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ResearcherID: S-5723-2016

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Charles University, Faculty of Medicine in Hradec Králové: Hradec Králové, CZ

(Department of Medical Biochemistry)
Employment
Source: Self-asserted source
Radim Havelek

Works (50 of 89)

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Page 1 of 2

Second-generation piperazine derivatives as promising radiation countermeasures

RSC Medicinal Chemistry
2024 | Journal article | Author
DOI: 10.1039/d4md00311j
Part of ISSN: 2632-8682
Contributors: Vojtěch Chmil; Natálie Živná; Marcela Milanová; Alžběta Filipová; Jaroslav Pejchal; Lukáš Prchal; Darina Muthná; Vít Řeháček; Martina Rezacova; Jan Marek et al.
Source: Self-asserted source
Radim Havelek

Undescribed Amaryllidaceae Alkaloids from <i>Zephyranthes citrina</i> and Their Cytotoxicity

Journal of Natural Products
2024-09-27 | Journal article | Author
DOI: 10.1021/acs.jnatprod.4c00825
Part of ISSN: 0163-3864
Part of ISSN: 1520-6025
Contributors: Jana Maříková; Eliška Kohelová; Darina Muthná; Jiří Kuneš; Radim Havelek; Rudolf Vrabec; Milan Malaník; Daniela Suchánková; Jakub Chlebek; Jaroslav Jenčo et al.
Source: Self-asserted source
Radim Havelek

The anticancer properties of harmine and its derivatives

Phytochemistry Reviews
2024-09-17 | Journal article
DOI: 10.1007/s11101-024-09978-0
Part of ISSN: 1568-7767
Part of ISSN: 1572-980X
Contributors: Abdul Aziz Timbilla; Rudolf Vrabec; Radim Havelek; Martina Rezacova; Jakub Chlebek; Gerald Blunden; Lucie Cahlíková
Source: Self-asserted source
Radim Havelek

Antiproliferative activity and apoptosis-inducing mechanism of Amaryllidaceae alkaloid montanine on A549 and MOLT-4 human cancer cells

Biomedicine &amp; Pharmacotherapy
2023-10 | Journal article | Author
DOI: 10.1016/j.biopha.2023.115295
Part of ISSN: 0753-3322
Contributors: Darja Koutova; Negar Maafi; Darina; Karel Kralovec; Jana Maříková; Filip Pidaný; Abdul Aziz Timbilla; Eva Čermáková; Lucie Cahlikova; Martina Rezacova et al.
Source: Self-asserted source
Radim Havelek

Rh(III) and Ru(II) Complexes With Phosphanyl–Alkylamines: Inhibition of DNA Synthesis Induced By Anticancer Rh Complex

Future Medicinal Chemistry
2023-09 | Journal article | Author
DOI: 10.4155/fmc-2023-0170
Part of ISSN: 1756-8919
Part of ISSN: 1756-8927
Contributors: Alena Mrkvicova; Eva Peterová; Ivan Nemec; Radka Křikavová; Darina; Radim Havelek; Petra Kazimírová; Martina Rezacova; Pavel Starha
Source: Self-asserted source
Radim Havelek

Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities

Saudi Pharmaceutical Journal
2023-08 | Journal article | Author
DOI: 10.1016/j.jsps.2023.06.017
Part of ISSN: 1319-0164
Contributors: Aneta Ritomská; Darja Koutova; Jana Křoustková; Karel Královec; Darina Muthná; Jiří Kuneš; Lucie Nováková; Radim Havelek; Lucie Cahlíková
Source: Self-asserted source
Radim Havelek

Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest

Scientific Reports
2023-04-12 | Journal article
DOI: 10.1038/s41598-023-33047-9
Part of ISSN: 2045-2322
Contributors: Barbora Vítovcová; Veronika Skarková; Radim Havelek; Jiří Soukup; Ananya Pande; Kateřina Caltová; Emil Rudolf
Source: Self-asserted source
Radim Havelek

7-Azaindole, 2,7-diazaindole, and 1H-pyrazole as core structures for novel anticancer agents with potential chemosensitizing properties

European Journal of Medicinal Chemistry
2022-10 | Journal article
DOI: 10.1016/j.ejmech.2022.114580
Part of ISSN: 0223-5234
Contributors: Lukas Gorecki; Darina Muthna; Sara Merdita; Martin Andrs; Tomas Kucera; Radim Havelek; Lubica Muckova; Tereza Kobrlova; Jiri Soukup; Petr Krupa et al.
Source: Self-asserted source
Radim Havelek

Monoclonal anti-endoglin antibody TRC105 (carotuximab) prevents hypercholesterolemia and hyperglycemia-induced endothelial dysfunction in human aortic endothelial cells

Frontiers in Medicine
2022-09-07 | Journal article
DOI: 10.3389/fmed.2022.845918
Part of ISSN: 2296-858X
Contributors: Katarina Tripska; Ivone Cristina Igreja Sá; Martina Vasinova; Matej Vicen; Radim Havelek; Samira Eissazadeh; Zuzana Svobodova; Barbora Vitverova; Charles Theuer; Carmelo Bernabeu et al.
Source: Self-asserted source
Radim Havelek

The Effect of Chronic Exposure of Graphene Nanoplates on the Viability and Motility of A549 Cells

Nanomaterials
2022-06 | Journal article | Author
DOI: 10.3390/nano12122074
Contributors: Blanka Šestáková; Ladislava Schröterová; Aleš Bezrouk; Dana Čížková; Moustafa Elkalaf; Radim Havelek; Emil Rudolf; Věra Králová
Source: check_circle
Multidisciplinary Digital Publishing Institute

Multimodal Contrast Agent Enabling pH Sensing Based on Organically Functionalized Gold Nanoshells with Mn-Zn Ferrite Cores

Nanomaterials
2022-01 | Journal article | Author
DOI: 10.3390/nano12030428
Contributors: Duong Thuy Bui; Radim Havelek; Karel Královec; Lenka Kubíčková; Jarmila Kuličková; Petr Matouš; Vít Herynek; Jaroslav Kupčík; Darina Muthná; Pavel Rezanka et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Heterobimetallic platinum(<scp>ii</scp>) complexes with increased cytotoxicity against ovarian cancer cell lines

New Journal of Chemistry
2021 | Journal article | Author
DOI: 10.1039/d1nj03533a
Part of ISSN: 1144-0546
Part of ISSN: 1369-9261
Contributors: Lucie Melounková; Miriam Syková; Robert Jirásko; Roman Jambor; Radim Havelek; Eva Peterová; Jan Honzíček; Jaromír Vinklárek
Source: Self-asserted source
Radim Havelek

Pancracine, a Montanine-Type Amaryllidaceae Alkaloid, Inhibits Proliferation of A549 Lung Adenocarcinoma Cells and Induces Apoptotic Cell Death in MOLT-4 Leukemic Cells

International Journal of Molecular Sciences
2021-06 | Journal article | Author
DOI: 10.3390/ijms22137014
Contributors: Darja Koutová; Radim Havelek; Eva Peterová; Darina Muthná; Karel Královec; Kateřina Breiterová; Lucie Cahlíková; Martina Rezacova
Source: check_circle
Multidisciplinary Digital Publishing Institute

Disruption of Cell Adhesion and Cytoskeletal Networks by Thiol-Functionalized Silica-Coated Iron Oxide Nanoparticles

International Journal of Molecular Sciences
2020-12-08 | Journal article
DOI: 10.3390/ijms21249350
Part of ISSN: 1422-0067
Source: Self-asserted source
Radim Havelek

Magnetic nanoparticles of Ga‐substituted ε‐Fe 2 O 3 for biomedical applications: Magnetic properties, transverse relaxivity, and effects of silica‐coated particles on cytoskeletal networks

Journal of Biomedical Materials Research Part A
2020-07 | Journal article
DOI: 10.1002/jbm.a.36926
Part of ISSN: 1549-3296
Part of ISSN: 1552-4965
Source: Self-asserted source
Radim Havelek

Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family

Molecules
2020-05 | Journal article | Author
DOI: 10.3390/molecules25102337
Contributors: Darja Koutová; Negar Maafi; Radim Havelek; Lubomír Opletal; Gerald Blunden; Martina Rezacova; Lucie Cahlíková
Source: check_circle
Multidisciplinary Digital Publishing Institute

The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs

Phytochemistry Reviews
2020-05-07 | Journal article
DOI: 10.1007/s11101-020-09675-8
Part of ISSN: 1568-7767
Part of ISSN: 1572-980X
Source: Self-asserted source
Radim Havelek
grade
Preferred source (of 2)‎

A novel class of small molecule inhibitors with radioprotective properties

European Journal of Medicinal Chemistry
2020-02 | Journal article
DOI: 10.1016/j.ejmech.2019.111606
Part of ISSN: 0223-5234
Source: Self-asserted source
Radim Havelek

Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells

Molecules
2020-02 | Journal article | Author
DOI: 10.3390/molecules25040964
Contributors: Darja Koutova; Monika Kulhava; Radim Havelek; Martina Majorosova; Karel Královec; Klara Habartova; Anna Hostalkova; Lubomír Opletal; Lucie Cahlíková; Martina Rezacova
Source: check_circle
Multidisciplinary Digital Publishing Institute

Substituted Piperazines as Novel Potential Radioprotective Agents.

Molecules (Basel, Switzerland)
2020-01-25 | Journal article
DOI: 10.3390/molecules25030532
PMID: 31991816
PMC: PMC7038073
Source: Self-asserted source
Radim Havelek

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity.

Plants (Basel, Switzerland)
2020-01-22 | Journal article
DOI: 10.3390/plants9020137
PMID: 31978967
PMC: PMC7076679
Source: Self-asserted source
Radim Havelek

INVESTIGATION OF THE RADIOPROTECTIVE EFFECT OF ORTHOVANADATE IN MICE AFTER TOTAL BODY IRRADIATION.

Radiation protection dosimetry
2019-12-01 | Journal article
DOI: 10.1093/rpd/ncz192
PMID: 31711201
Source: Self-asserted source
Radim Havelek

Enhanced cytotoxicity of indenyl molybdenum(ii) compounds bearing a thiophene function.

Dalton transactions (Cambridge, England : 2003)
2019-07-08 | Journal article
DOI: 10.1039/c9dt01698h
PMID: 31281913
Source: Self-asserted source
Radim Havelek

Silica coated iron oxide nanoparticles-induced cytotoxicity, genotoxicity and its underlying mechanism in human HK-2 renal proximal tubule epithelial cells.

Mutation research
2019-05-30 | Journal article
DOI: 10.1016/j.mrgentox.2019.05.015
PMID: 31326033
Source: Self-asserted source
Radim Havelek

Rod-like particles of silica-coated maghemite: Synthesis via akaganeite, characterization and biological properties

Journal of Magnetism and Magnetic Materials
2019-04 | Journal article
DOI: 10.1016/j.jmmm.2018.12.037
Part of ISSN: 0304-8853
Source: Self-asserted source
Radim Havelek

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease.

Molecules (Basel, Switzerland)
2019-04-03 | Journal article
DOI: 10.3390/molecules24071307
PMID: 30987121
PMC: PMC6480460
Source: Self-asserted source
Radim Havelek

Vanadocene complexes bearing N,N'-chelating ligands: Synthesis, structures and in vitro cytotoxic studies on the A549 lung adenocarcinoma cell line.

Journal of inorganic biochemistry
2019-03-22 | Journal article
DOI: 10.1016/j.jinorgbio.2019.03.015
PMID: 30959320
Source: Self-asserted source
Radim Havelek

Regulation and role of endoglin in cholesterol-induced endothelial and vascular dysfunction in vivo and in vitro.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2019-02-12 | Journal article
DOI: 10.1096/fj.201802245r
PMID: 30753095
Source: Self-asserted source
Radim Havelek

The effect of sodium butyrate and cisplatin on expression of EMT markers.

PloS one
2019-01-17 | Journal article
DOI: 10.1371/journal.pone.0210889
PMID: 30653577
PMC: PMC6336326
Source: Self-asserted source
Radim Havelek

Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity

Archives of Pharmacal Research
2018 | Journal article
DOI: 10.1007/s12272-017-1000-4
WOSUID:

WOS:000424689700007
Contributors: Safratova, Marcela; Host'alkova, Anna; Hulcova, Daniela; Breiterova, Katerina; Hrabcova, Veronika; Machado, Marta; Fontinha, Diana; Prudencio, Miguel; Kunes, Jiri; Chlebek, Jakub et al.
Source: Self-asserted source
Radim Havelek via ResearcherID

Dose dependent effect of 7-ketocholesterol treatment on the expression of the membrane endoglin and cell adhesion molecules in human aortic endothelial cells: pilot study

Angiogenesis
2018 | Journal article
WOSUID:

WOS:000425279800166
Contributors: Vicen, M.; Varejckova, M.; Havelek, R.; VitverovA, B.; Dolezelova, E.; Blazickova, K.; Nachtigal, P.
Source: Self-asserted source
Radim Havelek via ResearcherID

Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells

Scientific Reports
2018 | Journal article
DOI: 10.1038/s41598-018-22862-0
WOSUID:

WOS:000427688100022
Contributors: Habartova, Klara; Havelek, Radim; Seifrtova, Martina; Kralovec, Karel; Cahlikova, Lucie; Chlebek, Jakub; Cermakova, Eva; Mazankova, Nadezda; Marikova, Jana; Kunes, Jiri et al.
Source: Self-asserted source
Radim Havelek via ResearcherID

Novel quinazolin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.

Bioorganic chemistry
2018-10-06 | Journal article
DOI: 10.1016/j.bioorg.2018.10.001
PMID: 30326402
Source: Self-asserted source
Radim Havelek

Purin-6-one and pyrrolo[2,3-d]pyrimidin-4-one derivatives as potentiating agents of doxorubicin cytotoxicity.

Future medicinal chemistry
2018-08-01 | Journal article
DOI: 10.4155/fmc-2018-0086
PMID: 30067076
Source: Self-asserted source
Radim Havelek

New Light on An Old Friend: Targeting PUMA in Radioprotection and Therapy of Cardiovascular and Neurodegenerative Diseases.

Current drug targets
2018-01-01 | Journal article
DOI: 10.2174/1389450119666180406110743
PMID: 29623837
Source: Self-asserted source
Radim Havelek

7-KETOCHOLESTEROL TREATMENT MODULATES EXPRESSION OF THE CELL ADHESION MOLECULES IN HUMAN AORTIC ENDOTHELIAL CELLS-PILOT STUDY

Atherosclerosis
2017 | Journal article
DOI: 10.1016/j.atherosclerosis.2017.06.430
WOSUID:

WOS:000407634000394
Contributors: Vicen, Matej; Varejckova, Michala; Havelek, Radim; Vitverova, Barbora; Fikrova, Petra; Dolezelova, Eva; Rathouska, Jana; Blazickova, Katerina; Nemeckova, Ivana; Nachtigal, Petr
Source: Self-asserted source
Radim Havelek via ResearcherID

A new isoquinoline alkaloid bersavine as a possible anticancer agent

Annals of Oncology
2017 | Journal article
WOSUID:

WOS:000411324000075
Contributors: Habartova, K.; Havelek, R.; Seifrtova, M.; Hostalkova, A.; Cahlikova, L.; Rezacova, M.
Source: Self-asserted source
Radim Havelek via ResearcherID

Anticancer potential of Amaryllidaceae alkaloids evaluated by screening with a panel of human cells, real-time cellular analysis and Ehrlich tumor-bearing mice

Chemico-Biological Interactions
2017 | Journal article
DOI: 10.1016/j.cbi.2017.07.018
WOSUID:

WOS:000410631400012
Contributors: Havelek, Radim; Muthna, Darina; Tomsik, Pavel; Kralovec, Karel; Seifrtova, Martina; Cahlikova, Lucie; Hostalkova, Anna; Safratova, Marcela; Perwein, Maria; Cermakova, Eva et al.
Source: Self-asserted source
Radim Havelek via ResearcherID

Chelidonine and Homochelidonine Induce Cell Death through Cell Cycle Checkpoints and MAP Kinase Pathways

Natural Product Communications
2017 | Journal article
WOSUID:

WOS:000412968400010
Contributors: Havelek, Radim; Seifrtova, Martina; Kralovec, Karel; Habartova, Klara; Cahlikova, Lucie; Rezacova, Martina
Source: Self-asserted source
Radim Havelek via ResearcherID

Haemanthamine alters sodium butyrate-induced histone acetylation, p21(WAF1/Cip1) expression, Chk1 and Chk2 activation and leads to increased growth inhibition and death in A2780 ovarian cancer cells

Phytomedicine
2017 | Journal article
DOI: 10.1016/j.phymed.2017.08.019
WOSUID:

WOS:000412339700001
Contributors: Seifrtova, Martina; Havelek, Radim; Cahlikova, Lucie; Hulcova, Daniela; Mazankova, Nadezda; Rezacova, Martina
Source: Self-asserted source
Radim Havelek via ResearcherID

Magnetic oxide particles with gold nanoshells: Synthesis, properties and cytotoxic effects

Colloids and Surfaces a-Physicochemical and Engineering Aspects
2017 | Journal article
DOI: 10.1016/j.colsurfa.2017.02.052
WOSUID:

WOS:000401401100103
Contributors: Koktan, Jakub; Kralovec, Karel; Havelek, Radim; Kulickova, Jarmila; Rezanka, Pavel; Kaman, Ondrej
Source: Self-asserted source
Radim Havelek via ResearcherID

Mn-Zn Ferrite Nanoparticles With Silica and Titania Coatings: Synthesis, Transverse Relaxivity, and Cytotoxicity

Ieee Transactions on Magnetics
2017 | Journal article
DOI: 10.1109/TMAG.2017.2721365
WOSUID:

WOS:000413981300227
Contributors: Kaman, Ondrej; Kulickova, Jarmila; Marysko, Miroslav; Veverka, Pavel; Herynek, Vit; Havelek, Radim; Kralovec, Karel; Kubaniova, Denisa; Kohout, Jaroslav; Dvorak, Petr et al.
Source: Self-asserted source
Radim Havelek via ResearcherID

Novel derivatives of substituted 6-fluorobenzothiazole diamides: synthesis, antifungal activity and cytotoxicity

Medicinal Chemistry Research
2017 | Journal article
DOI: 10.1007/s00044-017-1894-x
WOSUID:

WOS:000406602000002
Contributors: Pejchalova, Marcela; Havelek, Radim; Kralovec, Karel; Ruzickova, Zdenka; Pejchal, Vladimir
Source: Self-asserted source
Radim Havelek via ResearcherID

Boldine Inhibits Mouse Mammary Carcinoma In Vivo and Human MCF-7 Breast Cancer Cells In Vitro

Planta Medica
2016 | Journal article
DOI: 10.1055/s-0042-113611
WOSUID:

WOS:000386680200005
Contributors: Tomsik, Pavel; Micuda, Stanislav; Muthna, Darina; Cermakova, Eva; Havelek, Radim; Rudolf, Emil; Hroch, Milos; Kadova, Zuzana; Rezacova, Martina; Cmielova, Jana et al.
Source: Self-asserted source
Radim Havelek via ResearcherID

Comparative cytotoxicity of chelidonine and homochelidonine, the dimethoxy analogues isolated from Chelidonium majus L. (Papaveraceae), against human leukemic and lung carcinoma cells

Phytomedicine
2016 | Journal article
DOI: 10.1016/j.phymed.2016.01.001
WOSUID:

WOS:000371781500003
Contributors: Havelek, Radim; Seifrtova, Martina; Kralovec, Karel; Krocova, Eliska; Tejkalova, Veronika; Novotny, Ivan; Cahlikova, Lucie; Safratova, Marcela; Opletal, Lubomir; Bilkova, Zuzana et al.
Source: Self-asserted source
Radim Havelek via ResearcherID

Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types

Natural Product Communications
2016 | Journal article
WOSUID:

WOS:000379631600014
Contributors: Chlebek, Jakub; Doskocil, Ivo; Hulcova, Daniela; Breiterova, Katefina; Safratova, Marcela; Havelek, Radim; Habartova, Klara; Host'alkova, Anna; Volstatova, Tereza; Cahlikova, Lucie
Source: Self-asserted source
Radim Havelek via ResearcherID

Effective Method of Purification of Betulin from Birch Bark: The Importance of Its Purity for Scientific and Medicinal Use

Plos One
2016 | Journal article
DOI: 10.1371/journal.pone.0154933
WOSUID:

WOS:000375677000047
Contributors: Siman, Pavel; Filipova, Alzbeta; Ticha, Alena; Niang, Mohamed; Bezrouk, Ales; Havelek, Radim
Source: Self-asserted source
Radim Havelek via ResearcherID

In-vitro and in-vivo evaluation of the anticancer activity of diruthenium-2, a new trithiolato arene ruthenium complex [(eta(6)-p-MeC6H4Pri)(2)Ru-2(mu-S-p-C6H4OH)(3)]Cl

Anti-Cancer Drugs
2016 | Journal article
DOI: 10.1097/CAD.0000000000000374
WOSUID:

WOS:000379037900006
Contributors: Muthna, Darina; Tomsik, Pavel; Havelek, Radim; Kohlerova, Renata; Kasilingam, Vidhya; Cermakova, Eva; Stibal, David; Rezacova, Martina; Suss-Fink, Georg
Source: Self-asserted source
Radim Havelek via ResearcherID

Isoquinoline alkaloid scoulerine affects proliferation and viability of leukemia cells, induces apoptosis and arrests cell cycle

International Journal of Molecular Medicine
2016 | Journal article
WOSUID:

WOS:000383733000122
Contributors: Habartova, Klara; Havelek, Radim; Cahlikova, Lucie; Rezacova, Martina
Source: Self-asserted source
Radim Havelek via ResearcherID

LC-MS/MS method for the determination of haemanthamine in rat plasma, bile and urine and its application to a pilot pharmacokinetic study

Biomedical Chromatography
2016 | Journal article
DOI: 10.1002/bmc.3653
WOSUID:

WOS:000378537900013
Contributors: Hroch, Milos; Micuda, Stanislav; Havelek, Radim; Cermanova, Jolana; Cahlikova, Lucie; Hostalkova, Anna; Hulcova, Daniela; Rezacova, Martina
Source: Self-asserted source
Radim Havelek via ResearcherID
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