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Employment (3)

Harvard Medical School: Boston, MA, US

2023-07-01 to present | Assistant Professor (Department of Biomedical Informatics)
Employment
Source: Self-asserted source
Luke O'Connor

Broad Institute: MA, MA, US

2019-08-01 to 2023-07-01 | Principal investigator
Employment
Source: Self-asserted source
Luke O'Connor

Harvard T.H. Chan School of Public Health: Boston, MA, US

2015-09-01 to 2019-07-31 | PhD Student (Epidemiology)
Employment
Source: Self-asserted source
Luke O'Connor

Works (17)

Effect heterogeneity reveals complex pleiotropic effects of rare coding variants

2024-10-02 | Preprint
DOI: 10.1101/2024.10.01.614806
Contributors: Wenhan Lu; Siwei Chen; Danielle Posthuma; Benjamin M. Neale; Luke J. O’Connor; Konrad J. Karczewski
Source: check_circle
Crossref

Transcriptome-wide characterization of genetic perturbations

2024-07-03 | Preprint
DOI: 10.1101/2024.07.03.601903
Contributors: Ajay Nadig; Joseph M. Replogle; Angela N. Pogson; Steven A McCarroll; Jonathan S. Weissman; Elise B. Robinson; Luke J. O’Connor
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Crossref

Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies

Nature Genetics
2023-09 | Journal article
DOI: 10.1038/s41588-023-01487-8
Contributors: Pouria Salehi Nowbandegani; Anthony Wilder Wohns; Jenna L. Ballard; Eric S. Lander; Alex Bloemendal; Benjamin M. Neale; Luke J. O’Connor
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Crossref

Polygenic architecture of rare coding variation across 394,783 exomes

Nature
2023-02-16 | Journal article
DOI: 10.1038/s41586-022-05684-z
Contributors: Daniel J. Weiner; Ajay Nadig; Karthik A. Jagadeesh; Kushal K. Dey; Benjamin M. Neale; Elise B. Robinson; Konrad J. Karczewski; Luke J. O’Connor
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Crossref

HAPNEST: efficient, large-scale generation and evaluation of synthetic datasets for genotypes and phenotypes

2022-12-22 | Preprint
DOI: 10.1101/2022.12.22.521552
Contributors: Sophie Wharrie; Zhiyu Yang; Vishnu Raj; Remo Monti; Rahul Gupta; Ying Wang; Alicia Martin; Luke J O’Connor; Samuel Kaski; Pekka Marttinen et al.
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Crossref

Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies

2022-09-08 | Preprint
DOI: 10.1101/2022.09.06.506858
Contributors: Pouria Salehi Nowbandegani; Anthony Wilder Wohns; Jenna L. Ballard; Eric S. Lander; Alex Bloemendal; Benjamin M. Neale; Luke J. O’Connor
Source: check_circle
Crossref

Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity

Nature Genetics
2022-06 | Journal article
DOI: 10.1038/s41588-022-01087-y
Contributors: Steven Gazal; Omer Weissbrod; Farhad Hormozdiari; Kushal K. Dey; Joseph Nasser; Karthik A. Jagadeesh; Daniel J. Weiner; Huwenbo Shi; Charles P. Fulco; Luke J. O’Connor et al.
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Crossref

Shared components of heritability across genetically correlated traits

2021-11-30 | Other
DOI: 10.1101/2021.11.25.470021
Contributors: Jenna Lee Ballard; Luke Jen O’Connor
Source: check_circle
Crossref

The distribution of common-variant effect sizes

Nature Genetics
2021-08-29 | Journal article
DOI: 10.1038/s41588-021-00901-3
Contributors: Luke J. O’Connor
Source: check_circle
Crossref

Significance testing for small annotations in stratified LD-Score regression

2021-03-24 | Other
DOI: 10.1101/2021.03.13.21249938
Contributors: Katherine C. Tashman; Ran Cui; Luke J. O’Connor; Benjamin M. Neale; Hilary K. Finucane
Source: check_circle
Crossref

Negative short-range genomic autocorrelation of causal effects on human complex traits

2020-09-24 | Other
DOI: 10.1101/2020.09.23.310748
Contributors: Armin P. Schoech; Omer Weissbrod; Luke J. O’Connor; Nick Patterson; Huwenbo Shi; Yakir Reshef; Alkes L. Price
Source: check_circle
Crossref

The distribution of common-variant effect sizes

2020-09-20 | Preprint
DOI: 10.1101/2020.09.19.304097
Contributors: Luke Jen O’Connor
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Crossref

Quantifying genetic effects on disease mediated by assayed gene expression levels

Nature Genetics
2020-06-18 | Journal article
DOI: 10.1038/s41588-020-0625-2
Contributors: Douglas W. Yao; Luke J. O’Connor; Alkes L. Price; Alexander Gusev
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Crossref

Functional disease architectures reveal unique biological role of transposable elements

Nature Communications
2019-09-06 | Journal article
DOI: 10.1038/s41467-019-11957-5
Contributors: Farhad Hormozdiari; Bryce van de Geijn; Joseph Nasser; Omer Weissbrod; Steven Gazal; Chelsea J. -T. Ju; Luke O’ Connor; Margaux L. A. Hujoel; Jesse Engreitz; Fereydoun Hormozdiari et al.
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Crossref

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Nature Communications
2019-02-15 | Journal article
DOI: 10.1038/s41467-019-08424-6
Contributors: Armin P. Schoech; Daniel M. Jordan; Po-Ru Loh; Steven Gazal; Luke J. O’Connor; Daniel J. Balick; Pier F. Palamara; Hilary K. Finucane; Shamil R. Sunyaev; Alkes L. Price
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Crossref

Author Correction: Distinguishing genetic correlation from causation across 52 diseases and complex traits

Nature Genetics
2018-12-06 | Journal article
DOI: 10.1038/s41588-018-0296-4
Contributors: Luke J. O’Connor; Alkes L. Price
Source: check_circle
Crossref

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Nature Genetics
2018-10-03 | Journal article
DOI: 10.1038/s41588-018-0196-7
Contributors: Yakir A. Reshef; Hilary K. Finucane; David R. Kelley; Alexander Gusev; Dylan Kotliar; Jacob C. Ulirsch; Farhad Hormozdiari; Joseph Nasser; Luke O’Connor; Bryce van de Geijn et al.
Source: check_circle
Crossref

Peer review (23 reviews for 9 publications/grants)

Review activity for American journal of human genetics. (2)
Review activity for Cell genomics. (1)
Review activity for Nature (2)
Review activity for Nature aging. (1)
Review activity for Nature communications (3)
Review activity for Nature genetics. (5)
Review activity for Nature reviews. (1)
Review activity for PLoS biology. (2)
Review activity for PLOS genetics. (6)
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