Personal information

machine learning, Medicinal Chemistry, Chemical biology, AI, Electron beams
Japan

Biography

Yasunobu Yamashita graduated from the Faculty of Pharmacy of Keio University in 2012 (Bachelor degree) and obtained his Master degree from the Graduate School of Pharmaceutical Sciences at Keio University in 2014. In 2017 he received his PhD from the Graduate school of Pharmaceutical Sciences, Keio University under the supervision of Prof. Dr. Sugai. From 2017 to 2019 he was a post-doctoral fellow in the research group of Prof. Dr. Gröger at the Bielefeld University. From 2020, he is an assistant professor in the group of Prof. Dr. Takayoshi Suzuki at Osaka University, SANKEN. His research interest includes medicical chemistry and chemical biology.

Activities

Employment (2)

Osaka University: Osaka, JP

2020-01-01 to present | Assistant Professor (SANKEN)
Employment
Source: Self-asserted source
Yasunobu Yamashita

Bielefeld University: Bielefeld, DE

2017-08-01 to 2019-12-31 | Post-doctoral researcher
Employment
Source: Self-asserted source
Yasunobu Yamashita

Education and qualifications (1)

Keio University: Tokyo, JP

2012-04-01 to 2017-03-31
Education
Source: Self-asserted source
Yasunobu Yamashita

Professional activities (2)

Alexander von Humboldt Foundation: Bonn, DE

2017 to 2019
Membership
Source: Self-asserted source
Yasunobu Yamashita

Japan Society for the Promotion of Science: Tokyo, JP

2015 to 2017 | DC2
Membership
Source: Self-asserted source
Yasunobu Yamashita

Funding (4)

Development of innovative drug candidates by target guided synthesis

2021-04-05 to 2024-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 21H04795
Source: Self-asserted source
Yasunobu Yamashita via DimensionsWizard

深層学習を用いた新規活性予測器の開発とHDAC阻害薬探索への応用

2021-04-01 to 2026-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 21K15226
Source: Self-asserted source
Yasunobu Yamashita via DimensionsWizard

抗炎症作用と気管支拡張作用を併せ持つ既承認薬、メペンゾラートに関する創薬研究

2015-04-24 to 2017-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 15J00535
Source: Self-asserted source
Yasunobu Yamashita via DimensionsWizard

Combinations of chemical oxidations of N-Boc-propargylic and related amines with enzymatic reductions of their corresponding imines in one-pot process

Salary award
Alexander von Humboldt Foundation (Bonn, DE)
Source: Self-asserted source
Yasunobu Yamashita

Works (33)

創薬モダリティの高度化と次世代動物評価モデル 4.タンパク質間相互作用阻害を標的とした創薬モダリティ

実験医学
2024 | Book chapter
Contributors: Yasunobu Yamashita
Source: Self-asserted source
Yasunobu Yamashita

Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents

Chemical and Pharmaceutical Bulletin
2024-07-01 | Journal article
Part of ISSN: 0009-2363
Part of ISSN: 1347-5223
Contributors: Yasunobu Yamashita; Yukihiro Itoh; Yuri Takada; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule

Bioorganic & Medicinal Chemistry Letters
2024-06 | Journal article
Part of ISSN: 0960-894X
Contributors: Siyao Ni; Yuri Takada; Takaaki Ando; Shengwang Yu; Yasunobu Yamashita; Yukari Takahashi; Miho Sawada; Makoto Oba; Yukihiro Itoh; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells

Bioorganic & Medicinal Chemistry
2024-02 | Journal article
Part of ISSN: 0968-0896
Contributors: Yosuke Ota; Yukihiro Itoh; Yuri Takada; Yasunobu Yamashita; Chenliang Hu; Mano Horinaka; Yoshihiro Sowa; Mitsuharu Masuda; Toshiyuki Sakai; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 1

Chemical and Pharmaceutical Bulletin
2024-02-01 | Journal article
Part of ISSN: 0009-2363
Part of ISSN: 1347-5223
Contributors: Yuri Takada; Kyohei Adachi; Yuka Fujinaga; Yasunobu Yamashita; Yukihiro Itoh; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning

Chemical and Pharmaceutical Bulletin
2024-02-01 | Journal article
Part of ISSN: 0009-2363
Part of ISSN: 1347-5223
Contributors: Atika Nurani; Yasunobu Yamashita; Yuuki Taki; Yuri Takada; Yukihiro Itoh; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity

Bioorganic & Medicinal Chemistry
2024-01 | Journal article
Contributors: Mitsuhiro Terao; Yasunobu Yamashita; Yuri Takada; Yukihiro Itoh; Takayoshi Suzuki
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation

Journal of Medicinal Chemistry
2023-11-23 | Journal article | Author
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Yukihiro Itoh; Peng Zhan; Toshifumi Tojo; Pattaporn Jaikhan; Yosuke Ota; Miki Suzuki; Ying Li; Zi Hui; Yukiko Moriyama; Yuri Takada et al.
Source: Self-asserted source
Yasunobu Yamashita

HDAC8選択的阻害薬の創製とPROTACへの応用

MEDCHEM NEWS
2023-11-01 | Book review
Part of ISSN: 24328618
Part of ISSN: 24328618
Part of ISSN: 24328626
Contributors: 泰信 山下; 悠里 高田; 幸裕 伊藤; 孝禎 鈴木
Source: Self-asserted source
Yasunobu Yamashita

Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)

Chemical Communications
2022 | Journal article
Part of ISSN: 1359-7345
Part of ISSN: 1364-548X
Contributors: Jiranan Chotitumnavee; Yasunobu Yamashita; Yukari Takahashi; Yuri Takada; Tetsuya Iida; Makoto Oba; Yukihiro Itoh; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Cancer-Cell-Selective Targeting by Arylcyclopropylamine–Vorinostat Conjugates

ACS Medicinal Chemistry Letters
2022-09-12 | Journal article
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Contributors: Yasunobu Yamashita
Source: Self-asserted source
Yasunobu Yamashita
grade
Preferred source (of 3)‎

Medicinal Chemistry Research on Targeting Epigenetic Complexes

Journal of Synthetic Organic Chemistry, Japan
2022-07-01 | Journal article
Part of ISSN: 0037-9980
Part of ISSN: 1883-6526
Contributors: Yuri Takada; Yasunobu Yamashita; Yukihiro Itoh; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Recent progress on small molecules targeting epigenetic complexes

Current Opinion in Chemical Biology
2022-04 | Journal article
Part of ISSN: 1367-5931
Contributors: Yukihiro Itoh; Yuri Takada; Yasunobu Yamashita; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Identification of Novel Histone Deacetylase 6‐Selective Inhibitors Bearing 3,3,3‐Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group

ChemBioChem
2021-11-16 | Journal article
Part of ISSN: 1439-4227
Part of ISSN: 1439-7633
Contributors: Takashi Kurohara; Keita Tanaka; Daisuke Takahashi; Satoshi Ueda; Yasunobu Yamashita; Yuri Takada; Hirokazu Takeshima; Shengwang Yu; Yukihiro Itoh; Koji Hase et al.
Source: Self-asserted source
Yasunobu Yamashita

Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach

Journal of Medicinal Chemistry
2021-11-11 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Muthuraj Prakash; Yukihiro Itoh; Yoshie Fujiwara; Yukari Takahashi; Yuri Takada; Paolo Mellini; Elghareeb E. Elboray; Mitsuhiro Terao; Yasunobu Yamashita; Chika Yamamoto et al.
Source: Self-asserted source
Yasunobu Yamashita
grade
Preferred source (of 2)‎

Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders

ChemMedChem
2021-05-18 | Journal article
Part of ISSN: 1860-7179
Part of ISSN: 1860-7187
Contributors: Tetsuya Iida; Yukihiro Itoh; Yukari Takahashi; Yasunobu Yamashita; Takashi Kurohara; Yuka Miyake; Makoto Oba; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Learning about Enzyme Stability against Organic Cosolvents from Structural Insights by Ion Mobility Mass Spectrometry

ChemBioChem
2020-07-16 | Journal article
Part of ISSN: 1439-4227
Part of ISSN: 1439-7633
Contributors: Jens Sproß; Yasunobu Yamashita; Harald Gröger
Source: Self-asserted source
Yasunobu Yamashita

Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor

ACS Catalysis
2020-05-15 | Journal article
Part of ISSN: 2155-5435
Part of ISSN: 2155-5435
Contributors: Yuka Miyake; Yukihiro Itoh; Yoshinori Suzuma; Hidehiko Kodama; Takashi Kurohara; Yasunobu Yamashita; Remy Narozny; Yutaro Hanatani; Shusaku Uchida; Takayoshi Suzuki
Source: Self-asserted source
Yasunobu Yamashita

Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity

Bioorganic & Medicinal Chemistry
2019-08 | Journal article
Part of ISSN: 0968-0896
Contributors: Yasunobu Yamashita; Ken-ichiro Tanaka; Naoki Yamakawa; Teita Asano; Yuki Kanda; Ayaka Takafuji; Masahiro Kawahara; Mitsuko Takenaga; Yoshifumi Fukunishi; Tohru Mizushima
Source: Self-asserted source
Yasunobu Yamashita

An Asymmetric Organocatalytic Aldol Reaction of a Hydrophobic Aldehyde in Aqueous Medium Running in Flow Mode

Synthesis
2019-03 | Journal article
Part of ISSN: 0039-7881
Part of ISSN: 1437-210X
Contributors: Lukas Schober; Shahilan Ratnam; Yasunobu Yamashita; Niklas Adebar; Matthias Pieper; Albrecht Berkessel; Volker Hessel; Harald Gröger
Source: Self-asserted source
Yasunobu Yamashita

Prediction of Protein−compound Binding Energies from Known Activity Data: Docking‐score‐based Method and its Applications

Molecular Informatics
2018-07 | Journal article
Part of ISSN: 1868-1743
Part of ISSN: 1868-1751
Contributors: Yoshifumi Fukunishi; Yasunobu Yamashita; Tadaaki Mashimo; Haruki Nakamura
Source: Self-asserted source
Yasunobu Yamashita

Identification of Mepenzolate Derivatives With Long-Acting Bronchodilatory Activity

Frontiers in Pharmacology
2018-04-10 | Journal article
Part of ISSN: 1663-9812
Contributors: Ken-Ichiro Tanaka; Naoki Yamakawa; Yasunobu Yamashita; Teita Asano; Yuki Kanda; Ayaka Takafuji; Masahiro Kawahara; Mitsuko Takenaga; Yoshifumi Fukunishi; Tohru Mizushima
Source: Self-asserted source
Yasunobu Yamashita

Preparation of (R)-3-Hydroxy-N-methylpiperidine, a Synthetic Key Intermediate of (R)-Mepenzolate, Based on the Lipase-Catalyzed Resolution of the Racemic Form

HETEROCYCLES
2017 | Journal article
Part of ISSN: 0385-5414
Contributors: Takeshi Sugai; Yasunobu Yamashita; Kengo Hanaya; Mitsuru Shoji
Source: Self-asserted source
Yasunobu Yamashita
grade
Preferred source (of 2)‎

Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation

Bioscience, Biotechnology, and Biochemistry
2017-07-03 | Journal article
Part of ISSN: 0916-8451
Part of ISSN: 1347-6947
Contributors: Yasunobu Yamashita; Alan Biard; Kengo Hanaya; Mitsuru Shoji; Takeshi Sugai
Source: Self-asserted source
Yasunobu Yamashita

Recent Advances for Synthesis of Scyphostatin and Utilization of Oxabicyclo[2.2.1]Heptene Toward Ethyl Shikimate

Studies in Natural Products Chemistry
2016 | Book chapter
Part of ISSN: 1572-5995
Contributors: Kazuaki Kuwata; Yasunobu Yamashita; Kengo Hanaya; Takeshi Sugai; Tohru Mizushima; Mitsuru Shoji
Source: Self-asserted source
Yasunobu Yamashita

Simple Synthesis of Sakuranetin and Selinone <i>via</i> a Common Intermediate, Utilizing Complementary Regioselectivity in the Deacetylation of Naringenin Triacetate

CHEMICAL & PHARMACEUTICAL BULLETIN
2016 | Journal article
Part of ISSN: 0009-2363
Part of ISSN: 1347-5223
Contributors: Yasunobu Yamashita; Kengo Hanaya; Mitsuru Shoji; Takeshi Sugai
Source: Self-asserted source
Yasunobu Yamashita

Ex Situ Enantioconvergent Approaches for the Effective Use of Undesired­ Isomers: Stereochemical Convergence of a Substrate with Multiple Chiral Centers and Recycling of a Decarboxylated Byproduct

Synthesis
2016-05-11 | Journal article
Part of ISSN: 0039-7881
Part of ISSN: 1437-210X
Contributors: Kengo Hanaya; Yasunobu Yamashita; Tohru Kurihara; Takanobu Horiguchi; Atsushi Miki; Mitsuru Shoji; Takeshi Sugai
Source: Self-asserted source
Yasunobu Yamashita

Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities

Bioorganic & Medicinal Chemistry
2014-07 | Journal article
Part of ISSN: 0968-0896
Contributors: Yasunobu Yamashita; Ken-Ichiro Tanaka; Teita Asano; Naoki Yamakawa; Daisuke kobayashi; Tomoaki Ishihara; Kengo Hanaya; Mitsuru Shoji; Takeshi Sugai; Mitsuhito Wada et al.
Source: Self-asserted source
Yasunobu Yamashita

Structure–activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity

Bioorganic & Medicinal Chemistry
2014-04 | Journal article
Part of ISSN: 0968-0896
Contributors: Naoki Yamakawa; Koichiro Suzuki; Yasunobu Yamashita; Takashi Katsu; Kengo Hanaya; Mitsuru Shoji; Takeshi Sugai; Tohru Mizushima
Source: Self-asserted source
Yasunobu Yamashita

Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease

Scientific Reports
2014-03-28 | Journal article
Part of ISSN: 2045-2322
Contributors: Ken-Ichiro Tanaka; Shota Kurotsu; Teita Asano; Naoki Yamakawa; Daisuke Kobayashi; Yasunobu Yamashita; Hiroshi Yamazaki; Tomoaki Ishihara; Hiroshi Watanabe; Toru Maruyama et al.
Source: Self-asserted source
Yasunobu Yamashita

Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease

Nature Communications
2013-11-05 | Journal article
Part of ISSN: 2041-1723
Contributors: Ken-Ichiro Tanaka; Tomoaki Ishihara; Toshifumi Sugizaki; Daisuke Kobayashi; Yasunobu Yamashita; Kayoko Tahara; Naoki Yamakawa; Kumiko Iijima; Kaoru Mogushi; Hiroshi Tanaka et al.
Source: Self-asserted source
Yasunobu Yamashita

Chemo-enzymatic enantioconvergent approach toward ethyl shikimate from ethyl 5-hydroxy-3,4-isopropylidenedioxycyclohex-1-enecarboxylate

Tetrahedron
2013-08 | Journal article
Part of ISSN: 0040-4020
Contributors: Yasunobu Yamashita; Kengo Hanaya; Takeshi Sugai; Tohru Mizushima; Mitsuru Shoji
Source: Self-asserted source
Yasunobu Yamashita

Prostaglandin E1-containing nanoparticles improve walking activity in an experimental rat model of intermittent claudication

Journal of Pharmacy and Pharmacology
2013-07-10 | Journal article
Part of ISSN: 2042-7158
Part of ISSN: 0022-3573
Contributors: Tomoaki Ishihara; Yasunobu Yamashita; Naoko Takasaki; Shuhei Yamamoto; Erika Hayashi; Kayoko Tahara; Mitsuko Takenaga; Naoki Yamakawa; Tsutomu Ishihara; Tadashi Kasahara et al.
Source: Self-asserted source
Yasunobu Yamashita

Peer review (5 reviews for 3 publications/grants)

Review activity for Bioorganic & medicinal chemistry. (1)
Review activity for Biophysical chemistry. (2)
Review activity for Journal of medicinal chemistry. (2)