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Scopus Author ID: 56240755700

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Employment (1)

Ludwig-Maximilians-Universität München: Munich, DE

2007-12-01 to present | Professor for Cellular Immunology (Institute for Immunology)
Employment
Source: Self-asserted source
Ludger Klein

Funding (11)

Clonal Deletion versus Clonal Diversion: Footprints of Self-Tolerance in the T CellRepertoire

2017-10-01 to 2022-09-30 | Grant
European Research Council (Brussels, BE)
URL: https://app.dimensions.ai/details/grant/grant.7031223
GRANT_NUMBER: 742290
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Aire-expressing lymph node cells

2014-01-01 to 2018-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4836746
GRANT_NUMBER: 262976230
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Determinants of Intrathymic T-Cell Fate Decisions (A01)

2013-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4824781
GRANT_NUMBER: 230007042
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Integrated Research Training Group "Cell-Fate Decisions in the Immune System" (MGK)

2013-01-01 to present | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4828100
GRANT_NUMBER: 230093235
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Functional adaptation of intrathymically differentiating B cells for central T cell tolerance

2013-01-01 to 2018-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4834875
GRANT_NUMBER: 248337665
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Control of development and tolerogenic properties of thymic epithelial cells by micro RNAs

2011-01-01 to 2015-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4823393
GRANT_NUMBER: 200496832
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Exploring the tolerogenic function of medullary thymic epithelial cells using tissue-specific knockdown in transgenic mice

2009-01-01 to 2018-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4813068
GRANT_NUMBER: 153724361
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Autophagy in thymic epithelium and T cell tolerance

2009-01-01 to 2013-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4802786
GRANT_NUMBER: 116141321
Source: Self-asserted source
Ludger Klein via DimensionsWizard

A Phenotypic and molecular roadmap of regulatory T cell development (B09)

2008-01-01 to 2011-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4805379
GRANT_NUMBER: 67806983
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Spezifische Induktion dominanter T Zelltoleranz durch intrathymischen Transfer modifizierter thymischer Epithel-Vorläuferzellen (B20)

2008-01-01 to 2010-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4802576
GRANT_NUMBER: 66454750
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Einfluß der Tumorprogression auf Tumor-spezifische T-Zellen in einem transgenen Modell

1998-01-01 to 2002-12-31 | Grant
German Research Foundation (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.4741849
GRANT_NUMBER: 5154742
Source: Self-asserted source
Ludger Klein via DimensionsWizard

Works (50 of 56)

Items per page:
Page 1 of 2

Recollections of the discovery of promiscuous antigen expression in mTECs

Nature Immunology
2020-11 | Journal article
DOI: 10.1038/s41590-020-0771-9
Contributors: Ludger Klein
Source: check_circle
Crossref

B cells latently infected with murine gammaherpesvirus 68 (MHV-68) are present in the mouse thymus–A step toward immune evasion?

European Journal of Immunology
2019 | Journal article
DOI: 10.1002/eji.201847886
EID:

2-s2.0-85058240748
Contributors: Yamano, T.; Steinert, M.; Steer, B.; Klein, L.; Hammerschmidt, W.; Adler, H.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Central CD4<sup>+</sup> T cell tolerance: deletion versus regulatory T cell differentiation

Nature Reviews Immunology
2019 | Journal article
DOI: 10.1038/s41577-018-0083-6
EID:

2-s2.0-85056457732
Contributors: Klein, L.; Robey, E.A.; Hsieh, C.-S.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire

European Journal of Immunology
2018 | Journal article
DOI: 10.1002/eji.201747267
EID:

2-s2.0-85043388289
Contributors: Dobeš, J.; Edenhofer, F.; Vobořil, M.; Brabec, T.; Dobešová, M.; Čepková, A.; Klein, L.; Rajewsky, K.; Filipp, D.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Bruno Kyewski 1950–2018

Nature Immunology
2018 | Journal article
DOI: 10.1038/s41590-018-0095-1
EID:

2-s2.0-85045191154
Contributors: Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Epitope-specific tolerance modes differentially specify susceptibility to proteolipid protein-induced experimental autoimmune encephalomyelitis

Frontiers in Immunology
2017 | Journal article
DOI: 10.3389/fimmu.2017.01511
EID:

2-s2.0-85034091764
Contributors: Wang, L.; Winnewisser, J.; Federle, C.; Jessberger, G.; Nave, K.-A.; Werner, H.B.; Kyewski, B.; Klein, L.; Hinterberger, M.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

Journal of Immunology
2016 | Journal article
DOI: 10.1038/ni723
EID:

2-s2.0-84962492381
Contributors: Derbinski, J.; Schulte, A.; Kyewski, B.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells

Development (Cambridge)
2016 | Journal article
DOI: 10.1242/dev.130203
EID:

2-s2.0-84968779632
Contributors: Pasquarella, A.; Ebert, A.; de Almeida, G.P.; Hinterberger, M.; Kazerani, M.; Nuber, A.; Ellwart, J.; Klein, L.; Busslinger, M.; Schotta, G.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Thymic CD4 T cell selection requires attenuation of March8-mediated MHC II turnover in cortical epithelial cells through CD83

Journal of Experimental Medicine
2016 | Journal article
DOI: 10.1084/jem.20160316
EID:

2-s2.0-84984856739
Contributors: von Rohrscheidt, J.; Petrozziello, E.; Nedjic, J.; Federle, C.; Krzyzak, L.; Ploegh, H.L.; Ishido, S.; Steinkasserer, A.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Aire Gets Company for Immune Tolerance

Cell
2015 | Journal article
DOI: 10.1016/j.cell.2015.10.057
EID:

2-s2.0-84946228030
Contributors: Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Induced miR-99a expression represses Mtor cooperatively with miR-150 to promote regulatory T-cell differentiation

EMBO Journal
2015 | Journal article
DOI: 10.15252/embj.201489589
EID:

2-s2.0-84929027816
Contributors: Warth, S.C.; Hoefig, K.P.; Hiekel, A.; Schallenberg, S.; Jovanovic, K.; Klein, L.; Kretschmer, K.; Ansel, K.M.; Heissmeyer, V.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Thymic B cells and central T cell tolerance

Frontiers in Immunology
2015 | Journal article
DOI: 10.3389/fimmu.2015.00376
EID:

2-s2.0-84938524665
Contributors: Yamano, T.; Steinert, M.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

Immunity
2015 | Journal article
DOI: 10.1016/j.immuni.2015.05.013
EID:

2-s2.0-84937631527
Contributors: Yamano, T.; Nedjic, J.; Hinterberger, M.; Steinert, M.; Koser, S.; Pinto, S.; Gerdes, N.; Lutgens, E.; Ishimaru, N.; Busslinger, M. et al.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

Immunity
2014 | Journal article
DOI: 10.1016/j.immuni.2014.10.012
EID:

2-s2.0-84912113033
Contributors: Vahl, J.; Drees, C.; Heger, K.; Heink, S.; Fischer, J.C.; Nedjic, J.; Ohkura, N.; Morikawa, H.; Poeck, H.; Schallenberg, S. et al.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Positive and negative selection of the T cell repertoire: What thymocytes see (and don't see)

Nature Reviews Immunology
2014 | Journal article
DOI: 10.1038/nri3667
EID:

2-s2.0-84901487911
Contributors: Klein, L.; Kyewski, B.; Allen, P.M.; Hogquist, K.A.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

Journal of Experimental Medicine
2013 | Journal article
DOI: 10.1084/jem.20122149
EID:

2-s2.0-84874565064
Contributors: Aichinger, M.; Wu, C.; Nedjic, J.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Thymic epithelial cells use macroautophagy to turn their inside out for CD4 T cell tolerance

Autophagy
2013 | Journal article
DOI: 10.4161/auto.24374
EID:

2-s2.0-84880855085
Contributors: Wu, C.; Aichinger, M.; Nedjic, J.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy

Autophagy
2012 | Journal article
DOI: 10.4161/auto.19496
EID:

2-s2.0-84862295360
Contributors: Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; Agnello, M.; Agostinis, P.; Aguirre-Ghiso, J.A. et al.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Probing gene function in thymic epithelial cells

European Journal of Cell Biology
2012 | Journal article
DOI: 10.1016/j.ejcb.2011.01.005
EID:

2-s2.0-84855920146
Contributors: Aichinger, M.; Hinterberger, M.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Regulatory T Cell Differentiation: Turning Harmful into Useful

Immunity
2012 | Journal article
DOI: 10.1016/j.immuni.2012.09.002
EID:

2-s2.0-84866495624
Contributors: Klein, L.; Jovanovic, K.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance

Trends in Immunology
2011 | Journal article
DOI: 10.1016/j.it.2011.03.002
EID:

2-s2.0-79955625097
Contributors: Klein, L.; Hinterberger, M.; von Rohrscheidt, J.; Aichinger, M.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

B7/CD28 in central tolerance: Costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion

Frontiers in Immunology
2011 | Journal article
DOI: 10.3389/fimmu.2011.00030
EID:

2-s2.0-82155170171
Contributors: Hinterberger, M.; Wirnsberger, G.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Loss of Roquin induces early death and immune deregulation but not autoimmunity

Journal of Experimental Medicine
2011 | Journal article
DOI: 10.1084/jem.20110578
EID:

2-s2.0-80054842844
Contributors: Bertossi, A.; Aichinger, M.; Sansonetti, P.; Lech, M.; Neff, F.; Pal, M.; Wunderlich, F.T.; Anders, H.-J.; Klein, L.; Schmidt-Supprian, M.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Regulatory T cell lineage commitment in the thymus

Seminars in Immunology
2011 | Journal article
DOI: 10.1016/j.smim.2011.06.003
EID:

2-s2.0-82755198003
Contributors: Klein, L.; Jovanovic, K.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes

Immunology and Cell Biology
2011 | Journal article
DOI: 10.1038/icb.2010.123
EID:

2-s2.0-78651091811
Contributors: Wirnsberger, G.; Hinterberger, M.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Autonomous role of medullary thymic epithelial cells in central CD4<sup>+</sup>T cell tolerance

Nature Immunology
2010 | Journal article
DOI: 10.1038/ni.1874
EID:

2-s2.0-77952568022
Contributors: Hinterberger, M.; Aichinger, M.; Da Costa, O.P.; Voehringer, D.; Hoffmann, R.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Autophagy-mediated antigen processing in CD4<sup>+</sup> T cell tolerance and immunity

FEBS Letters
2010 | Journal article
DOI: 10.1016/j.febslet.2010.01.008
EID:

2-s2.0-77950510828
Contributors: Klein, L.; Münz, C.; Lünemann, J.D.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Antigen presentation in the thymus for positive selection and central tolerance induction

Nature Reviews Immunology
2009 | Journal article
DOI: 10.1038/nri2669
EID:

2-s2.0-72949104779
Contributors: Klein, L.; Hinterberger, M.; Wirnsberger, G.; Kyewski, B.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Dead man walking: How thymocytes scan the medulla

Nature Immunology
2009 | Journal article
DOI: 10.1038/ni0809-809
EID:

2-s2.0-67651177609
Contributors: Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Macroautophagy, endogenous MHC II loading and T cell selection: the benefits of breaking the rules

Current Opinion in Immunology
2009 | Journal article
DOI: 10.1016/j.coi.2009.01.013
EID:

2-s2.0-64049084637
Contributors: Nedjic, J.; Aichinger, M.; Mizushima, N.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

Proceedings of the National Academy of Sciences of the United States of America
2009 | Journal article
DOI: 10.1073/pnas.0901877106
EID:

2-s2.0-67649844269
Contributors: Wirnsberger, G.; Mair, F.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

A novel role for autophagy in T cell education

Autophagy
2008 | Journal article
DOI: 10.4161/auto.7139
EID:

2-s2.0-58149089664
Contributors: Nedjic, J.; Aichinger, M.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Autophagy and T cell education in the thymus: Eat yourself to know yourself

Cell Cycle
2008 | Journal article
DOI: 10.4161/cc.7.23.7121
EID:

2-s2.0-57349184583
Contributors: Nedjic, J.; Aichinger, M.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

Nature
2008 | Journal article
DOI: 10.1038/nature07208
EID:

2-s2.0-52149099867
Contributors: Nedjic, J.; Aichinger, M.; Emmerich, J.; Mizushima, N.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Selection of Foxp3<sup>+</sup>regulatory T cells specific for self antigen expressed and presented by Aire<sup>+</sup>medullary thymic epithelial cells

Nature Immunology
2007 | Journal article
DOI: 10.1038/ni1444
EID:

2-s2.0-34248598295
Contributors: Aschenbrenner, K.; D'Cruz, L.M.; Vollmann, E.H.; Hinterberger, M.; Emmerich, J.; Swee, L.K.; Rolink, A.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

A central role for central tolerance

Annual Review of Immunology
2006 | Book
DOI: 10.1146/annurev.immunol.23.021704.115601
EID:

2-s2.0-33646165128
Contributors: Kyewski, B.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

Nature Immunology
2005 | Journal article
DOI: 10.1038/ni1264
EID:

2-s2.0-27544446622
Contributors: D'Cruz, L.M.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire

Cancer Research
2005 | Journal article
DOI: 10.1158/0008-5472.CAN-05-0666
EID:

2-s2.0-22244447452
Contributors: Bos, R.; Van Duikeren, S.; Van Hall, T.; Kaaijk, P.; Taubert, R.; Kyewski, B.; Klein, L.; Melief, C.J.M.; Offringa, R.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Expression of the B7.1 costimulatory molecule on pancreatic β cells abrogates the requirement for CD4 T cells in the development, of type 1 diabetes

Journal of Immunology
2004 | Journal article
EID:

2-s2.0-3142694831
Contributors: Havari, E.; Lennon-Dumenil, A.M.; Klein, L.; Neely, D.; Taylor, J.A.; McInerney, M.F.; Wucherpfennig, K.W.; Lipes, M.A.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro

Proceedings of the National Academy of Sciences of the United States of America
2003 | Journal article
DOI: 10.1073/pnas.1533365100
EID:

2-s2.0-0041806547
Contributors: Klein, L.; Khazaie, K.; Von Boehmer, H.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase

Journal of Experimental Medicine
2003 | Journal article
DOI: 10.1084/jem.20030215
EID:

2-s2.0-0038204841
Contributors: Jaeckel, E.; Klein, L.; Martin-Orozco, N.; Von Boehmer, H.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Thymic selection revisited: How essential is it?

Immunological Reviews
2003 | Journal article
DOI: 10.1034/j.1600-065X.2003.00010.x
EID:

2-s2.0-0037304536
Contributors: Von Boehmer, H.; Aifantis, I.; Gounari, F.; Azogui, O.; Haughn, L.; Apostolou, I.; Jaeckel, E.; Grassi, F.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Visualizing the course of antigen-specific CD8 and CD4 T cell responses to a growing tumor

European Journal of Immunology
2003 | Journal article
DOI: 10.1002/eji.200323800
EID:

2-s2.0-0037352724
Contributors: Klein, L.; Trautman, L.; Psarras, S.; Schnell, S.; Siermann, A.; Liblau, R.; von Boehmer, H.; Khazaie, K.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Cutting edge: Attenuated experimental autoimmune encephalomyelitis in ETA-1/osteopontin-deficient mice

Journal of Immunology
2002 | Journal article
DOI: 10.4049/jimmunol.168.5.2096
EID:

2-s2.0-0036499086
Contributors: Jansson, M.; Panoutsakopoulou, V.; Baker, J.; Klein, L.; Cantor, H.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Origin of regulatory T cells with known specificity for antigen

Nature Immunology
2002 | Journal article
DOI: 10.1038/ni816
EID:

2-s2.0-0036345337
Contributors: Apostolou, I.; Sarukhan, A.; Klein, L.; Von Boehmer, H.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Projection of an immunological self shadow within the thymus by the aire protein

Science
2002 | Journal article
DOI: 10.1126/science.1075958
EID:

2-s2.0-0037112047
Contributors: Anderson, M.S.; Venanzi, E.S.; Klein, L.; Chen, Z.; Berzins, S.P.; Turley, S.J.; Von Boehmer, H.; Bronson, R.; Dierich, A.; Benoist, C. et al.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Promiscuous gene expression and central T-cell tolerance: More than meets the eye

Trends in Immunology
2002 | Journal article
DOI: 10.1016/S1471-4906(02)02248-2
EID:

2-s2.0-0036644686
Contributors: Kyewski, B.; Derbinski, J.; Gotter, J.; Klein, L.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Stabilization of β-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia

Oncogene
2002 | Journal article
DOI: 10.1038/sj.onc.1205562
EID:

2-s2.0-0037071903
Contributors: Gounari, F.; Signoretti, S.; Bronson, R.; Klein, L.; Sellers, W.R.; Kum, J.; Siermann, A.; Taketo, M.M.; Von Boehmer, H.; Khazaie, K.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

European Journal of Immunology
2001 | Journal article
DOI: 10.1002/1521-4141(200108)31:8<2476::AID-IMMU2476>3.0.CO;2-T
EID:

2-s2.0-0034857910
Contributors: Klein, L.; Roettinger, B.; Kyewski, B.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier

'Promiscuous' expression of tissue antigens in the thymus: A key to T-cell tolerance and autoimmunity?

Journal of Molecular Medicine
2000 | Journal article
DOI: 10.1007/s001090000146
EID:

2-s2.0-0033673148
Contributors: Klein, L.; Kyewski, B.
Source: Self-asserted source
Ludger Klein via Scopus - Elsevier
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