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Employment (3)

University of Guelph: Guelph, Ontario, CA

2020-10-01 to present | Assistant Professor (Chemistry)
Employment
Source: Self-asserted source
Derek O'Flaherty

Alnylam Pharmaceuticals Inc: Cambridge, MA, US

2019-03-15 to 2020-09-15 | Scientist (RNAi Discovery)
Employment
Source: Self-asserted source
Derek O'Flaherty

Massachusetts General Hospital: Boston, MA, US

2016-04-01 to 2019-03-14 | Postdoctoral Research Fellow (Molecular Biology)
Employment
Source: Self-asserted source
Derek O'Flaherty

Works (30)

Aqueous Compatible Post‐Synthetic On‐Column Conjugation of Nucleic Acids Using Amino‐Modifiers

ChemBioChem
2025-01-02 | Journal article
DOI: 10.1002/cbic.202400643
Contributors: Jagandeep S. Saraya; Scott R. Sammons; Derek K. O'Flaherty
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Crossref

Cover Feature: Aqueous Compatible Post‐Synthetic On‐Column Conjugation of Nucleic Acids Using Amino‐Modifiers (ChemBioChem 1/2025)

ChemBioChem
2025-01-02 | Journal article
DOI: 10.1002/cbic.202580104
Contributors: Jagandeep S. Saraya; Scott R. Sammons; Derek K. O'Flaherty
Source: check_circle
Crossref

Efficient synthesis of the 2-aminoimidazolium-bridged diguanosyl intermediate for nonenzymatic primer extension

Canadian Journal of Chemistry
2024-11-01 | Journal article
DOI: 10.1139/cjc-2024-0005
Contributors: Scott R. Sammons; James D. Robinson; Derek K. O'Flaherty
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Crossref

Preparation of 2‐Aminoimidazole‐Activated Substrates for the Study of Nonenzymatic Genome Replication

Current Protocols
2024-08 | Journal article
DOI: 10.1002/cpz1.1119
Contributors: James D. Robinson; Scott R. Sammons; Derek K. O'Flaherty
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Crossref

A Facile and General Tandem Oligonucleotide Synthesis Methodology for DNA and RNA

ChemBioChem
2024-03-15 | Journal article
DOI: 10.1002/cbic.202300870
Contributors: Jagandeep S. Saraya; Derek K. O'Flaherty
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Crossref

Front Cover: A Facile and General Tandem Oligonucleotide Synthesis Methodology for DNA and RNA (ChemBioChem 6/2024)

ChemBioChem
2024-03-15 | Journal article
DOI: 10.1002/cbic.202400113
Contributors: Jagandeep S. Saraya; Derek K. O'Flaherty
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Crossref

Unusual Base Pair between Two 2-Thiouridines and Its Implication for Nonenzymatic RNA Copying

Journal of the American Chemical Society
2024-02-14 | Journal article
DOI: 10.1021/jacs.3c11158
Contributors: Dian Ding; Ziyuan Fang; Seohyun Chris Kim; Derek K. O’Flaherty; Xiwen Jia; Talbot B. Stone; Lijun Zhou; Jack W. Szostak
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Crossref

Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells

Journal of the American Chemical Society
2021-10-13 | Journal article
DOI: 10.1021/jacs.1c06595
Contributors: Roger Rubio-Sánchez; Derek K. O’Flaherty; Anna Wang; Francesca Coscia; Gianluca Petris; Lorenzo Di Michele; Pietro Cicuta; Claudia Bonfio
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Crossref

Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides

The Journal of Physical Chemistry Letters
2021-07-22 | Journal article
DOI: 10.1021/acs.jpclett.1c01384
Contributors: Mikołaj J. Janicki; Corinna L. Kufner; Zoe R. Todd; Seohyun C. Kim; Derek K. O’Flaherty; Jack W. Szostak; Jiří Šponer; Robert W. Góra; Dimitar D. Sasselov; Rafał Szabla
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Crossref

The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis

Journal of the American Chemical Society
2021-03-10 | Journal article
DOI: 10.1021/jacs.0c12955
Contributors: Seohyun Chris Kim; Derek K. O’Flaherty; Constantin Giurgiu; Lijun Zhou; Jack W. Szostak
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Crossref

Template‐Directed Copying of RNA by Non‐enzymatic Ligation

Angewandte Chemie International Edition
2020-09 | Journal article
DOI: 10.1002/anie.202004934
Contributors: Lijun Zhou; Derek K. O'Flaherty; Jack W. Szostak
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Crossref

Template‐Directed Copying of RNA by Non‐enzymatic Ligation

Angewandte Chemie
2020-09 | Journal article
DOI: 10.1002/ange.202004934
Contributors: Lijun Zhou; Derek K. O'Flaherty; Jack W. Szostak
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Crossref

Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation

Journal of the American Chemical Society
2020-09-16 | Journal article
DOI: 10.1021/jacs.0c06722
Contributors: Lijun Zhou; Derek K. O’Flaherty; Jack W. Szostak
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Crossref

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides

Journal of the American Chemical Society
2020-02-05 | Journal article
DOI: 10.1021/jacs.9b11239
Contributors: Seohyun Chris Kim; Lijun Zhou; Wen Zhang; Derek K. O’Flaherty; Valeria Rondo-Brovetto; Jack W. Szostak
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Crossref

Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage

Journal of the American Chemical Society
2019-11-13 | Journal article
DOI: 10.1021/jacs.9b08237
Contributors: Tom H. Wright; Constantin Giurgiu; Wen Zhang; Aleksandar Radakovic; Derek K. O’Flaherty; Lijun Zhou; Jack W. Szostak
Source: check_circle
Crossref

Non-enzymatic primer extension with strand displacement

eLife
2019-11-08 | Journal article
DOI: 10.7554/eLife.51888
Contributors: Lijun Zhou; Seohyun Chris Kim; Katherine H Ho; Derek K O'Flaherty; Constantin Giurgiu; Tom H Wright; Jack W Szostak
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Crossref

A model for the emergence of RNA from a prebiotically plausible mixture of ribonucleotides, arabinonucleotides and 2’-deoxynucleotides

2019-10-22 | Other
DOI: 10.1101/813675
Contributors: Seohyun Chris Kim; Lijun Zhou; Wen Zhang; Derek K. O’Flaherty; Valeria Rondo-Brovetto; Jack W. Szostak
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Crossref

DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates

Nucleic Acids Research
2019-09-26 | Journal article
DOI: 10.1093/nar/gkz707
Contributors: Victor S Lelyveld; Derek K O’Flaherty; Lijun Zhou; Enver Cagri Izgu; Jack W Szostak
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Crossref

Non-enzymatic primer extension with strand displacement

2019-09-16 | Other
DOI: 10.1101/770578
Contributors: Lijun Zhou; Seohyun Chris Kim; Katherine H. Ho; Derek K. O’Flaherty; Constantin Giurgiu; Tom H. Wright; Jack W. Szostak
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Crossref

Prebiotically Plausible ‘Patching’ of RNA Backbone Cleavage Through a 3′-5′ Pyrophosphate Linkage

2019-08-10 | Other
DOI: 10.1101/731125
Contributors: Tom H. Wright; Constantin Giurgiu; Aleksandar Radakovic; Derek K. O’Flaherty; Lijun Zhou; Jack W. Szostak
Source: check_circle
Crossref

Assembly of a functional ribozyme from short oligomers by enhanced non-enzymatic ligation

2019-07-16 | Other
DOI: 10.1101/700229
Contributors: Lijun Zhou; Derek K. O’Flaherty; Jack W. Szostak
Source: check_circle
Crossref

Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells

Journal of the American Chemical Society
2019-07-03 | Journal article
DOI: 10.1021/jacs.9b04858
Contributors: Derek K. O’Flaherty; Lijun Zhou; Jack W. Szostak
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Crossref

Covalent capture of OGT's active site using engineered human-E. coli chimera and intrastrand DNA cross-links

Organic & Biomolecular Chemistry
2018 | Journal article
DOI: 10.1039/C8OB02453G
Contributors: William Copp; Derek K. O'Flaherty; Christopher J. Wilds
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Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

Proceedings of the National Academy of Sciences
2018-12-26 | Journal article
DOI: 10.1073/pnas.1814367115
Contributors: Seohyun Chris Kim; Derek K. O’Flaherty; Lijun Zhou; Victor S. Lelyveld; Jack W. Szostak
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Crossref

A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying

Angewandte Chemie International Edition
2018-07-26 | Journal article
DOI: 10.1002/anie.201805785
Contributors: Constantin Giurgiu; Tom H. Wright; Derek K. O'Flaherty; Jack W. Szostak
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Crossref

A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying

Angewandte Chemie
2018-07-26 | Journal article
DOI: 10.1002/ange.201805785
Contributors: Constantin Giurgiu; Tom H. Wright; Derek K. O'Flaherty; Jack W. Szostak
Source: check_circle
Crossref

Copying of Mixed-Sequence RNA Templates inside Model Protocells

Journal of the American Chemical Society
2018-04-18 | Journal article
DOI: 10.1021/jacs.8b00639
Contributors: Derek K. O’Flaherty; Neha P. Kamat; Fatima N. Mirza; Li Li; Noam Prywes; Jack W. Szostak
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Crossref

Structural basis of interstrand cross-link repair by O6-alkylguanine DNA alkyltransferase

Organic & Biomolecular Chemistry
2017 | Journal article
DOI: 10.1039/C7OB02093G
Contributors: Alexey Y. Denisov; Francis P. McManus; Derek K. O'Flaherty; Anne M. Noronha; Christopher J. Wilds
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Crossref

AGT Activity Towards Intrastrand Crosslinked DNA is Modulated by the Alkylene Linker

ChemBioChem
2017-12-05 | Journal article
DOI: 10.1002/cbic.201700450
Contributors: Derek K. O'Flaherty; Christopher J. Wilds
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Crossref

Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein

Molecules
2017-11-11 | Journal article
DOI: 10.3390/molecules22111948
Part of ISSN: 1420-3049
Source: Self-asserted source
Derek O'Flaherty

Peer review (9 reviews for 6 publications/grants)

Review activity for ChemBioChem. (4)
Review activity for Chemistry. (1)
Review activity for ChemSystemsChem. (1)
Review activity for Communications chemistry. (1)
Review activity for Nature chemistry. (1)
Review activity for Nature communications (1)
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