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Keywords

pDC, Type I interferon, T cells

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Czech Republic

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Employment (2)

University of Lausanne: Lausanne, Vaud, CH

2021-09-01 to present | postdoctoral fellow (Department of Immunobiology)
Employment
Source: Self-asserted source
Aleš Drobek

Institute of Molecular Genetics: Prague, CZ

2016-01-01 to 2021-08-31 | postdoc (Laboratory of adaptive immunity)
Employment
Source: Self-asserted source
Aleš Drobek

Education and qualifications (2)

Institute of Molecular Genetics: Prague, CZ

2010-10-01 to 2015-12-14 | Ph.D. (Laboratory of leukocyte signaling)
Education
Source: Self-asserted source
Aleš Drobek

Katedra Buněčné Biologie a Genetiky Palackého Univerzita v Olomouci: Olomouc, CZ

2008-09-01 to 2010-06-30 | MSc
Education
Source: Self-asserted source
Aleš Drobek

Works (18)

CCDC134 controls TLR biogenesis through the ER chaperone Gp96

Journal of Experimental Medicine
2025-03-03 | Journal article
DOI: 10.1084/jem.20240825
Contributors: Léa Bernaleau; Michaela Drobek; Fenja Blank; Philipp Walch; Maeva Delacrétaz; Ales Drobek; Marta Monguió-Tortajada; Petr Broz; Olivia Majer; Manuele Rebsamen
Source: check_circle
Crossref

The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse

Nature Communications
2025-01-24 | Journal article
DOI: 10.1038/s41467-024-55692-y
Contributors: Ales Drobek; Léa Bernaleau; Maeva Delacrétaz; Sandra Calderon Copete; Claire Royer-Chardon; Mélissa Longepierre; Marta Monguió-Tortajada; Jakub Korzeniowski; Samuel Rotman; Julien Marquis et al.
Source: check_circle
Crossref

TBK1-associated adapters TANK and AZI2 protect mice against TNF-induced cell death and severe autoinflammatory diseases

Nature Communications
2024-11-19 | Journal article
DOI: 10.1038/s41467-024-54399-4
Contributors: Andrea Ujevic; Daniela Knizkova; Alzbeta Synackova; Michaela Pribikova; Tijana Trivic; Anna Dalinskaya; Ales Drobek; Veronika Niederlova; Darina Paprckova; Roldan De Guia et al.
Source: check_circle
Crossref

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

2023-10-30 | Preprint
DOI: 10.1101/2023.10.25.563918
Contributors: Sarka Janusova; Darina Paprckova; Juraj Michalik; Valeria Uleri; Ales Drobek; Eva Salyova; Louise Chorfi; Ales Neuwirth; Jan Prochazka; Radislav Sedlacek et al.
Source: check_circle
Crossref

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells

Nature Immunology
2023-01 | Journal article
DOI: 10.1038/s41590-022-01366-0
Contributors: Veronika Horkova; Ales Drobek; Darina Paprckova; Veronika Niederlova; Avishek Prasai; Valeria Uleri; Daniela Glatzova; Markus Kraller; Michaela Cesnekova; Sarka Janusova et al.
Source: check_circle
Crossref

Phenotypic and Clonal Stability of Antigen-Inexperienced Memory-like T Cells across the Genetic Background, Hygienic Status, and Aging

The Journal of Immunology
2021-05-01 | Journal article
DOI: 10.4049/jimmunol.2001028
Contributors: Alena Moudra; Veronika Niederlova; Jiri Novotny; Lucie Schmiedova; Jan Kubovciak; Tereza Matejkova; Ales Drobek; Michaela Pribikova; Romana Stopkova; Dagmar Cizkova et al.
Source: check_circle
Crossref

Bardet–Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self‐tolerance

EMBO reports
2021-02-03 | Journal article
DOI: 10.15252/embr.202050785
Contributors: Oksana Tsyklauri; Veronika Niederlova; Elizabeth Forsythe; Avishek Prasai; Ales Drobek; Petr Kasparek; Kathryn Sparks; Zdenek Trachtulec; Jan Prochazka; Radislav Sedlacek et al.
Source: check_circle
Crossref

Systematic analysis of the IL ‐17 receptor signalosome reveals a robust regulatory feedback loop

The EMBO Journal
2020-09 | Journal article
DOI: 10.15252/embj.2019104202
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Source: Self-asserted source
Aleš Drobek

Phenotypic and clonal stability of antigen-inexperienced memory-like T cells across the genetic background, hygienic status, and aging

2020-09-01 | Preprint
DOI: 10.1101/2020.09.01.277004
Contributors: Alena Moudra; Veronika Niederlova; Jiri Novotny; Lucie Schmiedova; Jan Kubovciak; Tereza Matejkova; Ales Drobek; Michaela Pribikova; Romana Stopkova; Dagmar Cizkova et al.
Source: check_circle
Crossref

Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis

The Journal of Immunology
2020-03-15 | Journal article
DOI: 10.4049/jimmunol.1900953
Contributors: Jarmila Kralova; Ales Drobek; Jan Prochazka; Frantisek Spoutil; Matej Fabisik; Daniela Glatzova; Simon Borna; Jana Pokorna; Tereza Skopcova; Pavla Angelisova et al.
Source: check_circle
Crossref

Altered hematopoietic system and self-tolerance in Bardet-Biedl Syndrome

2020-02-25 | Preprint
DOI: 10.1101/2020.02.24.962886
Contributors: Oksana Tsyklauri; Veronika Niederlova; Elizabeth Forsythe; Ales Drobek; Avishek Prasai; Kathryn Sparks; Zdenek Trachtulec; Philip Beales; Martina Huranova; Ondrej Stepanek
Source: check_circle
Crossref

Dynamics of the Coreceptor-LCK Interactions during T Cell Development Shape the Self-Reactivity of Peripheral CD4 and CD8 T Cells.

Cell reports
2020-02-01 | Journal article
DOI: 10.1016/j.celrep.2020.01.008
PMID: 32023465
PMC: PMC7003063
Source: Self-asserted source
Aleš Drobek

Transmembrane adaptor protein WBP1L regulates CXCR4 signalling and murine haematopoiesis.

Journal of cellular and molecular medicine
2019-12-17 | Journal article
DOI: 10.1111/jcmm.14895
PMID: 31845480
PMC: PMC6991692
Source: Self-asserted source
Aleš Drobek

Strong homeostatic TCR signals induce formation of self‐tolerant virtual memory CD8 T cells

The EMBO Journal
2018-07-13 | Journal article
DOI: 10.15252/embj.201798518
Contributors: Ales Drobek; Alena Moudra; Daniel Mueller; Martina Huranova; Veronika Horkova; Michaela Pribikova; Robert Ivanek; Susanne Oberle; Dietmar Zehn; Kathy D McCoy et al.
Source: check_circle
Crossref

Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice.

European journal of immunology
2016-06-08 | Journal article
DOI: 10.1002/eji.201545909
PMID: 27188212
Source: Self-asserted source
Aleš Drobek

PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk.

Journal of Immunology
2015-10-01 | Journal article
DOI: 10.4049/jimmunol.1401494
Source: Self-asserted source
Aleš Drobek

Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling.

Journal of immunology (Baltimore, Md. : 1950)
2013-01-18 | Journal article
DOI: 10.4049/jimmunol.1202401
PMID: 23335753
Source: Self-asserted source
Aleš Drobek

LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.

The Journal of biological chemistry
2012-05-15 | Journal article
DOI: 10.1074/jbc.M112.339143
PMID: 22589543
PMC: PMC3391116
Source: Self-asserted source
Aleš Drobek
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