Personal information

Other IDs

Scopus Author ID: 57146726700
SciProfiles: 1472898

Keywords

G-quadruplex, Nucleolin, Infectious diseases, Blood-brain barrier

Countries

Portugal

Activities

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Employment (3)

Instituto de Soldadura e Qualidade: Porto Salvo, Lisbon, PT

2024-06-19 to present | PhD Researcher (R&D+i Division)
Employment
Source: Self-asserted source
Santos T.

VectorB2B: Lisboa, Lisboa, PT

2022-11-07 to present | Staff Scientist
Employment
Source: Self-asserted source
Santos T.

Universidade da Beira Interior: Covilha, Castelo Branco, PT

2018-06-01 to 2022-10-07 | PhD Research Fellow (Health Sciences)
Employment
Source: Self-asserted source
Santos T.

Education and qualifications (3)

Universidade da Beira Interior: Covilhã, Castelo Branco, PT

2018-06-01 to 2022-10-07 | PhD in Biomedicine (Health Sciences)
Education
Source: Self-asserted source
Santos T.

Universidade da Beira Interior: Covilhã, Castelo Branco, PT

2013-07-01 to 2015-07-13 | MSc (Health Sciences)
Education
Source: Self-asserted source
Santos T.

Universidade da Beira Interior: Covilhã, Castelo Branco, PT

2009-09-01 to 2013-07-01 | BSc degree (Health Sciences)
Education
Source: Self-asserted source
Santos T.

Funding (5)

Acridine orange derivatives binding to RNA G-quadruplex and potential use in nucleolin targeting

2018-07 to present | Award
CICS-UBI/Santander Totta (Covilhã, PT)
Source: Self-asserted source
Santos T.

Recognition of G-quadruplexes (G4s) in microRNA precursors by nucleolin (NCL) and its implications in cancer

2018-06 to present | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PD/BD/142851/2018
Source: Self-asserted source
Santos T.

Nucleolin targeting by G-quadruplex aptamers for cervical cancer therapy

2017-10 to 2018-05 | Grant
Universidade da Beira Centro de Investigação em Ciências da Saúde (Covilhã, PT)
GRANT_NUMBER:

IF/00959/2015
Source: check_circle
CIÊNCIAVITAE

Innovative diagnosis of prostate cancer based on pre-miRNA G-quadruplex

2016-11 to present | Award
Universidade da Beira Interior/Santander Totta (Covilhã, PT)
Source: Self-asserted source
Santos T.

Innovative diagnosis of prostate cancer based on pre-miRNA G-quadruplexes

2016-10 to 2017-08 | Grant
Santander Totta/UBI (Covilhã, PT)
GRANT_NUMBER:

Ref BID/ICI-FCS/CICS/Santander Universidades-UBI/2016
Source: Self-asserted source
Santos T.
grade
Preferred source (of 2)‎

Works (26)

Exploring the G-Quadruplex Formation of AS1411 Derivatives

Molecules
2025-04-08 | Journal article
DOI: 10.3390/molecules30081673
Contributors: Pedro Lourenço; David Moreira; André Miranda; Jéssica Lopes-Nunes; Izamara Maocha; Tiago Santos; Pedro L. Ferreira; Fani Sousa; Artur Paiva; Carla Cruz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Design of Natterins-based peptides improves antimicrobial and antiviral activities

Biotechnology Reports
2025-03 | Journal article
DOI: 10.1016/j.btre.2024.e00867
Contributors: Gabrielle L. de Cena; Dayane B. Tada; Danilo B.M. Lucchi; Tiago A.A. Santos; Montserrat Heras; Maria Juliano; Carla Torres Braconi; Miguel A.R.B. Castanho; Mônica Lopes-Ferreira; Katia Conceição
Source: check_circle
Crossref

Aptamer-based microfluidics for circulating tumor cells

Aptamers Engineered Nanocarriers for Cancer Therapy
2023 | Book chapter
DOI: 10.1016/b978-0-323-85881-6.00004-x
Part of ISBN: 9780323858816
Contributors: Carla Cruz; André Miranda; Tiago Santos
Source: Self-asserted source
Santos T.

A Structural Perspective into the Interaction of an Oncogenesis‐Relevant pre‐miRNA G‐Quadruplex Ligand Carrier with the Protein Nucleolin

Chemistry – A European Journal
2023-04-28 | Journal article
DOI: 10.1002/chem.202301181
Part of ISSN: 0947-6539
Part of ISSN: 1521-3765
Contributors: Tiago Santos; Micael Silva; Lionel Imbert; Maria P. C. Campello; António Paulo; Samir Amrane; Gilmar F. Salgado; Carla Cruz; Eurico J Cabrita
Source: Self-asserted source
Santos T.
grade
Preferred source (of 2)‎

G-Quadruplex Aptamer-Ligand Characterization

Molecules
2022-10-11 | Journal article
DOI: 10.3390/molecules27206781
Contributors: David Moreira; Daniela Leitão; Jéssica Lopes-Nunes; Tiago Santos; Joana Figueiredo; André Miranda; Daniela Alexandre; Cândida Tomaz; Jean-Louis Mergny; Carla Cruz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Stabilization of a DNA aptamer by ligand binding

Biochimie
2022-09 | Journal article
DOI: 10.1016/j.biochi.2022.05.002
Part of ISSN: 0300-9084
Contributors: Tiago Santos; Jéssica Lopes-Nunes; Daniela Alexandre; André Miranda; Joana Figueiredo; Micael S. Silva; Jean-Louis Mergny; Carla Cruz
Source: Self-asserted source
Santos T.

Targeting a G-quadruplex from let-7e pre-miRNA with small molecules and nucleolin

Journal of Pharmaceutical and Biomedical Analysis
2022-06 | Journal article
DOI: 10.1016/j.jpba.2022.114757
Part of ISSN: 0731-7085
Source: Self-asserted source
Santos T.

Nucleolin: a binding partner of G-quadruplex structures

Trends in Cell Biology
2022-04 | Journal article
DOI: 10.1016/j.tcb.2022.03.003
Part of ISSN: 0962-8924
Source: Self-asserted source
Santos T.

Diketopyrrolo[3,4–c]pyrrole derivative as a promising ligand for the stabilization of G-quadruplex DNA structures

Bioorganic Chemistry
2022-02 | Journal article
DOI: 10.1016/j.bioorg.2022.105703
Part of ISSN: 0045-2068
Source: Self-asserted source
Santos T.

Pre-miRNA-149 G-quadruplex as a molecular agent to capture nucleolin

European Journal of Pharmaceutical Sciences
2022-02 | Journal article
DOI: 10.1016/j.ejps.2021.106093
Part of ISSN: 0928-0987
Source: Self-asserted source
Santos T.

Molecular Beacon Assay Development for Severe Acute Respiratory Syndrome Coronavirus 2 Detection

Sensors
2021-10 | Journal article | Author
DOI: 10.3390/s21217015
Contributors: Josué Carvalho; Jéssica Lopes-Nunes; Joana Figueiredo; Santos T.; André Filipe Rodrigues Miranda; Micaela Riscado; Sousa F; Duarte, A. P.; Socorro S; C. T. Tomaz et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Ligands as Stabilizers of G-Quadruplexes in Non-Coding RNAs

Molecules
2021-10-13 | Journal article
DOI: 10.3390/molecules26206164
Contributors: Joana Figueiredo; Tiago Santos; André Miranda; Daniela Alexandre; Bernardo Teixeira; Pedro Simões; Jéssica Lopes-Nunes; Carla Cruz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

G-Quadruplexes and Their Ligands: Biophysical Methods to Unravel G-Quadruplex/Ligand Interactions

Pharmaceuticals
2021-08-05 | Journal article
DOI: 10.3390/ph14080769
Contributors: Tiago Santos; Gilmar F. Salgado; Eurico J. Cabrita; Carla Cruz
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Locking up the AS1411 Aptamer with a Flanking Duplex: Towards an Improved Nucleolin-Targeting.

Pharmaceuticals (Basel, Switzerland)
2021-02-04 | Journal article
DOI: 10.3390/ph14020121
PMID: 33557379
Source: Self-asserted source
Santos T.
grade
Preferred source (of 2)‎

Aptamer-based microfluidic assay to detect nucleolin in prostate cancer

Talanta
2020-12 | Journal article
DOI: 10.1016/j.talanta.2020.122037
Contributors: André Miranda; Tiago Santos; Josué Carvalho; Daniela Alexandre; Andreia Jardim; Catarina R.F. Caneira; Vírgilio Vaz; Bruno Pereira; Ricardo Godinho; Duarte Brito et al.
Source: check_circle
Crossref

Microfluidic assay based on G-quadruplex aptamer for nucleolin detection in prostate cancer

Proceedings of The 1st International Electronic Conference on Biosensors
2020-11-02 | Conference paper
DOI: 10.3390/iecb2020-07064
Contributors: André Miranda; Carla Cruz; Tiago Santos; Josué Carvalho; Daniela Alexandre; Andreia Jardim; Catarina Caneira; Virgílio Vaz; Bruno Pereira; Virginia Chu et al.
Source: Self-asserted source
Santos T.
grade
Preferred source (of 2)‎

Nucleolin as a potential biomarker for canine malignant neoplasia

Research in Veterinary Science
2020-10 | Journal article
DOI: 10.1016/j.rvsc.2020.10.004
Part of ISSN: 0034-5288
Source: Self-asserted source
Santos T.

Recognition of Nucleolin Through Interaction with RNA G-Quadruplex

Biochemical Pharmacology
2020-08 | Journal article
DOI: 10.1016/j.bcp.2020.114208
Part of ISSN: 0006-2952
Source: Self-asserted source
Santos T.

Ligand screening to pre-miRNA 149 G-quadruplex investigated by molecular dynamics

Journal of Biomolecular Structure and Dynamics
2020-05-23 | Journal article
DOI: 10.1080/07391102.2019.1632743
Contributors: Josué Carvalho; Tiago Santos; Rui Carrilho; Fani Sousa; Gilmar F. Salgado; João António Queiroz; Carla Cruz
Source: check_circle
Crossref

Plasmid production and purification: An integrated experiment-based biochemistry and biotechnology laboratory course

Biochemistry and Molecular Biology Education
2019-08-07 | Journal article
DOI: 10.1002/bmb.21290
Part of ISSN: 1470-8175
Source: Self-asserted source
Santos T.

RNA G-quadruplex as supramolecular carrier for cancer-selective delivery

European Journal of Pharmaceutics and Biopharmaceutics
2019-07-15 | Journal article
DOI: 10.1016/j.ejpb.2019.07.017
Part of ISSN: 0939-6411
Source: Self-asserted source
Santos T.

Influenza DNA vaccine purification using pHEMA cryogel support

Separation and Purification Technology
2018-11 | Journal article
DOI: 10.1016/j.seppur.2018.06.002
Part of ISSN: 1383-5866
Source: Self-asserted source
Santos T.

Naphthalene amine support for G-quadruplex isolation

The Analyst
2017 | Journal article
DOI: 10.1039/C7AN00648A
Contributors: João Ferreira; Tiago Santos; Patrícia Pereira; Marta C. Corvo; João A. Queiroz; Fani Sousa; Carla Cruz
Source: check_circle
Crossref

Plasmid purification by using a new naphthalene tripodal support

Separation and Purification Technology
2017-11 | Journal article
DOI: 10.1016/j.seppur.2017.06.072
Part of ISSN: 1383-5866
Source: Self-asserted source
Santos T.
grade
Preferred source (of 2)‎

L-tryptophan and dipeptide derivatives for supercoiled plasmid DNA purification

International Journal of Biological Macromolecules
2016 | Journal article
DOI: 10.1016/j.ijbiomac.2016.02.079
EID:

2-s2.0-84960079870
Contributors: Santos, T.; Carvalho, J.; Corvo, M.C.; Cabrita, E.J.; Queiroz, J.A.; Cruz, C.
Source: Self-asserted source
Santos T. via Scopus - Elsevier

Purification of supercoiled G-quadruplex pDNA for in vitro transcription

Separation and Purification Technology
2016 | Journal article
DOI: 10.1016/j.seppur.2016.02.036
EID:

2-s2.0-84959323606
Contributors: Santos, T.; Pereira, P.; Sousa, F.; Queiroz, J.A.; Cruz, C.
Source: Self-asserted source
Santos T. via Scopus - Elsevier

Peer review (4 reviews for 2 publications/grants)

Review activity for Biochemical pharmacology. (2)
Review activity for Chemical engineering journal. (2)
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