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Works (45)

Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential

Antioxidants
2025-02 | Journal article | Author
DOI: 10.3390/antiox14030264
Contributors: Antonio José Cabrera Serrano; José Manuel Sánchez-Maldonado; Carmen González Olmedo; María Carretero Fernández; Leticia Diaz Beltran; Juan Francisco Gutiérrez-Bautista; Francisco José García-Verdejo; Fernando Gálvez-Montosa; José Antonio López-López; Paloma García-Martín et al.
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Semisynthesis and Antitumour Evaluation of Natural Derivatives from <i>ent</i>-Kaurene <i>ent</i>-15α-Angeloyloxykaur-l6-en-3β-ol Isolated from <i>Distichoselinum tenuifolium</i>

International Journal of Molecular Sciences
2024-12 | Journal article | Author
DOI: 10.3390/ijms252313222
Contributors: Yass K. Yasser; Daniel Gil; HOUDA ZENTAR; María Jesús Durán Peña; Belen Prados-Lopez; Jorge Juárez-Moreno; José Manuel Botubol-Ares; Ali Haidour Benamin; JUAN SAINZ; Antonio Jesús Fernández Vargas et al.
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Multidisciplinary Digital Publishing Institute

Principal Bioactive Properties of Oleanolic Acid, Its Derivatives, and Analogues

Molecules
2024-07-12 | Journal article
DOI: 10.3390/molecules29143291
Contributors: Fatin Jannus; Juan Sainz; Fernando J. Reyes-Zurita
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Evaluation of Anticancer and Anti-Inflammatory Activities of Some Synthetic Rearranged Abietanes

International Journal of Molecular Sciences
2023-09-01 | Journal article
DOI: 10.3390/ijms241713583
Contributors: Mustapha Ait El Had; Houda Zentar; Blanca Ruiz-Muñoz; Juan Sainz; Juan J. Guardia; Antonio Fernández; José Justicia; Enrique Alvarez-Manzaneda; Fernando J. Reyes-Zurita; Rachid Chahboun
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Synthesis of Tricyclic Pterolobirin H Analogue: Evaluation of Anticancer and Anti-Inflammatory Activities and Molecular Docking Investigations

Molecules
2023-08-23 | Journal article
DOI: 10.3390/molecules28176208
Contributors: Houda Zentar; Fatin Jannus; Marta Medina-O’Donnell; Az-eddine El Mansouri; Antonio Fernández; José Justicia; Enrique Alvarez-Manzaneda; Fernando J. Reyes-Zurita; Rachid Chahboun
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CONSIDERATIONS ABOUT THE FINAL DEGREE PROJECT (FDP)

2022-11 | Conference paper
DOI: 10.21125/iceri.2022.0727
Contributors: Fernando Jesús Reyes Zurita; Juan Sainz Pérez; Marta Medina O'Donnell
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THE USE OF PASCAL AS TEACHING TOOL FOR PROTEIN ENGINEERING

2022-11 | Conference paper
DOI: 10.21125/iceri.2022.0716
Contributors: Juan Sainz Pérez; Marta Medina O'Donnell; Fernando Jesús Reyes Zurita
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Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

Molecules
2022-09-04 | Journal article
DOI: 10.3390/molecules27175705
Contributors: Houda Zentar; Fatin Jannus; Marta Medina-O’Donnell; José A. Lupiáñez; José Justicia; Ramón Alvarez-Manzaneda; Fernando J. Reyes-Zurita; Enrique Alvarez-Manzaneda; Rachid Chahboun
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Nutraceutical Role of Polyphenols and Triterpenes Present in the Extracts of Fruits and Leaves of <i>Olea europaea</i> as Antioxidants, Anti-Infectives and Anticancer Agents on Healthy Growth

Molecules
2022-04 | Journal article | Author
DOI: 10.3390/molecules27072341
Contributors: Eva E. Rufino-Palomares; Amalia Pérez-Jiménez; Encarnacion Leticia Garcia Salguero; khalida mokhtari; Fernando J. Reyes-Zurita; Peragón, Juan; José Antonio Lupiáñez
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Effects of Erythrodiol on the Antioxidant Response and Proteome of HepG2 Cells

Antioxidants
2021-12 | Journal article | Author
DOI: 10.3390/antiox11010073
Contributors: Juan Luis Peñas-Fuentes; Siles, E.; Eva E. Rufino-Palomares; Amalia Pérez-Jiménez; Fernando J. Reyes-Zurita; José Antonio Lupiáñez; Carlos Fuentes-Almagro; Peragón, Juan
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Efficient In Vitro and In Vivo Anti-Inflammatory Activity of a Diamine-PEGylated Oleanolic Acid Derivative

International Journal of Molecular Sciences
2021-07 | Journal article | Author
DOI: 10.3390/ijms22158158
Contributors: Fatin Jannus; Marta Medina-O’Donnell; Veronika Elisabeth Neubrand; Milagros Marín; María José Saez Lara; M. Rosario Sepulveda; Eva E. Rufino-Palomares; Antonio Martinez; José Antonio Lupiáñez; Andres Parra et al.
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Multidisciplinary Digital Publishing Institute

Diclofenac N-Derivatives as Therapeutic Agents with Anti-Inflammatory and Anti-Cancer Effect

International Journal of Molecular Sciences
2021-05 | Journal article | Author
DOI: 10.3390/ijms22105067
Contributors: Alberto Galisteo; Fatin Jannus; Amalia García-García; Houssam Aheget; Sara Rojas; José Antonio Lupiáñez; Antonio Rodríguez Diéguez; Fernando J. Reyes-Zurita; Jose Francisco Quilez Del Moral
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A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells

Biomolecules
2020-09 | Journal article | Author
DOI: 10.3390/biom10101375
Contributors: Fatin Jannus; Marta Medina-O’Donnell; Francisco Rivas; Luis Díaz-Ruiz; Eva E. Rufino-Palomares; José Antonio Lupiáñez; Andrés Parra; Fernando J. Reyes-Zurita
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Antiproliferative and Pro-Apoptotic Effect of Uvaol in Human Hepatocarcinoma HepG2 Cells by Affecting G0/G1 Cell Cycle Arrest, ROS Production and AKT/PI3K Signaling Pathway

Molecules
2020-09 | Journal article | Author
DOI: 10.3390/molecules25184254
Contributors: Gloria C. Bonel-Pérez; Amalia Pérez-Jiménez; Isabel Gris-Cárdenas; Alberto M. Parra-Perez; José Antonio Lupiáñez; Fernando J. Reyes-Zurita; Siles, E.; René Csuk; Peragón, Juan; Eva E. Rufino-Palomares
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Multidisciplinary Digital Publishing Institute
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Designing Single-Molecule Magnets as Drugs with Dual Anti-Inflammatory and Anti-Diabetic Effects

International Journal of Molecular Sciences
2020-04 | Journal article | Author
DOI: 10.3390/ijms21093146
Contributors: Arturo Navas; Fatin Jannus; María Belén Fernández López; Javier Cepeda; Marta Medina O'Donnell; Luis Díaz-Ruiz; Sanchez Gonzalez Cristina; Juan Llopis; José M. Seco; Eva E. Rufino-Palomares et al.
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Multidisciplinary Digital Publishing Institute

Oleanolic Acid Derivatives as Potential Inhibitors of HIV-1 Protease

Journal of Natural Products
2019 | Journal article
DOI: 10.1021/acs.jnatprod.9b00649
EID:

2-s2.0-85073820204
Contributors: Medina-O'donnell, M.; Rivas, F.; Reyes-Zurita, F.J.; Cano-Muñoz, M.; Martinez, A.; Lupiañez, J.A.; Parra, A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Diamine and PEGylated-diamine conjugates of triterpenic acids as potential anticancer agents

European Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1016/j.ejmech.2018.02.044
EID:

2-s2.0-85042181313
Contributors: Medina-O'Donnell, M.; Rivas, F.; Reyes-Zurita, F.J.; Martinez, A.; Lupiañez, J.A.; Parra, A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Modulating Anticancer Potential by Modifying the Structural Properties of a Family of Zinc Metal-Organic Chains Based on 4-Nitro-1H-pyrazole

Crystal Growth and Design
2018 | Journal article
DOI: 10.1021/acs.cgd.7b01443
EID:

2-s2.0-85041929700
Contributors: Fernández, B.; Fernández, I.; Cepeda, J.; Medina-O'Donnell, M.; Rufino-Palomares, E.E.; Raya-Barón, Á.; Gómez-Ruiz, S.; Pérez-Jiménez, A.; Lupiáñez, J.A.; Reyes-Zurita, F.J. et al.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Synthesis and in vitro antiproliferative evaluation of PEGylated triterpene acids

Fitoterapia
2017 | Journal article
DOI: 10.1016/j.fitote.2017.05.006
EID:

2-s2.0-85019743062
Contributors: Medina-O'Donnell, M.; Rivas, F.; Reyes-Zurita, F.J.; Martinez, A.; Galisteo-González, F.; Lupiañez, J.A.; Parra, A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Maslinic acid, a natural triterpene, induces a death receptor-mediated apoptotic mechanism in caco-2 p53-deficient colon adenocarcinoma cells

PLoS ONE
2016 | Journal article
DOI: 10.1371/journal.pone.0146178
EID:

2-s2.0-84954448499
Contributors: Reyes-Zurita, F.J.; Rufino-Palomares, E.E.; García-Salguero, L.; Peragón, J.; Medina, P.P.; Parra, A.; Cascante, M.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

NADPH production, a growth marker, is stimulated by maslinic acid in gilthead sea bream by increased NADP-IDH and ME expression

Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology
2016 | Journal article
DOI: 10.1016/j.cbpc.2016.05.002
EID:

2-s2.0-84969523827
Contributors: Rufino-Palomares, E.E.; Reyes-Zurita, F.J.; García-Salguero, L.; Peragón, J.; De La Higuera, M.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Semi-synthesis and antiproliferative evaluation of PEGylated pentacyclic triterpenes

European Journal of Medicinal Chemistry
2016 | Journal article
DOI: 10.1016/j.ejmech.2016.04.016
EID:

2-s2.0-84964444615
Contributors: Medina-O'Donnell, M.; Rivas, F.; Reyes-Zurita, F.J.; Martinez, A.; Martin-Fonseca, S.; Garcia-Granados, A.; Ferrer-Martín, R.M.; Lupiañez, J.A.; Parra, A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea

Phytomedicine
2016 | Journal article
DOI: 10.1016/j.phymed.2016.07.001
EID:

2-s2.0-84980319982
Contributors: Pérez-Jiménez, A.; Rufino-Palomares, E.E.; Fernández-Gallego, N.; Ortuño-Costela, M.C.; Reyes-Zurita, F.J.; Peragón, J.; García-Salguero, L.; Mokhtari, K.; Medina, P.P.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

The oleanolic acid derivative, 3-: O -succinyl-28- O -benzyl oleanolate, induces apoptosis in B16-F10 melanoma cells via the mitochondrial apoptotic pathway

RSC Advances
2016 | Journal article
DOI: 10.1039/c6ra18879f
EID:

2-s2.0-84991010602
Contributors: Reyes-Zurita, F.J.; Medina-O'Donnell, M.; Ferrer-Martin, R.M.; Rufino-Palomares, E.E.; Martin-Fonseca, S.; Rivas, F.; Martínez, A.; García-Granados, A.; Pérez-Jiménez, A.; García-Salguero, L. et al.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

A new HPLC-MS method for measuring maslinic acid and oleanolic acid in HT29 and HepG2 human cancer cells

International Journal of Molecular Sciences
2015 | Journal article
DOI: 10.3390/ijms160921681
EID:

2-s2.0-84941236477
Contributors: Peragón, J.; Rufino-Palomares, E.E.; Muñoz-Espada, I.; Reyes-Zurita, F.J.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Anti-cancer and anti-angiogenic properties of various natural pentacyclic tri-terpenoids and some of their chemical derivatives

Current Organic Chemistry
2015 | Journal article
DOI: 10.2174/1385272819666150119225952
EID:

2-s2.0-84930985465
Contributors: Rufino-Palomares, E.E.; Pérez-Jiménez, A.; Reyes-Zurita, F.J.; García-Salguero, L.; Mokhtari, K.; Herrera-Merchán, A.; Medina, P.P.; Peragón, J.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Expression inactivation of SMARCA4 by microRNAs in lung tumors

Human Molecular Genetics
2015 | Journal article
DOI: 10.1093/hmg/ddu554
EID:

2-s2.0-84924503083
Contributors: Coira, I.F.; Rufino-Palomares, E.E.; Romero, O.A.; Peinado, P.; Metheetrairut, C.; Boyero-Corral, L.; Carretero, J.; Farez-Vidal, E.; Cuadros, M.; Reyes-Zurita, F.J. et al.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions

Evidence-based Complementary and Alternative Medicine
2015 | Journal article
DOI: 10.1155/2015/272457
EID:

2-s2.0-84937682045
Contributors: Mokhtari, K.; Rufino-Palomares, E.E.; Pérez-Jiménez, A.; Reyes-Zurita, F.J.; Figuera, C.; García-Salguero, L.; Medina, P.P.; Peragón, J.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents

European Journal of Medicinal Chemistry
2014 | Journal article
DOI: 10.1016/j.ejmech.2013.12.049
EID:

2-s2.0-84893183833
Contributors: Parra, A.; Martin-Fonseca, S.; Rivas, F.; Reyes-Zurita, F.J.; Medina-O'Donnell, M.; Martinez, A.; Garcia-Granados, A.; Lupiañez, J.A.; Albericio, F.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Solid-phase library synthesis of bi-functional derivatives of oleanolic and maslinic acids and their cytotoxicity on three cancer cell lines

ACS Combinatorial Science
2014 | Journal article
DOI: 10.1021/co500051z
EID:

2-s2.0-84905868830
Contributors: Parra, A.; Martin-Fonseca, S.; Rivas, F.; Reyes-Zurita, F.J.; Medina-O'Donnell, M.; Rufino-Palomares, E.E.; Martinez, A.; Garcia-Granados, A.; Lupiañez, J.A.; Albericio, F.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells

Biochimie
2013 | Journal article
DOI: 10.1016/j.biochi.2013.08.017
EID:

2-s2.0-84885063950
Contributors: Reyes-Zurita, F.J.; Rufino-Palomares, E.E.; Medina, P.P.; Leticia García-Salguero, E.; Peragón, J.; Cascante, M.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Maslinic acid, a triterpenic anti-tumoural agent, interferes with cytoskeleton protein expression in HT29 human colon-cancer cells

Journal of Proteomics
2013 | Journal article
DOI: 10.1016/j.jprot.2013.02.031
EID:

2-s2.0-84876300843
Contributors: Rufino-Palomares, E.E.; Reyes-Zurita, F.J.; García-Salguero, L.; Mokhtari, K.; Medina, P.P.; Lupiáñez, J.A.; Peragón, J.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Maslinic Acid-Enriched Diet Decreases Intestinal Tumorigenesis in Apc<sup>Min/+</sup> Mice through Transcriptomic and Metabolomic Reprogramming

PLoS ONE
2013 | Journal article
DOI: 10.1371/journal.pone.0059392
EID:

2-s2.0-84875063952
Contributors: Sánchez-Tena, S.; Reyes-Zurita, F.J.; Díaz-Moralli, S.; Vinardell, M.P.; Reed, M.; García-García, F.; Dopazo, J.; Lupiáñez, J.A.; Günther, U.; Cascante, M.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

MicroRNAs as Oncogenes and Tumor Suppressors

MicroRNAs in Medicine
2013 | Book
Part of DOI: 10.1002/9781118300312.ch14
EID:

2-s2.0-85017611131
Contributors: Rufino-Palomares, E.E.; Reyes-Zurita, F.J.; Lupiáñez, J.A.; Medina, P.P.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

The role of maslinic acid in the pentose phosphate pathway during growth of gilthead sea bream (Sparus Aurata)

Aquaculture Nutrition
2013 | Journal article
DOI: 10.1111/anu.12018
EID:

2-s2.0-84883194147
Contributors: Rufino-Palomares, E.E.; Reyes-Zurita, F.J.; García-Salguero, L.; Peragón, J.; de la Higuera, M.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Maslinic acid and ration size enhanced hepatic protein-turnover rates of gilthead sea bream (Sparus aurata)

Aquaculture Nutrition
2012 | Journal article
DOI: 10.1111/j.1365-2095.2011.00882.x
EID:

2-s2.0-84858291348
Contributors: Rufino-Palomares, E.E.; Reyes-Zurita, F.J.; García-Salguero, L.; Peragón, J.; De La Higuera, M.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Maslinic acid, a natural triterpene, and ration size increased growth and protein turnover of white muscle in gilthead sea bream (Sparus aurata)

Aquaculture Nutrition
2012 | Journal article
DOI: 10.1111/j.1365-2095.2011.00933.x
EID:

2-s2.0-84865716867
Contributors: Rufino-Palomares, E.E.; Reyes-Zurita, F.J.; García-Salguero, L.; Peragón, J.; De La Higuera, M.; Lupiañez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Proteomics in the liver of gilthead sea bream (Sparus aurata) to elucidate the cellular response induced by the intake of maslinic acid

Proteomics
2011 | Journal article
DOI: 10.1002/pmic.201000271
EID:

2-s2.0-79960805558
Contributors: Rufino-Palomares, E.; Reyes-Zurita, F.J.; Fuentes-Almagro, C.A.; de la Higuera, M.; Lupiáñez, J.A.; Peragón, J.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism

BMC Cancer
2011 | Journal article
DOI: 10.1186/1471-2407-11-154
EID:

2-s2.0-79955139265
Contributors: Reyes-Zurita, F.J.; Pachón-Peña, G.; Lizárraga, D.; Rufino-Palomares, E.E.; Cascante, M.; Lupiáñez, J.A.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Antiproliferative effect of flavomannin-6,6′-dimethylether from Tricholoma equestre on Caco-2 cells

Toxicology
2009 | Journal article
DOI: 10.1016/j.tox.2009.08.009
EID:

2-s2.0-70349192674
Contributors: Pachón-Peña, G.; Reyes-Zurita, F.J.; Deffieux, G.; Azqueta, A.; de Cerain, A.L.; Centelles, J.J.; Creppy, E.E.; Cascante, M.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway

Cancer Letters
2009 | Journal article
DOI: 10.1016/j.canlet.2008.07.033
EID:

2-s2.0-56349099145
Contributors: Reyes-Zurita, F.J.; Rufino-Palomares, E.E.; Lupiáñez, J.A.; Cascante, M.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Witch Hazel (Hamamelis virginiana) fractions and the importance of gallate moieties - Electron transfer capacities in their antitumoral properties

Journal of Agricultural and Food Chemistry
2008 | Journal article
DOI: 10.1021/jf802345x
EID:

2-s2.0-58849094112
Contributors: Lizárraga, D.; Touriño, S.; Reyes-Zurita, F.J.; De Kok, T.M.; Van Delft, J.H.; Maas, L.M.; Briedé, J.J.; Centelles, J.J.; Torres, J.L.; Cascante, M.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

(2α,3β)-2,3-Dihydroxyolean-12-en-28-oic acid, a new natural triterpene from Olea europea, induces caspase dependent apoptosis selectively in colon adenocarcinoma cells

FEBS Letters
2006 | Journal article
DOI: 10.1016/j.febslet.2006.10.038
EID:

2-s2.0-33751275468
Contributors: Reyes, F.J.; Centelles, J.J.; Lupiáñez, J.A.; Cascante, M.
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Fernando J. Reyes-Zurita via Scopus - Elsevier

Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential
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Multidisciplinary Digital Publishing Institute

Uvaol Exerts Anti-Proliferative and Pro-Apoptotic Effects on Human Hepatocarcinoma Cells by Modulating AKT/PI3K Signaling Pathway
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