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critical care

Biography

Jan De Waele is a surgery-trained intensivist and works at the surgical ICU of the Ghent University Hospital in Belgium. Clinical interests include severe infections and abdominal catastrophes such as the abdominal compartment syndrome. He has a specific interest in infections in critically ill patients and his research activities currently focus on optimising antibiotic therapy in severely ill, infected patients to improve outcome and combat resistance development.

Activities

Professional activities (4)

European Society of Intensive Care Medicine: Brussels, Brussels, BE

2022 to present | President Elect
Service
Source: Self-asserted source
Jan De Waele

European Society of Intensive Care Medicine: Brussels, BE

2001 to present | Ordinary Member
Membership
Source: Self-asserted source
Jan De Waele

European Society of Intensive Care Medicine: Brussels, BE

2018 to 2021-10-05 | Chair, Research Committee
Service
Source: Self-asserted source
Jan De Waele

European Society of Intensive Care Medicine: Brussels, BE

2015 to 2018 | Chair, INF section
Service
Source: Self-asserted source
Jan De Waele

Funding (3)

Optimaliseren van antibiotica therapie voor ernstige infecties op intensieve zorg

2019-10-01 to 2024-09-30 | Grant
Research Foundation - Flanders (Brussels, BE)
GRANT_NUMBER:

1881020N

Source: Self-asserted source
Jan De Waele via DimensionsWizard

Antibiotica behandeling op maat van de patient voor ernstige infecties op intensieve zorg

2014-10-01 to 2019-09-30 | Grant
Research Foundation - Flanders (Brussels, BE)
GRANT_NUMBER:

1881015N

Source: Self-asserted source
Jan De Waele via DimensionsWizard

Nieuwe strategieën in de behandeling van ernstige acute pancreatitis : een kritische analyse.

2003-10-01 to 2005-09-30 | Grant
Research Foundation - Flanders (Brussels, BE)
GRANT_NUMBER:

1760304N

Source: Self-asserted source
Jan De Waele via DimensionsWizard

Works (50 of 229)

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Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study

Intensive Care Medicine
2025-02 | Journal article
Contributors: Jason A. Roberts; Fekade B. Sime; Jeffrey Lipman; María Patricia Hernández-Mitre; João Pedro Baptista; Roger J. Brüggemann; Jai Darvall; Jan J. De Waele; George Dimopoulos; Jean-Yves Lefrant et al.
Source: check_circle
Crossref

Does artificial intelligence close gaps in clinical pharmacology in the ICU?

Intensive Care Medicine
2025-02 | Journal article
Contributors: Matthias Gijsen; Jan J. De Waele
Source: check_circle
Crossref

The impact of Intensive Care Strain on Patients’ Outcomes during COVID-19 - a UNITE COVID study

2025-02-27 | Preprint
Contributors: Katharina Kohler; Thomas De Corte; Massimiliano Greco; Pedro Povoa; Maurizio Cecconi; Marlies Ostermann; Jan De Waele; Andrew Conway Morris
Source: check_circle
Crossref

Environmental sustainability in intensive care: the path forward. An ESICM Green Paper

Intensive Care Medicine
2024-11 | Journal article
Contributors: Jan J. De Waele; Nicole Hunfeld; Heather Baid; Ricard Ferrer; Katerina Iliopoulou; Ana-Maria Ioan; Marc Leone; Marlies Ostermann; Gaetano Scaramuzzo; Maria Theodorakopoulou et al.
Source: check_circle
Crossref

Selective digestive tract decontamination implementation

Intensive Care Medicine
2024-10 | Journal article
Contributors: Jeroen Schouten; Margo van Mol; Jan J. De Waele
Source: check_circle
Crossref

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

EMBO Molecular Medicine
2024-09-11 | Journal article
Contributors: Céline Van Dender; Steven Timmermans; Ville Paakinaho; Tineke Vanderhaeghen; Jolien Vandewalle; Maarten Claes; Bruno Garcia; Bart Roman; Jan De Waele; Siska Croubels et al.
Source: check_circle
Crossref

Characteristics of co-infection and secondary infection amongst critically ill COVID-19 patients in the first two waves of the pandemic

Intensive Care Medicine
2024-06 | Journal article
Contributors: Thomas De Corte; Katharina Kohler; Maurizio Cecconi; Jan J. De Waele; Andrew Conway Morris; Jan J. De Waele; Maurizio Cecconi; Elie Azoulay; Massimo Antonelli; Giuseppe Citerio et al.
Source: check_circle
Crossref

Designing a Pharmacokinetic Machine Learning Model for Optimizing Beta-Lactam Antimicrobial Dosing in Critically Ill Patients

2024-05-17 | Conference paper
Contributors: Jarne Verhaeghe; Thomas De Corte; Jan J. De Waele; Femke Ongenae; Sofie Van Hoecke
Source: check_circle
Crossref

Environmental sustainability and antimicrobials: an underestimated problem with far-reaching consequences

Intensive Care Medicine
2024-03 | Journal article
Contributors: Jan J. De Waele; Isabel Leroux-Roels; Andrew Conway-Morris
Source: check_circle
Crossref

The environmental impact of laboratory measurements in high-resource ICUs

Intensive Care Medicine
2024-03 | Journal article
Contributors: Marlies Ostermann; Jan J. De Waele; Joerg C. Schefold
Source: check_circle
Crossref

Optimized Treatment of Nosocomial Peritonitis

Antibiotics
2023-12-08 | Journal article
Contributors: Jan De Waele; Federico Coccolini; Leonel Lagunes; Emilio Maseda; Stefano Rausei; Ines Rubio-Perez; Maria Theodorakopoulou; Kostoula Arvaniti
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Crossref
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Selective digestive decontamination - Pro

Intensive Care Medicine
2023-08 | Journal article
Contributors: Jan J. De Waele; Isabel Leroux-Roels; Pieter Depuydt
Source: check_circle
Crossref

Generalizable calibrated machine learning models for real-time atrial fibrillation risk prediction in ICU patients

International Journal of Medical Informatics
2023-07 | Journal article
Contributors: Jarne Verhaeghe; Thomas De Corte; Christopher M. Sauer; Tom Hendriks; Olivier W.M. Thijssens; Femke Ongenae; Paul Elbers; Jan De Waele; Sofie Van Hoecke
Source: check_circle
Crossref

Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, and Combinations as Complementary Diagnostic Tools for Acute Kidney Injury after Pediatric Cardiac Surgery: A Prospective Cohort Study

Diagnostics
2023-03 | Journal article | Author
Contributors: Wim Vandenberghe; Jorien De Loor; Katrien Francois; Kristof Vandekerckhove; Ingrid Herck; Vande Walle; Harlinde Peperstraete; Thierry Bove; Daniel De Wolf; Lieve Nuytinck et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Adequate Antimicrobial Dosing in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation: Where to Go from Here?

American Journal of Respiratory and Critical Care Medicine
2023-03-15 | Journal article
Contributors: Isabel Spriet; Jan J. De Waele
Source: check_circle
Crossref

Source control in the management of sepsis and septic shock

Intensive Care Medicine
2022-12 | Journal article
Contributors: Jan J. De Waele; Massimo Girardis; Ignacio Martin-Loeches
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Crossref

Fluid Management, Intra-Abdominal Hypertension and the Abdominal Compartment Syndrome: A Narrative Review

Life
2022-09 | Journal article | Author
Contributors: Rita Jacobs; Robert D. Wise; Ivan Myatchin; Domien Vanhonacker; Andrea Minini; Michaël Mekeirele; Andrew W. Kirkpatrick; Bruno M. Pereira; michael sugrue; Bart De Keulenaer et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study

International Journal of Antimicrobial Agents
2022-07 | Journal article
Contributors: Kostoula Arvaniti; George Dimopoulos; Massimo Antonelli; Koen Blot; Ben Creagh-Brown; Mieke Deschepper; Dylan de Lange; Jan De Waele; Yalim Dikmen; Christian Eckmann et al.
Source: check_circle
Crossref

Why We May Need Higher Doses of Beta-Lactam Antibiotics: Introducing the ‘Maximum Tolerable Dose’

Antibiotics
2022-07-04 | Journal article
Contributors: Sofie A. M. Dhaese; Eric A. Hoste; Jan J. De Waele
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Crossref
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The Role of Abdominal Drain Cultures in Managing Abdominal Infections

Antibiotics
2022-05-20 | Journal article
Contributors: Jan J. De Waele; Jerina Boelens; Dirk Van De Putte; Diana Huis In ‘t Veld; Tom Coenye
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Crossref
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Antimicrobial Lessons From a Large Observational Cohort on Intra-abdominal Infections in Intensive Care Units

Drugs
2021 | Journal article
EID:

2-s2.0-85106535833

Part of ISSN: 11791950 00126667
Contributors: Vogelaers, D.; Blot, S.; Van den Berge, A.; Montravers, P.; Francois, G.; Labeau, S.; Blot, K.; Deschepper, M.; Antonelli, M.; Lipman, J. et al.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Corrigendum to “Personal protective equipment and intensive care unit healthcare worker safety in the COVID-19 Era (PPE-SAFE): An international survey” [Journal of Critical Care, Volume 59, October 2020, Pages 70–75](S088394412030592X)(10.1016/j.jcrc.2020.06.005)

Journal of Critical Care
2021 | Journal article
EID:

2-s2.0-85092933452

Part of ISSN: 15578615 08839441
Contributors: Tabah, A.; Ramanan, M.; Laupland, K.B.; Buetti, N.; Cortegiani, A.; Mellinghoff, J.; Conway Morris, A.; Camporota, L.; Zappella, N.; Elhadi, M. et al.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Editorial: The gastrointestinal system in critical care: current insights and perspectives

Current opinion in critical care
2021 | Journal article
EID:

2-s2.0-85102538538

Part of ISSN: 15317072
Contributors: de Waele, J.J.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Empiric cone-beam CT-guided embolization in acute lower gastrointestinal bleeding

European Radiology
2021 | Journal article
EID:

2-s2.0-85091316994

Part of ISSN: 14321084 09387994
Contributors: Hermie, L.; Dhondt, E.; Vanlangenhove, P.; De Waele, J.; Degroote, H.; Defreyne, L.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Pharmacokinetics and Pharmacodynamics of Ceftolozane/Tazobactam in Critically Ill Patients With Augmented Renal Clearance

International Journal of Antimicrobial Agents
2021 | Journal article
EID:

2-s2.0-85102130865

Part of ISSN: 18727913 09248579
Contributors: Nicolau, D.P.; De Waele, J.; Kuti, J.L.; Caro, L.; Larson, K.B.; Yu, B.; Gadzicki, E.; Zeng, Z.; Rhee, E.G.; Rizk, M.L.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

The Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2021 | Journal article
EID:

2-s2.0-85105765911

Part of ISSN: 15376591
Contributors: Roberts, J.A.; Joynt, G.M.; Lee, A.; Choi, G.; Bellomo, R.; Kanji, S.; Mudaliar, M.Y.; Peake, S.L.; Stephens, D.; Taccone, F.S. et al.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

The future of antimicrobial dosing in the ICU: an opportunity for data science

Intensive Care Medicine
2021-12 | Journal article
Contributors: Thomas De Corte; Paul Elbers; Jan De Waele
Source: check_circle
Crossref

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Critical care medicine
2021-11-01 | Journal article
Source: Self-asserted source
Jan De Waele

Antimicrobial stewardship in the ICU in COVID-19 times: the known unknowns

International Journal of Antimicrobial Agents
2021-10 | Journal article
Contributors: Jeroen Schouten; Jan De Waele; Christian Lanckohr; Despoina Koulenti; Nisrine Haddad; Nesrine Rizk; Fredrik Sjövall; Souha S. Kanj
Source: check_circle
Crossref

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Intensive care medicine
2021-10-02 | Journal article
Source: Self-asserted source
Jan De Waele

Pilot study of oral fluid and plasma meropenem and piperacillin concentrations in the intensive care unit.

Clinica chimica acta; international journal of clinical chemistry
2021-09-08 | Journal article
Source: Self-asserted source
Jan De Waele

Augmented renal clearance in critically ill COVID-19 patients: Forewarned is forearmed.

Journal of critical care
2021-09-06 | Journal article
Source: Self-asserted source
Jan De Waele

Antimicrobial stewardship, therapeutic drug monitoring and infection management in the ICU: results from the international A- TEAMICU survey.

Annals of intensive care
2021-08-26 | Journal article
Source: Self-asserted source
Jan De Waele

Initial antimicrobial management of sepsis.

Critical care (London, England)
2021-08-26 | Journal article
Source: Self-asserted source
Jan De Waele

A three-day antimicrobial course for community-acquired pneumonia? Still no evidence in intensive care unit

Anaesthesia Critical Care & Pain Medicine
2021-06 | Journal article
Contributors: Marc Leone; Alexandre Lopez; Caroline Userovici; Jan De Waele
Source: check_circle
Crossref
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Preferred source (of 2)‎

Development and validation of a liquid chromatography high-resolution mass spectrometry orbitrap method for the sensitive quantification of amoxicillin, piperacillin, tazobactam and meropenem in human faeces.

Analytica chimica acta
2021-06-16 | Journal article
Source: Self-asserted source
Jan De Waele
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Preferred source (of 4)‎

Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?

Intensive Care Medicine
2021-01-17 | Journal article
Contributors: Jan J. De Waele; Lennie Derde; Matteo Bassetti
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

A Clinician's Guide to Management of Intra-Abdominal Hypertension and Abdominal Compartment Syndrome in Critically Ill Patients

Critical Care
2020 | Journal article
EID:

2-s2.0-85082139539

Part of ISSN: 1466609X 13648535
Contributors: De Laet, I.E.; Malbrain, M.L.N.G.; De Waele, J.J.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Antimicrobial de-escalation in critically ill patients: a position statement from a task force of the European Society of Intensive Care Medicine (ESICM) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Critically Ill Patients Study Group (ESGCIP)

Intensive Care Medicine
2020 | Journal article
EID:

2-s2.0-85075663010

Part of ISSN: 14321238 03424642
Contributors: Tabah, A.; Bassetti, M.; Kollef, M.H.; Zahar, J.-R.; Paiva, J.-A.; Timsit, J.-F.; Roberts, J.A.; Schouten, J.; Giamarellou, H.; Rello, J. et al.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

Intensive Care Medicine
2020 | Journal article
EID:

2-s2.0-85086169918

Part of ISSN: 14321238 03424642
Contributors: De Bus, L.; Depuydt, P.; Steen, J.; Dhaese, S.; De Smet, K.; Tabah, A.; Akova, M.; Cotta, M.O.; De Pascale, G.; Dimopoulos, G. et al.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Antimicrobial De-Escalation in the ICU: From Recommendations to Level of Evidence

Advances in Therapy
2020 | Journal article
EID:

2-s2.0-85085469459

Part of ISSN: 18658652 0741238X
Contributors: Lakbar, I.; De Waele, J.J.; Tabah, A.; Einav, S.; Martin-Loeches, I.; Leone, M.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper<inf>#</inf>

Intensive Care Medicine
2020 | Journal article
EID:

2-s2.0-85084310195

Part of ISSN: 14321238 03424642
Contributors: Abdul-Aziz, M.H.; Alffenaar, J.-W.C.; Bassetti, M.; Bracht, H.; Dimopoulos, G.; Marriott, D.; Neely, M.N.; Paiva, J.-A.; Pea, F.; Sjovall, F. et al.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Conventional amphotericin B must be avoided in Candida infections

Intensive Care Medicine
2020 | Journal article
EID:

2-s2.0-85075689723

Part of ISSN: 14321238 03424642
Contributors: Martin-Loeches, I.; De Waele, J.J.; Timsit, J.F.; Bassetti, M.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Erratum to ‘When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit’ [Clin Microbiol Infect 26 (1) (January 2020) 35–40] (Clinical Microbiology and Infection (2020) 26(1) (35–40), (S1198743X19303969), (10.1016/j.cmi.2019.07.007))

Clinical Microbiology and Infection
2020 | Journal article
EID:

2-s2.0-85079863601

Part of ISSN: 14690691 1198743X
Contributors: Denny, K.J.; De Waele, J.; Laupland, K.B.; Harris, P.N.A.; Lipman, J.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

European intensive care physicians' experience of infections due to antibiotic-resistant bacteria

Antimicrobial Resistance and Infection Control
2020 | Journal article
EID:

2-s2.0-85077360166

Part of ISSN: 20472994
Contributors: Lepape, A.; Jean, A.; De Waele, J.; Friggeri, A.; Savey, A.; Vanhems, P.; Gustin, M.P.; Monnet, D.L.; Garnacho-Montero, J.; Kohlenberg, A.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

How to improve research on management of critically ill patients: Lessons learned from negative randomised clinical trials in the intensive care unit

Anaesthesia Critical Care and Pain Medicine
2020 | Journal article
EID:

2-s2.0-85079843589

Part of ISSN: 23525568
Contributors: Rello, J.; Blanch, L.; Preiser, J.-C.; De Waele, J.J.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Improving care for the ICU patient with suspected infection: a multidisciplinary perspective

Clinical Microbiology and Infection
2020 | Journal article
EID:

2-s2.0-85070663945

Part of ISSN: 14690691 1198743X
Contributors: Leone, M.; Pulcini, C.; De Waele, J.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

International variation in the management of severe COVID-19 patients

Critical Care
2020 | Journal article
EID:

2-s2.0-85089170472

Part of ISSN: 1466609X 13648535
Contributors: Azoulay, E.; De Waele, J.; Ferrer, R.; Staudinger, T.; Borkowska, M.; Povoa, P.; Iliopoulou, K.; Artigas, A.; Schaller, S.J.; Shankar-Hari, M. et al.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia

Journal of Antimicrobial Chemotherapy
2020 | Journal article
EID:

2-s2.0-85083459443

Part of ISSN: 14602091 03057453
Contributors: Caro, L.; Nicolau, D.P.; de Waele, J.J.; Kuti, J.L.; Larson, K.B.; Gadzicki, E.; Yu, B.; Zeng, Z.; Adedoyin, A.; Rhee, E.G.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier

Multidrug Resistant bacteria in ICU: Fact or myth

Current Opinion in Anaesthesiology
2020 | Journal article
EID:

2-s2.0-85081087615

Part of ISSN: 14736500 09527907
Contributors: De Waele, J.J.; Boelens, J.; Leroux-Roels, I.
Source: Self-asserted source
Jan De Waele via Scopus - Elsevier
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Peer review (22 reviews for 2 publications/grants)

Review activity for Annals of intensive care. (1)
Review activity for Intensive care medicine. (21)