Personal information

Emails & domains

Verified email domains

Other IDs

SciProfiles: 2013645

Keywords

Biochemistry, Hydrogen/Deuterium coupled to Mass Spectrometry, Toxoplasma Gondii, Structural biology, Lipid signaling

Activities

Collapse all

Employment (3)

University of Geneva: Geneva, CH

2018-02-01 to present (Microbiology and Molecular Medicine)
Employment
Source: Self-asserted source
Oscar Vadas

University of Geneva: Geneva, CH

2013-01-01 to 2017-12-31 | Project leader (Pharmacy Section)
Employment
Source: Self-asserted source
Oscar Vadas

MRC Laboratory of Molecular Biology: Cambridge, Cambridgeshire, GB

2009-09-01 to 2012-12-31 | Postdoc (PNAC)
Employment
Source: Self-asserted source
Oscar Vadas

Education and qualifications (1)

University of Geneva: Geneva, CH

2005-06-01 to 2009-04-05 | PhD (Faculty of Medicine, Department of Structural Biology and Bioinformatics)
Education
Source: Self-asserted source
Oscar Vadas

Funding (5)

Structural investigations of phosphoinositide 3-kinase (PI3K) regulation

2019-09 to 2020-08 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER:

PBGEP3-125905
Source: Self-asserted source
Oscar Vadas

How do kinases define specificity in lipid signaling?

2013 to 2016 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER:

PZ00P3_148269
Source: Self-asserted source
Oscar Vadas

How is PI3Kbeta regulated by G-Protein Coupled Receptors and by Rab-5?

2011 to 2012 | Grant
FP7 People: Marie-Curie Actions (Bruxelles, BE)
GRANT_NUMBER:

FP7-PEOPLE-2010-IEF 275880
Source: Self-asserted source
Oscar Vadas

How is PI3Kbeta regulated by Receptor Tyrosine Kinases and by GPCRs?

2011 to 2011 | Grant
Swiss National Science Foundation (Bern, CH)
GRANT_NUMBER:

PA00P3_134202
Source: Self-asserted source
Oscar Vadas

Structural and functional characterisation of class I PI3Kbeta regulation

2010 to 2010 | Grant
EMBO (Heidelberg, DE)
Source: Self-asserted source
Oscar Vadas

Works (41)

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

Nature Communications
2025-02-19 | Journal article
DOI: 10.1038/s41467-025-56937-0
Contributors: Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn
Source: check_circle
Crossref

An inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly

Nature Communications
2024-11-22 | Journal article
DOI: 10.1038/s41467-024-54584-5
Contributors: Daniela Portugal-Calisto; Alexander Gregor Geiger; Julius Rabl; Oscar Vadas; Michaela Oborská-Oplová; Jarosław Mazur; Federica Richina; Purnima Klingauf-Nerurkar; Erich Michel; Alexander Leitner et al.
Source: check_circle
Crossref

Soluble αβ-tubulins reversibly sequester TTC5 to regulate tubulin mRNA decay

Nature Communications
2024-11-17 | Journal article
DOI: 10.1038/s41467-024-54036-0
Contributors: Alina Batiuk; Markus Höpfler; Ana C. Almeida; Deryn Teoh En-Jie; Oscar Vadas; Evangelia Vartholomaiou; Ramanujan S. Hegde; Zhewang Lin; Ivana Gasic
Source: check_circle
Crossref

A small signaling domain controls PPIP5K phosphatase activity in phosphate homeostasis

2024-09-12 | Preprint
DOI: 10.1101/2024.09.12.612650
Contributors: Pierre Raia; Kitaik Lee; Simon M. Bartsch; Felix Rico-Resendiz; Daniela Portugal-Calisto; Oscar Vadas; Vikram Govind Panse; Dorothea Fiedler; Michael Hothorn
Source: check_circle
Crossref

Non-Invasive Delivery of Negatively Charged Nanobodies by Anodal Iontophoresis: When Electroosmosis Dominates Electromigration

Pharmaceutics
2024-04-13 | Journal article
DOI: 10.3390/pharmaceutics16040539
Contributors: Phedra Firdaws Sahraoui; Oscar Vadas; Yogeshvar N. Kalia
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Effective Inhibition of TDP‐43 Aggregation by Native State Stabilization

Angewandte Chemie International Edition
2024-01-15 | Journal article
DOI: 10.1002/anie.202314587
Contributors: Lixin Yang; Yllza Jasiqi; Agnès Zettor; Oscar Vadas; Jeanne Chiaravalli; Fabrice Agou; Hilal A. Lashuel
Source: check_circle
Crossref

Effective Inhibition of TDP‐43 Aggregation by Native State Stabilization

Angewandte Chemie
2024-01-15 | Journal article
DOI: 10.1002/ange.202314587
Contributors: Lixin Yang; Yllza Jasiqi; Agnès Zettor; Oscar Vadas; Jeanne Chiaravalli; Fabrice Agou; Hilal A. Lashuel
Source: check_circle
Crossref

Architecture of the MKK6-p38α complex defines the basis of MAPK specificity and activation

Science
2023-09-15 | Journal article
DOI: 10.1126/science.add7859
Contributors: Pauline Juyoux; Ioannis Galdadas; Dorothea Gobbo; Jill von Velsen; Martin Pelosse; Mark Tully; Oscar Vadas; Francesco Luigi Gervasio; Erika Pellegrini; Matthew W. Bowler
Source: check_circle
Crossref

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

eLife
2023-04-04 | Journal article | Author
DOI: 10.7554/elife.86049
Part of ISSN: 2050-084X
Contributors: Amit Kumar; Oscar Vadas; Nicolas Dos Santos Pacheco; Xu Zhang; Kin Chao; Nicolas Darvill; Helena Østergaard Rasmussen; Yingqi Xu; Gloria Meng-Hsuan Lin; Fisentzos A Stylianou et al.
Source: Self-asserted source
Oscar Vadas
grade
Preferred source (of 2)‎

Conoid extrusion regulates glideosome assembly to control motility and invasion in Apicomplexa

Nature Microbiology
2022-09-15 | Journal article | Author
DOI: 10.1038/s41564-022-01212-x
Part of ISSN: 2058-5276
Contributors: Nicolas Dos Santos Pacheco; Lorenzo Brusini; Romuald Haase; Nicolò Tosetti; Bohumil Maco; Mathieu Brochet; Oscar Vadas; Dominique Soldati-Favre
Source: Self-asserted source
Oscar Vadas

Structural basis of phosphatidylinositol 3-kinase C2α function

Nature Structural & Molecular Biology
2022-03 | Journal article
DOI: 10.1038/s41594-022-00730-w
Contributors: Wen-Ting Lo; Yingyi Zhang; Oscar Vadas; Yvette Roske; Federico Gulluni; Maria Chiara De Santis; Andreja Vujicic Zagar; Heike Stephanowitz; Emilio Hirsch; Fan Liu et al.
Source: check_circle
Crossref

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondii

Nature Communications
2022-01-17 | Journal article
DOI: 10.1038/s41467-022-27996-4
Contributors: Matteo Lunghi; Joachim Kloehn; Aarti Krishnan; Emmanuel Varesio; Oscar Vadas; Dominique Soldati-Favre
Source: check_circle
Crossref

Secondary Structure and X-ray Crystallographic Analysis of the Glideosome-Associated Connector (GAC) from Toxoplasma gondii

Crystals
2022-01-15 | Journal article
DOI: 10.3390/cryst12010110
Contributors: Amit Kumar; Xu Zhang; Oscar Vadas; Fisentzos A. Stylianou; Nicolas Dos Santos Pacheco; Sarah L. Rouse; Marc L. Morgan; Dominique Soldati-Favre; Steve Matthews
Source: check_circle
Crossref

PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

Science (New York, N.Y.)
2021-12-10 | Journal article | Author
DOI: 10.1126/science.abk0410
PMID: 34882480
PMC: PMC7612254
Contributors: Federico GULLUNI; Lorenzo Prever; Huayi Li; Petra Krafcikova; Ilaria Corrado; Wen-Ting Lo; Jean Piero Margaria; Anlu Chen; Maria Chiara De Santis; Sophie Cnudde et al.
Source: Self-asserted source
Oscar Vadas

SUV39 SET domains mediate crosstalk of heterochromatic histone marks

eLife
2021-09-15 | Journal article
DOI: 10.7554/eLife.62682
Contributors: Alessandro Stirpe; Nora Guidotti; Sarah J Northall; Sinan Kilic; Alexandre Hainard; Oscar Vadas; Beat Fierz; Thomas Schalch
Source: check_circle
Crossref

Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation.

Science advances
2021-08-27 | Journal article | Author
DOI: 10.1126/sciadv.abj4282
PMID: 34452907
PMC: PMC8397274
Contributors: Manoj Rathinaswamy; Udit Dalwadi; Kaelin Fleming; Adams C; Jordan Stariha; Els Pardon; Minkyung Baek; Oscar Vadas; Frank DiMaio; Jan Steyaert et al.
Source: Self-asserted source
Oscar Vadas
grade
Preferred source (of 2)‎

Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion

Nature Communications
2021-06-18 | Journal article | Author
DOI: 10.1038/s41467-021-24083-y
Part of ISSN: 2041-1723
Contributors: Gaelle Lentini; Rouaa Ben Chaabene; Oscar Vadas; Chandra Ramakrishnan; Budhaditya mukherjee; Ved Mehta; Matteo Lunghi; Jonas Grossmann; Bohumil Maco; Rémy Visentin et al.
Source: Self-asserted source
Oscar Vadas

Naturally acquired blocking human monoclonal antibodies to Plasmodium vivax reticulocyte binding protein 2b

Nature Communications
2021-03-09 | Journal article | Author
DOI: 10.1038/s41467-021-21811-2
Part of ISSN: 2041-1723
Contributors: Li-Jin Chan; Anugraha Gandhirajan; Lenore L. Carias; Melanie H. Dietrich; Oscar Vadas; Remy Visentin; Camila França; Sebastien Menant; Dominique Soldati-Favre; Ivo Mueller et al.
Source: Self-asserted source
Oscar Vadas

Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.

Science signaling
2020-11-03 | Journal article | Author
DOI: 10.1126/scisignal.aaz4003
PMID: 33144519
PMC: PMC7610408
Contributors: Natalie Rynkiewicz; Karen Anderson; Suire S; Danny Collins; Karanasios E; Oscar Vadas; Roger Williams; Oxley D; Clark J; len stephens et al.
Source: Self-asserted source
Oscar Vadas
grade
Preferred source (of 2)‎

Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma.

PloS one
2020-09-09 | Journal article | Author
DOI: 10.1371/journal.pone.0238089
PMID: 32903266
PMC: PMC7480855
Contributors: Farrera-Soler L; Jean Pierre Daguer; Sofia Barluenga ; Oscar Vadas; Cohen P; Pagano S; sabine yerly; Laurent Kaiser; Vuilleumier N; Nicolas Winssinger
Source: Self-asserted source
Oscar Vadas

SUV39 SET domains mediate crosstalk of heterochromatic histone marks

2020-07-02 | Preprint
DOI: 10.1101/2020.06.30.177071
Contributors: Alessandro Stirpe; Nora Guidotti; Sarah J. Northall; Sinan Kilic; Alexandre Hainard; Oscar Vadas; Beat Fierz; Thomas Schalch
Source: check_circle
Crossref

Naturally acquired blocking human monoclonal antibodies toPlasmodium vivaxreticulocyte binding protein 2b

2020-05-13 | Preprint
DOI: 10.1101/2020.05.12.091900
Contributors: Li-Jin Chan; Anugraha Gandhirajan; Lenore L. Carias; Melanie H. Dietrich; Oscar Vadas; Remy Visentin; Camila T. França; Sebastien Menant; Dominique Soldati-Favre; Ivo Mueller et al.
Source: check_circle
Crossref

Auxiliary domains of the HrpB bacterial DExH-box helicase shape its RNA preferences

RNA Biology
2020-05-03 | Journal article | Author
DOI: 10.1080/15476286.2020.1720376
Part of ISSN: 1547-6286
Part of ISSN: 1555-8584
Contributors: Stéphane Hausmann; Johan Geiser; Oscar Vadas; Verena Ducret; Karl Perron; Martina Valentini
Source: Self-asserted source
Oscar Vadas

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module

Molecular Cell
2018-07 | Journal article | Author
DOI: 10.1016/j.molcel.2018.06.042
Part of ISSN: 1097-2765
Contributors: Haibin Wang; Wen-Ting Lo; Andreja Vujičić Žagar; Federico Gulluni; Martin Lehmann; Leonardo Scapozza; Volker Haucke; Oscar Vadas
Source: Self-asserted source
Oscar Vadas

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch

Developmental Cell
2017-11 | Journal article
DOI: 10.1016/j.devcel.2017.10.019
Part of ISSN: 1534-5807
Contributors: Wen-Ting Lo; Andreja Vujičić Žagar; Fabian Gerth; Martin Lehmann; Dymtro Puchkov; Oxana Krylova; Christian Freund; Leonardo Scapozza; Oscar Vadas; Volker Haucke
Source: Self-asserted source
Oscar Vadas

Design and purification of active truncated phosphoinositide 3-kinase gamma protein constructs for structural studies

Protein Expression and Purification
2017-07 | Journal article
DOI: 10.1016/j.pep.2017.04.011
Contributors: A. Vujičić Žagar; L. Scapozza; O. Vadas
Source: check_circle
Crossref

Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1

Proceedings of the National Academy of Sciences of the United States of America
2017-02-06 | Journal article
DOI: 10.1073/pnas.1617244114
PMID: 28167755
PMC: PMC5338455
Contributors: Gillian Leigh Dornan; Siempelkamp BD; Meredith L Jenkins; Vadas O; Carrie Lucas; John Burke
Source: Self-asserted source
Oscar Vadas

Probing the dynamic regulation of peripheral membrane proteins using hydrogen deuterium exchange-MS (HDX-MS).

Biochemical Society transactions
2015-10-01 | Journal article
DOI: 10.1042/bst20150065
PMID: 26517882
Contributors: Vadas O; John Burke
Source: Self-asserted source
Oscar Vadas

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

The Biochemical journal
2015-07-01 | Journal article
DOI: 10.1042/bj20150099
PMID: 26173259
PMC: PMC4655608
Contributors: Shymanets A; Prajwal; Vadas O; Czupalla C; Jaclyn LoPiccolo; Brenowitz M; Alessandra Ghigo; Emilio Hirsch; Krause E; Wetzker R et al.
Source: Self-asserted source
Oscar Vadas

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Proceedings of the National Academy of Sciences
2013-11-19 | Journal article
DOI: 10.1073/pnas.1304801110
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Oscar Vadas; Hashem A. Dbouk; Aliaksei Shymanets; Olga Perisic; John E. Burke; Widian F. Abi Saab; Bassem D. Khalil; Christian Harteneck; Anne R. Bresnick; Bernd Nürnberg et al.
Source: Self-asserted source
Oscar Vadas

Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

Science
2013-11-15 | Journal article
DOI: 10.1126/science.1243292
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Contributors: Ivan Angulo; Oscar Vadas; Fabien Garçon; Edward Banham-Hall; Vincent Plagnol; Timothy R. Leahy; Helen Baxendale; Tanya Coulter; James Curtis; Changxin Wu et al.
Source: Self-asserted source
Oscar Vadas

G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness

Science Signaling
2012-12-04 | Journal article
DOI: 10.1126/scisignal.2003264
Part of ISSN: 1945-0877
Part of ISSN: 1937-9145
Contributors: Hashem A. Dbouk; Oscar Vadas; Aliaksei Shymanets; John E. Burke; Rachel S. Salamon; Bassem D. Khalil; Mathew O. Barrett; Gary L. Waldo; Chinmay Surve; Christine Hsueh et al.
Source: Self-asserted source
Oscar Vadas

PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

Oncotarget
2012-12-01 | Journal article
DOI: 10.18632/oncotarget.787
PMID: 23328076
PMC: PMC3681480
Contributors: hashem dbouk; Vadas O; Roger Williams; Backer JM
Source: Self-asserted source
Oscar Vadas

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α ( <i>PIK3CA</i> )

Proceedings of the National Academy of Sciences
2012-09-18 | Journal article
DOI: 10.1073/pnas.1205508109
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: John E. Burke; Olga Perisic; Glenn R. Masson; Oscar Vadas; Roger L. Williams
Source: Self-asserted source
Oscar Vadas

Structural basis for activation and inhibition of class I phosphoinositide 3-kinases.

Science signaling
2011-10-18 | Journal article
DOI: 10.1126/scisignal.2002165
PMID: 22009150
Contributors: Vadas O; John Burke; Zhang X; Berndt A; Roger Williams
Source: Self-asserted source
Oscar Vadas

Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α.

Structure (London, England : 1993)
2011-08-01 | Journal article
DOI: 10.1016/j.str.2011.06.003
PMID: 21827948
PMC: PMC3155019
Contributors: John Burke; Vadas O; Berndt A; Finegan T; Olga Perisic; Roger Williams
Source: Self-asserted source
Oscar Vadas

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

Molecular Cell
2011-03 | Journal article
DOI: 10.1016/j.molcel.2011.01.026
Part of ISSN: 1097-2765
Contributors: Xuxiao Zhang; Oscar Vadas; Olga Perisic; Karen E. Anderson; Jonathan Clark; Phillip T. Hawkins; Len R. Stephens; Roger L. Williams
Source: Self-asserted source
Oscar Vadas

Multimeric peptides as agonists of the erythropoietin receptor.

Advances in experimental medicine and biology
2009-01-01 | Journal article
DOI: 10.1007/978-0-387-73657-0_219
PMID: 19400286
Contributors: Vadas O; Rose K
Source: Self-asserted source
Oscar Vadas

PICarver: a software tool and strategy for peptides isoelectric focusing.

Journal of proteome research
2008-09-11 | Journal article
DOI: 10.1021/pr8002672
PMID: 18783261
Contributors: Vaezzadeh AR; Céline Hernandez; Vadas O; Deshusses JJ; Pierre Lescuyer; Frederique LISACEK; Hochstrasser DF
Source: Self-asserted source
Oscar Vadas

Characterization of new multimeric erythropoietin receptor agonists.

Biopolymers
2008-01-01 | Journal article
DOI: 10.1002/bip.20959
PMID: 18273892
Contributors: Vadas O; Hartley O; Rose K
Source: Self-asserted source
Oscar Vadas

Multivalency - a way to enhance binding avidities and bioactivity - preliminary applications to EPO.

Journal of peptide science : an official publication of the European Peptide Society
2007-09-01 | Journal article
DOI: 10.1002/psc.794
PMID: 17631671
Contributors: Vadas O; Rose K
Source: Self-asserted source
Oscar Vadas

Peer review (3 reviews for 3 publications/grants)

Review activity for Communications biology. (1)
Review activity for Nature communications (1)
Review activity for PLOS pathogens : (1)
How many people are using ORCID?