Lisa Strug (0000-0003-0503-9740)

Personal information

Biography

Dr. Strug is Professor in the Departments of Statistical Sciences, Computer Science and cross-appointed in Biostatistics at the University of Toronto and is a Senior Scientist in the Program in Genetics and Genome Biology at the Hospital for Sick Children. Dr. Strug is the inaugural Director of the Data Sciences Institute (DSI), a tri-campus, multi-divisional, multi-institutional, multi-disciplinary hub for data science activity at the University of Toronto and affiliated Research Institutes. The DSI’s goal is to accelerate the impact of data sciences across the disciplines to address pressing societal questions and drive positive social change. Dr. Strug holds several other leadership positions at the University of Toronto including the Director of the Canadian Statistical Sciences Institute Ontario Region (CANSSI Ontario), and at the Hospital for Sick Children as Associate Director of the Centre for Applied Genomics and the Lead of the Canadian Cystic Fibrosis Gene Modifier Consortium and the Biology of Juvenile Myoclonic Epilepsy International Consortium. She is a statistical geneticist and her research focuses on the development of novel statistical approaches to analyze and integrate multi-omics data to identify genetic contributors to complex human disease. She has received several honours including the Tier 1 Canada Research Chair in Genome Data Science.

Activities

Collapse all

University of Toronto: Toronto, ON, CA

2021 to present | Professor (Department of Statistical Sciences)

Employment

Lisa Strug

https://orcid.org/0000-0003-0503-9740

Personal information

Websites & social links

Keywords

Countries

Biography

Activities

Employment (7)

University of Toronto: Toronto, ON, CA

University of Toronto: ON, ON, CA

University of Toronto: ON, ON, CA

Canadian Statistical Sciences Institute (CANSSI): Toronto, ON, CA

The Hospital for Sick Children: Toronto, ON, CA

University of Toronto: Toronto, ON, CA

Hospital for Sick Children: Toronto, Ontario, CA

Education and qualifications (5)

Columbia University: New York, New York, US

University of Toronto: ON, ON, CA

Johns Hopkins University: Baltimore, Maryland, US

University of Toronto: Toronto, ON, CA

Western University: London, ON, CA

Professional activities (2)

The Hospital for Sick Children: Toronto, ON, CA

University of Toronto: Toronto, ON, CA

Works (50 of 100)

Directional integration and pathway enrichment analysis for multi-omics data

RoPE: A robust profile likelihood method for differential gene expression analysis

A robust association test leveraging unknown genetic interactions: Application to cystic fibrosis lung disease

Expression of cystic fibrosis lung disease modifier genes in human airway models

RoPE: a robust profile likelihood method for differential gene expression analysis

Leveraging TOPMed imputation server and constructing a cohort-specific imputation reference panel to enhance genotype imputation among cystic fibrosis patients

A flexible summary statistics-based colocalization method with application to the mucin cystic fibrosis lung disease modifier locus

Sex-specific disease modifiers in juvenile kyoclonic epilepsy.

649: Pharmacologic response of rare CFTR folding variants is mediated by a silent polymorphism that alters ribosome velocity

Correction to: Cystic fibrosis–related diabetes onset can be predicted using biomarkers measured at birth

The X factor: A robust and powerful approach to X‐chromosome‐inclusive whole‐genome association studies

Implementation of serological and molecular tools to inform COVID-19 patient management: protocol for the GENCOV prospective cohort study

Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder

Cystic fibrosis–related diabetes onset can be predicted using biomarkers measured at birth

Trait impulsivity in Juvenile Myoclonic Epilepsy

Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity

PHI-Compliant Computing and Storage: a critical need for Canadian biomedical and health research

Statistical power in COVID-19 case-control host genomic study design

A Distributed Whole Genome Sequencing Benchmark Study

Mining GWAS and eQTL data for CF lung disease modifiers by gene expression imputation

Genome‐wide association study of word reading: Overlap with risk genes for neurodevelopmental disorders

The CFTR Mutation c.3453G > C (D1152H) Confers an Anion Selectivity Defect in Primary Airway Tissue that Can be Rescued by Ivacaftor

Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits

Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease

Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1

LocusFocus: A web-based colocalization tool for the annotation and functional follow-up of GWAS

Impact of DNA source on genetic variant detection from human whole-genome sequencing data

VikNGS: A C ++ Variant Integration Kit for Next Generation Sequencing Association Analysis

Visceral fat-related systemic inflammation and the adolescent brain: a mediating role of circulating glycerophosphocholines

Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci

AGTR2 absence or antagonism prevents cystic fibrosis pulmonary manifestations

The CF Canada-Sick Kids Program in individual CF therapy: A resource for the advancement of personalized medicine in CF

Genetic association analysis with pedigrees: Direct inference using the composite likelihood ratio

Improving imputation in disease-relevant regions: lessons from cystic fibrosis

The evidential statistical paradigm in genetics

Recent advances in developing therapeutics for cystic fibrosis

SLC26A9 Gene Is Associated With Lung Function Response to Ivacaftor in Patients With Cystic Fibrosis

Reference percentiles of FEV1 for the Canadian cystic fibrosis population: comparisons across time and countries

Testing Calibration of Cox Survival Models at Extremes of Event Risk

Translational research to enable personalized treatment of cystic fibrosis

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants

Airway Mucosal Host Defense Is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity

Don't judge a book by its cover: the emerging challenge of diagnosing CF in non-Caucasians

Leveraging cell type specific regulatory regions to detect SNPs associated with tissue factor pathway inhibitor plasma levels

Reply to: Is a microRNA-328 binding site in PAX6 associated with Rolandic epilepsy?

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder

Sources of Variation in Sweat Chloride Measurements in Cystic Fibrosis

Novel variation at chr11p13 associated with cystic fibrosis lung disease severity

Glycerophosphocholine Metabolites and Cardiovascular Disease Risk Factors in Adolescents

Peer review (2 reviews for 2 publications/grants)