Personal information

Emails & domains

Verified email domains

Websites & social links

Lab website

Other IDs

Researcher Name Resolver ID: 1000010593684

Keywords

SARS-CoV-2, Spillover, Evolutionary arms race, HIV, Lentivirus, Humanized mouse

Countries

Japan

Activities

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Employment (8)

The University of Tokyo: Tokyo, Minato-ku, JP

2022-04-01 to present | Professor (Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science)
Employment
Source: Self-asserted source
Kei Sato

The University of Tokyo: Minato-ku, Tokyo, JP

2018-04 to 2022-03 | Associate Professor (Principal Investigator) (Division of Systems Virology, International Research Center for Infectious Diseases, The Institute of Medical Science)
Employment
Source: Self-asserted source
Kei Sato

Kyoto University: Kyoto, Kyoto, JP

2016-10 to 2018-03 | Lecturer/Associate Professor (Laboratory of Systems Virology, Department of Biosystems Science, Institute for Frontier Life and Medical Sciences)
Employment
Source: Self-asserted source
Kei Sato

Kyoto University: Kyoto, Kyoto, JP

2016-03 to 2016-09 | Lecturer/Associate Professor (Laboratory of Viral Pathogenesis, Institute for Virus Research)
Employment
Source: Self-asserted source
Kei Sato

Kyoto University: Kyoto, Kyoto, JP

2012-08 to 2016-02 | Assistant Professor (Laboratory of Viral Pathogenesis, Institute for Virus Research)
Employment
Source: Self-asserted source
Kei Sato

University of Glasgow: Glasgow, Scotland, GB

2015-07 to 2015-10 | Visiting Scientist (Centre for Virus Research)
Employment
Source: Self-asserted source
Kei Sato

Kyoto University: Kyoto, Kyoto, JP

2010-07 to 2012-07 | Assistant Professor (Center for Emerging Virus Research, Institute for Virus Research)
Employment
Source: Self-asserted source
Kei Sato

Kyoto University: Kyoto, Kyoto, JP

2010-04 to 2010-06 | Postdoctoral Fellow (JSPS PD) (Laboratory of Viral Pathogenesis, Institute for Virus Research)
Employment
Source: Self-asserted source
Kei Sato

Education and qualifications (3)

Kyoto University: Kyoto, Kyoto, JP

2010-03 | Ph.D (Medicine. One-year early graduation) (Laboratory of Viral Pathogenesis)
Education
Source: Self-asserted source
Kei Sato

Kyoto University: Kyoto, Kyoto, JP

2007-03 | Master (Biostudies) (Laboratory of Viral Pathogenesis, Institute for Virus Research)
Education
Source: Self-asserted source
Kei Sato

Tohoku University: Sendai, Miyagi, JP

2005-03 | Bachelor (Agriculture) (Laboratory of Molecular Biology)
Education
Source: Self-asserted source
Kei Sato

Works (40)

Genetic diversity of pangolin coronaviruses reveals a key immuno-evasive substitution at spike residue 519

2025-04-02 | Preprint
DOI: 10.1101/2025.04.01.646621
Contributors: Maximilian Stanley Yo; Yu Kaku; Yusuke Kosugi; Jarel Elgin Tolentino; yunlong Richard Cao; Kei Sato
Source: check_circle
Crossref

Pathogen genomic surveillance and the AI revolution

Journal of Virology
2025-02-25 | Journal article
DOI: 10.1128/jvi.01601-24
Contributors: Spyros Lytras; Kieran D. Lamb; Jumpei Ito; Joe Grove; Ke Yuan; Kei Sato; Joseph Hughes; David L. Robertson; Suchetana Mukhopadhyay
Source: check_circle
Crossref

Inferring context-specific site variation with evotuned protein language models

2025-02-20 | Preprint
DOI: 10.1101/2025.02.19.639211
Contributors: Spyros Lytras; Adam Strange; Jumpei Ito; Kei Sato
Source: check_circle
Crossref

Sustainable and portable CRISPR-based diagnostics for high-sensitivity Mpox detection

2024-11-23 | Preprint
DOI: 10.1101/2024.11.20.24317678
Contributors: Rika Hirano; Kazuto Yoshimi; Koji Asano; Kohei Takeshita; Ken J. Ishii; Kei Sato; Tomoji Mashimo
Source: check_circle
Crossref

Molecular and structural insights into SARS-CoV-2 evolution: from BA.2 to XBB subvariants

mBio
2024-10-16 | Journal article
DOI: 10.1128/mbio.03220-23
Contributors: Hisano Yajima; Tomo Nomai; Kaho Okumura; Katsumi Maenaka; Jumpei Ito; Takao Hashiguchi; Kei Sato; Vinayaka R. Prasad; Keita Matsuno; Naganori Nao et al.
Source: check_circle
Crossref

Vulnerability to APOBEC3G linked to the pathogenicity of deltaretroviruses

Proceedings of the National Academy of Sciences
2024-03-26 | Journal article
DOI: 10.1073/pnas.2309925121
Contributors: Takafumi Shichijo; Jun-ichirou Yasunaga; Kei Sato; Kisato Nosaka; Kosuke Toyoda; Miho Watanabe; Wenyi Zhang; Yoshio Koyanagi; Edward L. Murphy; Roberta L. Bruhn et al.
Source: check_circle
Crossref

A Protein Language Model for Exploring Viral Fitness Landscapes

2024-03-18 | Preprint
DOI: 10.1101/2024.03.15.584819
Contributors: Jumpei Ito; Adam Strange; Wei Liu; Gustav Joas; Spyros Lytras; Kei Sato
Source: check_circle
Crossref

SARS-CoV-2 ORF7a Mutation Found in BF.5 and BF.7 Sublineages Impacts Its Functions

International Journal of Molecular Sciences
2024-02-16 | Journal article
DOI: 10.3390/ijms25042351
Contributors: Uddhav Timilsina; Emily B. Ivey; Sean Duffy; Arnon Plianchaisuk; Jumpei Ito; Kei Sato; Spyridon Stavrou
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses to Rhinolophus bat ACE2

Journal of Virology
2023-10-31 | Journal article
DOI: 10.1128/jvi.00990-23
Contributors: Shigeru Fujita; Yusuke Kosugi; Izumi Kimura; Kenzo Tokunaga; Jumpei Ito; Kei Sato; Tom Gallagher; Keita Matsuno; Naganori Nao; Hirofumi Sawa et al.
Source: check_circle
Crossref

SARS-CoV-2 ORF7a mutation found in BF.5 and BF.7 sublineages impacts its functions

2023-09-07 | Preprint
DOI: 10.1101/2023.09.06.556547
Contributors: Uddhav Timilsina; Sean R. Duffy; Arnon Plianchaisuk; Jumpei Ito; Kei Sato; Spyridon Stavrou
Source: check_circle
Crossref

Impact of imprinted immunity induced by mRNA vaccination in an experimental animal model

2023-06-23 | Other
DOI: 10.1093/infdis/jiad230
Contributors: Kei Sato; Hirofumi Sawa; Jumpei Ito; Koshiro Tabata
Source: check_circle
Crossref

Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections

GigaScience
2022-12-28 | Journal article
DOI: 10.1093/gigascience/giad086
Contributors: Hirofumi Aso; Jumpei Ito; Haruka Ozaki; Yukie Kashima; Yutaka Suzuki; Yoshio Koyanagi; Kei Sato
Source: check_circle
Crossref

Structural Insight into the Resistance of the SARS-CoV-2 Omicron BA.4 and BA.5 Variants to Cilgavimab

Viruses
2022-11-29 | Journal article
DOI: 10.3390/v14122677
Contributors: Shigeru Fujita; Yusuke Kosugi; Izumi Kimura; Daichi Yamasoba; Kei Sato
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Neutralization sensitivity of Omicron BA.2.75 to therapeutic monoclonal antibodies

2022-07-15 | Preprint
DOI: 10.1101/2022.07.14.500041
Contributors: Daichi Yamasoba; Izumi Kimura; Yusuke Kosugi; Keiya Uriu; Shigeru Fujita; Jumpei Ito; Kei Sato
Source: check_circle
Crossref

A hominoid-specific endogenous retrovirus may have rewired the gene regulatory network shared between primordial germ cells and naïve pluripotent cells

PLOS Genetics
2022-05-12 | Journal article
DOI: 10.1371/journal.pgen.1009846
Contributors: Jumpei Ito; Cédric Feschotte; Yasunari Seita; Shohei Kojima; Nicholas F. Parrish; Kotaro Sasaki; Kei Sato
Source: check_circle
Crossref

Characterization of the immune resistance of SARS-CoV-2 Mu variant and the robust immunity induced by Mu infection

The Journal of Infectious Diseases
2022-02-18 | Journal article
DOI: 10.1093/infdis/jiac053
Contributors: Keiya Uriu; Paúl Cárdenas; Erika Muñoz; Veronica Barragan; Yusuke Kosugi; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kei Sato
Source: check_circle
Crossref

Neutralization of the SARS-CoV-2 Mu Variant by Convalescent and Vaccine Serum

New England Journal of Medicine
2021-12-16 | Journal article
DOI: 10.1056/NEJMc2114706
Contributors: Keiya Uriu; Izumi Kimura; Kotaro Shirakawa; Akifumi Takaori-Kondo; Taka-aki Nakada; Atsushi Kaneda; So Nakagawa; Kei Sato
Source: check_circle
Crossref

Characterization of the immune resistance of SARS-CoV-2 Mu variant and the immunity induced by Mu infection

2021-11-24 | Other
DOI: 10.1101/2021.11.23.469770
Contributors: Keiya Uriu; Paúl Cárdenas; Erika Muñoz; Veronica Barragan; Yusuke Kosugi; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kei Sato
Source: check_circle
Crossref

Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage

PLOS Pathogens
2021-11-15 | Journal article
DOI: 10.1371/journal.ppat.1009728
Contributors: Zhe Zhao; Raul Andino; Riku Fagerlund; Helena Tossavainen; Kristina Hopfensperger; Rishikesh Lotke; Smitha Srinivasachar Badarinarayan; Frank Kirchhoff; Perttu Permi; Kei Sato et al.
Source: check_circle
Crossref

An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

Cell Reports
2021-09 | Journal article
DOI: 10.1016/j.celrep.2021.109735
Contributors: Matteo Bosso; Christina M. Stürzel; Dorota Kmiec; Smitha Srinivasachar Badarinarayan; Elisabeth Braun; Jumpei Ito; Kei Sato; Beatrice H. Hahn; Konstantin M.J. Sparrer; Daniel Sauter et al.
Source: check_circle
Crossref

Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera

2021-09-07 | Other
DOI: 10.1101/2021.09.06.459005
Contributors: Keiya Uriu; Izumi Kimura; Kotaro Shirakawa; Akifumi Takaori-Kondo; Taka-aki Nakada; Atsushi Kaneda; So Nakagawa; Kei Sato
Source: check_circle
Crossref

Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome: A homology-based resolution

Virology
2021-06 | Journal article
DOI: 10.1016/j.virol.2021.02.013
Contributors: Irwin Jungreis; Chase W. Nelson; Zachary Ardern; Yaara Finkel; Nevan J. Krogan; Kei Sato; John Ziebuhr; Noam Stern-Ginossar; Angelo Pavesi; Andrew E. Firth et al.
Source: check_circle
Crossref

Elucidation of the Complicated Scenario of Primate APOBEC3 Gene Evolution

Journal of Virology
2021-05-24 | Journal article
DOI: 10.1128/JVI.00144-21
Contributors: Keiya Uriu; Yusuke Kosugi; Narumi Suzuki; Jumpei Ito; Kei Sato; Frank Kirchhoff
Source: check_circle
Crossref

Sarbecovirus ORF6 proteins hamper induction of interferon signaling

Cell Reports
2021-03 | Journal article
DOI: 10.1016/j.celrep.2021.108916
Contributors: Izumi Kimura; Yoriyuki Konno; Keiya Uriu; Kristina Hopfensperger; Daniel Sauter; So Nakagawa; Kei Sato
Source: check_circle
Crossref

Endogenous retrovirus rewired the gene regulatory network shared between primordial germ cells and naïve pluripotent cells in hominoids

2021-03-10 | Other
DOI: 10.1101/2021.03.09.434541
Contributors: Jumpei Ito; Yasunari Seita; Shohei Kojima; Nicholas F. Parrish; Kotaro Sasaki; Kei Sato
Source: check_circle
Crossref

HIV‐1 tracing method of systemic viremia in vivo using an artificially mutated virus pool

Microbiology and Immunology
2021-01 | Journal article
DOI: 10.1111/1348-0421.12862
Contributors: Andrew Soper; Yoshio Koyanagi; Kei Sato
Source: check_circle
Crossref

The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present

Viruses
2021-01-17 | Journal article
DOI: 10.3390/v13010124
Contributors: Keiya Uriu; Yusuke Kosugi; Jumpei Ito; Kei Sato
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

A tissue level atlas of the healthy human virome

BMC Biology
2020-12 | Journal article
DOI: 10.1186/s12915-020-00785-5
Contributors: Ryuichi Kumata; Jumpei Ito; Kenta Takahashi; Tadaki Suzuki; Kei Sato
Source: check_circle
Crossref

Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells

Nature Communications
2020-11-09 | Journal article
DOI: 10.1038/s41467-020-19350-3
Contributors: Young Sun Hwang; Shinnosuke Suzuki; Yasunari Seita; Jumpei Ito; Yuka Sakata; Hirofumi Aso; Kei Sato; Brian P. Hermann; Kotaro Sasaki
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Crossref

Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression

Science Advances
2020-10-23 | Journal article
DOI: 10.1126/sciadv.abc3020
Contributors: Jumpei Ito; Izumi Kimura; Andrew Soper; Alexandre Coudray; Yoshio Koyanagi; Hirofumi Nakaoka; Ituro Inoue; Priscilla Turelli; Didier Trono; Kei Sato
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Crossref

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

Cell Reports
2020-09 | Journal article
DOI: 10.1016/j.celrep.2020.108185
Contributors: Yoriyuki Konno; Izumi Kimura; Keiya Uriu; Masaya Fukushi; Takashi Irie; Yoshio Koyanagi; Daniel Sauter; Robert J. Gifford; So Nakagawa; Kei Sato
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Crossref

Inherited chromosomally integrated HHV-6 possibly modulates human gene expression

Virus Genes
2020-06-17 | Journal article
DOI: 10.1007/s11262-020-01745-5
Contributors: Ryuichi Kumata; Jumpei Ito; Kei Sato
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Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection

2020-03-25 | Preprint
DOI: 10.1101/2020.03.23.004440
Contributors: Tomoki Inagaki; Yoshitaka Sato; Jumpei Ito; Mitsuaki Takaki; Yusuke Okuno; Masahiro Yaguchi; H. M. Abdullah Al Masud; Takahiro Watanabe; Kei Sato; Shingo Iwami et al.
Source: check_circle
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Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression

2020-02-03 | Preprint
DOI: 10.1101/2020.02.02.931501
Contributors: Jumpei Ito; Izumi Kimura; Andrew Soper; Alexandre Coudray; Yoshio Koyanagi; Hirofumi Nakaoka; Ituro Inoue; Priscilla Turelli; Didier Trono; Kei Sato
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Crossref

Retroviruses drive the rapid evolution of mammalian APOBEC3 genes

Proceedings of the National Academy of Sciences
2020-01-07 | Journal article
DOI: 10.1073/pnas.1914183116
Contributors: Jumpei Ito; Robert J. Gifford; Kei Sato
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Rapid evolution of antiviral APOBEC3 genes driven by the conflicts with ancient retroviruses

2019-07-18 | Other
DOI: 10.1101/707190
Contributors: Jumpei Ito; Robert J. Gifford; Kei Sato
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Experimental Adaptive Evolution of Simian Immunodeficiency Virus SIVcpz to Pandemic Human Immunodeficiency Virus Type 1 by Using a Humanized Mouse Model

Journal of Virology
2018-02-15 | Journal article
DOI: 10.1128/JVI.01905-17
Contributors: Kei Sato; Naoko Misawa; Junko S. Takeuchi; Tomoko Kobayashi; Taisuke Izumi; Hirofumi Aso; Shumpei Nagaoka; Keisuke Yamamoto; Izumi Kimura; Yoriyuki Konno et al.
Source: check_circle
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A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

Retrovirology
2017-12 | Journal article
DOI: 10.1186/s12977-017-0355-4
Contributors: Yusuke Nakano; Hirofumi Aso; Andrew Soper; Eri Yamada; Miyu Moriwaki; Guillermo Juarez-Fernandez; Yoshio Koyanagi; Kei Sato
Source: check_circle
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Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane

Scientific Reports
2017-11-21 | Journal article
DOI: 10.1038/s41598-017-16130-w
Contributors: Ming Chen; Chie Aoki-Utsubo; Masanori Kameoka; Lin Deng; Yutaka Terada; Wataru Kamitani; Kei Sato; Yoshio Koyanagi; Makoto Hijikata; Keiko Shindo et al.
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Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3

Journal of Virology
2017-06 | Journal article
DOI: 10.1128/JVI.00250-17
Contributors: Rokusuke Yoshikawa; Junko S. Takeuchi; Eri Yamada; Yusuke Nakano; Naoko Misawa; Yuichi Kimura; Fengrong Ren; Takayuki Miyazawa; Yoshio Koyanagi; Kei Sato et al.
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Peer review (24 reviews for 8 publications/grants)

Review activity for EBioMedicine. (2)
Review activity for Nature (1)
Review activity for Nature communications (2)
Review activity for Nature microbiology. (2)
Review activity for Nature reviews. (1)
Review activity for PLOS pathogens : (5)
Review activity for Retrovirology. (3)
Review activity for The lancet. (8)
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