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Employment (2)

University of Innsbruck: Innsbruck, AT

2019-08 to present
Employment
Source: Self-asserted source
Teresa Kaserer

Institute of Cancer Research: London, London, GB

2016-01 to 2019-05
Employment
Source: Self-asserted source
Teresa Kaserer

Education and qualifications (1)

University of Innsbruck: Innsbruck, AT

Mag. pharm (Institute of Pharmacy)
Education
Source: Self-asserted source
Teresa Kaserer

Works (29)

Disruptor: Computational identification of oncogenic mutants disrupting protein-protein and protein-DNA interactions

Communications Biology
2023-07-13 | Journal article
DOI: 10.1038/s42003-023-05089-2
Contributors: Valentina Kugler; Andreas Lieb; Nathan Guerin; Bruce R. Donald; Eduard Stefan; Teresa Kaserer
Source: check_circle
Crossref

Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?

British Journal of Pharmacology
2023-05 | Journal article
DOI: 10.1111/bph.16060
Contributors: Ludovica Filippini; Nadine J. Ortner; Teresa Kaserer; Jörg Striessnig
Source: check_circle
Crossref

DISRUPTOR: Computational identification of oncogenic mutants disrupting protein interactions

2022-11-03 | Preprint
DOI: 10.1101/2022.11.02.514903
Contributors: V Kugler; A Lieb; N Guerin; BR Donald; E Stefan; T Kaserer
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Crossref

Novel CACNA1A Variant p.Cys256Phe Disrupts Disulfide Bonds and Causes Spinocerebellar Ataxia

Movement Disorders
2022-02 | Journal article
DOI: 10.1002/mds.28835
Part of ISSN: 0885-3185
Part of ISSN: 1531-8257
Contributors: Teresa Kaserer
Source: Self-asserted source
Teresa Kaserer

Resistor: an algorithm for predicting resistance mutations using Pareto optimization over multistate protein design and mutational signatures

2022-01-20 | Preprint
DOI: 10.1101/2022.01.18.476733
Contributors: Nathan Guerin; Andreas Feichtner; Eduard Stefan; Teresa Kaserer; Bruce R. Donald
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Crossref

Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides

Biomedicines
2021-12-11 | Journal article
DOI: 10.3390/biomedicines9121882
Contributors: Andreas Lieb; Germana Thaler; Barbara Fogli; Olga Trovato; Mitja Amon Posch; Teresa Kaserer; Luca Zangrandi
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Crossref
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Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists

Scientific Reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-70493-1
Part of ISSN: 2045-2322
Source: Self-asserted source
Teresa Kaserer

De novo CACAN1D Ca2+ channelopathies: clinical phenotypes and molecular mechanism

Pflügers Archiv - European Journal of Physiology
2020-06-24 | Journal article
DOI: 10.1007/s00424-020-02418-w
Part of ISSN: 0031-6768
Part of ISSN: 1432-2013
Source: Self-asserted source
Teresa Kaserer

A systematic molecular and pharmacologic evaluation of AKT inhibitors reveals new insight into their biological activity

British Journal of Cancer
2020-05-22 | Journal article
DOI: 10.1038/s41416-020-0889-4
Part of ISSN: 0007-0920
Part of ISSN: 1532-1827
Source: Self-asserted source
Teresa Kaserer

Steroid sulfatase inhibiting lanostane triterpenes – Structure activity relationship and in silico insights

Bioorganic Chemistry
2020-01 | Journal article
DOI: 10.1016/j.bioorg.2019.103495
Part of ISSN: 0045-2068
Source: Self-asserted source
Teresa Kaserer

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action

mAbs
2020-01-01 | Journal article
DOI: 10.1080/19420862.2020.1801230
Part of ISSN: 1942-0862
Part of ISSN: 1942-0870
Source: Self-asserted source
Teresa Kaserer

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

eLife
2019-12-04 | Journal article
DOI: 10.7554/eLife.48876
Contributors: Judith Hagenbuchner; Veronika Obsilova; Teresa Kaserer; Nora Kaiser; Bettina Rass; Katarina Psenakova; Vojtech Docekal; Miroslava Alblova; Klara Kohoutova; Daniela Schuster et al.
Source: check_circle
Crossref

A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma.

Oncogene
2019-10-07 | Journal article
DOI: 10.1038/s41388-019-1044-7
PMID: 31591479
Source: Self-asserted source
Teresa Kaserer

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase.

The Journal of steroid biochemistry and molecular biology
2019-04-06 | Journal article
DOI: 10.1016/j.jsbmb.2019.04.007
PMID: 30965118
Source: Self-asserted source
Teresa Kaserer

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

Science Advances
2019-04-05 | Journal article
DOI: 10.1126/sciadv.aaw1567
Contributors: Mikail Weston; Teresa Kaserer; Angela Wu; Alexandre Mouravlev; Jenna C. Carpenter; Albert Snowball; Samuel Knauss; Melanie von Schimmelmann; Matthew J. During; Gabriele Lignani et al.
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Crossref

De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder.

American journal of human genetics
2019-03-21 | Journal article
DOI: 10.1016/j.ajhg.2019.02.006
PMID: 30905399
Source: Self-asserted source
Teresa Kaserer

Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates.

ACS chemical biology
2018-08-27 | Journal article
DOI: 10.1021/acschembio.8b00639
PMID: 30130388
PMC: PMC6430498
Source: Self-asserted source
Teresa Kaserer

Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer.

Cell chemical biology
2018-08-23 | Journal article
DOI: 10.1016/j.chembiol.2018.07.013
PMID: 30146241
PMC: PMC6242700
Source: Self-asserted source
Teresa Kaserer

Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases.

International journal of molecular sciences
2017-09-19 | Journal article
DOI: 10.3390/ijms18092007
PMID: 28925944
PMC: PMC5618656
Source: Self-asserted source
Teresa Kaserer

Virtual screening applications in short-chain dehydrogenase/reductase research.

The Journal of steroid biochemistry and molecular biology
2017-03-09 | Journal article
DOI: 10.1016/j.jsbmb.2017.03.008
PMID: 28286207
Source: Self-asserted source
Teresa Kaserer

Evaluation of selected 3D virtual screening tools for the prospective identification of peroxisome proliferator-activated receptor (PPAR) γ partial agonists

European Journal of Medicinal Chemistry
2016-11 | Journal article
DOI: 10.1016/j.ejmech.2016.07.072
Part of ISSN: 0223-5234
Source: Self-asserted source
Teresa Kaserer

Optimized Virtual Screening Workflow for the Identification of Novel G-Quadruplex Ligands.

Journal of chemical information and modeling
2016-03-01 | Journal article
DOI: 10.1021/acs.jcim.5b00658
PMID: 26841201
Source: Self-asserted source
Teresa Kaserer

μ Opioid receptor: novel antagonists and structural modeling.

Scientific reports
2016-02-18 | Journal article
DOI: 10.1038/srep21548
PMID: 26888328
PMC: PMC4757823
Source: Self-asserted source
Teresa Kaserer

Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases.

Molecules (Basel, Switzerland)
2015-12-19 | Journal article
DOI: 10.3390/molecules201219880
PMID: 26703541
PMC: PMC6332202
Source: Self-asserted source
Teresa Kaserer

Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2.

European journal of medicinal chemistry
2015-07-10 | Journal article
DOI: 10.1016/j.ejmech.2015.07.003
PMID: 26197159
Source: Self-asserted source
Teresa Kaserer

In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance.

Molecular informatics
2015-06-23 | Journal article
DOI: 10.1002/minf.201400192
PMID: 27490388
Source: Self-asserted source
Teresa Kaserer

Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2.

European journal of medicinal chemistry
2015-04-08 | Journal article
DOI: 10.1016/j.ejmech.2015.04.017
PMID: 25916906
PMC: PMC4444576
Source: Self-asserted source
Teresa Kaserer

Accessing biological actions of Ganoderma secondary metabolites by in silico profiling.

Phytochemistry
2014-11-06 | Journal article
DOI: 10.1016/j.phytochem.2014.10.010
PMID: 25457486
PMC: PMC4948669
Source: Self-asserted source
Teresa Kaserer

Pharmacophore modeling for COX-1 and -2 inhibitors with LigandScout in comparison to Discovery Studio.

Future medicinal chemistry
2014-01-01 | Journal article
DOI: 10.4155/fmc.14.114
PMID: 25495981
Source: Self-asserted source
Teresa Kaserer
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