, A. A.; Panicker, C. Y.; Zitko, J.; Dolezal, M.; VanAlsenoy, C.
Source: Self-asserted source
Jan Zitko via ResearcherID

Alkylamino derivatives of N-benzylpyrazine-2-carboxamide: synthesis and antimycobacterial evaluation

Medchemcomm
2015 | Journal article
DOI: 10.1039/c5md00178a
WOSUID:

WOS:000357786200012
Contributors: Servusova-Vanaskova, B.; Jandourek, O.; Paterova, P.; Kordulakova, J.; Plevakova, M.; Kubicek, V.; Kucera, R.; Garaj, V.; Naesens, L.; Kunes, J. et al.
Source: Self-asserted source
Jan Zitko via ResearcherID

Indole-2-carboxamide derivatives: a patent evaluation of WO2015036412A1

Expert Opinion on Therapeutic Patents
2015 | Journal article
DOI: 10.1517/13543776.2015.1101066
WOSUID:

WOS:000366528500003
Contributors: Zitko, J.; Dolezal, M.
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis and anti-infective evaluation of 5-amino-N-phenylpyrazine-2-carboxamides

Ceska Slov Farm
2015 | Journal article
SOURCE-WORK-ID:

1209160825113-520
Contributors: Zitko, J.; Franco, F.; Paterova, P.
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis and anti-infective evaluation of 5-amino-N-phenylpyrazine-2-carboxamides

Ceska a Slovenska Farmacie
2015 | Journal article
EID:

2-s2.0-84937458327
Contributors: Zitko, J.; Franco, F.; Paterová, P.
Source: Self-asserted source
Jan Zitko via Scopus - Elsevier

Synthesis and Antimicrobial Evaluation of 6-Alkylamino-N-phenylpyrazine-2-carboxamides

Chemical Biology &amp; Drug Design
2015 | Journal article
DOI: 10.1111/cbdd.12536
WOSUID:

WOS:000362163500031
Contributors: Servusova-Vanaskova, B.; Paterova, P.; Garaj, V.; Mandikova, J.; Kunes, J.; Naesens, L.; Jilek, P.; Dolezal, M.; Zitko, J.
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis and antimycobacterial evaluation of 5-alkylamino-N-phenylpyrazine-2-carboxamides

Bioorganic &amp; Medicinal Chemistry
2015 | Journal article
DOI: 10.1016/j.bmc.2014.11.014
WOSUID:

WOS:000346586400018
Contributors: Zitko, Jan; Servusova, Barbora; Janoutova, Alena; Paterova, Pavla; Mandikova, Jana; Garaj, Vladimir; Vejsova, Marcela; Marek, Jan; Dolezal, Martin
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis and Biological Evaluation of N-Alkyl-3-(alkylamino)-pyrazine-2-carboxamides

Molecules
2015 | Journal article
DOI: 10.3390/molecules20058687
WOSUID:

WOS:000357157600074
Contributors: Semelkova, L.; Konecna, K.; Paterova, P.; Kubicek, V.; Kunes, J.; Novakova, L.; Marek, J.; Naesens, L.; Pesko, M.; Kralova, K. et al.
Source: Self-asserted source
Jan Zitko via ResearcherID

Alkylamino derivatives of pyrazinamide: Synthesis and antimycobacterial evaluation

Bioorganic &amp; Medicinal Chemistry Letters
2014 | Journal article
DOI: 10.1016/j.bmcl.2013.12.054
WOSUID:

WOS:000329430600007
Contributors: Servusova, B.; Paterova, P.; Mandikova, J.; Kubicek, V.; Kucera, R.; Kunes, J.; Dolezal, M.; Zitko, J.
Source: Self-asserted source
Jan Zitko via ResearcherID

New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions

Molecules
2014 | Journal article
DOI: 10.3390/molecules19079318
WOSUID:

WOS:000340036200039
Contributors: Jandourek, O.; Dolezal, M.; Kunes, J.; Kubicek, V.; Paterova, P.; Pesko, M.; Buchta, V.; Kralova, K.; Zitko, J.
Source: Self-asserted source
Jan Zitko via ResearcherID
grade
Preferred source (of 2)‎

Pyrazine derivatives: a patent review (June 2012-present)

Expert Opinion on Therapeutic Patents
2014 | Journal article
DOI: 10.1517/13543776.2014.982533
WOSUID:

WOS:000346742700004
Contributors: Dolezal, Martin; Zitko, Jan
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis and antimycobacterial evaluation of N-substituted 5-chloropyrazine-2-carboxamides

Bioorganic &amp; Medicinal Chemistry Letters
2013 | Journal article
DOI: 10.1016/j.bmcl.2013.04.021
WOSUID:

WOS:000319268500023
Contributors: Servusova, B.; Vobickova, J.; Paterova, P.; Kubicek, V.; Kunes, J.; Dolezal, M.; Zitko, J.
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis and antimycobacterial evaluation of pyrazinamide derivatives with benzylamino substitution

Bioorganic &amp; Medicinal Chemistry Letters
2013 | Journal article
DOI: 10.1016/j.bmcl.2012.11.052
WOSUID:

WOS:000312959600018
Contributors: Zitko, J.; Paterova, P.; Kubicek, V.; Mandikova, J.; Trejtnar, F.; Kunes, J.; Dolezal, M.
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis, Antimycobacterial Activity and In Vitro Cytotoxicity of 5-Chloro-N-phenylpyrazine-2-carboxamides

Molecules
2013 | Journal article
DOI: 10.3390/molecules181214807
WOSUID:

WOS:000330315700023
Contributors: Zitko, J.; Servusova, B.; Paterova, P.; Mandikova, J.; Kubicek, V.; Kucera, R.; Hrabcova, V.; Kunes, J.; Soukup, O.; Dolezal, M.
Source: Self-asserted source
Jan Zitko via ResearcherID
grade
Preferred source (of 2)‎

Erratum: Synthesis and antimycobacterial evaluation of N-substituted 3-aminopyrazine-2,5-dicarbonitriles (Bioorganic and Medicinal Chemistry Letters (2012) 22 (1598-1601))

Bioorganic and Medicinal Chemistry Letters
2012 | Journal article
DOI: 10.1016/j.bmcl.2012.02.018
EID:

2-s2.0-84858705425
Contributors: Zitko, J.; Jampílek, J.; Dobrovolný, L.; Svobodová, M.; Kuneš, J.; Doležal, M.
Source: Self-asserted source
Jan Zitko via Scopus - Elsevier

Synthesis and antimycobacterial evaluation of N-substituted 3-aminopyrazine-2,5-dicarbonitriles

Bioorganic &amp; Medicinal Chemistry Letters
2012 | Journal article
DOI: 10.1016/j.bmcl.2011.12.129
WOSUID:

WOS:000300404900022
Contributors: Zitko, J.; Jampilek, J.; Dobrovolny, L.; Svobodova, M.; Kunes, J.; Dolezal, M.
Source: Self-asserted source
Jan Zitko via ResearcherID

Antimycobacterial evaluation of pyrazinoic acid reversible derivatives

Current Pharmaceutical Design
2011 | Journal article
DOI: 10.2174/138161211798194477
EID:

2-s2.0-82055161621
Contributors: Dolezal, M.; Kesetovic, D.; Zitko, J.
Source: Self-asserted source
Jan Zitko via Scopus - Elsevier

Antimycobacterial Evaluation of Pyrazinoic Acid Reversible Derivatives

Current Pharmaceutical Design
2011 | Journal article
WOSUID:

WOS:000299637000004
Contributors: Dolezal, M.; Kesetovic, D.; Zitko, J.
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis and antimycobacterial properties of N-substituted 6-amino-5-cyanopyrazine-2-carboxamides

Bioorganic &amp; Medicinal Chemistry
2011 | Journal article
DOI: 10.1016/j.bmc.2010.12.054
WOSUID:

WOS:000287592100012
Contributors: Zitko, J.; Dolezal, M.; Svobodova, M.; Vejsova, M.; Kunes, J.; Kucera, R.; Jilek, P.
Source: Self-asserted source
Jan Zitko via ResearcherID

Synthesis, Antimycobacterial, Antifungal and Photosynthesis-Inhibiting Activity of Chlorinated N-phenylpyrazine-2-carboxamides

Molecules
2010 | Journal article
DOI: 10.3390/molecules15128567
WOSUID:

WOS:000285709000004
Contributors: Dolezal, M.; Zitko, J.; Osicka, Z.; Kunes, J.; Vejsova, M.; Buchta, V.; Dohnal, J.; Jampilek, J.; Kralova, K.
Source: Self-asserted source
Jan Zitko via ResearcherID
grade
Preferred source (of 2)‎

Substituted N-Phenylpyrazine-2-carboxamides: Synthesis and Antimycobacterial Evaluation

Molecules
2009 | Journal article
DOI: 10.3390/molecules14104180
WOSUID:

WOS:000271265300025
Contributors: Dolezal, M.; Zitko, J.; Kesetovicova, D.; Kunes, J.; Svobodova, M.
Source: Self-asserted source
Jan Zitko via ResearcherID
grade
Preferred source (of 2)‎

Peer review (31 reviews for 13 publications/grants)

Review activity for Antibiotics. (1)
Review activity for Antioxidants. (1)
Review activity for ChemistrySelect (2)
Review activity for ChemMedChem. (2)
Review activity for International journal of molecular sciences. (1)
Review activity for Journal of medicinal chemistry. (1)
Review activity for Marine drugs. (1)
Review activity for Molbank. (1)
Review activity for Molecules. (16)
Review activity for Pharmaceuticals. (1)
Review activity for Pharmaceutics. (2)
Review activity for Pharmacological Reports. (1)
Review activity for Plants. (1)
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