Personal information

Websites & social links

https://www.ciil.fr/teams/plague-yersinia-pestis

Other IDs

Scopus Author ID: 6508073757
Loop profile: 127360

Keywords

Microbioloy, Bacteriology, Arthropod-Borne Diseases, Pathogenesis, Molecular biology, Vaccine, Antimicrobial, Yersiniosis, Yersinia, Plague, Flea, Genomics, Evolution

Countries

France

Biography

I received my Ph.D. degree in Biology and Health in 2002 from the University of Lille, characterizing the urease locus of Yersinia pseudotuberculosis and Yersinia pestis. In 2002, I joined Rocky Mountain Laboratories (National Institute of Allergy and Infectious Diseases) in Montana USA as a postdoctoral fellow, where I developed and used animal models to study the physiopathology and the molecular mechanisms of flea-borne plague. In 2006, I moved back to France to work on plague as junior Inserm researcher in the Inserm U801 team located at the Institut Pasteur de Lille. In 2014, I advanced in a senior Inserm researcher position. Since 2010, I am the head of the Plague and Yersinia pestis team of the CIIL located at the Institut Pasteur de Lille. Starting 2020, I am the co-head of a Pasteur International Unit with the Drs Javier Pizzaro-Cerda (Institut Pasteur de Paris), Minorarisoa Rajerison and Mirelle Harmalala (Institut Pasteur de Madagascar).

Activities

Collapse all

Employment (1)

Senior Inserm Researcher: Lille, FR

2006-09-01 to present (Nord)
Employment
Source: Self-asserted source
Florent Sebbane

Works (50 of 51)

Items per page:
Page 1 of 2

Protection Elicited by Glutamine Auxotroph of <i>Yersinia pestis</i>

Vaccines
2025-03 | Journal article | Author
DOI: 10.3390/vaccines13040353
Contributors: Svetlana V. Dentovskaya; Anastasiya Vagaiskaya; Михаил Платонов; Alexandra Trunyakova; Ekaterina Krasil'nikova ; Елизавета Мазурина; Tat’yana V. Gapel’chenkova; Nadezhda Lipatnikova; Rima Shaykhutinova; Sergei A. Ivanov et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

The CpxAR signaling system confers a fitness advantage for flea gut colonization by the plague bacillus

Journal of Bacteriology
2024-09-19 | Journal article | Author
DOI: 10.1128/jb.00173-24
Part of ISSN: 0021-9193
Part of ISSN: 1098-5530
Contributors: Brandon ROBIN; Amélie Dewitte; Alaimo Véronique; Cecile Lecoeur; François Pierre; Gabriel BILLON; Florent Sebbane; Sébastien BONTEMPS-GALLO
Source: Self-asserted source
Florent Sebbane

Preclinical safety and efficacy characterization of an LpxC inhibitor against Gram-negative pathogens

Science Translational Medicine
2023-08-09 | Journal article
DOI: 10.1126/scitranslmed.adf5668
Part of ISSN: 1946-6234
Part of ISSN: 1946-6242
Contributors: Jinshi Zhao; C. Skyler Cochrane; Javaria Najeeb; David Gooden; Carly Sciandra; Ping Fan; Nadine Lemaitre; Kate Newns; Robert Nicholas; Ziqiang Guan et al.
Source: Self-asserted source
Florent Sebbane

A Widefield Light Microscopy-Based Approach Provides Further Insights into the Colonization of the Flea Proventriculus by Yersinia pestis

Applied and Environmental Microbiology
2023-04-26 | Journal article | Author
DOI: 10.1128/aem.02091-22
Part of ISSN: 0099-2240
Part of ISSN: 1098-5336
Contributors: Amélie Dewitte; Elisabeth Werkmeister; François PIERRE; Florent Sebbane; Sébastien BONTEMPS-GALLO
Source: Self-asserted source
Florent Sebbane

Reply to Alfani: Reconstructing past plague ecology to understand human history

Proceedings of the National Academy of Sciences
2023-03-14 | Journal article | Author
DOI: 10.1073/pnas.2300760120
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Nils Christian Stenseth; Barbara Bramanti; Ulf Buentgen; Henry G. Fell; Samuel Cohn; Florent Sebbane; Philip Slavin; Chutian Zhang; Ruifu Yang; Lei Xu
Source: Self-asserted source
Florent Sebbane

Yersinia pestis and Plague: Some Knowns and Unknowns

Zoonoses
2023-01-19 | Journal article
DOI: 10.15212/zoonoses-2022-0040
Part of ISSN: 2737-7466
Part of ISSN: 2737-7474
Contributors: Ruifu Yang; Steve Atkinson; Ziqi Chen; Yujun Cui; Zongmin Du; Yanping Han; Florent Sebbane; Philip Slavin; Yajun Song; Yanfeng Yan et al.
Source: Self-asserted source
Florent Sebbane

No evidence for persistent natural plague reservoirs in historical and modern Europe

Proceedings of the National Academy of Sciences
2022-12-20 | Journal article | Author
DOI: 10.1073/pnas.2209816119
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Nils Christian Stenseth; Yuxin Tao; Chutian Zhang; Barbara Bramanti; Ulf Büntgen; Xianbin Cong; Yujun Cui; Hu Zhou; Lorna A. Dawson; Sacha Mooney et al.
Source: Self-asserted source
Florent Sebbane

Emergence and spread of ancestral <i>Yersinia pestis</i> in Late-Neolithic and Bronze-Age Eurasia, <i>ca</i> . 5,000 to 1,500 y B.P.

Proceedings of the National Academy of Sciences
2022-05-24 | Journal article
DOI: 10.1073/pnas.2204044119
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Florent Sebbane

What do we know about osmoadaptation of Yersinia pestis?

Archives of Microbiology
2022-01 | Journal article
DOI: 10.1007/s00203-021-02610-1
Part of ISSN: 0302-8933
Part of ISSN: 1432-072X
Source: Self-asserted source
Florent Sebbane

Antibiotic Therapy of Plague: A Review

Biomolecules
2021-05 | Journal article | Author
DOI: 10.3390/biom11050724
Contributors: Florent Sebbane; Nadine Lemaître
Source: check_circle
Multidisciplinary Digital Publishing Institute

Interplay between Yersinia pestis and its flea vector in lipoate metabolism.

The ISME journal
2021-01 | Journal article
DOI: 10.1038/s41396-020-00839-0
PMID: 33479491
Contributors: Bouvenot T; Dewitte A; Bennaceur N; Pradel E; Pierre F; Bontemps-Gallo S; Sebbane F
Source: Self-asserted source
Florent Sebbane via Europe PubMed Central

Yersinia pestis Plasminogen Activator

Biomolecules
2020-11-14 | Journal article
DOI: 10.3390/biom10111554
Part of ISSN: 2218-273X
Source: Self-asserted source
Florent Sebbane

A refined model of how Yersinia pestis produces a transmissible infection in its flea vector

PLoS Pathogens
2020-04-15 | Journal article
DOI: 10.1371/journal.ppat.1008440
Part of ISSN: 1553-7374
Source: Self-asserted source
Florent Sebbane

Transcriptomic studies and assessment of Yersinia pestis reference genes in various conditions

Scientific Reports
2019-12 | Journal article
DOI: 10.1038/s41598-019-39072-x
Part of ISSN: 2045-2322
Source: Self-asserted source
Florent Sebbane

Nutrient depletion may trigger the Yersinia pestis OmpR‐EnvZ regulatory system to promote flea‐borne plague transmission

Molecular Microbiology
2019-08-19 | Journal article
DOI: 10.1111/mmi.14372
Part of ISSN: 0950-382X
Part of ISSN: 1365-2958
Source: Self-asserted source
Florent Sebbane

Polymorphism in the Yersinia LcrV Antigen Enables Immune Escape From the Protection Conferred by an LcrV-Secreting Lactococcus Lactis in a Pseudotuberculosis Mouse Model

Frontiers in Immunology
2019-08-02 | Journal article
DOI: 10.3389/fimmu.2019.01830
Part of ISSN: 1664-3224
Source: Self-asserted source
Florent Sebbane

To block or not to block: The adaptive manipulation of plague transmission

Evolution Letters
2019-04 | Journal article
DOI: 10.1002/evl3.111
Part of ISSN: 2056-3744
Source: Self-asserted source
Florent Sebbane

Plague: Bridging gaps towards better disease control

Médecine et Maladies Infectieuses
2018-08 | Journal article
DOI: 10.1016/j.medmal.2018.04.393
URI: pasteur-01919329
PMID: 29773334
Contributors: E. D’ortenzio; Nicolas Lemaître; C. Brouat; P. Loubet; F. Sebbane; M. Rajerison; L. Baril; Y. Yazdanpanah
Source: Self-asserted source
Florent Sebbane via HAL

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.

mBio
2017-07 | Journal article
DOI: 10.1128/mbio.00674-17
PMID: 28743813
PMC: PMC5527309
Contributors: Lemaître N; Liang X; Najeeb J; Lee CJ; Titecat M; Leteurtre E; Simonet M; Toone EJ; Zhou P; Sebbane F
Source: Self-asserted source
Florent Sebbane via Europe PubMed Central

Characterization of the protective immune response to Yersinia pseudotuberculosis infection in mice vaccinated with an LcrV-secreting strain of Lactococcus lactis

Vaccine
2016 | Journal article
DOI: 10.1016/j.vaccine.2016.09.060
EID:

2-s2.0-84992554920
Contributors: Daniel, C.; Titecat, M.; Poiret, S.; Cayet, D.; Boutillier, D.; Simonet, M.; Sirard, J.-C.; Lemaître, N.; Sebbane, F.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Drug design from the cryptic inhibitor envelope

Nature Communications
2016 | Journal article
DOI: 10.1038/ncomms10638
EID:

2-s2.0-84959441617
Contributors: Lee, C.-J.; Liang, X.; Wu, Q.; Najeeb, J.; Zhao, J.; Gopalaswamy, R.; Titecat, M.; Sebbane, F.; Lemaitre, N.; Toone, E.J. et al.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

Journal of Antimicrobial Chemotherapy
2016 | Journal article
DOI: 10.1093/jac/dkw210
EID:

2-s2.0-84994728083
Contributors: Titecat, M.; Liang, X.; Lee, C.-J.; Charlet, A.; Hocquet, D.; Lambert, T.; Pagès, J.-M.; Courcol, R.; Sebbane, F.; Toone, E.J. et al.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Evaluation of the role of the opgGH operon in Yersinia pseudotuberculosis and its deletion during the emergence of Yersinia pestis

Infection and Immunity
2015 | Journal article
DOI: 10.1128/IAI.00482-15
EID:

2-s2.0-84939521860
Contributors: Quintard, K.; Dewitte, A.; Reboul, A.; Madec, E.; Bontemps-Gallo, S.; Dondeyne, J.; Marceau, M.; Simonet, M.; Lacroix, J.-M.; Sebbane, F.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Superantigenic Yersinia pseudotuberculosis induces the expression of granzymes and perforin by CD4&lt;sup&gt;+&lt;/sup&gt; T Cells

Infection and Immunity
2015 | Journal article
DOI: 10.1128/IAI.02339-14
EID:

2-s2.0-84928179350
Contributors: Goubard, A.; Loïez, C.; Abe, J.; Fichel, C.; Herwegh, S.; Faveeuw, C.; Porte, R.; Cayet, D.; Sebbane, F.; Penet, S. et al.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of yersinia pestis

Journal of Bacteriology
2014 | Journal article
DOI: 10.1128/JB.01932-14
EID:

2-s2.0-84907842145
Contributors: Bibi-Triki, S.; de la Sierra-Gallay, I.L.; Lazar, N.; Leroy, A.; Van Tilbeurgh, H.; Sebbane, F.; Pradel, E.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague

PLoS Pathogens
2014 | Journal article
DOI: 10.1371/journal.ppat.1004029
EID:

2-s2.0-84897393547
Contributors: Pradel, E.; Lemaître, N.; Merchez, M.; Ricard, I.; Reboul, A.; Dewitte, A.; Sebbane, F.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Yersinia pestis requires the 2-component regulatory system OmpR-EnvZ to resist innate immunity during the early and late stages of plague

Journal of Infectious Diseases
2014 | Journal article
DOI: 10.1093/infdis/jiu274
EID:

2-s2.0-84922020935
Contributors: Reboul, A.; Lemaître, N.; Titecat, M.; Merchez, M.; Deloison, G.; Ricard, I.; Pradel, E.; Marceau, M.; Sebbane, F.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Inheritance of the lysozyme inhibitor Ivy was an important evolutionary step by Yersinia pestis to avoid the host innate immune response

Journal of Infectious Diseases
2013 | Journal article
DOI: 10.1093/infdis/jit057
EID:

2-s2.0-84876554747
Contributors: Derbise, A.; Pierre, F.; Merchez, M.; Pradel, E.; Laouami, S.; Ricard, I.; Sirard, J.-C.; Fritz, J.; Lemaître, N.; Akinbi, H. et al.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Efficacy of Ciprofloxacin-Gentamicin Combination Therapy in Murine Bubonic Plague

PLoS ONE
2012 | Journal article
DOI: 10.1371/journal.pone.0052503
EID:

2-s2.0-84871454878
Contributors: Lemaître, N.; Ricard, I.; Pradel, E.; Foligné, B.; Courcol, R.; Simonet, M.; Sebbane, F.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages

Cellular Microbiology
2010 | Journal article
DOI: 10.1111/j.1462-5822.2010.01456.x
EID:

2-s2.0-77953019211
Contributors: Moreau, K.; Lacas-Gervais, S.; Fujita, N.; Sebbane, F.; Yoshimori, T.; Simonet, M.; Lafont, F.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Body lice, yersinia pestis orientalis, and black death

Emerging Infectious Diseases
2010 | Journal article
DOI: 10.3201/eid1605.091280
EID:

2-s2.0-77951167360
Contributors: Ayyadurai, S.; Sebbane, F.; Raoult, D.; Drancourt, M.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Role of the Yersinia pestis Yersiniabactin Iron Acquisition System in the Incidence of Flea-Borne Plague

PLoS ONE
2010 | Journal article
DOI: 10.1371/journal.pone.0014379
EID:

2-s2.0-78650736463
Contributors: Sebbane, F.; Jarrett, C.; Gardner, D.; Long, D.; Joseph Hinnebusch, B.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3negCD127+ immune cells in spleen and mucosa

Journal of Immunology
2010 | Journal article
DOI: 10.4049/jimmunol.1000115
EID:

2-s2.0-77955499820
Contributors: Van Maele, L.; Carnoy, C.; Cayet, D.; Songhet, P.; Dumoutier, L.; Ferrero, I.; Janot, L.; Erard, F.; Bertout, J.; Leger, H. et al.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Transit through the flea vector induces a pretransmission innate immunity resistance phenotype in Yersinia pestis

PLoS Pathogens
2010 | Journal article
DOI: 10.1371/journal.ppat.1000783
EID:

2-s2.0-77649242321
Contributors: Vadyvaloo, V.; Jarrett, C.; Sturdevant, D.E.; Sebbane, F.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV

Vaccine
2009 | Journal article
DOI: 10.1016/j.vaccine.2008.12.022
EID:

2-s2.0-59049095067
Contributors: Daniel, C.; Sebbane, F.; Poiret, S.; Goudercourt, D.; Dewulf, J.; Mullet, C.; Simonet, M.; Pot, B.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

The Yersinia pestis caflMlAl fimbrial capsule operon promotes transmission by flea bite in a mouse model of bubonic plague

Infection and Immunity
2009 | Journal article
DOI: 10.1128/IAI.00950-08
EID:

2-s2.0-62449133978
Contributors: Sebbane, F.; Jarrett, C.; Gardner, D.; Long, D.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Analysis of Yersinia pestis gene expression in the flea vector

Advances in Experimental Medicine and Biology
2007 | Book
DOI: 10.1007/978-0-387-72124-8_16
EID:

2-s2.0-84934439323
Contributors: Vadyvaloo, V.; Sebbane, F.; Hinnebusch, B.J.; Sturdevant, D.; Jarrett, C.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Analysis of Yersinia pestis gene expression in the flea vector.

Advances in experimental medicine and biology
2007 | Journal article
EID:

2-s2.0-38449117715
Contributors: Vadyvaloo, V.; Jarrett, C.; Sturdevant, D.; Sebbane, F.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague

Proceedings of the National Academy of Sciences of the United States of America
2006 | Journal article
DOI: 10.1073/pnas.0601182103
EID:

2-s2.0-33746806940
Contributors: Sebbane, F.; Lemaître, N.; Sturdevant, D.E.; Rebeil, R.; Virtaneva, K.; Porcella, S.F.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Role of the Yersinia pestis plasminogen activator in the incidence of distinct septicemic and bubonic forms of flea-borne plague

Proceedings of the National Academy of Sciences of the United States of America
2006 | Journal article
DOI: 10.1073/pnas.0509544103
EID:

2-s2.0-33645788354
Contributors: Sebbane, F.; Jarrett, C.O.; Gardner, D.; Long, D.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Yersinia pestis YopJ suppresses tumor necrosis factor alpha induction and contributes to apoptosis of immune cells in the lymph node but is not required for virulence in a rat model of bubonic plague

Infection and Immunity
2006 | Journal article
DOI: 10.1128/IAI.00219-06
EID:

2-s2.0-33748045153
Contributors: Lemaître, N.; Sebbane, F.; Long, D.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Kinetics of disease progression and host response in a rat model of bubonic plague

American Journal of Pathology
2005 | Journal article
EID:

2-s2.0-17844375136
Contributors: Sebbane, F.; Gardner, D.; Long, D.; Gowen, B.B.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Poor vector competence of fleas and the evolution of hypervirulence in Yersinia pestis

Journal of Infectious Diseases
2005 | Journal article
DOI: 10.1086/429931
EID:

2-s2.0-18944383741
Contributors: Lorange, E.A.; Race, B.L.; Sebbane, F.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Evaluation of the role of constitutive isocitrate lyase activity in Yersinia pestis infection of the flea vector and mammalian host

Infection and Immunity
2004 | Journal article
DOI: 10.1128/IAI.72.12.7334-7337.2004
EID:

2-s2.0-9244225662
Contributors: Sebbane, F.; Jarrett, C.O.; Linkenhoker, J.R.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Flea-Borne Transmission Model to Evaluate Vaccine Efficacy against Naturally Acquired Bubonic Plague

Infection and Immunity
2004 | Journal article
DOI: 10.1128/IAI.72.4.2052-2056.2004
EID:

2-s2.0-1842484204
Contributors: Jarrett, C.O.; Sebbane, F.; Adamovicz, J.J.; Andrews, G.P.; Hinnebusch, B.J.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

The pmrF polymyxin-resistance operon of Yersinia pseudotuberculosis is upregulated by the PhoP-PhoQ two-component system but not by PmrA-PmrB, and is not required for virulence

Microbiology
2004 | Journal article
DOI: 10.1099/mic.0.27426-0
EID:

2-s2.0-11044228090
Contributors: Marceau, M.; Sebbane, F.; Ewann, F.; Collyn, F.; Lindner, B.; Campos, M.A.; Bengoechea, J.-A.; Simonet, M.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Function and regulation of the Salmonella-like pmrF antimicrobial peptide resistance operon in Yersinia pseudotuberculosis

Advances in Experimental Medicine and Biology
2003 | Book
EID:

2-s2.0-0038130587
Contributors: Marceau, M.; Sebbane, F.; Collyn, F.; Simonet, M.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

Genes encoding specific nickel transport systems flank the chromosomal urease locus of pathogenic yersiniae

Journal of Bacteriology
2002 | Journal article
DOI: 10.1128/JB.184.20.5706-5713.2002
EID:

2-s2.0-0036785325
Contributors: Sebbane, F.; Mandrand-Berthelot, M.-A.; Simonet, M.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

The superantigen gene ypm is located in an unstable chromosomal locus of Yersinia pseudotuberculosis

Journal of Bacteriology
2002 | Journal article
DOI: 10.1128/JB.184.16.4489-4499.2002
EID:

2-s2.0-0036330794
Contributors: Carnoy, C.; Floquet, S.; Marceau, M.; Sebbane, F.; Haentjens-Herwegh, S.; Devalckenaere, A.; Simonet, M.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier

The Yersinia pseudotuberculosis Yut protein, a new type of urea transporter homologous to eukaryotic channels and functionally interchangeable in vitro with the Helicobacter pylori Urel protein

Molecular Microbiology
2002 | Journal article
DOI: 10.1046/j.1365-2958.2002.03096.x
EID:

2-s2.0-0036037358
Contributors: Sebbane, F.; Bury-Moné, S.; Cailliau, K.; Browaeys-Poly, E.; De Reuse, H.; Simonet, M.
Source: Self-asserted source
Florent Sebbane via Scopus - Elsevier
Items per page:
Page 1 of 2
How many people are using ORCID?