Personal information

Other IDs

ResearcherID: E-9658-2015
Scopus Author ID: 7601462187

Keywords

amyloid, protein aggregation, protein-lipid interaction, fluorescence, alpha-synuclein

Countries

United States

Activities

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Employment (2)

National Institutes of Health: Bethesda, MD, US

2016-03-22 to present | Senior Investigator
Employment
Source: Self-asserted source
Jennifer Lee

National Institutes of Health: Bethesda, MD, US

2006-10-01 to 2016-03-21 | Investigator
Employment
Source: Self-asserted source
Jennifer Lee

Education and qualifications (3)

California Institute of Technology: Pasadena, CA, US

1997 to 2002 | Ph.D. (Chemistry)
Education
Source: Self-asserted source
Jennifer Lee

University of California Berkeley: Berkeley, CA, US

1993 to 1997 | B.S. (Chemistry)
Education
Source: Self-asserted source
Jennifer Lee

University of California Berkeley: Berkeley, CA, US

1993 to 1997 | B.A. (Economics)
Education
Source: Self-asserted source
Jennifer Lee

Works (50 of 88)

Items per page:
Page 1 of 2

Raman spectroscopy and imaging of protein droplet formation and aggregation

Current Opinion in Structural Biology
2025-06 | Journal article
DOI: 10.1016/j.sbi.2025.103041
Contributors: Matthew D. Watson; Jennifer C. Lee
Source: check_circle
Crossref

Raman spectroscopy in the study of amyloid formation and phase separation

Biochemical Society Transactions
2024-06-26 | Journal article
DOI: 10.1042/BST20230599
Contributors: Sashary Ramos; Jennifer C. Lee
Source: check_circle
Crossref

Water bend–libration as a cellular Raman imaging probe of hydration

Proceedings of the National Academy of Sciences
2023-10-17 | Journal article
DOI: 10.1073/pnas.2313133120
Contributors: Sashary Ramos; Jennifer C. Lee
Source: check_circle
Crossref

Genetically Encoded Aryl Alkyne for Raman Spectral Imaging of Intracellular α-Synuclein Fibrils

Journal of Molecular Biology
2023-01 | Journal article
DOI: 10.1016/j.jmb.2022.167716
Part of ISSN: 0022-2836
Contributors: Matthew D. Watson; Jennifer C. Lee
Source: Self-asserted source
Jennifer Lee

Watching liquid droplets of TDP-43CTD age by Raman spectroscopy

Journal of Biological Chemistry
2022-02 | Journal article
DOI: 10.1016/j.jbc.2021.101528
Contributors: Sydney O. Shuster; Jennifer C. Lee
Source: check_circle
Crossref

Purification and characterization of an amyloidogenic repeat domain from the functional amyloid Pmel17

Protein Expression and Purification
2021-11 | Journal article
DOI: 10.1016/j.pep.2021.105944
Contributors: Dexter N. Dean; Jennifer C. Lee
Source: check_circle
Crossref

Coupling chemical biology and vibrational spectroscopy for studies of amyloids in vitro and in cells

Current Opinion in Chemical Biology
2021-10 | Journal article
DOI: 10.1016/j.cbpa.2021.05.005
Part of ISSN: 1367-5931
Contributors: Matthew Watson; Jennifer C. Lee
Source: Self-asserted source
Jennifer Lee

The N terminus of α-synuclein dictates fibril formation

Proceedings of the National Academy of Sciences
2021-08-31 | Journal article
DOI: 10.1073/pnas.2023487118
Contributors: Ryan P. McGlinchey; Xiaodan Ni; Jared A. Shadish; Jiansen Jiang; Jennifer C. Lee
Source: check_circle
Crossref

Linking Parkinson's Disease and Melanoma: Interplay Between α‐Synuclein and Pmel17 Amyloid Formation

Movement Disorders
2021-07 | Journal article
DOI: 10.1002/mds.28655
Contributors: Dexter N. Dean; Jennifer C. Lee
Source: check_circle
Crossref

Tryptophan Probes of TDP-43 C-Terminal Domain Amyloid Formation

The Journal of Physical Chemistry B
2021-04-22 | Journal article
DOI: 10.1021/acs.jpcb.1c00767
Contributors: Sydney O. Shuster; Jennifer C. Lee
Source: check_circle
Crossref

Raman spectral imaging of 13C2H15N-labeled α-synuclein amyloid fibrils in cells

Biophysical Chemistry
2021-02 | Journal article
DOI: 10.1016/j.bpc.2020.106528
Part of ISSN: 0301-4622
Contributors: Matthew D. Watson; Jessica D. Flynn; Jennifer C. Lee
Source: Self-asserted source
Jennifer Lee

Membrane Interactions of α-Synuclein Probed by Neutrons and Photons

Accounts of Chemical Research
2021-01-19 | Journal article
DOI: 10.1021/acs.accounts.0c00453
Contributors: Upneet Kaur; Jennifer C. Lee
Source: check_circle
Crossref

Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins

ACS Chemical Neuroscience
2020-12-16 | Journal article
DOI: 10.1021/acschemneuro.0c00588
Contributors: Michele F. Sciacca; Fabio Lolicato; Carmelo Tempra; Federica Scollo; Bikash R. Sahoo; Matthew D. Watson; Sara García-Viñuales; Danilo Milardi; Antonio Raudino; Jennifer C. Lee et al.
Source: check_circle
Crossref

In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning

Nature Communications
2020-12-15 | Journal article
DOI: 10.1038/s41467-020-20088-1
Part of ISSN: 2041-1723
Contributors: Dvir Gur; Emily J. Bain; Kory R. Johnson; Andy J. Aman; Hilda Amalia Pasolli; Jessica D. Flynn; Michael Allen; Dimitri Deheyn; Jennifer C. Lee; Jennifer Lippincott-Schwartz et al.
Source: Self-asserted source
Jennifer Lee

Cathepsin K is a potent disaggregase of α-synuclein fibrils

Biochemical and Biophysical Research Communications
2020-09 | Journal article
DOI: 10.1016/j.bbrc.2020.06.155
Contributors: Ryan P. McGlinchey; Shannon M. Lacy; Robert L. Walker, III; Jennifer C. Lee
Source: check_circle
Crossref

Defining an amyloid link Between Parkinson’s disease and melanoma

Proceedings of the National Academy of Sciences
2020-09-15 | Journal article
DOI: 10.1073/pnas.2009702117
Contributors: Dexter N. Dean; Jennifer C. Lee
Source: check_circle
Crossref

Unroofing site-specific α-synuclein–lipid interactions at the plasma membrane

Proceedings of the National Academy of Sciences
2020-08-11 | Journal article
DOI: 10.1073/pnas.2006291117
Contributors: Upneet Kaur; Jennifer C. Lee
Source: check_circle
Crossref

Terminal Alkynes as Raman Probes of α‐Synuclein in Solution and in Cells

ChemBioChem
2020-06-02 | Journal article
DOI: 10.1002/cbic.202000026
Contributors: Jessica D. Flynn; Megan Y. Gimmen; Dexter N. Dean; Shannon M. Lacy; Jennifer C. Lee
Source: check_circle
Crossref

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17

Journal of Biological Chemistry
2020-05 | Journal article
DOI: 10.1074/jbc.RA120.013012
Contributors: Dexter N. Dean; Jennifer C. Lee
Source: check_circle
Crossref

pH-Dependent fibril maturation of a Pmel17 repeat domain isoform revealed by tryptophan fluorescence

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
2019-10 | Journal article
DOI: 10.1016/j.bbapap.2019.01.012
Part of ISSN: 1570-9639
Source: Self-asserted source
Jennifer Lee

N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism

Biochemistry
2019-09-03 | Journal article
DOI: 10.1021/acs.biochem.9b00629
Contributors: Matthew D. Watson; Jennifer C. Lee
Source: check_circle
Crossref

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

Journal of Molecular Biology
2019-07 | Journal article
DOI: 10.1016/j.jmb.2019.07.001
Part of ISSN: 0022-2836
Source: Self-asserted source
Jennifer Lee

C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson’s disease

Journal of Biological Chemistry
2019-06 | Journal article
DOI: 10.1074/jbc.RA119.008930
Contributors: Ryan P. McGlinchey; Shannon M. Lacy; Katherine E. Huffer; Nahid Tayebi; Ellen Sidransky; Jennifer C. Lee
Source: check_circle
Crossref

Fate plasticity and reprogramming in genetically distinct populations of <i>Danio</i> leucophores

Proceedings of the National Academy of Sciences
2019-06-11 | Journal article | Author
DOI: 10.1073/pnas.1901021116
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Victor M. Lewis; Lauren M. Saunders; Tracy A. Larson; Emily J. Bain; Samantha L. Sturiale; Dvir Gur; Sarwat Chowdhury; Jessica D. Flynn; Michael C. Allen; Dimitri D. Deheyn et al.
Source: Self-asserted source
Jennifer Lee

Interplay between α-synuclein amyloid formation and membrane structure

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
2019-05 | Journal article
DOI: 10.1016/j.bbapap.2018.09.012
Part of ISSN: 1570-9639
Source: Self-asserted source
Jennifer Lee

Lysophospholipids induce fibrillation of the repeat domain of Pmel17 through intermediate core-shell structures

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
2019-05 | Journal article
DOI: 10.1016/j.bbapap.2018.11.007
Part of ISSN: 1570-9639
Source: Self-asserted source
Jennifer Lee
grade
Preferred source (of 2)‎

Probing Membrane Association of α-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern

Scientific Reports
2019-03-14 | Journal article
DOI: 10.1038/s41598-019-40979-8
Contributors: Daniel Jacobs; David P. Hoogerheide; Amandine Rovini; Zhiping Jiang; Jennifer C. Lee; Tatiana K. Rostovtseva; Sergey M. Bezrukov
Source: check_circle
Crossref

Raman fingerprints of amyloid structures

Chemical Communications
2018 | Journal article
DOI: 10.1039/C8CC03217C
Contributors: Jessica D. Flynn; Jennifer C. Lee
Source: check_circle
Crossref

Stimulation of α-synuclein amyloid formation by phosphatidylglycerol micellar tubules

Biochimica et Biophysica Acta - Biomembranes
2018 | Journal article
DOI: 10.1016/j.bbamem.2018.02.025
Source: Self-asserted source
Jennifer Lee

Segmental 13C‐Labeling and Raman Microspectroscopy of α‐Synuclein Amyloid Formation

Angewandte Chemie International Edition
2018-12-21 | Journal article
DOI: 10.1002/anie.201809865
Contributors: Jessica D. Flynn; Zhiping Jiang; Jennifer C. Lee
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Why Study Functional Amyloids? Lessons from the Repeat Domain of Pmel17

Journal of Molecular Biology
2018-10 | Journal article
DOI: 10.1016/j.jmb.2018.06.011
Part of ISSN: 0022-2836
Source: Self-asserted source
Jennifer Lee

Effects of phosphatidylcholine membrane fluidity on the conformation and aggregation of N-terminally acetylated α-synuclein

Journal of Biological Chemistry
2018-07 | Journal article
DOI: 10.1074/jbc.RA118.002780
Contributors: Emma I. O'Leary; Zhiping Jiang; Marie-Paule Strub; Jennifer C. Lee
Source: check_circle
Crossref

Structural features of α-synuclein amyloid fibrils revealed by Raman spectroscopy

Journal of Biological Chemistry
2018-01 | Journal article
DOI: 10.1074/jbc.M117.812388
Contributors: Jessica D. Flynn; Ryan P. McGlinchey; Robert L. Walker, III; Jennifer C. Lee
Source: check_circle
Crossref

Reversing the Amyloid Trend: Mechanism of Fibril Assembly and Dissolution of the Repeat Domain from a Human Functional Amyloid

Israel Journal of Chemistry
2017 | Journal article
DOI: 10.1002/ijch.201600080
Source: Self-asserted source
Jennifer Lee

Taking a Bite Out of Amyloid: Mechanistic Insights into α-Synuclein Degradation by Cathepsin L

Biochemistry
2017-08-01 | Journal article
DOI: 10.1021/acs.biochem.7b00360
Contributors: Ryan P. McGlinchey; Gifty A. Dominah; Jennifer C. Lee
Source: check_circle
Crossref

Physical Chemistry in Biomedical Research: From Cuvettes toward Cellular Insights

The Journal of Physical Chemistry Letters
2017-05-04 | Journal article
DOI: 10.1021/acs.jpclett.7b00549
Contributors: Jessica D. Flynn; Jennifer C. Lee
Source: check_circle
Crossref

Segmental Deuteration of α-Synuclein for Neutron Reflectometry on Tethered Bilayers

The Journal of Physical Chemistry Letters
2017-01-05 | Journal article
DOI: 10.1021/acs.jpclett.6b02304
Contributors: Zhiping Jiang; Frank Heinrich; Ryan P. McGlinchey; James M. Gruschus; Jennifer C. Lee
Source: check_circle
Crossref

Apolipoprotein C-III Nanodiscs Studied by Site-Specific Tryptophan Fluorescence

Biochemistry
2016 | Journal article
DOI: 10.1021/acs.biochem.6b00599
WOSUID:

WOS:000382805500006
Contributors: Brisbois, Chase A.; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Single-Particle Tracking of Human Lipoproteins

Analytical Chemistry
2016 | Journal article
DOI: 10.1021/acs.analchem.5b03749
WOSUID:

WOS:000367866100031
Contributors: de Messieres, Michel; Ng, Abby; Duarte, Cornelio J.; Remaley, Alan T.; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

alpha-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease

Journal of Biological Chemistry
2015 | Journal article
DOI: 10.1074/jbc.M115.641746
WOSUID:

WOS:000358512100018
Contributors: Rostovtseva, Tatiana K.; Gurnev, Philip A.; Protchenko, Olga; Hoogerheide, David P.; Yap, Thai Leong; Philpott, Caroline C.; Lee, Jennifer C.; Bezrukov, Sergey M.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Cysteine cathepsins are essential in lysosomal degradation of alpha-synuclein

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
DOI: 10.1073/pnas.1500937112
WOSUID:

WOS:000358656500060
Contributors: McGlinchey, Ryan P.; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C

Biochemical and Biophysical Research Communications
2015 | Journal article
DOI:

10.1016/j.bbrc.2015.01.024

WOSUID:

WOS:000350838800012
Contributors: Gruschus, James M.; Jiang, Zhiping; Yap, Thai Leong; Hill, Stephanie A.; Grishaev, Alexander; Piszczek, Grzegorz; Sidransky, Ellen; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Molecular Details of alpha-Synuclein Membrane Association Revealed by Neutrons and Photons

Journal of Physical Chemistry B
2015 | Journal article
WOSUID:

CCC:000352823200002
Contributors: Jiang, Zhiping; Hess, Sara K.; Heinrich, Frank; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Structural Features of Membrane-bound Glucocerebrosidase and alpha-Synuclein Probed by Neutron Reflectometry and Fluorescence Spectroscopy

Journal of Biological Chemistry
2015 | Journal article
DOI:

10.1074/jbc.M114.610584

WOSUID:

WOS:000347778200005
Contributors: Yap, Thai Leong; Jiang, Zhiping; Heinrich, Frank; Gruschus, James M.; Pfefferkorn, Candace M.; Barros, Marilia; Curtis, Joseph E.; Sidransky, Ellen; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Tryptophan probes reveal residue-specific phospholipid interactions of apolipoprotein C-III

Biochimica Et Biophysica Acta-Biomembranes
2015 | Journal article
DOI: 10.1016/j.bbamem.2015.08.018
WOSUID:

WOS:000364270800007
Contributors: Pfefferkorn, Candace M.; Walker, Robert L., III; He, Yi; Gruschus, James M.; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Alpha-Synuclein Lipid-Dependent Membrane Binding and Translocation through the alpha-Hemolysin Channel

Biophysical Journal
2014 | Journal article
DOI:

10.1016/j.bpj.2013.12.028

WOSUID:

WOS:000330724800008
Contributors: Gurnev, Philip A.; Yap, Thai Leong; Pfefferkorn, Candace M.; Rostovtseva, Tatiana K.; Berezhkovskii, Alexander M.; Lee, Jennifer C.; Parsegian, V. Adrian; Bezrukov, Sergey M.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III

Biochemistry
2014 | Journal article
DOI:

10.1021/bi500502d

WOSUID:

WOS:000336636300001
Contributors: de Messieres, Michel; Huang, Rick K.; He, Yi; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Lysophospholipid-Containing Membranes Modulate the Fibril Formation of the Repeat Domain of a Human Functional Amyloid, Pmel17

Journal of Molecular Biology
2014 | Journal article
DOI:

10.1016/j.jmb.2014.10.009

WOSUID:

WOS:000347657000013
Contributors: Jiang, Zhiping; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID

Mechanism of assembly of the non-covalent spectrin tetramerization domain from intrinsically disordered partners

Journal of Molecular Biology
2014 | Journal article
DOI: 10.1016/j.jmb.2013.08.027
Source: Self-asserted source
Jennifer Lee

Molecular Origin of pH-Dependent Fibril Formation of a Functional Amyloid

Chembiochem
2014 | Journal article
DOI: 10.1002/cbic.201402074
WOSUID:

WOS:000339502900004
Contributors: McGlinchey, Ryan P.; Jiang, Zhiping; Lee, Jennifer C.
Source: Self-asserted source
Jennifer Lee via ResearcherID
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